LOCUS       NM_001415791            4968 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus pleckstrin homology and RhoGEF domain containing
            G2 (Plekhg2), transcript variant 1, mRNA.
ACCESSION   NM_001415791 XM_039104091
VERSION     NM_001415791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4968)
  AUTHORS   Edvardson,S., Wang,H., Dor,T., Atawneh,O., Yaacov,B., Gartner,J.,
            Cinnamon,Y., Chen,S. and Elpeleg,O.
  TITLE     Microcephaly-dystonia due to mutated PLEKHG2 with impaired actin
            polymerization
  JOURNAL   Neurogenetics 17 (1), 25-30 (2016)
   PUBMED   26573021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 30, 2022 this sequence version replaced XM_039104091.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-710               JAXUCZ010000001.1  92791901-92792610   c
            711-841             JAXUCZ010000001.1  92791154-92791284   c
            842-1101            JAXUCZ010000001.1  92790300-92790559   c
            1102-1202           JAXUCZ010000001.1  92790121-92790221   c
            1203-1269           JAXUCZ010000001.1  92788706-92788772   c
            1270-1316           JAXUCZ010000001.1  92788561-92788607   c
            1317-1467           JAXUCZ010000001.1  92788169-92788319   c
            1468-1605           JAXUCZ010000001.1  92787858-92787995   c
            1606-1806           JAXUCZ010000001.1  92787514-92787714   c
            1807-1899           JAXUCZ010000001.1  92785141-92785233   c
            1900-1986           JAXUCZ010000001.1  92784968-92785054   c
            1987-2020           JAXUCZ010000001.1  92784591-92784624   c
            2021-2122           JAXUCZ010000001.1  92784398-92784499   c
            2123-2170           JAXUCZ010000001.1  92784257-92784304   c
            2171-2206           JAXUCZ010000001.1  92784142-92784177   c
            2207-2223           JAXUCZ010000001.1  92783970-92783986   c
            2224-2400           JAXUCZ010000001.1  92782659-92782835   c
            2401-3301           JAXUCZ010000001.1  92781640-92782540   c
            3302-4968           JAXUCZ010000001.1  92779449-92781115   c
FEATURES             Location/Qualifiers
     source          1..4968
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..4968
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /note="pleckstrin homology and RhoGEF domain containing
                     G2"
                     /db_xref="GeneID:292750"
                     /db_xref="RGD:1310112"
     exon            1..710
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            711..841
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     CDS             733..4770
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pleckstrin homology domain-containing family G member 2;
                     pleckstrin homology domain containing, family G (with
                     RhoGef domain) member 2"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family G
                     member 2 isoform 1"
                     /protein_id="NP_001402720.1"
                     /db_xref="GeneID:292750"
                     /db_xref="RGD:1310112"
                     /translation="MPEGARGLSLSKPSLRLGCGHQGEVCDCAAVSDTPTAAPAAPNM
                     ASPRGSGSSTSLSTVGSEGDPSPACSASKPEPLPEPPIRLHLSPVGIQGSVKLSMLER
                     VAREIVETERAYVRDLRSIVEDYLGPLMDGRALGLNVEQVGTLFANIEDIYEFSSELL
                     EDLEGCSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPATVWLQERQA
                     QLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPDTGGREMVEEAIVSMTAVAWY
                     INDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGTFRGGGGGGPRLRGGERLL
                     FLFSRMLLVAKRRGPEYTYKGHIFCCNLSVSETPRDPLGFKVSDLTIPKHRHLFQAKN
                     QEEKRLWIHCLQRLFFENHPASIPAKAKQVLLENSLHCAPKSKHIPEPPTSPLDSPRP
                     RDARSFTPSRRNPAPSPRLSGSRRGRRQSESKDPYVILPQNDKPQVKHAGSEGELHPP
                     SELQPPVTAPGPPEDLEDAGPPTLDPSGTSITEEILELLNQRGLRDSGPATHDIPKFP
                     RDSRVPVESETLPFQALPSRESSEEEEDEELEKDEREPSPLHVLEGLEGSSAAEVPCI
                     PSLPKIPSDMPDLPEIPEAPCLPSLSDIPGVFEVPCLSPMSSVPDIPSLANTPSFPCG
                     SWLPGPLQEAAQSQATRRELLTGSNLGRLSEPPSESRAGQEEDTEGVSFPAVQTQDGT
                     PVQGFPEELEYRSCSEIRSAWQALEQGQLARPGFPEPLLILEDSDLSGGSTSGKTRMP
                     HSERSASRVRELARLYSERIQQMQRAETRASTNAPRRRPRVLAQPQPCPCPPQEEAEP
                     GALPAFGHVLVCELAFPLNCAQESVPLGPAALVQAATPLCTQGDDLSGQSLTVSDLPK
                     QGHLSNNCIPPPVPLPGQSNFQSLQVPSASLLPKQDPPDVQLPTASTLPDTGQLQVPA
                     AAPSTEHRNYVEIQVQSTTTSLPGQECPADFQMPTTAALPRQEGHEDSRSPNSAPGAE
                     QRDVGVDQGPTAVDGQAVSPLPACTSSPDHHQIPATPLPLSPDLPDMEGAGALPLPAQ
                     QGHPDCCVPCDPLPSLPQDVQTPTVIPMSQPQGLTDVRAKVPPSFPTQEEAPEFLGPE
                     PSLTDTPAPRLLPSSGQQNTTDGHVSTAAVPCPEQGCPQDIQGLITSPVQTTMELPKP
                     RGLVSRVATSESLDLTPPHSPSLSTRQLLGPSAAALSRYLAASYISQSLARRQGPGGE
                     GMAASQGHWSSSAPTSRAPSPPPQPQPPAPPARRLSYATTVSIQVGGGGRLRPARAQV
                     RLNHPALLAAPHPGAFGPSQGPEGS"
     exon            842..1101
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1202
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1269
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1316
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1467
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1605
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1806
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1899
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..1986
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2020
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2122
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2170
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2206
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2223
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2400
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..3301
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..4968
                     /gene="Plekhg2"
                     /gene_synonym="RGD1310112"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatacggcg ccgcccccag agccccagga cactcattcg ggagcccgag gcgtccatag
       61 tgtcggaccc aggcgtccgg gacctctgtc ccgcgtctta agagacccgc aagtcctggc
      121 tcccgtgcag agtccgggac ctgatgccca gcgccccctt ctggaggagg cgggggctcg
      181 ggaagtcagc cccgaggctg gaggccggtc ccgcgcccgg cttcgaagac cgtaggattt
      241 gtggccgtgc atccctgcca tggggtccca actctgagtc cgagaccccc tcctggagcc
      301 acttggggac aggatctcgc gcctcgactt agggctgcaa catccatcac ctccaggaga
      361 ccgagagtta gccagtcctt gcggtccctc ccggaggtga cttcatccca gcccctcggg
      421 ttctggaaac tctggagtcc cggtgccccc cgacaacaca cagccctacc tagaagactg
      481 aggaatttgg gtccccagcg ccctgttctg agactcgagt agagggttgc agcatcttct
      541 aattagaaca ccaagacttc ggactccgga tcccaactct ccccggattc tggagtccaa
      601 gaaccccaag ttcacgacct taagcctggg ttgtgagcct cccccgggac cgcgcgttac
      661 cgtgcagacg cgcgggactc ccgacctcaa ggcccgtggc tcccccggag gtccgagttg
      721 tgcccctcag ccatgccaga gggagcccgg ggactcagcc tgtccaaacc cagccttagg
      781 ctcgggtgtg gtcaccaagg tgaagtttgc gactgcgcag ctgtgagtga tactccaaca
      841 gcagctcccg cagcccccaa catggcttct ccaaggggct ctggcagctc cacctctttg
      901 agcaccgtgg gctctgaggg ggacccatct ccagcttgct cagcctccaa gccagagccc
      961 ctgccagagc cccccatacg cctgcacctg tcgccagtgg ggatccaggg gtcagtgaaa
     1021 ctgtccatgc tggaacgagt ggccagggag attgtggaga cagagcgggc atatgtccgg
     1081 gaccttcgca gcatcgtgga ggattacctg ggccctctga tggatggcag ggccctaggg
     1141 ctgaacgtgg agcaggtggg cactctgttt gcaaacatcg aggacatcta tgagtttagc
     1201 agtgagctcc tggaggactt ggagggctgc agcagtgcag ggggcatcgc cgagtgcttc
     1261 gtgcaaagga gcgaagattt tgacatctac acattgtact gcatgaacta cccgagctcc
     1321 ctggccctgc tccgagagct gtcactgtcc ccgccagcca ctgtgtggct gcaggagcgt
     1381 caggcccagc tccgtcactc cctgcctctg cagagcttct tgctgaagcc tgttcagcgc
     1441 atcctgaagt accatctcct gctgcaggaa ctgggcaagc actgggcaga aggcccagac
     1501 accggagggc gagagatggt ggaggaagcc atcgtgtcca tgaccgcagt ggcctggtac
     1561 atcaatgata tgaagcgcaa gcaagagcac gcagcacgcc tgcaggaagt gcagcggcgg
     1621 ctgggtggct ggactggccc ggagctcagt gcctttggag agctggtcct ggaaggcacc
     1681 ttccgtgggg gaggcggggg aggcccaagg cttcgtgggg gcgagcgcct gctcttcctg
     1741 ttctcccgaa tgctgctggt agccaagcgt cgggggcctg aatacaccta caagggtcac
     1801 atcttttgtt gtaacctgag tgtaagcgag actcctcgag atcccctagg atttaaggtg
     1861 tcagacctga ccatccccaa gcacagacac ctgtttcagg ccaagaacca agaagagaag
     1921 cggttgtgga tccactgtct ccagcgcctc ttcttcgaga accacccggc ttccatccct
     1981 gccaaggcaa agcaagttct cttggaaaac agcctgcact gtgccccaaa aagcaaacac
     2041 atcccagaac ccccaacatc ccctctggac tctccccgac ctcgagatgc tcgaagtttt
     2101 acccccagca gaaggaaccc agctccatct ccaagacttt ctggcagtcg ccgtggccgc
     2161 aggcagtctg agtcaaagga cccttatgtc atccttcccc agaacgataa gcctcaagtc
     2221 aagcatgctg gcagtgaagg tgaactccat cccccatctg agttgcagcc accagtaact
     2281 gctcctggtc cccctgaaga cctggaggat gctgggcccc ccacattgga cccatcgggg
     2341 acgtccataa ctgaggaaat tctagaactg ctgaaccaga gaggcctcag ggactcgggg
     2401 ccagccaccc acgacattcc caagttcccc agagactcca gggtgcccgt tgaaagtgaa
     2461 accctcccgt tccaagctct gcccagccga gagtcttcag aagaggagga ggatgaagag
     2521 ctggagaaag atgaacggga gccttccccg ctccatgtct tagaggggct ggaaggttcc
     2581 agtgcagctg aagttccctg cattcccagc cttcctaaga ttcccagtga catgcccgac
     2641 cttccagaaa ttcccgaggc tccctgcctt ccaagtctct ctgatatccc tggtgttttt
     2701 gaggtgccct gtctttcacc catgtccagt gtgcctgaca ttcccagctt ggccaacacc
     2761 ccgtccttcc cctgtggctc ctggctccct ggacccctgc aggaggcagc ccagtctcaa
     2821 gccaccagga gggaactgtt gactgggagc aacctgggaa gactgagtga gccaccctca
     2881 gaaagcagag ccgggcagga ggaagacaca gaaggcgtgt ccttcccagc tgtgcagacc
     2941 caggatggca ccccagtcca aggattcccg gaagaactgg aataccgctc ctgttcagaa
     3001 atccggagtg cctggcaagc actggagcag gggcagctgg cccggcctgg cttcccagaa
     3061 cctctgctga tcctggagga ctctgatctt agtggaggca gcaccagtgg gaagacaaga
     3121 atgccacatt cagagcggtc agcgtcacgg gtgcgagagt tggctcggct ctacagcgag
     3181 cggatccagc agatgcagcg agctgagact agggcatcca ccaatgcacc ccgccgcaga
     3241 cctcgagtcc tggcccaacc ccagccatgc ccttgcccac cccaggaaga ggctgaacca
     3301 ggagccctgc ctgcatttgg acatgtgctt gtatgtgagc tggccttccc actgaactgt
     3361 gcccaggagt ctgtccctct gggccctgct gctctggttc aagctgccac acctttgtgt
     3421 acacaaggag atgacctgag tggccagagt ctgactgttt cagatttgcc caagcaaggc
     3481 catctgagta ataactgcat tccacctcct gtccctttgc ctgggcaaag caacttccag
     3541 agcctccagg ttccatctgc atcccttttg cccaagcaag atcctccaga tgttcagctc
     3601 ccaactgcct caaccttgcc tgatacaggt cagctgcaag ttccagctgc ggctccttca
     3661 actgagcata gaaactatgt ggagatccag gttcagtcca ccaccacttc ccttcctggc
     3721 caagagtgtc cggcagactt tcagatgcca accactgcgg cattgcccag gcaagaaggt
     3781 catgaagaca gccgaagccc aaacagtgct ccaggagccg agcaaagaga tgtcggcgtc
     3841 gatcagggcc ccactgctgt tgatggccaa gctgtcagcc ctctgccagc gtgcacaagc
     3901 agccctgacc atcatcagat cccagccact ccgctgccat tgtcacctga cctcccagac
     3961 atggagggtg ctggtgcctt acctctgccc gcacagcaag gtcatccaga ctgctgcgtc
     4021 ccatgcgacc ctctaccatc tctgccccaa gacgttcaga cgccaacggt catccccatg
     4081 tcccagcctc aaggccttac agacgtcagg gccaaagtgc ccccgtcttt ccccacacag
     4141 gaggaagctc cagagtttct gggtccagag cccagcctca cagacacccc agctcccaga
     4201 ctcttacctt catcaggcca acagaacacc acagatggcc atgtttcaac agctgccgtg
     4261 ccttgccctg aacaaggatg ccctcaagat attcaaggcc taataacttc cccggtccag
     4321 acgaccatgg agctacccaa accaaggggt ttagtctctc gggttgccac ttcagagtct
     4381 ctggacttga ccccgccaca tagcccctcg ctgtccactc gccagctcct gggacccagc
     4441 gcagctgccc tctcaaggta cctggcagct tcgtacatca gccagagctt ggctcggcgc
     4501 cagggccctg ggggagaggg catggcagcc tcccagggtc actggtcctc ctctgccccc
     4561 acatcacggg caccttcacc cccacctcag ccccagcccc cagctcctcc agctaggagg
     4621 ctcagctatg ccaccacagt gagcattcag gtaggaggtg gtgggaggct acgaccagct
     4681 agagctcagg tccggctaaa ccaccctgct ctcttggcag ccccccaccc aggagccttc
     4741 gggccttccc agggcccaga aggctcctga tactactttt catatgtaag cctggacact
     4801 ggcttcaaga acattcacca ggtgccaccc atccctatga catccagagt ctggacatgg
     4861 gtccagaaat ggctgtagct ttctagctcc aggaatctgc ccacagatgg ccctcctgag
     4921 ggcgtggtta ttttgttaat tttataaaat gctgtggttt tgactttc
//
