LOCUS       NM_199101               2833 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus pleckstrin homology domain containing A4
            (Plekha4), mRNA.
ACCESSION   NM_199101 XM_218650
VERSION     NM_199101.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2833)
  AUTHORS   Shami Shah,A., Batrouni,A.G., Kim,D., Punyala,A., Cao,W., Han,C.,
            Goldberg,M.L., Smolka,M.B. and Baskin,J.M.
  TITLE     PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate
            Wnt and Planar Cell Polarity Signaling
  JOURNAL   Cell Rep 27 (7), 2157-2170 (2019)
   PUBMED   31091453
REFERENCE   2  (bases 1 to 2833)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061738.1.
            
            On Jan 1, 2004 this sequence version replaced XM_218650.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2833
                     /gene="Plekha4"
                     /note="pleckstrin homology domain containing A4"
                     /db_xref="GeneID:308584"
                     /db_xref="RGD:735133"
     exon            1..259
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            260..349
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..2605
                     /gene="Plekha4"
                     /note="pleckstrin homology domain containing, family A
                     (phosphoinositide binding specific) member 4; PEPP-1;
                     phosphoinositol 3-phosphate-binding protein 1; PH
                     domain-containing family A member 4"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 4"
                     /protein_id="NP_954532.1"
                     /db_xref="GeneID:308584"
                     /db_xref="RGD:735133"
                     /translation="MEQGRPRSSLSLTSSASTVSSLSSLSAKKPTRVVHKVHAFGKRN
                     NALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLP
                     SYSVRPDGPGAPRGRRFTFTAEHPGMRTYVLAADTLEDLRGWLRALGKASRAEGEDCG
                     LPRSPARPRPGEGPGGPGGPPEVNRREEGRTSESPEVAPLSRGPGRHEMHAPGSSADL
                     QPDTWSRRTRSPEPFSPLSRPPSPLSLPRPRSAPVRRPPLSAGDISFPARPHTPLSRI
                     DVRPPLDWGPQRQTLSRPPIPRRGPFSEAGGGRPPRSPQLRTPEHRTQSTQVSSGSST
                     YLQLPPRPPGTQASMILLPGPPVDSTLHQSLETDTLLTKLCGQDRLLRQLQEDLDKRQ
                     EEKEQLEAALELTRQQLGQATREAAASGKAWGRQRLLQDRLVNVRAALCHLTQERERV
                     WDTYSGLEQDLGTLRETLEYLLHLGSPQDRASAQQQLWMVEDTLAGLGGPQKQPPHTE
                     PKSPSPAPQREESSERESLSESLELSSPQSPEVDWGQPPGGDRALSSSQSGVGSPRVS
                     RASSPECRQQSSPLLRTKAPLARPRMSAQEQLERMRRNQACGLSLPRPTSPRLLTLGR
                     TLSPVPRQPDMEQRPIVGAAKWLRSSGSWSSPRHSTTYSPVSGGHRERVLSLSQALAT
                     EASQWHRLMTASPERNLDTRGDCLQPSPQPPSEELPQVTSSPTSHKANSATTGFSCQG
                     SGRGLAPWEPRWDPGKAPPALAQEEGAWPLRVTLLQSSF"
     exon            350..457
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            458..530
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            531..631
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            632..741
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            742..957
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1237
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1321
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1369
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1450
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1600
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1699
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1840
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1940
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2017
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2179
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2229
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2342
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2803
                     /gene="Plekha4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcagcagt caggtaggga gagggactgg gagaggtgac ataggcagag gggaggggag
       61 agagagagag agagaggaag agacagagac accgagagac acagtgggag agacagaaag
      121 agacagagag gggggagaca gagagctcac aaaacagaga agaaaagaaa gcaagtatca
      181 ggtgaggaga ccaactctga gaggcagtgt ctaagacaca aaaagaggtg acatcctgtc
      241 accgggacac cagagctggc tctcgatgga gcagggccga cccaggagca gcctcagcct
      301 gaccagcagt gcttccactg tatcctccct gagcagcctg agcgccaaga agcctactcg
      361 tgtggtacac aaggtccatg cctttgggaa aaggaacaat gcacttcggc gagaccccaa
      421 cctgcctgtg cacattcgtg gctggctgca taaacaggat agctcaggcc tccggctgtg
      481 gaaacgccgt tggttcgtcc tttcaggcca ttgcctcttc tactacaagg acagcagaga
      541 agagagtgtc ctgggcagtg tactgttacc cagctacagt gtcaggccgg atgggccagg
      601 agccccacga ggccggcgat tcaccttcac ggcagagcac ccgggcatga ggacctatgt
      661 ccttgcagct gacacattgg aagacctgag aggttggctt cgagcactgg gaaaggcctc
      721 tcgtgcagag ggggaagatt gtggactacc gaggtcccct gcacgtccca ggcctgggga
      781 aggtcccggg ggtcccggag gaccccccga ggtgaacaga agggaagagg ggcgaacctc
      841 agaatcacca gaggtagctc cgctctccag aggtcctggc agacatgaaa tgcacgctcc
      901 cggctcttca gctgatctgc agcctgacac ctggagtcgg agaaccagga gcccagagcc
      961 gttctcaccc ctctcccggc ctccctcccc tctgagcctt ccccgtcctc gttctgctcc
     1021 ggtcaggcga ccacctctct cagcaggaga catttcattt cctgctcgac cgcacactcc
     1081 cttgagtcgc atcgatgtcc gacctcctct ggattgggga ccccaaagac agaccctctc
     1141 ccgacctccc attccacgcc gaggaccttt ctctgaagca ggcggaggac ggccacccag
     1201 gagcccccag ctccggacac cagagcatag aacacagtct acccaggtct cctctggttc
     1261 atccacctac ctccagctgc ccccaagacc ccctggcacc caggcttcca tgattttgct
     1321 gccaggaccc cctgtggact caactttgca tcagagcttg gagacagata ctttgttgac
     1381 caagctgtgt gggcaggacc ggctcctgag gcagctacaa gaggatctgg acaagaggca
     1441 ggaagagaag gagcagctag aggcagcctt ggagctgacc cggcagcagc tgggtcaggc
     1501 tacccgggag gctgcagctt ctgggaaggc ctggggtcgc caacgcctcc tgcaggaccg
     1561 gctggtgaat gtgagggctg ctctgtgtca cctgactcag gagcgagagc gggtttggga
     1621 cacgtacagc ggcctggagc aggatctcgg cacgttaaga gagactctcg agtacctgct
     1681 gcacctcggg tctccccagg accgtgcgtc tgcccagcag cagctgtgga tggtggagga
     1741 cacattggca ggtctaggtg gcccccagaa acagccccca catactgagc ccaagtctcc
     1801 atcccctgca ccccaacgag aggagtcctc agagcgggag agcctttcag agtcactgga
     1861 gctcagctcc cctcagtccc ctgaggtgga ctggggtcaa cccccaggag gtgacagagc
     1921 cctcagcagc tctcagtcag gtgtcgggtc tccaagagtc tcccgggcat ccagccctga
     1981 atgtcgccaa cagtcatctc cgctgctgag aactaaggcc ccgctggcgc ggcctaggat
     2041 gagcgctcag gagcagctgg agcgcatgcg tagaaaccaa gcatgtgggc tctctcttcc
     2101 tcgccctacc tccccaaggc tcctgaccct gggaaggaca ctatccccag ttccacgcca
     2161 gcctgacatg gagcagaggc ctattgtagg agctgcgaaa tggctcagga gttccgggtc
     2221 atggagtagt cctaggcact ccacaaccta ctcacccgtg tctggaggcc accgggaacg
     2281 agtgctcagc ctctcccaag ctcttgctac agaggcttcc cagtggcaca ggctgatgac
     2341 agcctctcca gagagaaatt tggacaccag gggagactgt ctccagccaa gtccacagcc
     2401 tcccagtgaa gagctgcccc aggtcacctc gtccccaact tctcacaagg ctaactcggc
     2461 taccacaggg ttctcatgcc aagggagtgg gagaggcctg gctccgtggg agcccaggtg
     2521 ggaccctggg aaggcccctc cagctctggc ccaggaagag ggggcatggc ccctgagagt
     2581 cactctgctg cagtccagct tttgactcct gcctttgcac tgggtgctaa aggctggaag
     2641 cacaaccttg aggtgtggga ccattcagga ccacagggga gaggttcatt tcagcctgtg
     2701 ttctaggagg gccggggcta tgatggtcaa agattgatta tcccaacact gtccgaactt
     2761 ggattaaaac tttgaactag tcaataaata gctttattct ctcaaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa aaa
//
