LOCUS       NM_001114180            1553 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus pleckstrin 2 (Plek2), mRNA.
ACCESSION   NM_001114180 XM_001080879 XM_234329
VERSION     NM_001114180.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1553)
  AUTHORS   Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench
            JG, Feng G, Root DE and Ji P.
  TITLE     Targeted shRNA screening identified critical roles of pleckstrin-2
            in erythropoiesis
  JOURNAL   Haematologica 99 (7), 1157-1167 (2014)
   PUBMED   24747950
REFERENCE   2  (bases 1 to 1553)
  AUTHORS   Bach TL, Kerr WT, Wang Y, Bauman EM, Kine P, Whiteman EL, Morgan
            RS, Williamson EK, Ostap EM, Burkhardt JK, Koretzky GA, Birnbaum MJ
            and Abrams CS.
  TITLE     PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization
  JOURNAL   Blood 109 (3), 1147-1155 (2007)
   PUBMED   17008542
REFERENCE   3  (bases 1 to 1553)
  AUTHORS   Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP and
            Alessi DR.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
REFERENCE   4  (bases 1 to 1553)
  AUTHORS   Inazu T, Yamada K and Miyamoto K.
  TITLE     Cloning and expression of pleckstrin 2, a novel member of the
            pleckstrin family
  JOURNAL   Biochem Biophys Res Commun 265 (1), 87-93 (1999)
   PUBMED   10548495
REFERENCE   5  (bases 1 to 1553)
  AUTHORS   Hu MH, Bauman EM, Roll RL, Yeilding N and Abrams CS.
  TITLE     Pleckstrin 2, a widely expressed paralog of pleckstrin involved in
            actin rearrangement
  JOURNAL   J Biol Chem 274 (31), 21515-21518 (1999)
   PUBMED   10419454
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1553
                     /gene="Plek2"
                     /note="pleckstrin 2"
                     /db_xref="GeneID:314260"
                     /db_xref="RGD:1305786"
     exon            1..60
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1080
                     /gene="Plek2"
                     /codon_start=1
                     /product="pleckstrin-2"
                     /protein_id="NP_001107652.1"
                     /db_xref="GeneID:314260"
                     /db_xref="RGD:1305786"
                     /translation="MEDGVLKEGFLVKRGHIVHNWKARWFILRQNTLLYYKLEGGRRV
                     TPPKGRIVLDGCTITCPCLEYENRPLLIKLKTRTSTEYFLEACSREERDAWAFEITGA
                     IHAGQPGKIQQLHILKNSFKLSPNISLHRIVDKMHDTSSGLRPSPNMEQGSTYKKTFL
                     GSSLVDWLISSNFAASRLEAVTLASMLMEENFLRPVGVRSMDAIRSGDLAEQFLDDST
                     ALYTFAESYKKKVSSKEEISLSTMELSGIVVKQGYLSKQGHKRKNWKVRRFVLRKDPA
                     FLHYYDPSKEDNRPVGGFSLRGSLVSALEDNGVPTGVKGNVQGNLFKVITKDDTHYYI
                     QASNKAERAEWIEAIKKLT"
     exon            61..225
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..407
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..499
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..687
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..789
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..873
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..952
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1553
                     /gene="Plek2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcacctgga ctggcgacat ggaggacggc gtgcttaagg agggtttcct tgtgaagagg
       61 ggccacattg tccacaactg gaaggcacga tggttcatcc tccggcagaa cacactcctg
      121 tattacaagc tggagggcgg ccggcgagtg accccgccca aggggaggat cgtcctcgat
      181 ggctgcacca tcacctgtcc ctgcctggag tatgaaaacc ggccgctcct cattaaactg
      241 aagacccgaa cttccactga gtacttcctg gaggcctgtt ctcgagagga gagagatgcc
      301 tgggcctttg agataacagg ggctatccac gcagggcagc cgggaaagat ccaacaactc
      361 cacatactaa agaactcctt caagttatcc ccgaacatca gcctgcatcg aattgtggac
      421 aagatgcatg acaccagcag cggactccgg ccgagcccca acatggagca gggaagcacc
      481 tacaaaaaga ccttcctggg ctcctccctg gtggactggc tcatctccag caactttgca
      541 gccagccgtc tggaggcagt gaccctggcc tccatgctta tggaagagaa cttcctcagg
      601 ccagtagggg tccggagcat ggatgctatt cgctctgggg atctggccga gcagtttctg
      661 gatgactcca cagccctgta cacttttgct gaaagctaca agaagaaggt aagctccaag
      721 gaggaaatca gtctcagcac catggagtta agtggcatag tggtcaaaca aggctaccta
      781 tccaagcagg ggcacaagag gaagaactgg aaggtacgcc gatttgttct gaggaaggac
      841 ccagctttcc tgcattacta tgacccttcc aaagaagata acaggccagt aggtgggttt
      901 tctcttcgtg gttcccttgt gtctgcactg gaggataatg gtgttcctac tggagttaaa
      961 ggtaatgtcc aaggaaacct cttcaaagtg attacgaagg atgacacaca ctattatatc
     1021 caggccagca acaaggctga gcgagcagaa tggattgaag ctatcaagaa gctaacatga
     1081 tctaaggagc agaccagggt cctcattgga tacagatgag actacctgga gaactggagt
     1141 acttttgggg ctggggatgt ggctcagtgt tagaggacct gcctggcaat cttgaggccc
     1201 caggttcaat tcttggtacc gtttaaaaaa acaaaaaaac caaaaaacct ttaccattgt
     1261 acatttgcac ctctttggag actgctcaag ttggctcctc acatgacagt ggggattcga
     1321 tttcctgtct tcttatgacc aactttcaaa gctggaccag ctcttaggtg agcagcatct
     1381 tgactttgct cttcagaaca gaaatctgcg tccttgggga ccatagtacc acctctcaat
     1441 tggaacacta actctggttt tgctatatta aataccctag tctcaagaca gctctcttaa
     1501 ctgatttcag caactcagta tctctgggct taataaagat tgacatctgt ctc
//
