LOCUS       NM_139340               4792 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus pleckstrin homology domain containing A5
            (Plekha5), mRNA.
ACCESSION   NM_139340 XM_001073627 XM_342781
VERSION     NM_139340.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4792)
  AUTHORS   Pandya,N.J., Koopmans,F., Slotman,J.A., Paliukhovich,I.,
            Houtsmuller,A.B., Smit,A.B. and Li,K.W.
  TITLE     Correlation profiling of brain sub-cellular proteomes reveals
            co-assembly of synaptic proteins and subcellular distribution
  JOURNAL   Sci Rep 7 (1), 12107 (2017)
   PUBMED   28935861
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4792)
  AUTHORS   Yamada,K., Nomura,N., Yamano,A., Yamada,Y. and Wakamatsu,N.
  TITLE     Identification and characterization of splicing variants of PLEKHA5
            (Plekha5) during brain development
  JOURNAL   Gene 492 (1), 270-275 (2012)
   PUBMED   22037487
REFERENCE   3  (bases 1 to 4792)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   4  (bases 1 to 4792)
  AUTHORS   Lim,P., Robson,M., Spaliviero,J., McTavish,K.J., Jimenez,M.,
            Zajac,J.D., Handelsman,D.J. and Allan,C.M.
  TITLE     Sertoli cell androgen receptor DNA binding domain is essential for
            the completion of spermatogenesis
  JOURNAL   Endocrinology 150 (10), 4755-4765 (2009)
   PUBMED   19574395
REFERENCE   5  (bases 1 to 4792)
  AUTHORS   Wayne,C.M., MacLean,J.A., Cornwall,G. and Wilkinson,M.F.
  TITLE     Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2,
            selectively expressed in the testis
  JOURNAL   Gene 301 (1-2), 1-11 (2002)
   PUBMED   12490318
REFERENCE   6  (bases 1 to 4792)
  AUTHORS   Han,X.B., Zhou,X.C., Hu,Z.Y., Zhang,Z.H. and Liu,Y.X.
  TITLE     Cloning and characterization of temperature-related gene TRS1
  JOURNAL   Arch Androl 48 (4), 273-280 (2002)
   PUBMED   12137588
  REMARK    GeneRIF: cloning and characterization; mainly expressed in
            spermatocyte and round spermatids in testis; expression level
            decreased in cryptorchid testis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Feb 10, 2021 this sequence version replaced NM_139340.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               JAXUCZ010000004.1  175065183-175065368
            187-266             JAXUCZ010000004.1  175065493-175065572
            267-324             JAXUCZ010000004.1  175067713-175067770
            325-408             JAXUCZ010000004.1  175160717-175160800
            409-529             JAXUCZ010000004.1  175161899-175162019
            530-634             JAXUCZ010000004.1  175162510-175162614
            635-707             JAXUCZ010000004.1  175164499-175164571
            708-808             JAXUCZ010000004.1  175170578-175170678
            809-924             JAXUCZ010000004.1  175173931-175174046
            925-942             JAXUCZ010000004.1  175174338-175174355
            943-1410            JAXUCZ010000004.1  175180661-175181128
            1411-1873           JAXUCZ010000004.1  175187962-175188424
            1874-1957           JAXUCZ010000004.1  175190036-175190119
            1958-2077           JAXUCZ010000004.1  175193259-175193378
            2078-2131           JAXUCZ010000004.1  175194141-175194194
            2132-2212           JAXUCZ010000004.1  175202859-175202939
            2213-2248           JAXUCZ010000004.1  175207804-175207839
            2249-2311           JAXUCZ010000004.1  175208335-175208397
            2312-2392           JAXUCZ010000004.1  175209103-175209183
            2393-2542           JAXUCZ010000004.1  175209317-175209466
            2543-2644           JAXUCZ010000004.1  175212506-175212607
            2645-2756           JAXUCZ010000004.1  175215689-175215800
            2757-2803           JAXUCZ010000004.1  175217817-175217863
            2804-2992           JAXUCZ010000004.1  175218765-175218953
            2993-3113           JAXUCZ010000004.1  175220269-175220389
            3114-3229           JAXUCZ010000004.1  175221769-175221884
            3230-3439           JAXUCZ010000004.1  175224331-175224540
            3440-3580           JAXUCZ010000004.1  175227868-175228008
            3581-3708           JAXUCZ010000004.1  175228536-175228663
            3709-3845           JAXUCZ010000004.1  175229961-175230097
            3846-3948           JAXUCZ010000004.1  175231760-175231862
            3949-4792           JAXUCZ010000004.1  175233829-175234672
FEATURES             Location/Qualifiers
     source          1..4792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..4792
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /note="pleckstrin homology domain containing A5"
                     /db_xref="GeneID:246237"
                     /db_xref="RGD:621175"
     exon            1..186
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3940
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /note="phosphoinositol 3-phosphate-binding protein 2;
                     pleckstrin homology domain containing, family A member 5"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 5"
                     /protein_id="NP_647556.1"
                     /db_xref="GeneID:246237"
                     /db_xref="RGD:621175"
                     /translation="MAADLNLEWICSLPRSWTYGITRGGRVFFINEEAKSTTWLHPVT
                     GEAVVTGHRRQSTDLPTGWEEAYTFEGARYYINHNERKVTCKHPVTGQPSQDNCIFVV
                     NDQTVATMTSEEKKERPISMINEASNYNMASDYTVHPMSPVGRTSRASKKVHNFGKRS
                     NSIKRNPNAPVVRRGWLYKQDSTGMKLWKKRWFVLSDLCLFYYRDEKEEGILGSILLP
                     SFQIAMLTAEDHINRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAMLDAALVQTEPVK
                     RITFNFRVDKITTESASTKETNNIPNHRVLIRPEVQNNQKNKEISKIEEKRALEAERY
                     GFQKDGQDRPLTKINSVKLNSLPSEYESGPACPPQNIHYRPINVNNSDSKAVNVSLAD
                     VRGGSHPNTGPLATEADRVIQRTNSMQQLEQWIKVQKGRGLEEEPRGVISYQTLPRNM
                     PSHRAQILARYPEGYRTLPRNSKTRPESICSVTPSGHEKTGPGAEEKRRSMRDDTMWQ
                     LYEWQQRQFYHKQSTLPRHSCLSSPKAMGKVSDQTMHSIPTSPSHVPAAAYQGFSPQR
                     TYRSEVSSPIQRGDVTIDRRHRPHHPKHVYVPDRRSMPAGLALQAVSPQSLHGRTPEE
                     LTLLLIKLRRQQAELSSIREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKE
                     NEPIITMVHTMIENSALRPQLYQQFLRQKNKISLYCLSQDECRGTLYKYRPEEVDIDA
                     KLSRLCEQDKVVRALEEKLQQLHKEKYTLEQALLSASQEIEMNADNPAAIQTVVLQRD
                     DLQNGLLSTCRELSRATAELERAWREYDKLEYDVTVTRNQMQDQLDRLGEVQSESAGI
                     QRAQIQKELWRIQDVMEGLSKHKQQRGSSETGLAGPKPFPAVKYKSEEEEVVPPRPPL
                     PRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKSHQVQGYPRNGSHCGPDYRL
                     YKSEPELTTVAEVDESNGEEKSEPASEAEAPVVRGSHFPVGVPLRTKSPTPESSTIAS
                     YVTLRKTKKMVELRTERPRSAVEQLCLAESTRPRMTVEEQLERIRRHQQACLREKKKG
                     LNVLSASDPSPSQSPSSVRDSPSRVPQTVRRDDNTKELDAVHRENDGKPDYDTSAAET
                     AHPEEAEPQSADVGRKLKRTESIFYEMLYTPEPLNGLTSEEVMAKERQEEQVPEGAVC
                     SLQEEAAMANHQAEGPPEEAESLHEEEEALASCEPAPETPRENQTTVKSLSPSPDSST
                     AADPPTPPQLTEGSHFMCV"
     exon            187..266
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..324
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..408
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..529
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..634
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..707
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..808
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..924
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..942
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1410
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1873
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1957
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2077
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2131
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2212
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2248
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2311
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2392
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2542
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2644
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2756
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2803
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2992
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2993..3113
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3229
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3230..3439
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3580
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3581..3708
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3845
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..3948
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
     exon            3949..4792
                     /gene="Plekha5"
                     /gene_synonym="Pepp2; TRS1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggttcgctc gctcgctcgc tcgctcgctc gcgccctcct tcctcagcag cggcggcagc
       61 ggcggcacaa ggcggcggcg gccggggagc agacatggcg gccgacctga acctggagtg
      121 gatttgttcg ctgccgcgct cctggacgta cgggatcact aggggcggcc gcgtcttctt
      181 catcaacgag gaggccaaga gcaccacctg gctgcacccg gtcaccggcg aggccgtggt
      241 caccgggcac cggcggcaga gcacagattt gcccactggc tgggaagaag catatacatt
      301 tgaaggcgca agatactata taaaccacaa tgaaaggaaa gtaacctgca agcatccagt
      361 cacaggacag ccatcccagg acaactgtat ctttgtcgtg aatgaccaga ctgttgcaac
      421 catgacatct gaagaaaaga aggagcgacc cataagtatg ataaatgaag cttccaatta
      481 caacatggct tcagactata ctgtgcatcc tatgagcccc gtgggcagga catcacgggc
      541 ctccaaaaag gttcataatt ttgggaaaag gtccaattca attaaaagga accctaatgc
      601 ccctgtggtc aggcgcggct ggctgtataa gcaggacagc accggcatga agctgtggaa
      661 gaagcgctgg tttgtgcttt ctgacctttg ccttttttac tacagagatg agaaggagga
      721 gggtattttg ggaagcatcc tgctgcccag ttttcagata gccatgctta ctgccgagga
      781 ccacatcaat cgcaaatatg cttttaaggc agcccaccca aacatgcgga cctattattt
      841 ctgcactgat acaggcaagg aaatggagct atggatgaag gccatgttag atgctgctct
      901 ggtgcagaca gaacctgtga aaagaattac ctttaatttc cgagtggaca agattacaac
      961 agaaagtgca tcaactaaag aaaccaataa cattcccaac cacagagtcc tcattagacc
     1021 tgaggtccaa aacaatcaga aaaataagga aataagcaaa attgaagaaa aaagggcctt
     1081 agaagctgaa agatacgggt ttcagaagga tgggcaagat agaccattaa caaaaattaa
     1141 cagtgtaaag ttgaactcgc tgccatcaga atatgaaagc gggccagcct gcccacctca
     1201 gaatatacac tacagaccca tcaatgtgaa taattctgac agcaaagcag tgaatgtcag
     1261 cttggcagat gtccggggtg ggagtcaccc aaatacaggg cccctagcca cagaagctga
     1321 tcgagtcatt cagagaacga attcaatgca gcagctggag cagtggatta aagttcagaa
     1381 aggacggggt cttgaagagg agcccagagg agtaatttct tatcaaacat tgccaagaaa
     1441 tatgccaagc caccgagccc agattctggc ccgctaccct gaaggttacc gaacactccc
     1501 aagaaacagc aagaccagac cagagagtat ctgcagtgta acgccttctg gtcatgagaa
     1561 gacagggcct ggggcagagg agaagcggcg gtccatgagg gatgacacca tgtggcagct
     1621 gtatgagtgg cagcagcgcc agttttacca caagcagagc accctccctc ggcacagctg
     1681 cctgagcagc cctaaagcca tggggaaggt ttctgaccag acaatgcact ccatccccac
     1741 gtcaccgtcc catgtgccag ctgctgctta ccagggcttc tcccctcagc ggacatacag
     1801 gtcagaagtg tcctcgccaa tccagagagg agatgtgaca atagaccgca ggcacaggcc
     1861 tcatcaccct aagcatgtct atgtacctga cagaaggtca atgccggctg gcttagcctt
     1921 acaggctgtt agtcctcaga gcctccacgg caggacgcca gaggagctta cgctgctgct
     1981 gataaagctg agacggcagc aagcagagct gagtagtatc cgggagcaca ccttagcaca
     2041 gctcatgcag ctgaaactcg aggcccacag cccgaagaat gaaattcttt cacatcatct
     2101 tcaaaggaac accatatatt tggatcatca gatgaaagaa aatgaaccta ttatcaccat
     2161 ggttcacacc atgattgaga actcggcgct aagaccacaa ctgtaccaac aattcttaag
     2221 acagaagaac aagataagtc tctattgtct ctcacaagat gagtgtagag gcacattata
     2281 caaatacaga cctgaggaag tagatatcga tgccaaatta agccgattgt gtgaacagga
     2341 taaggtggtc cgtgcactgg aggagaagct gcagcagctg cacaaggaga aatacacgct
     2401 tgagcaagcc ttgctgtcag ccagccaaga gatagagatg aatgcagata acccagccgc
     2461 cattcagacg gtggtgctgc agagggacga cctgcagaac gggctgctga gcacgtgtcg
     2521 ggaactctcc cgagccaccg ctgagctgga acgagcctgg agagaatatg acaagttaga
     2581 atatgatgtg actgttacca ggaaccagat gcaagatcag cttgatcgcc ttggagaagt
     2641 gcagagtgag tcggcaggaa ttcaacgggc acagattcaa aaagaacttt ggagaattca
     2701 agatgtcatg gaggggttga gcaaacacaa acagcaaaga ggctcttcag aaacaggtct
     2761 ggcaggacca aagcctttcc cagcagttaa gtacaaaagc gaggaagagg aagtagtccc
     2821 acctcggcct ccacttcctc ggtcttatga ctttacagag cagcctccca taatcccccc
     2881 tctgcccagt gatagcagct ccttgctctg ttatagcagg ggccccgtgc atctgcctga
     2941 agaaaagaag agtcaccaag ttcaaggata tccaagaaat ggatctcact gtggtccaga
     3001 ttatagactc tacaagagcg agccagagtt gaccacagtg gcagaagttg atgaatctaa
     3061 tggagaagaa aaatcagagc cagcttctga ggcagaagct ccggttgtta gaggttccca
     3121 ctttccagtt ggagttcctc tgagaacgaa gtcacctaca cctgagtcct caacgatagc
     3181 ttcctatgtg accttgagga agacgaagaa gatggtggag ctaagaacgg aaagaccgag
     3241 aagtgccgtg gaacagctct gtctggcgga aagtactcgg cctcggatga ctgtggaaga
     3301 gcagctggag agaatcagga ggcaccagca ggcctgcctg agggagaaga agaaggggct
     3361 gaacgtcctc agtgcatccg acccatctcc ctcacaaagt ccttcaagcg tgagggacag
     3421 tccttccaga gttcctcaga ctgtaaggag ggatgataac actaaggagc tagacgccgt
     3481 ccacagagaa aatgatggaa agccagacta tgacacttca gcagcagaaa ctgctcaccc
     3541 agaagaagct gaaccccaaa gtgcagatgt cggccgaaag ctaaagagaa ctgaaagtat
     3601 tttttatgaa atgctttaca cgcctgaacc tttaaatgga ctgacttctg aggaagtgat
     3661 ggctaaggag aggcaggaag agcaggtgcc tgaaggtgcc gtgtgcagcc ttcaggaaga
     3721 ggctgccatg gcaaaccatc aggcagaagg cccccctgag gaagcagaga gtcttcatga
     3781 agaggaggaa gctctggctt cctgtgagcc agctcctgag actcctaggg agaatcaaac
     3841 cacagtgaaa agtctgtctc cgtctcctga ctcctccacg gcagcagacc cgcccactcc
     3901 gccccagctc acagaaggat cacatttcat gtgtgtgtag tctcagaacc gcattgccgt
     3961 ctgtggagag cacacagagc tgaagccgtg gacggaccct cagtggtgta agaagatgta
     4021 cagtatacct taaatctatg aaattcatag ttcagatgct tctgaccaca gagcatcatt
     4081 ttatcacctt tggaaaatgt ttattccaaa atagctttaa tggcccgtat gtgcactccc
     4141 tccttagtgt caaggtcacc gtcctccaca ggctgcttca gttcagagcc tcagtcagct
     4201 gctttctccc ccgcgccgct ccatgcagag cttgcttggt tgcagtcccc acatttggat
     4261 gcttaagtct cagtgaactt ggctttcttt tgcttctcag tgagcctacc ctttcctgtg
     4321 aggcttattt gctttgtttt ttttttcttc cctttttggc ttctgcagtg cttcgtttga
     4381 cacttgattt gtaaaaattt tatataaata tatttaaaat gtgccatttt atcactgcta
     4441 agtgaagtct gtcctgttct cggctcgggc ctcctcagtg agactgcacc gtcagcagtt
     4501 ctgccgcgct ccgtctgctc cacaagtgct gctgctcagc ttttccgtgg agagccaaac
     4561 aattccaagt gtgggtattt tgaagtactg gacattacgt cacggggcta gacgtgtcca
     4621 gcaataagcg ggcttctaga gcccgtgctt ggtctgtgta cagatgtaat atgttcattg
     4681 tgcggacgtc acacagtgag cacatgtaat aaggctgcgg actatagtct gatgcaaatg
     4741 ttcatagctc atttcttttt tatcatgtta aataaatgtt gatgttctta aa
//
