LOCUS       NM_001126288            1989 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus phospholipase D family, member 4 (Pld4), mRNA.
ACCESSION   NM_001126288 XM_001072894 XM_576106
VERSION     NM_001126288.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K,
            Suda T, Nakamura T, Wolff L, Honda H and Inaba T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Otani Y, Yamaguchi Y, Sato Y, Furuichi T, Ikenaka K, Kitani H and
            Baba H.
  TITLE     PLD$ is involved in phagocytosis of microglia: expression and
            localization changes of PLD4 are correlated with activation state
            of microglia
  JOURNAL   PLoS One 6 (11), e27544 (2011)
   PUBMED   22102906
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Yoshikawa F, Banno Y, Otani Y, Yamaguchi Y, Nagakura-Takagi Y,
            Morita N, Sato Y, Saruta C, Nishibe H, Sadakata T, Shinoda Y,
            Hayashi K, Mishima Y, Baba H and Furuichi T.
  TITLE     Phospholipase D family member 4, a transmembrane glycoprotein with
            no phospholipase D activity, expression in spleen and early
            postnatal microglia
  JOURNAL   PLoS One 5 (11), e13932 (2010)
   PUBMED   21085684
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474034.2.
            
            On or before May 7, 2008 this sequence version replaced
            XM_001072894.1, XM_576106.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1989
                     /gene="Pld4"
                     /note="phospholipase D family, member 4"
                     /db_xref="GeneID:362792"
                     /db_xref="RGD:1598308"
     exon            1..125
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1610
                     /gene="Pld4"
                     /EC_number="3.1.4.4"
                     /note="phospholipase D4"
                     /codon_start=1
                     /product="5'-3' exonuclease PLD4"
                     /protein_id="NP_001119760.1"
                     /db_xref="GeneID:362792"
                     /db_xref="RGD:1598308"
                     /translation="MEGEATGQRGGRCLHRQGLQTMTGARMDKKKWHPEMLIPLQTTM
                     EVPDWPYSTPPHGPHNRVGMVLGMLAILGLGSVTLTLFLWQGPTSFTSPQMFPEEVPS
                     WFWETLKGDTEQNNSCQLILAESIPEDLPFAAGSPAAQPLAQAWLQLLDTAQESVHIA
                     SYYWSLTGQDVGVNDSSSQQGEALLQKFQQLLLRNISVVVATHSPTLAKTSTDLQVLA
                     AHGAQIRQVSMKQLTGGVLHSKFWVVDGRHVYVGSANMDWRSLSQVKELGAIIYNCSH
                     LAEDLEKTFQTYWVLGTPQAVLPKPWPRNFSTHINRFHPLRGLFDGVPTTAYFSASPP
                     SLCPHGRTRDLDAVLAVMGGAGEFIYVSVMEYFPTTRFTHPARYWPVLDNALRAAAFN
                     KGVRVRLLVSCWFNTDPTMFAYLRSLQAFSNPLAGISVDVKVFIVPVGNHSNIPFSRV
                     NHSKFMVTDKTAYIGTSNWSEDYFSGTAGVGLVVSQKTPSAQPAVTTVQEQLRQLFER
                     DWSSHYAMGLDRQIPSQDCVW"
     exon            126..212
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            213..376
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            377..560
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            682..809
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1010
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1150
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1316
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1413
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1989
                     /gene="Pld4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagaacaaa ggggaagtga atggaagggg aagcaacagg ccagagagga ggcaggtgcc
       61 tgcacaggca aggcctgcag acaatgactg gagccaggat ggacaagaaa aaatggcacc
      121 cagagatgct gatacctctg cagacaacaa tggaggtccc tgactggccc tactccactc
      181 cacctcatgg tccacacaac agagttggca tggtactagg gatgctggct atcctgggac
      241 tcggctctgt gactctcacc ttgttcctgt ggcaagggcc cacttctttc accagtcccc
      301 agatgttccc tgaggaagtg ccctcctggt tctgggagac cctgaaagga gacactgagc
      361 agaataactc ctgtcagctc atccttgcgg aaagtattcc cgaggacttg ccgtttgcag
      421 ccggcagccc cgctgcccag ccgctggccc aggcttggct gcagcttctt gacactgctc
      481 aggagagcgt ccacattgcc tcatactact ggtccctcac cggacaggac gttggagtca
      541 atgactcatc ttctcagcag ggagaggccc ttctacagaa gtttcaacag ctccttctca
      601 ggaatatctc tgtggtggtg gccacccaca gcccaacatt ggccaagaca tccactgacc
      661 tccaggtctt ggctgcccac ggtgcccaga tacgacaggt ttccatgaaa cagcttactg
      721 gtggtgtcct acactccaaa ttctgggttg tggatgggcg gcatgtctac gtgggcagtg
      781 ccaacatgga ctggcggtcc ctttctcagg tgaaggagct tggcgctatc atctacaact
      841 gcagtcacct ggctgaagac cttgagaaaa cattccagac ctactgggtg ctggggactc
      901 cccaagctgt tctccctaaa ccctggcctc ggaacttctc aacccacatc aaccggttcc
      961 atcccttgcg gggtctcttt gacggggttc ccaccacagc ctatttctcg gcctctcctc
     1021 cctcactctg cccccatggc cgtacccggg atctggacgc agtgttggca gtgatggggg
     1081 gtgctggcga gttcatctac gtctcagtga tggagtactt ccctaccacg cgcttcactc
     1141 acccagccag gtactggccc gtgctggaca atgcactacg ggctgcggcc ttcaataagg
     1201 gtgtgcgtgt gcgcttactg gtcagctgct ggttcaacac agaccccacc atgttcgctt
     1261 atctgaggtc cctgcaggct ttcagtaacc ccttggctgg catctcagtg gatgtgaaag
     1321 tcttcattgt acctgtggga aatcactcca acatcccatt cagccgcgtg aaccacagca
     1381 agttcatggt cacagacaag acagcctata taggcacctc taactggtca gaagactact
     1441 tcagcggcac cgccggtgtg ggcctggttg tcagccagaa gacccctagt gcccagccag
     1501 ccgtgaccac cgtgcaggag cagctgaggc aactctttga acgggactgg agttcccact
     1561 atgccatggg cctggacaga caaatcccga gccaggattg tgtctggtag ggctgagggt
     1621 tgatcccttt gactctggct tacagctcta ggtggacgca gatacccatc aggcttccgt
     1681 ccacccaagc tcagaaactg ggaaagcaaa aggcatctcc cggggcctga gattgtcacc
     1741 aggcaaacag cttctggcag agctctaaat ggcttttaaa tgaagaggag actaaagcag
     1801 aggagggcac acagtgacac ggaaagaaag caacctcatc taagtgaccc cagaacccag
     1861 ttggtcctcc ctgacctacc tacgatgagg gtctagggcc gtccccagat gtaatgttgg
     1921 tgctgtctgg ccacaacccc taataaaacc ccaccaccag cttgcacacc tgacccaggt
     1981 caaagtgag
//
