LOCUS       NM_001415980            3538 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus pleckstrin homology domain containing A1
            (Plekha1), transcript variant 1, mRNA.
ACCESSION   NM_001415980 XM_039083148
VERSION     NM_001415980.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3538)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 3538)
  AUTHORS   Schmahl,J., Rizzolo,K. and Soriano,P.
  TITLE     The PDGF signaling pathway controls multiple steroid-producing
            lineages
  JOURNAL   Genes Dev 22 (23), 3255-3267 (2008)
   PUBMED   19056881
REFERENCE   3  (bases 1 to 3538)
  AUTHORS   Manna,D., Albanese,A., Park,W.S. and Cho,W.
  TITLE     Mechanistic basis of differential cellular responses of
            phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol
            3,4,5-trisphosphate-binding pleckstrin homology domains
  JOURNAL   J Biol Chem 282 (44), 32093-32105 (2007)
   PUBMED   17823121
REFERENCE   4  (bases 1 to 3538)
  AUTHORS   Schmahl,J., Raymond,C.S. and Soriano,P.
  TITLE     PDGF signaling specificity is mediated through multiple immediate
            early genes
  JOURNAL   Nat Genet 39 (1), 52-60 (2007)
   PUBMED   17143286
REFERENCE   5  (bases 1 to 3538)
  AUTHORS   Hogan,A., Yakubchyk,Y., Chabot,J., Obagi,C., Daher,E., Maekawa,K.
            and Gee,S.H.
  TITLE     The phosphoinositol 3,4-bisphosphate-binding protein TAPP1
            interacts with syntrophins and regulates actin cytoskeletal
            organization
  JOURNAL   J Biol Chem 279 (51), 53717-53724 (2004)
   PUBMED   15485858
REFERENCE   6  (bases 1 to 3538)
  AUTHORS   Kimber,W.A., Deak,M., Prescott,A.R. and Alessi,D.R.
  TITLE     Interaction of the protein tyrosine phosphatase PTPL1 with the
            PtdIns(3,4)P2-binding adaptor protein TAPP1
  JOURNAL   Biochem J 376 (Pt 2), 525-535 (2003)
   PUBMED   14516276
REFERENCE   7  (bases 1 to 3538)
  AUTHORS   Marshall,A.J., Krahn,A.K., Ma,K., Duronio,V. and Hou,S.
  TITLE     TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase
            signaling in B cells: sustained plasma membrane recruitment
            triggered by the B-cell antigen receptor
  JOURNAL   Mol Cell Biol 22 (15), 5479-5491 (2002)
   PUBMED   12101241
REFERENCE   8  (bases 1 to 3538)
  AUTHORS   Kimber,W.A., Trinkle-Mulcahy,L., Cheung,P.C., Deak,M.,
            Marsden,L.J., Kieloch,A., Watt,S., Javier,R.T., Gray,A.,
            Downes,C.P., Lucocq,J.M. and Alessi,D.R.
  TITLE     Evidence that the tandem-pleckstrin-homology-domain-containing
            protein TAPP1 interacts with Ptd(3,4)P2 and the
            multi-PDZ-domain-containing protein MUPP1 in vivo
  JOURNAL   Biochem J 361 (Pt 3), 525-536 (2002)
   PUBMED   11802782
REFERENCE   9  (bases 1 to 3538)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2023 this sequence version replaced XM_039083148.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.3861.1,
                                           SRR26643299.4778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                JAXUCZ010000001.1  194858320-194858416
            98-258              JAXUCZ010000001.1  194870633-194870793
            259-315             JAXUCZ010000001.1  194876470-194876526
            316-361             JAXUCZ010000001.1  194879500-194879545
            362-459             JAXUCZ010000001.1  194886241-194886338
            460-585             JAXUCZ010000001.1  194891229-194891354
            586-729             JAXUCZ010000001.1  194895410-194895553
            730-798             JAXUCZ010000001.1  194897685-194897753
            799-863             JAXUCZ010000001.1  194901128-194901192
            864-927             JAXUCZ010000001.1  194901743-194901806
            928-1020            JAXUCZ010000001.1  194904396-194904488
            1021-1061           JAXUCZ010000001.1  194905686-194905726
            1062-3538           JAXUCZ010000001.1  194906942-194909418
FEATURES             Location/Qualifiers
     source          1..3538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..3538
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /note="pleckstrin homology domain containing A1"
                     /db_xref="GeneID:361659"
                     /db_xref="RGD:1564153"
     exon            1..97
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            98..258
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1275
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tandem PH domain containing protein-1; pleckstrin homology
                     domain-containing protein family A member 1; pleckstrin
                     homology domain-containing family A member 1; pleckstrin
                     homology domain containing, family A (phosphoinositide
                     binding specific) member 1"
                     /codon_start=1
                     /product="pleckstrin homology domain-containing family A
                     member 1 isoform 1"
                     /protein_id="NP_001402909.1"
                     /db_xref="GeneID:361659"
                     /db_xref="RGD:1564153"
                     /translation="MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMD
                     NPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVE
                     WVNVLNKAIKITVPKQSDSQPASDNLSRQGDCGKKQVSYRTDIVGGVPIITPTQKEEV
                     NECGESVDRNNLKRSQSHLPYFAPKPPADSAVIKAGYCVKQGAVMKNWKRRYFQLDEN
                     TIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEE
                     MHSWIKAVSGAIVAQRGPGRSSSSSMRQARRLSNPCIQRSIPAVLQNPNTLSVLPGQQ
                     PPPPHIPQPLAATLWSQAIPWRSEDFTNLLPRSSQGTSRSRLSLQENQLPK"
     exon            259..315
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            316..361
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            362..459
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            460..585
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            586..729
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            730..798
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            799..863
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            864..927
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1020
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1061
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..3538
                     /gene="Plekha1"
                     /gene_synonym="RGD1564153"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcgcggg cgggccgtcg tgggcgccgc tccgggcagc tgagtgcctg aaggagccgg
       61 gaccgcggtg gcgcgggtgc tccgggcgga ggccgcgtgt aatgttcaag cccagaaatg
      121 ccttatgtgg atcgacagaa tcgcatctgt ggttttctag acattgagga aaatgagaac
      181 agcgggaaat ttcttcgacg gtatttcatc ctggatacca gagaggacag ctttgtatgg
      241 tacatggata atccacagaa cctgccttca ggatcatcac gggttggagc cattaaactt
      301 acctacattt caaaggttag cgatgcgact aagttaaggc caaaggcaga gttttgtttt
      361 gttatgaatg caggaatgag aaaatacttt ctacaagcta atgatcagca ggacttagtg
      421 gagtgggtaa atgtcttgaa caaagctata aaaattacag taccaaagca gtcagactca
      481 cagccggcct ctgataacct gagtcgccaa ggtgactgtg gcaagaagca agtgtcttac
      541 agaactgata ttgttggtgg tgtacccatc atcactccaa cacagaaaga agaagtaaac
      601 gaatgtggtg agagtgtcga cagaaacaat ttgaaacggt cacaaagcca tcttccttac
      661 tttgctccta agccacctgc agacagtgca gtcatcaaag ctgggtattg tgtgaaacaa
      721 ggagcggtga tgaaaaactg gaagagaagg tattttcagc tggatgaaaa cacaataggc
      781 tacttcaagt ctgaactgga aaaggagcct ctgcgggtaa taccacttaa agaagttcac
      841 aaagtccaag agtgcaagca aagtgacatt atgatgaggg acaacctgtt tgaaatcgtg
      901 acaacgtctc ggactttcta tgtgcaggct gatagccctg aggagatgca cagttggatt
      961 aaagcagtct ctggagctat tgtagcacag cggggaccgg gcagatcatc atcatcttct
     1021 atgcggcagg ccagaaggct gtcgaaccct tgtatacaga ggagcattcc agctgtcctt
     1081 cagaatccaa atacactgtc cgtcttgccg gggcagcagc cgccgccacc tcacattccg
     1141 cagcctctcg cagccactct ctggtctcaa gctataccat ggagaagcga ggattttacg
     1201 aatctcttgc caaggtcaag ccagggaact tcaaggtcca gactgtctct ccaagagaac
     1261 cagcttccaa agtgactgaa catgctctgc ccagacctca gagtaaaaac ggccctcagg
     1321 gagaagatgg tgagccagtg gacttagatg acgccagcct gccagtcagc gatgtgtgag
     1381 gggggagcac gtgggctgcc tgcgccactc accctcagtg tccttccatg aggcttctcg
     1441 ccaaagatga tagagggtga atgatctcag tgcatatgtt agactgcctc gtgggtgtgc
     1501 tctgtaagct ggcaaactag gaggcaggga gtggctgagg caacataatt tctttaagaa
     1561 aggaaggaga aaagctgtgt ccatattgac tgtctgaagc tttacatgtt tgggtggcaa
     1621 aaatgtgtgt gtgatctttt ttttctctta gtgactttga aattttaaat aacaacttaa
     1681 aacattaaaa tttcttattt tggccattta aacatgctaa tatgactccc tatgaaatat
     1741 tcaatattta tacattctta tcagctaaca ttatcaagtg ggacattccc agacaaaaat
     1801 ttctcaactc atgatgtctg tggtgctgca gaatttatat cacaacgtgg accatttaga
     1861 aattctaacc gtttatgata ttctggctgt ccaggtgagt ggaaaatttc gcatagaaga
     1921 ttggattaca ctattggtgc aggtgggagt tgaacagggc tagaagaagg ggagattgga
     1981 ggtcagctat agctaatgtt tttttttttt ttcttttgtg gggagggtac ttttttattt
     2041 ttattttggt gactggattt ttctgtgtag ccatggctgt cctggaactc attctgtaga
     2101 ccagactgcc cttgaacttg tggtgatcct tctgctgcct ctgttgtctc ccaaattata
     2161 ggattgtgtc accaacttgc aacctaagac acttgtttta aaaagcttag tattttattt
     2221 tagtaaaaat tgtttggtca taaattttga aaagatctga tttttttttt ttaatcaaag
     2281 ttttgtaaat agatcttatt tctgaatttg gaccagtgaa agacctcagt tcacatgcta
     2341 agtcaaaatg gcccttagtc atgaacttgt tgtggctctc ccttttcatc attagtaacc
     2401 taccctcaag tgcctgtgtc ttctcatctc acttaggatt gtgccccaga gtcctacatg
     2461 attggcttta aatgtccaaa taaatgaatt tcagtagcgt agtttgatat tttaaataag
     2521 atagcatttt atatcagaga caccagaatg ttggtgttca tctgcctgtg caatatgtat
     2581 gtcttgaaaa ccagaattga gtatgcagta agcgtggggc tctcatacat agaagcacct
     2641 ctctggagga ccaagtgtct gctgtcaagt gctggcgggt ttgagcaagc actgttttgt
     2701 ggcaacattg tcagtgtttg cctgccccag gctgctgctc catggcatct ccagtcttgg
     2761 acttgtgtct tggagttgtg ggtgttagtg tttcgccttt ttatgttata agactacttg
     2821 tcggaggatg aaagatttgc tacagtggtc tagggttaag atgtgctatt tagttgccca
     2881 gcacaagaac gtaccactca ccttttctac tcataagcta atgtgttaga gttctatgtc
     2941 gttttctctt gtgcacctgc attagaaaac cataggacag caaggtcgtt aagtagctat
     3001 cacctctgct gccgtattca tgtccaggct ctcagaagtc cttcatgaac acacctaggg
     3061 acccttgtac agagtcttgg cagtatggat gagcctggca cggttttctt tggtacagcc
     3121 tccacagtgc acgttcattt tatcatattt tggtattggt aatttgataa catttcatgg
     3181 tggtaaaata ttagctctat tttgggactt tttatagaac tacatttatt cgaaagcata
     3241 ggaatatgtt cttgtgatta tcaggatctc ctaatattta tctcaattct tttgtaagct
     3301 tatggaaatt atttaattat tttaaagcat attttactgt aaatatgtca tatctgaagt
     3361 gtcagtagtt actttgaata ccgtactatt tgctgtattt tttcctgtgt gtatactgta
     3421 tccttccaga acaggagtgt acctcctaat gttcactgtc acactgctct atgtgtgtcc
     3481 ggttggttga acactgtact gacttgagaa taaactgctc gcaatccatt gtcactca
//
