LOCUS       NP_001012167             488 aa            linear   ROD 16-FEB-2025
DEFINITION  5'-3' exonuclease PLD3 [Rattus norvegicus].
ACCESSION   NP_001012167 XP_341812
VERSION     NP_001012167.1
DBSOURCE    REFSEQ: accession NM_001012167.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 488)
  AUTHORS   Gonzalez,A.C., Stroobants,S., Reisdorf,P., Gavin,A.L., Nemazee,D.,
            Schwudke,D., D'Hooge,R., Saftig,P. and Damme,M.
  TITLE     PLD3 and spinocerebellar ataxia
  JOURNAL   Brain 141 (11), e78 (2018)
   PUBMED   30312375
REFERENCE   2  (residues 1 to 488)
  AUTHORS   Gavin,A.L., Huang,D., Huber,C., Martensson,A., Tardif,V.,
            Skog,P.D., Blane,T.R., Thinnes,T.C., Osborn,K., Chong,H.S.,
            Kargaran,F., Kimm,P., Zeitjian,A., Sielski,R.L., Briggs,M.,
            Schulz,S.R., Zarpellon,A., Cravatt,B., Pang,E.S., Teijaro,J., de la
            Torre,J.C., O'Keeffe,M., Hochrein,H., Damme,M., Teyton,L.,
            Lawson,B.R. and Nemazee,D.
  TITLE     PLD3 and PLD4 are single-stranded acid exonucleases that regulate
            endosomal nucleic-acid sensing
  JOURNAL   Nat Immunol 19 (9), 942-953 (2018)
   PUBMED   30111894
REFERENCE   3  (residues 1 to 488)
  AUTHORS   Mukadam,A.S., Breusegem,S.Y. and Seaman,M.N.J.
  TITLE     Analysis of novel endosome-to-Golgi retrieval genes reveals a role
            for PLD3 in regulating endosomal protein sorting and amyloid
            precursor protein processing
  JOURNAL   Cell Mol Life Sci 75 (14), 2613-2625 (2018)
   PUBMED   29368044
REFERENCE   4  (residues 1 to 488)
  AUTHORS   Gonzalez,A.C., Schweizer,M., Jagdmann,S., Bernreuther,C.,
            Reinheckel,T., Saftig,P. and Damme,M.
  TITLE     Unconventional Trafficking of Mammalian Phospholipase D3 to
            Lysosomes
  JOURNAL   Cell Rep 22 (4), 1040-1053 (2018)
   PUBMED   29386126
REFERENCE   5  (residues 1 to 488)
  AUTHORS   Fazzari,P., Horre,K., Arranz,A.M., Frigerio,C.S., Saito,T.,
            Saido,T.C. and De Strooper,B.
  TITLE     PLD3 gene and processing of APP
  JOURNAL   Nature 541 (7638), E1-E2 (2017)
   PUBMED   28128235
REFERENCE   6  (residues 1 to 488)
  AUTHORS   Otani,Y., Yamaguchi,Y., Sato,Y., Furuichi,T., Ikenaka,K., Kitani,H.
            and Baba,H.
  TITLE     PLD$ is involved in phagocytosis of microglia: expression and
            localization changes of PLD4 are correlated with activation state
            of microglia
  JOURNAL   PLoS One 6 (11), e27544 (2011)
   PUBMED   22102906
REFERENCE   7  (residues 1 to 488)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   8  (residues 1 to 488)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (residues 1 to 488)
  AUTHORS   Munck,A., Bohm,C., Seibel,N.M., Hashemol Hosseini,Z. and Hampe,W.
  TITLE     Hu-K4 is a ubiquitously expressed type 2 transmembrane protein
            associated with the endoplasmic reticulum
  JOURNAL   FEBS J 272 (7), 1718-1726 (2005)
   PUBMED   15794758
REFERENCE   10 (residues 1 to 488)
  AUTHORS   Pedersen,K.M., Finsen,B., Celis,J.E. and Jensen,N.A.
  TITLE     Expression of a novel murine phospholipase D homolog coincides with
            late neuronal development in the forebrain
  JOURNAL   J Biol Chem 273 (47), 31494-31504 (1998)
   PUBMED   9813063
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089987.1.
            
            On Feb 11, 2005 this sequence version replaced XP_341812.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089987.1, SRR8487226.6574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..488
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     Protein         1..488
                     /product="5'-3' exonuclease PLD3"
                     /EC_number="3.1.16.1"
                     /note="PLD 3; choline phosphatase 3;
                     phosphatidylcholine-hydrolyzing phospholipase D3;
                     (S,S)-bis(monoacylglycero)phosphate synthase PLD3"
                     /calculated_mol_wt=54268
     Site            39..59
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5FVH2.1)"
     Site            71..72
                     /site_type="cleavage"
                     /note="Cleavage, by lysosomal cysteine proteases.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (Q5FVH2.1)"
     Region          77..488
                     /region_name="PHA02820"
                     /note="phospholipase-D-like protein; Provisional"
                     /db_xref="CDD:222934"
     Site            97
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (Q5FVH2.1)"
     Site            132
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (Q5FVH2.1)"
     Site            234
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (Q5FVH2.1)"
     Site            282
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000250|UniProtKB:Q8IV08; propagated from
                     UniProtKB/Swiss-Prot (Q5FVH2.1)"
     Site            385
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (Q5FVH2.1)"
     CDS             1..488
                     /gene="Pld3"
                     /coded_by="NM_001012167.1:82..1548"
                     /db_xref="GeneID:361527"
                     /db_xref="RGD:1308248"
ORIGIN      
        1 mkpklmyqel kvpveepage lpmneieawk aaekkarwvl lvlilavvgf galmtqlflw
       61 eygdlhlfgp nqhpapcydp ceavlvesip eglefpnatt snpstsqawl gllagahssl
      121 diasfywtlt nndthtqeps aqqgeevlqq lqalaprgvk vriavskpng pladlqsllq
      181 sgaqvrmvdm qklthgvlht kfwvvdqthf ylgsanmdwr sltqvkelgv vmyncsclar
      241 dltkifeayw flgqagssip stwprpfdtr ynqetpmeic lngtpalayl asappplcpg
      301 grtpdlkall svvdnarsfi yiavmnylpt mefshprrfw paiddglrra ayergvkvrl
      361 liscwghsep smrsfllsla alrdnhthsd iqvklfvvpa deaqaripya rvnhnkymvt
      421 erttyigtsn wsgsyfteta gtsllvtqng hgglrsqlea vflrdwespy shnldtsads
      481 vgnacrll
//
