LOCUS       NM_022401              15279 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus plectin (Plec), transcript variant 6, mRNA.
ACCESSION   NM_022401
VERSION     NM_022401.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 15279)
  AUTHORS   Ni,Y., Wang,X., Yin,X., Li,Y., Liu,X., Wang,H., Liu,X., Zhang,J.,
            Gao,H., Shi,B. and Zhao,S.
  TITLE     Plectin protects podocytes from adriamycin-induced apoptosis and
            F-actin cytoskeletal disruption through the integrin
            alpha6beta4/FAK/p38 MAPK pathway
  JOURNAL   J Cell Mol Med 22 (11), 5450-5467 (2018)
   PUBMED   30187999
  REMARK    GeneRIF: these findings indicated that plectin protects podocytes
            from ADR-induced apoptosis and F-actin cytoskeletal disruption by
            inhibiting integrin alpha6beta4/FAK/p38 pathway activation and that
            plectin may be a therapeutic target for podocyte injury-related
            glomerular diseases.
REFERENCE   2  (bases 1 to 15279)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15279)
  AUTHORS   Zanivan,S., Maione,F., Hein,M.Y., Hernandez-Fernaud,J.R.,
            Ostasiewicz,P., Giraudo,E. and Mann,M.
  TITLE     SILAC-based proteomics of human primary endothelial cell
            morphogenesis unveils tumor angiogenic markers
  JOURNAL   Mol Cell Proteomics 12 (12), 3599-3611 (2013)
   PUBMED   23979707
REFERENCE   4  (bases 1 to 15279)
  AUTHORS   Rezniczek,G.A., Walko,G. and Wiche,G.
  TITLE     Plectin gene defects lead to various forms of epidermolysis bullosa
            simplex
  JOURNAL   Dermatol Clin 28 (1), 33-41 (2010)
   PUBMED   19945614
  REMARK    Review article
            Erratum:[Dermatol Clin. 2010 Apr;28(2):439-41]
REFERENCE   5  (bases 1 to 15279)
  AUTHORS   Zhang,T., Haws,P. and Wu,Q.
  TITLE     Multiple variable first exons: a mechanism for cell- and
            tissue-specific gene regulation
  JOURNAL   Genome Res 14 (1), 79-89 (2004)
   PUBMED   14672974
REFERENCE   6  (bases 1 to 15279)
  AUTHORS   Rezniczek,G.A., Abrahamsberg,C., Fuchs,P., Spazierer,D. and
            Wiche,G.
  TITLE     Plectin 5'-transcript diversity: short alternative sequences
            determine stability of gene products, initiation of translation and
            subcellular localization of isoforms
  JOURNAL   Hum Mol Genet 12 (23), 3181-3194 (2003)
   PUBMED   14559777
REFERENCE   7  (bases 1 to 15279)
  AUTHORS   Fuchs,P., Zorer,M., Rezniczek,G.A., Spazierer,D., Oehler,S.,
            Castanon,M.J., Hauptmann,R. and Wiche,G.
  TITLE     Unusual 5' transcript complexity of plectin isoforms: novel
            tissue-specific exons modulate actin binding activity
  JOURNAL   Hum Mol Genet 8 (13), 2461-2472 (1999)
   PUBMED   10556294
REFERENCE   8  (bases 1 to 15279)
  AUTHORS   Elliott,C.E., Becker,B., Oehler,S., Castanon,M.J., Hauptmann,R. and
            Wiche,G.
  TITLE     Plectin transcript diversity: identification and tissue
            distribution of variants with distinct first coding exons and
            rodless isoforms
  JOURNAL   Genomics 42 (1), 115-125 (1997)
   PUBMED   9177781
REFERENCE   9  (bases 1 to 15279)
  AUTHORS   Liu,C.G., Maercker,C., Castanon,M.J., Hauptmann,R. and Wiche,G.
  TITLE     Human plectin: organization of the gene, sequence analysis, and
            chromosome localization (8q24)
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4278-4283 (1996)
   PUBMED   8633055
REFERENCE   10 (bases 1 to 15279)
  AUTHORS   Wiche,G., Becker,B., Luber,K., Weitzer,G., Castanon,M.J.,
            Hauptmann,R., Stratowa,C. and Stewart,M.
  TITLE     Cloning and sequencing of rat plectin indicates a 466-kD
            polypeptide chain with a three-domain structure based on a central
            alpha-helical coiled coil
  JOURNAL   J Cell Biol 114 (1), 83-99 (1991)
   PUBMED   2050743
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Gunther Rezniczek, Gerhard Wiche. The reference
            sequence was derived from JACYVU010000186.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_022401.4.
            
            On Feb 10, 2021 this sequence version replaced NM_022401.2.
            
            Summary: Plectin is a prominent member of an important family of
            structurally and in part functionally related proteins, termed
            plakins or cytolinkers, that are capable of interlinking different
            elements of the cytoskeleton. Plakins, with their multi-domain
            structure and enormous size, not only play crucial roles in
            maintaining cell and tissue integrity and orchestrating dynamic
            changes in cytoarchitecture and cell shape, but also serve as
            scaffolding platforms for the assembly, positioning, and regulation
            of signaling complexes (for reviews see PMID: 9701547, 11854008,
            and 17499243). Plectin is expressed as several protein isoforms in
            a wide range of cell types and tissues from a single gene located
            on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010,
            this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in
            mouse and rat) and the gene product had been referred to as
            'hemidesmosomal protein 1' or 'plectin 1, intermediate filament
            binding 500kDa'. These names were replaced by plectin. The plectin
            gene locus in mouse on chromosome 15 has been analyzed in detail
            (PMID: 10556294, 14559777), revealing a genomic exon-intron
            organization with well over 40 exons spanning over 62 kb and an
            unusual 5' transcript complexity of plectin isoforms. Eleven exons
            (1-1j) have been identified that alternatively splice directly into
            a common exon 2 which is the first exon to encode plectin's highly
            conserved actin binding domain (ABD). Three additional exons (-1,
            0a, and 0) splice into an alternative first coding exon (1c), and
            two additional exons (2alpha and 3alpha) are optionally spliced
            within the exons encoding the acting binding domain (exons 2-8).
            Analysis of the human locus has identified eight of the eleven
            alternative 5' exons found in mouse and rat (PMID: 14672974); exons
            1i, 1j and 1h have not been confirmed in human. Furthermore,
            isoforms lacking the central rod domain encoded by exon 31 have
            been detected in mouse (PMID:10556294), rat (PMID: 9177781), and
            human (PMID: 11441066, 10780662, 20052759). The short alternative
            amino-terminal sequences encoded by the different first exons
            direct the targeting of the various isoforms to distinct
            subcellular locations (PMID: 14559777). As the expression of
            specific plectin isoforms was found to be dependent on cell type
            (tissue) and stage of development (PMID: 10556294, 12542521,
            17389230) it appears that each cell type (tissue) contains a unique
            set (proportion and composition) of plectin isoforms, as if
            custom-made for specific requirements of the particular cells.
            Concordantly, individual isoforms were found to carry out distinct
            and specific functions (PMID: 14559777, 12542521, 18541706). In
            1996, a number of groups reported that patients suffering from
            epidermolysis bullosa simplex with muscular dystrophy (EBS-MD)
            lacked plectin expression in skin and muscle tissues due to defects
            in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687,
            8696340). Two other subtypes of plectin-related EBS have been
            described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of
            plectin-related diseases see PMID: 15810881, 19945614. Mutations in
            the plectin gene related to human diseases should be named based on
            the position in NM_000445 (human variant 1, isoform 1c), unless the
            mutation is located within one of the other alternative first
            exons, in which case the position in the respective Reference
            Sequence should be used. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (6) differs in the 5' UTR and the
            5' coding region compared to variant 1. The resulting protein
            (isoform 1) contains a distinct N-terminus compared to isoform 1c.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X59601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18541706, 17389230
            RefSeq Select criteria             :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-591               JACYVU010000186.1  1164951-1165541     c
            592-653             JACYVU010000186.1  1154007-1154068     c
            654-743             JACYVU010000186.1  1153608-1153697     c
            744-821             JACYVU010000186.1  1152740-1152817     c
            822-914             JACYVU010000186.1  1152541-1152633     c
            915-1081            JACYVU010000186.1  1151539-1151705     c
            1082-1197           JACYVU010000186.1  1150779-1150894     c
            1198-1304           JACYVU010000186.1  1150601-1150707     c
            1305-1424           JACYVU010000186.1  1150388-1150507     c
            1425-1520           JACYVU010000186.1  1150220-1150315     c
            1521-1648           JACYVU010000186.1  1149844-1149971     c
            1649-1742           JACYVU010000186.1  1149483-1149576     c
            1743-1897           JACYVU010000186.1  1148624-1148778     c
            1898-2207           JACYVU010000186.1  1148207-1148516     c
            2208-2285           JACYVU010000186.1  1148046-1148123     c
            2286-2447           JACYVU010000186.1  1147811-1147972     c
            2448-2552           JACYVU010000186.1  1147533-1147637     c
            2553-2648           JACYVU010000186.1  1147327-1147422     c
            2649-2774           JACYVU010000186.1  1146987-1147112     c
            2775-2927           JACYVU010000186.1  1145996-1146148     c
            2928-3082           JACYVU010000186.1  1145747-1145901     c
            3083-3209           JACYVU010000186.1  1145528-1145654     c
            3210-3393           JACYVU010000186.1  1145241-1145424     c
            3394-3551           JACYVU010000186.1  1145003-1145160     c
            3552-3730           JACYVU010000186.1  1144733-1144911     c
            3731-3869           JACYVU010000186.1  1143473-1143611     c
            3870-4226           JACYVU010000186.1  1143029-1143385     c
            4227-4310           JACYVU010000186.1  1142873-1142956     c
            4311-4415           JACYVU010000186.1  1142597-1142701     c
            4416-4514           JACYVU010000186.1  1142407-1142505     c
            4515-7895           JACYVU010000186.1  1138026-1141406     c
            7896-15279          JACYVU010000186.1  1130507-1137890     c
FEATURES             Location/Qualifiers
     source          1..15279
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..15279
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /note="plectin"
                     /db_xref="GeneID:64204"
                     /db_xref="RGD:621649"
     exon            1..591
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..14114
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /note="isoform 1 is encoded by transcript variant 6;
                     plectin 1"
                     /codon_start=1
                     /product="plectin isoform 1"
                     /protein_id="NP_071796.2"
                     /db_xref="GeneID:64204"
                     /db_xref="RGD:621649"
                     /translation="MVAGMLMPLDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVT
                     NLQVMRAMTSLKARGLVRETFAWCHFYWYLTNEGIDHLRQYLHLPPEIVPASLQRVRR
                     PVAMVMPARRRSPHVQTMQGPLGCPPKRGPLPAEDPAREERQVYRRKEREEGAPETPV
                     VSATIVGTLARPGPEPTPATDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHN
                     LISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLT
                     LGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGR
                     LFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEK
                     SIITYVSSLYDAMPRVPGAQDGVRANELQLRWQEYRELVLLLLQWIRHHTAAFEERKF
                     PSSFEEIEILWCQFLKFKETELPAKEADKNRSKGIYQSLEGAVQAGQLKIPPGYHPLD
                     VEKEWGKLHVAILEREKQLRSEFERLECLQRIVSKLQMEAGLCEEQLNQADSLLQSDI
                     RLLASGKAAQRAGEVERDLDKADGMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERL
                     VAIRTEYNLRLKAGVGAPVTQVTLQSTQRRPELEDSTLRYLHDLLAWVEENQRRIDGA
                     EWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAYRDCLGRLDLQ
                     YAKLLNSSKARLRSLESLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESY
                     SALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEA
                     HLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDRSITVTRLEDLLQDAQDEKEQL
                     NEYKGHLSGLAKRAKAIVQLKPRNPAHPVRGHVPLLAVCDYKQVEVTVHKGDQCQLVG
                     PAQPFHWKVLGGSSSEAAVPSVCFLVPPPNQEAQEAVARLEAQHQALVTLWHQLHVDM
                     KSLLAWQSLNRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGP
                     EDRLVAEREYGSCSRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHR
                     LRLPLDKDPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR
                     SELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEHLKEAQAVPATL
                     QELEVTKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRER
                     VTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSSWLQDAKSRQEQIQAVPI
                     ANSQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPV
                     ASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQ
                     RAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEARELQRRMQEEVTRREEAAVDAQ
                     QQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGG
                     AEDELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAA
                     REKQRALQALDELKLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFA
                     EKTAQLERTLQEEHVTVTQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL
                     RLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE
                     GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKV
                     RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ
                     LAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ
                     RRRLEEQAAQHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKASF
                     EKAAAGKAELELELGRIRSNAEDTMRSKELAEQEAARQRQLAAEEEQRRREAEERVQR
                     SLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAE
                     EKAHAFVVQQREEELQQTLQQEQNMLERLRSEAEAARRAAEEAEEAREQAEREAAQSR
                     KQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAE
                     MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRS
                     QVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAAR
                     LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ
                     EQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQAR
                     AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDQDAERLREAIAELE
                     REKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKA
                     KLEQLFQDEVAKAKQLQEEQQRQQQQMEQEKQELVASMEEARRRQREAEEGVRRKQEE
                     LQRLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEEIATSQAAATKALPNGR
                     DALDGPSMEAEPEYTFEGLRQKVPAQQLQEAGILSMEELQRLTQGHTTVAELTQREDV
                     HRYLKGGSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALILLEAQAASGFLLDPVRNR
                     RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHGIR
                     LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENL
                     TYLQLLERCVEDPETGLRLLPLTDKAAKGGELVYTDTEARDVFEKATVSAPFGKFQGK
                     TVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIVITVVEEHERKGQLCFEGLR
                     ALVPAAELLDSGVISHEVYQQLQRGERSVREVAEADEVRQALRGTSVIAGVWLEEAGQ
                     KLSIYEALRRDLLQPEVAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEMHEK
                     LLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRV
                     PLDVAYARGYLDKETNRALTSPRDDARVYLDPSTREPVTYSQLQQRCRSDQLTGLSLL
                     PLSEKAVRARQEEVYSELQARETLEKAKVEVPVGGFKGRALTVWELISSEYFTEEQRQ
                     ELLRQFRTGKVTVEKVIKILITIVEEVETQRQERLSFSGLRAPVPASELLASKILSRT
                     QFEQLKDGKTSVKDLSEVGSVRTLLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPST
                     ATLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKLLSAEKAVTGYKDPYSG
                     STISLFQAMKKGLVLRDHAIRLLEAQIATGGIIDPVHSHRLPVDVAYQRGYFDEEMNR
                     VLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLRLLPLRGAEKTEVVETTQVY
                     TEEETRRAFEETQIDIPGGGSHGGSSMSLWEVMQSDMIPEDQRARLMADFQAGRVTKE
                     RMIIIIIEIIEKTEIIRQQNLASYDYVRRRLTAEDLYEARIISLETYNLFREGTKSLR
                     EVLEMESAWRYLYGTGSVAGVYLPGSRQTLTIYQALKKGLLSAEVARLLLEAQAATGF
                     LLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQPISLFQAMKKEL
                     IPAEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVD
                     PSTDERLSYTQLLKRCRRDDNSGQMLLPLSDARKLTFRGLRKQITVEELVRSQVMDEA
                     TALQLQEGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAF
                     ELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL
                     ISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL
                     TDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRK
                     RRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIID
                     RRSGRQYDIDDAITKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSS
                     SYPISSAVPRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLL
                     EAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSA
                     AQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKLRDV
                     SAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSSKGYYSPYSVSGSGST
                     AGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGPSASLGGPES
                     AVA"
     exon            592..653
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            654..743
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            744..821
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            822..914
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1081
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1197
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1304
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1424
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1520
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1648
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1742
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1897
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2207
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2285
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2447
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2552
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2648
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2774
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2927
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3082
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3209
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3393
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3551
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3730
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            3731..3869
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            3870..4226
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4310
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            4311..4415
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            4416..4514
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            4515..7895
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
     exon            7896..15279
                     /gene="Plec"
                     /gene_synonym="Pcn; Plec1; Pltn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccacctg ctgtcctcac ccggtgctga ccggcaggct tccagcagcc atggtggctg
       61 gcatgctcat gccactggac cagcttcggg ccatctatga ggtgctcttt cgtgaggggg
      121 tgatggttgc caagaaggac cggcgacccc gaagcctgca tccccatgtg cccggcgtca
      181 ccaatctaca ggtcatgcgt gccatgacct cgctgaaagc tcggggcctg gtgcgggaga
      241 cctttgcctg gtgccacttc tactggtacc tgaccaacga gggcatcgac cacctacgcc
      301 agtacctaca cctgccaccg gagatcgtac ctgcctctct gcagcgtgtg cgccgccctg
      361 ttgccatggt gatgcctgca cgtcgtcgct ccccccatgt gcagaccatg caaggtccct
      421 taggctgtcc accaaagagg ggccctctgc cagctgagga ccctgcccgg gaggagcggc
      481 aggtctatcg caggaaggag cgtgaggaag gggcacctga aacccctgtg gtgtctgcca
      541 ccatcgtggg gaccctggcc aggccaggcc cagagcccac cccagccaca gatgaacgag
      601 accgtgtgca gaagaaaact ttcaccaagt gggtcaataa acaccttatc aaggctcaaa
      661 ggcacatcag tgacctgtat gaagacctcc gtgatggcca caacctcatc tccctgctgg
      721 aagtcctctc aggagacagc ctgccccgag agaaggggag gatgcgtttc cacaagctgc
      781 aaaacgttca gattgccctg gactatctcc gacatcggca ggtgaagttg gtgaacatca
      841 gaaatgatga catcgccgat ggcaacccca agctgaccct gggcctgatc tggacaatca
      901 tcctgcactt ccagatctca gacattcagg tgagcggcca gtccgaggac atgacagcca
      961 aggagaagct gctgctgtgg tctcagcgta tggtagaggg ctaccaaggc ctgcgctgtg
     1021 acaacttcac caccagctgg cgcgacggcc ggctcttcaa tgctatcatc cacaggcaca
     1081 agcccatgct catagacatg aataaagtgt accgacagac caacctggag aacctagacc
     1141 aggccttctc cgtggcagag cgggacctgg gagttaccag gctcctggac ccagaagatg
     1201 tggatgtccc tcagcctgat gagaagtcca tcatcaccta cgtttcatcc ctgtatgatg
     1261 ccatgccccg tgtgccgggc gcacaggatg gagtgagggc caatgagctg cagcttcgtt
     1321 ggcaagagta ccgggagctt gtgctgctgc tgctacagtg gatccggcac cacaccgctg
     1381 cttttgagga gcgcaagttc ccctccagct ttgaggagat tgagatccta tggtgccagt
     1441 ttctgaagtt caaggagaca gaacttcctg ccaaggaggc agacaagaac cggtccaaag
     1501 gcatctacca gtctttggag ggagcagtac aagcaggcca gctcaagatt ccccctggct
     1561 accacccgct agacgtggaa aaggagtggg gcaagctgca cgtggccatc ctggagcggg
     1621 agaagcaact ccggagcgag tttgagaggc tggagtgtct tcagcgcatt gtgagcaagc
     1681 tacagatgga ggctgggcta tgtgaggagc agctgaacca ggccgattcc ctactgcagt
     1741 cggatattcg gctgctggcc tcaggcaagg cggcacagcg ggctggggaa gtggagagag
     1801 acctggacaa ggctgatggt atgatccggc tgttgttcaa tgatgtgcag acccttaaag
     1861 atgggcggca tccacagggt gaacagatgt accggagggt gtatcgtctg catgagcgcc
     1921 tggtagccat ccgcactgaa tacaacctcc ggctgaaggc aggggtgggt gcccctgtga
     1981 cccaggtgac cctgcagagc acacagaggc gcccagagct agaggactcc acactgcgtt
     2041 acctgcacga cctgctggca tgggtggagg agaaccagcg tcgaatagac ggtgctgagt
     2101 ggggcgtgga cttgcccagt gtagaggcac agctgggcag ccaccgaggc atgcatcagt
     2161 ctattgagga attccgggcc aagatcgagc gggctcggaa tgatgagagc cagctctccc
     2221 ctgccacccg aggtgcctac cgagactgcc tgggccgcct ggacctgcag tatgcaaagc
     2281 tgctgaactc ctccaaggcc cgcctccggt ccctggagag cttgcatggg tttgtggcgg
     2341 cagctaccaa ggagctgatg tggctgaatg agaaggaaga ggaagaagtg ggctttgatt
     2401 ggagtgaccg caacaccaac atggctgcca agaaagaaag ttactcggcc ctgatgcgtg
     2461 agctggagat gaaggaaaag aaaattaagg agatccagaa cacgggggac aggttgctgc
     2521 gggaagacca tcctgcccgg cccacagtgg agtccttcca ggctgccctg cagacacagt
     2581 ggagctggat gctgcagctg tgttgctgca ttgaagcgca cttgaaagag aacacagcct
     2641 acttccagtt cttctcagat gttcgggagg ctgaggaaca gttgcagaaa ctacaggaga
     2701 cgttacgcag gaagtacagc tgtgaccgct ccatcactgt cacaaggctt gaggacctgc
     2761 tgcaggatgc ccaggatgag aaggagcaac tgaatgagta caaagggcac ctctcaggcc
     2821 tggccaagcg ggccaaggct attgtgcagc tgaagccacg caaccctgcc caccctgtgc
     2881 ggggtcacgt gcccctgcta gctgtgtgtg actacaagca ggtggaggtg actgtgcaca
     2941 agggtgacca atgccagctg gtgggccctg cccagccgtt ccactggaag gtgctcggtg
     3001 gttccagcag tgaggctgcc gtgccttctg tgtgctttct tgtgccgcca cccaaccagg
     3061 aggcccagga agctgttgct aggctggagg cccagcatca ggccctggtt actctgtggc
     3121 accagcttca cgtggacatg aagagtcttc tggcatggca gagcctcaat cgtgacatac
     3181 agctcatccg gtcctggtcc ctagtcacgt tccgcacgct gaagcccgag gagcagcggc
     3241 aagctctgcg caacctggag ttgcactacc aggccttcct tcgagacagc caggacgctg
     3301 gtggctttgg gcccgaggac cggctggtgg cagagcgcga atatggatct tgtagtcgcc
     3361 actaccagca gctgctacaa agcctggagc agggtgagca ggaggagtct cgctgtcagc
     3421 gatgcatctc ggagctcaag gacattcggc tgcaactgga ggcctgtgag actcggactg
     3481 tgcaccgtct gcggctgcca ctggataaag accccgcacg ggagtgtgcc cagcgcatcg
     3541 ctgagcaaca gaaagcacag gctgaggtgg aggggctggg caagggagtt gcccggctgt
     3601 ctgctgaggc tgagaaagtt ctggccttgc cagagccgtc acctgctgca ccaactctgc
     3661 gctcggagtt ggaattgacc ctgggcaagc tggaacaggt cagaagcctg tctgccatct
     3721 acttggagaa actcaagacc atcagcttgg taattcgcag tacccagggg gctgaggagg
     3781 tgcttaaaac acacgaggag cacctgaagg aggcccaggc cgtgcctgcc acactccaag
     3841 agctcgaagt caccaaggct tcactaaaga agctgcgggc ccaggcggag gcacagcagc
     3901 ctgtattcaa caccctacga gatgagctga ggggggcaca ggaagttggt gaacggctac
     3961 agcagcggca tggtgagcgg gacgtggaag tagagcgctg gcgagaacgt gtcactcagt
     4021 tgctggagcg ctggcaggct gtgctagccc agactgatgt gcggcagcgg gagcttgaac
     4081 agctgggccg ccaacttcgc tactaccgtg aaagtgcgga tccgctgagc tcctggctgc
     4141 aggatgccaa gagccggcaa gagcagatcc aggctgtgcc aatagccaac agtcaggctg
     4201 cacgagaaca gctgcgccag gagaaggccc tgctggagga gattgagcgc catggtgaga
     4261 aggttgagga gtgccagaag tttgctaagc agtacatcaa tgcaatcaag gactatgagc
     4321 tccagctgat cacctacaag gctcagcttg aacctgtggc ctcccccgcc aagaagccca
     4381 aggttcagtc tggatcggag agcgtcatcc aggagtacgt ggatctgcgt acacgctaca
     4441 gtgagctgac cacactcacg agtcagtaca tcaagttcat cagtgagaca ctgcgccgca
     4501 tggaagagga agagcggctg gctgagcaac agcgggcaga ggagcgggag cgcctggccg
     4561 aggtggaggc cgcgctggag aagcagcggc agctggctga ggcccatgcc caggccaagg
     4621 cacaggccga gctggaggca cgagaactgc agcggcgcat gcaggaggag gtgacgcggc
     4681 gcgaggaggc ggcggtggac gcacagcaac agaagcgcag catccaagag gagctgcagc
     4741 atctgcggca aagctcagag gcagagatcc aggccaaggc ccagcaggtg gaggctgcag
     4801 agcgcagccg catgcgcatt gaggaagaga tccgcgtagt ccgtctgcag ctagagacaa
     4861 ctgagcgtca gcgtggaggg gcggaggatg agctgcaggc tctgcgtgca cgggctgagg
     4921 aggcagaagc acagaagcgg caggctcagg aggaagccga gcgcttgcgg aggcaggtgc
     4981 aggatgagag ccaacgcaaa cggcaggcgg aggccgagct ggccctgcgt gtgaaggcag
     5041 aagcggaggc agcgcgagag aagcagcggg ccctgcaggc tctggatgaa ctgaaactgc
     5101 aggccgagga ggccgaacgg cggctgcgcc aagccgaggc agagagggct cgccaagtgc
     5161 aggtagccct ggagacagcg cagcgtagtg cagaagtgga gctgcagagc aagcgtgcgt
     5221 cctttgcaga gaagaccgca cagttggagc gcacgctgca ggaagagcac gtgacagtga
     5281 cacagctgcg ggaggaggcg gaacggcggg cacagcagca ggctgaagcc gagcgagccc
     5341 gtgaggaagc cgagcgggag ctggagcgct ggcagctgaa ggccaatgag gcgctgcggc
     5401 tgcggctgca ggcagaggag gtggcacagc agaagagcct ggcccaggcc gatgcagaga
     5461 agcagaagga agaggcagaa cgggaagccc ggcggcgggg caaggcagag gagcaggccg
     5521 tgcggcagcg agagctggct gagcaggagc tggagaagca gcggcagctg gcagagggca
     5581 ccgcccagca gcgcctggct gccgagcagg agctgattcg cctgcgggca gagacggagc
     5641 aaggtgagca gcagcggcag ctgctggagg aagagctggc ccggctacag cacgaagcga
     5701 cagcagccac acagaagcgc caggagctgg aggctgagct ggcgaaggtt cgggcagaga
     5761 tggaggtact gctggccagc aaggcacgag ccgaagagga gtctcgctcc accagtgaaa
     5821 agtccaagca gaggctggaa gctgaggcag ggcggtttcg agagctggct gaggaggctg
     5881 cccgcctgcg tgctctggcc gaggaggcca agcggcagcg gcagttggcc gaggaggacg
     5941 cggcacgcca gcgggccgag gcggagcgag tgcttacgga gaagctggct gccatcagtg
     6001 aggccacaag gctcaagacg gaggcagaga ttgcactcaa agagaaggag gccgagaacg
     6061 agcgcctgag gcgcctggct gaagatgagg ccttccagcg gcgccggctg gaggagcagg
     6121 cagcacagca caaggcagac atagaggagc gcctggccca gctgcgcaag gcatccgaga
     6181 gcgagctgga gcgacagaag gggttggtgg aggataccct gcggcagcgg cggcaggtgg
     6241 aggaggagat catggctctg aaggcgagct tcgagaaggc cgcggctggc aaggcagaac
     6301 tggagctgga gcttggccgc atccgcagca atgccgagga caccatgcgc agcaaggagc
     6361 tggccgagca ggaggcagcg cggcagcggc agttggcagc tgaggaggag cagaggcgcc
     6421 gggaagccga ggagcgggtg cagaggagcc tggcagcgga ggaggaagcc gcacggcagc
     6481 gcaaggtcgc actggaggaa gtcgagcggc tcaaggccaa ggttgaggaa gcgcggcgcc
     6541 tgcgagagcg agctgagcag gagtctgcga ggcagctgca gctggcccag gaggctgccc
     6601 agaaacggct gcaggcggag gagaaggcgc acgcctttgt ggtgcagcag cgagaagagg
     6661 agctgcagca gactcttcag caagagcaga acatgctgga gcggctgcgg agcgaggcag
     6721 aggcagcgcg gcgagctgct gaggaggcgg aggaggcccg ggagcaggca gaacgtgagg
     6781 cagcgcagtc taggaagcaa gtggaagagg ccgagcggct gaagcagtcg gcagaggagc
     6841 aggctcaggc ccaggcccag gcgcaggcgg ctgcagagaa actgcgcaag gaagcggagc
     6901 aggaggcggc gcgtcgggcc caggcggagc aggctgcgtt gaaacagaag caggcagccg
     6961 acgcggagat ggagaagcac aagaagtttg cagagcagac gctacggcag aaggctcagg
     7021 tagagcagga gctgaccacg ctgaggctgc agctcgagga gaccgaccac cagaagagca
     7081 tcctggatga ggagctgcag cggctaaagg ctgaggtaac agaggcagcc cggcagcgta
     7141 gccaggtaga ggaggagctc ttctctgtcc gcgtgcagat ggaggagctg ggcaaactca
     7201 aggctcgcat tgaagctgaa aaccgggcac tcatccttcg tgacaaggac aacacacagc
     7261 gcttcctgga ggaggaggcc gagaagatga aacaggtggc agaggaagct gcacggttga
     7321 gcgtagctgc ccaggaggca gcaaggctgc ggcagctagc cgaggaggac ctggcccagc
     7381 agcgggccct ggcggagaag atgctgaagg agaagatgca ggcggtgcag gaagccacaa
     7441 ggctcaaggc tgaggctgag ctgctgcagc agcagaagga gctggcacag gagcaggccc
     7501 ggcggctgca ggaggacaag gagcaaatgg ctcagcagtt ggtagaggag acacagggtt
     7561 tccagcggac cctggaggct gagcggcagc ggcagctaga aatgagcgca gaggctgaac
     7621 gcctcaagtt gcgcatggct gagatgagcc gggctcaggc ccgtgcagag gaggatgccc
     7681 agcgcttccg gaagcaggct gaagagatcg gcgaaaagct gcaccgcact gaactcgcta
     7741 cacaggagaa ggtgacattg gtgcagactc tcgagatcca gcgacagcag agtgaccaag
     7801 atgccgagcg tctgagggag gccattgctg agctggagcg tgagaaggag aagctcaagc
     7861 aggaggcgaa gttactgcag ctcaagtctg aggagatgca gactgtgcag caggagcaga
     7921 tactgcagga gacacaggcc ctgcagaaga gctttctctc tgagaaggac agcttgctgc
     7981 aacgcgaacg cttcatcgag caggagaagg ccaagctgga gcagcttttc caggacgagg
     8041 tggcaaaagc aaaacagctg caggaggagc agcagcggca gcagcagcag atggagcagg
     8101 aaaagcagga gctggtggcc agcatggagg aggcccggag gcggcagcgt gaggcagagg
     8161 agggtgtgag gcgcaagcaa gaggaactgc agcgtctgga gcagcagcgg cagcagcagg
     8221 agaaactact ggcagaggag aaccagaggc tgcgggagcg gctgcagcgc ctggaggaag
     8281 agcaccgagc tgcgttggcg cactctgagg agatcgccac ctcccaggct gctgccacaa
     8341 aagcactgcc caatggccgc gacgcacttg atggcccctc catggaggcc gagcccgagt
     8401 acaccttcga gggattacgt cagaaggtgc cagctcagca gctacaggaa gcaggcattc
     8461 tgagcatgga ggaactgcag cgtttgacac agggtcacac cacggtggct gagctcacgc
     8521 agcgggaaga tgtgcaccga tacctgaagg gcggcagcag catcgcagga ttgctcctga
     8581 agcccaccaa tgagaaactg agtgtctaca cagccctaca gcggcagctg ctcagccctg
     8641 gaacagccct tatcttgctt gaggcccagg cagcctcggg cttcctgctg gaccctgtgc
     8701 ggaaccggcg gctgacggtc aatgaggctg tgaaggaggg tgtggtgggt cccgagctgc
     8761 accacaagct gctgtcagct gagcgtgccg tcactggcta caaggaccct tacacaggag
     8821 aacagatctc tctcttccag gccatgaaga aggacctcat tgtcagggac catggcatcc
     8881 gcctgctgga agcccagatc gccacaggtg gcatcattga ccctgtacac agccaccgtg
     8941 ttcccgtgga cgtggcctac cagcgtggct acttcgatga ggagatgaac cgtgtgctgg
     9001 ctgacccaag cgatgacacc aagggcttct ttgaccccaa cactcacgag aacctcacgt
     9061 acctgcagct gctggagcgc tgtgtggagg accccgagac aggcctgcgc ctcctgccac
     9121 tcacagacaa ggctgccaag ggtggtgagc tggtgtacac tgacacggag gcccgtgacg
     9181 tcttcgaaaa ggccacagtg tctgcaccat tcggcaagtt ccagggcaag accgtgacca
     9241 tctgggagat catcaactca gagtacttca cagcggagca gcgacgggac ctgctccggc
     9301 agttccgcac gggccgcatc acggtggaga agatcatcaa gattgtcatc acggtggtag
     9361 aggaacacga gcggaagggc cagctctgct ttgagggcct ccgtgccctt gtgcctgctg
     9421 cagagctgct ggacagtgga gtcatcagtc atgaagtcta ccagcagctg cagcggggtg
     9481 agcgctctgt gcgggaagtg gccgaggcag acgaggtgag gcaggccctg cggggtacca
     9541 gtgtcattgc cggtgtgtgg ctggaagaag cagggcagaa gctgagcatc tatgaggccc
     9601 tgaggagaga tttgctgcag ccagaggtgg ctgtggcctt gctggaggcc caggctggca
     9661 ctgggcacat cattgaccct gccacgagtg ccaggctgac tgtggatgag gcagtgcgtg
     9721 ctggcctggt gggtcctgag atgcacgaga agctcttgtc agctgagaag gctgtaacag
     9781 gctataggga tccctactcg ggacagagcg tctcgctctt ccaggctctg aagaagggtc
     9841 tcatcccccg agaacagggc ctgcgcctgc tggatgccca gttatccact ggtggcattg
     9901 tagaccccag caaaagccac cgtgtgcccc tggatgttgc ctatgcccgg ggctacctgg
     9961 acaaagagac taacagggcc ctgacgtcac ccagagacga tgccagagtc taccttgacc
    10021 ccagcacccg ggagccagtc acctacagcc agctccaaca gcggtgccgg tctgaccagc
    10081 tgactgggtt gagcctactg cccctctcag agaaggccgt ccgggcccgg caggaagagg
    10141 tctactctga gctccaggcc cgtgagacat tggagaaggc caaggtggag gttcctgtgg
    10201 gcggctttaa gggcagggcg ctgacagtgt gggagctcat aagctcggaa tacttcactg
    10261 aggagcagcg gcaggagctg ctacggcagt tccgcacagg caaggtcact gtagagaagg
    10321 tcatcaagat tcttatcacc attgtggagg aggtggagac tcaacggcag gagagactgt
    10381 ccttcagtgg cctccgtgcc cctgtgccgg ccagtgagct cctggcctcc aagatcctca
    10441 gcagaactca gtttgagcag ctcaaggatg gcaagacatc agtcaaagat ctgtcagagg
    10501 tgggctctgt gcggacactg ctgcaaggca gcggctgcct ggctggcatc tatctggagg
    10561 actcgaagga gaaagtaacc atctatgagg ccatgcgccg gggcctcctc agacccagca
    10621 cagccacact cctgctggag gcccaggcgg ccactggttt tctagtggac cctgtgcgga
    10681 accaacgtct gtacgtccat gaagctgtca aggctggagt ggtgggcccg gagctccatg
    10741 agaagctgct gtcggctgag aaggcggtca ctggttacaa agatccctac tctggcagca
    10801 ccatctcgct gttccaggcc atgaagaagg gcttggtcct cagggaccat gccatccgcc
    10861 tgctggaggc ccagattgcc acaggtggca tcattgaccc tgtgcacagt caccgcctgc
    10921 ccgtagatgt tgcctaccag cgtggctact tcgatgagga gatgaaccgt gtgctggctg
    10981 acccaagtga tgacaccaag ggcttcttcg accccaacac ccacgagaac ctcacgtacc
    11041 tgcagctact ggagcgctgc gtggaggacc ccgagacagg cctgcgcctc ctgccactca
    11101 gaggggcaga gaagacagag gtggtagaaa ccacacaggt gtatactgag gaggagactc
    11161 ggagggcatt cgaggagacg cagattgaca tcccaggtgg tggcagccac ggtggctcct
    11221 ccatgtctct atgggaggtg atgcagtcag acatgatccc agaggaccag cgtgcccggc
    11281 tcatggccga ctttcaggct ggcagagtga ccaaggagcg catgatcatt atcatcatcg
    11341 aaatcattga gaagacggag atcatccgcc agcagaacct cgcctcctat gactacgtac
    11401 gccgccgcct caccgccgaa gacctgtatg aggcccggat catctccctt gagacctaca
    11461 acctcttccg ggaaggcacc aagagcctcc gtgaggttct ggagatggaa tctgcctggc
    11521 gctaccttta cggcacagga tcggtggccg gtgtctacct gcctggctct aggcagacgc
    11581 taaccatcta ccaggccctt aagaaggggc tgctgagtgc cgaggtggcc cgcttgctgc
    11641 tggaagcaca ggcagccaca ggctttctgc tggacccagt gaaaggcgag aggctgactg
    11701 tggacgaggc cgtgcggaag ggtctggtag gccccgagct gcacgatcgg ctcctctctg
    11761 ccgagcgagc tgtaactggc taccgagacc cctacaccga acagcccatc tcactcttcc
    11821 aggccatgaa gaaggagctg atccctgccg aggaggcact gaggctgctg gatgctcagc
    11881 tagccacagg aggcattgtg gacccccgcc tgggtttcca cctccccctg gaggtggctt
    11941 accaacgagg ctacctcaat aaggacacgc atgaccagtt gtcagagccc agtgaggtgc
    12001 gcagctatgt ggacccctcc acggatgagc gtctcagcta cacacagctg ctcaagcgtt
    12061 gccgccgtga cgacaacagc ggccagatgc tgctgccgct ctctgatgcc cgcaagctga
    12121 ccttccgcgg cctgcgcaag cagatcaccg tggaggagct ggtacgctct caggtcatgg
    12181 atgaggccac agcactgcag ctgcaagaag gcctgacctc cattgaggag gtcactaaga
    12241 acctgcagaa gttccttgag ggtaccagct gcattgctgg agtctttgtt gatgctacca
    12301 aggaacggct gtcggtgtac caggccatga agaagggcat catccgtccc gggacagcct
    12361 tcgagctcct ggaagcgcag gcagccaccg gctacgtcat tgaccctatc aaggggctca
    12421 agctgactgt ggaagaggcc gtgcgcatgg gtatcgtggg ccccgagttc aaggacaagc
    12481 tgctgtctgc tgagcgtgcg gtcactggct acaaggaccc ttactctggg aaactcatct
    12541 ctctcttcca ggccatgaag aagggcctga tcctgaagga ccatggcatc cgcctgctag
    12601 aggctcagat cgccaccggt ggcatcattg accctgagga gagccaccgc ctgcctgtgg
    12661 aagtggccta taagcgtggt ctctttgatg aggagatgaa cgagatcctg actgacccct
    12721 cagatgacac caagggcttc ttcgacccca acaccgagga gaacctcaca tacctgcagc
    12781 tgatggagcg ctgtatcact gacccccaga ctggcctgtg tctcctgccg ctgaaggaaa
    12841 agaagcggga gcggaagacg tcctccaagt cctcagtgcg caagcgccgc gtggtgattg
    12901 tggaccctga gacgggcaag gagatgtcag tgtatgaggc ctaccgcaag ggcctcatag
    12961 accaccagac atacctggag ttgtcagagc aggagtgcga gtgggaagaa atcaccatct
    13021 cttcctcgga cggcgtcgtc aaatctatga tcatcgaccg ccgctctggc cgccagtatg
    13081 acattgatga cgccatcacc aagaacctca ttgaccgctc agcactggac cagtaccgcg
    13141 ctggcacact ttctatcacc gagtttgccg acatgctctc aggcaacgct ggtggcttcc
    13201 gctcccgctc ctcctctgtg ggctcatctt cctcctaccc catcagttct gctgtcccta
    13261 ggacccagct agcctcctgg tctgatccta ctgaggagac tggcccagtg gccggcatcc
    13321 tagacacaga gactctggag aaggtgtcca tcacagaggc catgcaccgc aacctggtag
    13381 acaacatcac tggccagcgg ttgctggagg cacaggcctg caccgggggc atcattgacc
    13441 ccagcactgg tgagcgcttc ccggtcactg aggctgtcaa caagggcctg gtggacaaga
    13501 tcatggtaga ccgtatcaat ctggcccaga aggccttctg tgggtttgag gacccacgca
    13561 ccaagaccaa gatgtcagct gcccaggccc tgaagaaggg ctggctttac tacgaggcag
    13621 gccagcgttt cctcgaggtg cagtacctga cgggtggtct gattgagcct gacacacctg
    13681 gccgtgtgtc tcttgatgaa gccttgcaac gtggcactgt ggatgcccgc acagcccaga
    13741 agcttcgtga tgtcagtgcc tactccaagt acctcacgtg ccccaagacc aagctcaaga
    13801 tctcttacaa ggacgctctg gatcggagca tggtggagga gggcacaggg ctgaggctgc
    13861 tggaagccgc ggcacagtcc agcaagggct actacagccc gtacagtgtc agtggctctg
    13921 gctctactgc tggttcacgc actggttcac gcaccggctc cagggccggc tcccgtcgtg
    13981 gcagctttga tgccactggc tctggcttct ccatgacctt ttcttcttcc tcctactctt
    14041 cctcaggcta tggccgccgc tatgcctcag ggccttcagc ctctcttggg ggccctgagt
    14101 ctgcagtggc ctgatccccc agcctgtatc ctgccttccc gctctgcatg tcgccaggct
    14161 ccccgtggag gcgctggggt cttttctttc ttcttctttt tttttttttt tttttttttt
    14221 ttttaacatt taaaggtgtc ttcctcccaa gcggtgccta aaatctaacc aaaaagacca
    14281 gactaacaca ttaatatata tatatatatg cgatgtccag acagcctgtg tcttgggaaa
    14341 cagggctggc ccaggcccag tgaccactcc actctccttg ggcctcccta atcctttcta
    14401 cctgccactc accacagcta ggtgccttgg agaatccaga gctgggcact cagcccacta
    14461 ctcctgtctc tcctgggagg attgccatct gggaaaggcc cccagacctc taagccaacc
    14521 ccactggatg tctacctgct ggtcctagct gctgagggga actggggacg gtcctgtgag
    14581 cagacagctg ttgagtctct tgaggcctct gccctgagcc agctgcttct ccccagtgta
    14641 tacctgaata ttcagtgggt tttgctggca aaggaaagat cccaggccaa ccatctcttc
    14701 cagcctgccc agagaagccc cttccccatg ggaagataag gcctggtcct ggccccagcc
    14761 tcccgcctgg ctcctgcagc tgccattgga gctgtgcttt gtagctcact accccatact
    14821 tattcccttg agacctgagc ctctgcttca gccttccagc ctcaactccc cttgtaagtg
    14881 ccttctgtgt ccttgtaccc aggccctaaa gacccagacc cagggcaaga gatggacatt
    14941 ctggctgggc ggggctggag ggttctgcag atctgagaat tcttctccag aggcccaggg
    15001 gctcttcaag cctgtggaac ccctctgggt gctgctgccc accccactcc cagggagccc
    15061 tggccagccc agctgtgcta acataagtac ttggccagtt acactctccc ttccctggcc
    15121 ttggtggctc ctacccctgc ctccaccctc tgagtgagct ttgcatgttc cactaacctt
    15181 gagctggtga caggtggaga tgccaggcag aacactaacc tgaccatggg cgggggccct
    15241 gcggtgtccg cccctcaata aaagcaattc caaccttca
//
