LOCUS       NM_001012167            1874 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Rattus norvegicus phospholipase D family, member 3 (Pld3), mRNA.
ACCESSION   NM_001012167 XM_341811
VERSION     NM_001012167.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1874)
  AUTHORS   Gonzalez,A.C., Stroobants,S., Reisdorf,P., Gavin,A.L., Nemazee,D.,
            Schwudke,D., D'Hooge,R., Saftig,P. and Damme,M.
  TITLE     PLD3 and spinocerebellar ataxia
  JOURNAL   Brain 141 (11), e78 (2018)
   PUBMED   30312375
REFERENCE   2  (bases 1 to 1874)
  AUTHORS   Gavin,A.L., Huang,D., Huber,C., Martensson,A., Tardif,V.,
            Skog,P.D., Blane,T.R., Thinnes,T.C., Osborn,K., Chong,H.S.,
            Kargaran,F., Kimm,P., Zeitjian,A., Sielski,R.L., Briggs,M.,
            Schulz,S.R., Zarpellon,A., Cravatt,B., Pang,E.S., Teijaro,J., de la
            Torre,J.C., O'Keeffe,M., Hochrein,H., Damme,M., Teyton,L.,
            Lawson,B.R. and Nemazee,D.
  TITLE     PLD3 and PLD4 are single-stranded acid exonucleases that regulate
            endosomal nucleic-acid sensing
  JOURNAL   Nat Immunol 19 (9), 942-953 (2018)
   PUBMED   30111894
REFERENCE   3  (bases 1 to 1874)
  AUTHORS   Mukadam,A.S., Breusegem,S.Y. and Seaman,M.N.J.
  TITLE     Analysis of novel endosome-to-Golgi retrieval genes reveals a role
            for PLD3 in regulating endosomal protein sorting and amyloid
            precursor protein processing
  JOURNAL   Cell Mol Life Sci 75 (14), 2613-2625 (2018)
   PUBMED   29368044
REFERENCE   4  (bases 1 to 1874)
  AUTHORS   Gonzalez,A.C., Schweizer,M., Jagdmann,S., Bernreuther,C.,
            Reinheckel,T., Saftig,P. and Damme,M.
  TITLE     Unconventional Trafficking of Mammalian Phospholipase D3 to
            Lysosomes
  JOURNAL   Cell Rep 22 (4), 1040-1053 (2018)
   PUBMED   29386126
REFERENCE   5  (bases 1 to 1874)
  AUTHORS   Fazzari,P., Horre,K., Arranz,A.M., Frigerio,C.S., Saito,T.,
            Saido,T.C. and De Strooper,B.
  TITLE     PLD3 gene and processing of APP
  JOURNAL   Nature 541 (7638), E1-E2 (2017)
   PUBMED   28128235
REFERENCE   6  (bases 1 to 1874)
  AUTHORS   Otani,Y., Yamaguchi,Y., Sato,Y., Furuichi,T., Ikenaka,K., Kitani,H.
            and Baba,H.
  TITLE     PLD$ is involved in phagocytosis of microglia: expression and
            localization changes of PLD4 are correlated with activation state
            of microglia
  JOURNAL   PLoS One 6 (11), e27544 (2011)
   PUBMED   22102906
REFERENCE   7  (bases 1 to 1874)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (bases 1 to 1874)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 1874)
  AUTHORS   Munck,A., Bohm,C., Seibel,N.M., Hashemol Hosseini,Z. and Hampe,W.
  TITLE     Hu-K4 is a ubiquitously expressed type 2 transmembrane protein
            associated with the endoplasmic reticulum
  JOURNAL   FEBS J 272 (7), 1718-1726 (2005)
   PUBMED   15794758
REFERENCE   10 (bases 1 to 1874)
  AUTHORS   Pedersen,K.M., Finsen,B., Celis,J.E. and Jensen,N.A.
  TITLE     Expression of a novel murine phospholipase D homolog coincides with
            late neuronal development in the forebrain
  JOURNAL   J Biol Chem 273 (47), 31494-31504 (1998)
   PUBMED   9813063
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089987.1.
            
            On Feb 11, 2005 this sequence version replaced XM_341811.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089987.1, SRR8487226.6574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1874
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1874
                     /gene="Pld3"
                     /note="phospholipase D family, member 3"
                     /db_xref="GeneID:361527"
                     /db_xref="RGD:1308248"
     exon            1..22
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            23..108
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1548
                     /gene="Pld3"
                     /EC_number="3.1.16.1"
                     /note="PLD 3; choline phosphatase 3;
                     phosphatidylcholine-hydrolyzing phospholipase D3;
                     (S,S)-bis(monoacylglycero)phosphate synthase PLD3"
                     /codon_start=1
                     /product="5'-3' exonuclease PLD3"
                     /protein_id="NP_001012167.1"
                     /db_xref="GeneID:361527"
                     /db_xref="RGD:1308248"
                     /translation="MKPKLMYQELKVPVEEPAGELPMNEIEAWKAAEKKARWVLLVLI
                     LAVVGFGALMTQLFLWEYGDLHLFGPNQHPAPCYDPCEAVLVESIPEGLEFPNATTSN
                     PSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLQQLQALAPRGVK
                     VRIAVSKPNGPLADLQSLLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMD
                     WRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRPFDTRYNQETP
                     MEICLNGTPALAYLASAPPPLCPGGRTPDLKALLSVVDNARSFIYIAVMNYLPTMEFS
                     HPRRFWPAIDDGLRRAAYERGVKVRLLISCWGHSEPSMRSFLLSLAALRDNHTHSDIQ
                     VKLFVVPADEAQARIPYARVNHNKYMVTERTTYIGTSNWSGSYFTETAGTSLLVTQNG
                     HGGLRSQLEAVFLRDWESPYSHNLDTSADSVGNACRLL"
     exon            109..183
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            184..326
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            327..510
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..625
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..753
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            754..954
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1094
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1260
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1360
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1848
                     /gene="Pld3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaagaccgg tgtcgtttta ggtccctgac acacccacct tgccgcctcc gttctgcaga
       61 ggcccccagc tgccaggcaa tatgaagcct aaactgatgt accaggagct gaaggttcct
      121 gttgaggaac ctgcgggaga actgcccatg aatgaaatcg aggcatggaa ggcagcagag
      181 aagaaagccc gttgggtcct ccttgtcctt atcctggcgg tagtgggctt cggtgccctg
      241 atgactcagc tgtttctatg ggaatacggg gacttacatc tatttggccc gaatcagcac
      301 ccagccccct gctatgaccc ctgcgaggcg gtgctggtgg agagcattcc cgaggggctg
      361 gagtttccca atgccaccac aagcaacccc tccaccagcc aggcctggtt gggcctcctt
      421 gccggtgctc acagcagcct ggacatcgcg tccttctact ggactctcac aaacaatgat
      481 acccacacgc aagagccctc tgcccagcag ggtgaagagg ttcttcagca gcttcaggct
      541 ctggcacctc gaggtgtaaa ggttcgcatc gctgtgagca aacccaacgg acctctggct
      601 gatctgcagt ctctgctaca gagtggtgcc caggtgcgca tggtggacat gcagaagctg
      661 acccatggtg tcctgcacac caagttctgg gtggtggacc agacccactt ttacctgggc
      721 agtgccaaca tggactggcg atcgctgacc caggtcaagg agctgggcgt ggtcatgtac
      781 aactgcagct gcctggctcg cgacctcacc aagatttttg aagcctattg gttcctgggc
      841 caggcaggca gctccatccc ttcaacctgg ccacggccct ttgacacccg gtacaaccaa
      901 gaaacaccga tggagatctg cctcaatggc accccagccc tggcctacct ggcgagtgca
      961 cccccgccac tgtgtccagg tggccgcacc ccagacctga aggcactgct cagcgtggtg
     1021 gacaacgccc gaagcttcat ctacattgca gttatgaact acctgcccac catggagttc
     1081 tcccatccac gcaggttctg gccagcgatt gatgatgggc taagacgggc tgcgtatgaa
     1141 cgaggcgtca aagtgcgttt gctcatcagc tgctggggac actccgagcc atccatgcgg
     1201 tccttcctgc tctccctggc tgcccttcgt gacaaccata cccactctga catccaggtg
     1261 aaactgtttg tggtccctgc ggatgaggcc caagctcgaa tcccctatgc ccgcgtcaac
     1321 cacaacaagt acatggtgac tgaacgcacc acatacattg gaacctccaa ctggtctgga
     1381 agctacttca cagagacggc aggcacctcc ctgctggtga cacagaacgg gcacggtggc
     1441 ttgcgcagcc agctggaggc tgttttcctg agagactggg aatccccata cagccacaac
     1501 cttgacacct cagccgacag tgtgggcaat gcctgccgcc tgctttgagg ctcatctcga
     1561 tggacaggcc aaagccttct gggcccccct ggactcagca ctgggtcctg gttgctgtcc
     1621 ctgtgccctt gcttctgtct atcccattgt ggctctgtac tctctactac actcctgtgg
     1681 ctacctccac ctccactggt ctgacactct ggcccctgtg gacttagcag agctgaggga
     1741 ggatcgggcc ccaaagaagt gggggtgcat gctgggccca gacctttggc ccaccccaca
     1801 aaggggccaa gattataagt aaataattgt ctgtatagcc tgtgctaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaa
//
