LOCUS       NM_001398581             779 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus phospholipase D family, member 6 (Pld6),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001398581 XM_220517
VERSION     NM_001398581.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 779)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 779)
  AUTHORS   Baba,T., Kashiwagi,Y., Arimitsu,N., Kogure,T., Edo,A., Maruyama,T.,
            Nakao,K., Nakanishi,H., Kinoshita,M., Frohman,M.A., Yamamoto,A. and
            Tani,K.
  TITLE     Phosphatidic acid (PA)-preferring phospholipase A1 regulates
            mitochondrial dynamics
  JOURNAL   J Biol Chem 289 (16), 11497-11511 (2014)
   PUBMED   24599962
REFERENCE   3  (bases 1 to 779)
  AUTHORS   Nishimasu,H., Ishizu,H., Saito,K., Fukuhara,S., Kamatani,M.K.,
            Bonnefond,L., Matsumoto,N., Nishizawa,T., Nakanaga,K., Aoki,J.,
            Ishitani,R., Siomi,H., Siomi,M.C. and Nureki,O.
  TITLE     Structure and function of Zucchini endoribonuclease in piRNA
            biogenesis
  JOURNAL   Nature 491 (7423), 284-287 (2012)
   PUBMED   23064230
REFERENCE   4  (bases 1 to 779)
  AUTHORS   Ipsaro,J.J., Haase,A.D., Knott,S.R., Joshua-Tor,L. and Hannon,G.J.
  TITLE     The structural biochemistry of Zucchini implicates it as a nuclease
            in piRNA biogenesis
  JOURNAL   Nature 491 (7423), 279-283 (2012)
   PUBMED   23064227
REFERENCE   5  (bases 1 to 779)
  AUTHORS   Palmer,C.S., Osellame,L.D., Stojanovski,D. and Ryan,M.T.
  TITLE     The regulation of mitochondrial morphology: intricate mechanisms
            and dynamic machinery
  JOURNAL   Cell Signal 23 (10), 1534-1545 (2011)
   PUBMED   21683788
  REMARK    Review article
REFERENCE   6  (bases 1 to 779)
  AUTHORS   Huang,H., Gao,Q., Peng,X., Choi,S.Y., Sarma,K., Ren,H., Morris,A.J.
            and Frohman,M.A.
  TITLE     piRNA-associated germline nuage formation and spermatogenesis
            require MitoPLD profusogenic mitochondrial-surface lipid signaling
  JOURNAL   Dev Cell 20 (3), 376-387 (2011)
   PUBMED   21397848
REFERENCE   7  (bases 1 to 779)
  AUTHORS   Watanabe,T., Chuma,S., Yamamoto,Y., Kuramochi-Miyagawa,S.,
            Totoki,Y., Toyoda,A., Hoki,Y., Fujiyama,A., Shibata,T., Sado,T.,
            Noce,T., Nakano,T., Nakatsuji,N., Lin,H. and Sasaki,H.
  TITLE     MITOPLD is a mitochondrial protein essential for nuage formation
            and piRNA biogenesis in the mouse germline
  JOURNAL   Dev Cell 20 (3), 364-375 (2011)
   PUBMED   21397847
REFERENCE   8  (bases 1 to 779)
  AUTHORS   Choi,S.Y., Huang,P., Jenkins,G.M., Chan,D.C., Schiller,J. and
            Frohman,M.A.
  TITLE     A common lipid links Mfn-mediated mitochondrial fusion and
            SNARE-regulated exocytosis
  JOURNAL   Nat Cell Biol 8 (11), 1255-1262 (2006)
   PUBMED   17028579
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from JAXUCZ010000010.1.
            
            On Dec 20, 2021 this sequence version replaced XM_220517.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.36849.1,
                                           SRR26643293.63057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               JAXUCZ010000010.1  45080202-45080732   c
            532-779             JAXUCZ010000010.1  45078081-45078328   c
FEATURES             Location/Qualifiers
     source          1..779
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..779
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /note="phospholipase D family, member 6"
                     /db_xref="GeneID:287366"
                     /db_xref="RGD:1311987"
     exon            1..531
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..779
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /EC_number="3.1.4.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial cardiolipin hydrolase"
                     /codon_start=1
                     /product="mitochondrial cardiolipin hydrolase isoform 1"
                     /protein_id="NP_001385510.1"
                     /db_xref="GeneID:287366"
                     /db_xref="RGD:1311987"
                     /translation="MGRSSWRLVFAAGAGLALALEALPWLMRWLLAGRRPRREVLFFP
                     SQVTCTEALLQAPGLPPGPSSGCPCSLPHSESSLSRLLRALLAARSSLELCLFAFSSP
                     QLGRAVQLLHQRGVRVRVITDCDYMALNGSQIGLLRKAGIQVRHDQDLGYMHHKFAIV
                     DKKVLITGSLNWTTQAIQNNRENVLIMEDTEYVRLFLEEFERIWEEFDPTKYSFFPQK
                     HRGH"
     exon            532..779
                     /gene="Pld6"
                     /gene_synonym="RGD1311987"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgggggcgg gccccgtaag ggggcgtggc acacccgggg ttgggggcgg gtcggcacgt
       61 gttgggcgcg caagcgcttg gtgctacggc tgacctttga ggtggcggcc atggggcgct
      121 cgagttggcg gttggtgttc gcggccggtg cgggtctcgc gctggcccta gaggcactgc
      181 cgtggttgat gcgttggctg ctggctggga gacggccacg gcgcgaggtg ctcttcttcc
      241 cctcacaggt gacctgcacc gaggctttac tgcaggcccc aggcttgccc cccgggccct
      301 cctcgggctg cccgtgcagt ctcccacaca gcgagagttc gctgagccgc ctgctgcgcg
      361 cgctcttggc tgcccgctcc agcttggagc tctgcctctt cgccttctct agcccgcagc
      421 tgggacgtgc agtgcaacta ctgcaccagc gcggggtgcg cgtgcgggtc atcacggact
      481 gcgactacat ggccctcaac ggctctcaga tcggcctgct gcgcaaggca ggtatacagg
      541 tacggcatga ccaggaccta ggctacatgc accataagtt tgccatcgtt gacaagaagg
      601 tgctcatcac tggctccctc aattggacca cacaggccat ccagaacaac cgtgagaacg
      661 ttctgattat ggaggacacc gagtacgtgc ggctgttcct ggaggagttt gagcgcatct
      721 gggaagaatt tgaccccact aagtacagct ttttccccca aaagcatcga gggcactga
//
