LOCUS       NM_001399082            4929 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus phospholipase D1 (Pld1), transcript variant 1,
            mRNA.
ACCESSION   NM_001399082 XM_006232205
VERSION     NM_001399082.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4929)
  AUTHORS   Bills,B.L., Hulser,M.L. and Knowles,M.K.
  TITLE     Phospholipase D1 produces phosphatidic acid at sites of secretory
            vesicle docking and fusion
  JOURNAL   Mol Biol Cell 35 (3), ar39 (2024)
   PUBMED   38117597
  REMARK    GeneRIF: Phospholipase D1 produces phosphatidic acid at sites of
            secretory vesicle docking and fusion.
REFERENCE   2  (bases 1 to 4929)
  AUTHORS   Kang,M.J., Jin,N., Park,S.Y. and Han,J.S.
  TITLE     Phospholipase D1 promotes astrocytic differentiation through the
            FAK/AURKA/STAT3 signaling pathway in hippocampal neural
            stem/progenitor cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (12), 119361 (2022)
   PUBMED   36162649
  REMARK    GeneRIF: Phospholipase D1 promotes astrocytic differentiation
            through the FAK/AURKA/STAT3 signaling pathway in hippocampal neural
            stem/progenitor cells.
REFERENCE   3  (bases 1 to 4929)
  AUTHORS   Zhang,Z., Chen,X., Gao,B., Sun,G., Wang,Y., Wang,J., Zhang,T.,
            Qian,H., Zhang,Y., Huang,J., Sun,R., Wu,J. and Zhou,L.
  TITLE     PLD1 knockdown reduces metastasis and inflammation of
            fibroblast-like synoviocytes in rheumatoid arthritis by modulating
            NF-kappaB and Wnt/beta-catenin pathways
  JOURNAL   Autoimmunity 54 (7), 398-405 (2021)
   PUBMED   34431424
  REMARK    GeneRIF: PLD1 knockdown reduces metastasis and inflammation of
            fibroblast-like synoviocytes in rheumatoid arthritis by modulating
            NF-kappaB and Wnt/beta-catenin pathways.
REFERENCE   4  (bases 1 to 4929)
  AUTHORS   Huang,K., Deng,Y., Yuan,W., Geng,J., Wang,G. and Zou,F.
  TITLE     Phospholipase D1 Ameliorates Apoptosis in Chronic Renal Toxicity
            Caused by Low-Dose Cadmium Exposure
  JOURNAL   Biomed Res Int 2020, 7091053 (2020)
   PUBMED   32337269
  REMARK    GeneRIF: Phospholipase D1 Ameliorates Apoptosis in Chronic Renal
            Toxicity Caused by Low-Dose Cadmium Exposure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4929)
  AUTHORS   Li,W.Q., Luo,L.D., Hu,Z.W., Lyu,T.J., Cen,C. and Wang,Y.
  TITLE     PLD1 promotes dendritic spine morphogenesis via activating PKD1
  JOURNAL   Mol Cell Neurosci 99, 103394 (2019)
   PUBMED   31356881
  REMARK    GeneRIF: PLD1 directly interacts with PKD1.  The enzymatic activity
            of PLD1 is required to promote dendritic spine development.
REFERENCE   6  (bases 1 to 4929)
  AUTHORS   Laine,J., Bourgoin,S., Bourassa,J. and Morisset,J.
  TITLE     Subcellular distribution and characterization of rat pancreatic
            phospholipase D isoforms
  JOURNAL   Pancreas 20 (4), 323-336 (2000)
   PUBMED   10824686
REFERENCE   7  (bases 1 to 4929)
  AUTHORS   Katayama,K., Kodaki,T., Nagamachi,Y. and Yamashita,S.
  TITLE     Cloning, differential regulation and tissue distribution of
            alternatively spliced isoforms of ADP-ribosylation-factor-dependent
            phospholipase D from rat liver
  JOURNAL   Biochem J 329 (Pt 3) (Pt 3), 647-652 (1998)
   PUBMED   9445394
REFERENCE   8  (bases 1 to 4929)
  AUTHORS   Park,S.K., Provost,J.J., Bae,C.D., Ho,W.T. and Exton,J.H.
  TITLE     Cloning and characterization of phospholipase D from rat brain
  JOURNAL   J Biol Chem 272 (46), 29263-29271 (1997)
   PUBMED   9361006
REFERENCE   9  (bases 1 to 4929)
  AUTHORS   Nakashima,S., Matsuda,Y., Akao,Y., Yoshimura,S., Sakai,H.,
            Hayakawa,K., Andoh,M. and Nozawa,Y.
  TITLE     Molecular cloning and chromosome mapping of rat phospholipase D
            genes, Pld1a, Pld1b and Pld2
  JOURNAL   Cytogenet Cell Genet 79 (1-2), 109-113 (1997)
   PUBMED   9533024
REFERENCE   10 (bases 1 to 4929)
  AUTHORS   Yoshimura,S., Nakashima,S., Ohguchi,K., Sakai,H., Shinoda,J.,
            Sakai,N. and Nozawa,Y.
  TITLE     Differential mRNA expression of phospholipase D (PLD) isozymes
            during cAMP-induced differentiation in C6 glioma cells
  JOURNAL   Biochem Biophys Res Commun 225 (2), 494-499 (1996)
   PUBMED   8753790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 4, 2022 this sequence version replaced XM_006232205.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000778.1, AB003170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000002.1  112822176-112822359
            185-375             JAXUCZ010000002.1  112865744-112865934
            376-503             JAXUCZ010000002.1  112866799-112866926
            504-649             JAXUCZ010000002.1  112870367-112870512
            650-755             JAXUCZ010000002.1  112871131-112871236
            756-821             JAXUCZ010000002.1  112873237-112873302
            822-880             JAXUCZ010000002.1  112882669-112882727
            881-973             JAXUCZ010000002.1  112884107-112884199
            974-1126            JAXUCZ010000002.1  112888027-112888179
            1127-1276           JAXUCZ010000002.1  112890485-112890634
            1277-1360           JAXUCZ010000002.1  112891651-112891734
            1361-1442           JAXUCZ010000002.1  112895763-112895844
            1443-1553           JAXUCZ010000002.1  112903249-112903359
            1554-1754           JAXUCZ010000002.1  112906157-112906357
            1755-1968           JAXUCZ010000002.1  112907512-112907725
            1969-2082           JAXUCZ010000002.1  112908499-112908612
            2083-2211           JAXUCZ010000002.1  112915227-112915355
            2212-2330           JAXUCZ010000002.1  112916336-112916454
            2331-2444           JAXUCZ010000002.1  112917839-112917952
            2445-2555           JAXUCZ010000002.1  112928851-112928961
            2556-2644           JAXUCZ010000002.1  112932852-112932940
            2645-2758           JAXUCZ010000002.1  112945250-112945363
            2759-2808           JAXUCZ010000002.1  112947970-112948019
            2809-2943           JAXUCZ010000002.1  112955033-112955167
            2944-3097           JAXUCZ010000002.1  112959922-112960075
            3098-3215           JAXUCZ010000002.1  112972357-112972474
            3216-4929           JAXUCZ010000002.1  112974144-112975857
FEATURES             Location/Qualifiers
     source          1..4929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..4929
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /note="phospholipase D1"
                     /db_xref="GeneID:25096"
                     /db_xref="RGD:3349"
     exon            1..184
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            185..375
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3440
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /EC_number="3.1.4.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phospholipase D gene 1, probably with two splicing
                     variants A and B; PLD 1; rPLD1; choline phosphatase 1;
                     phosphatidylcholine-hydrolyzing phospholipase D1;
                     Phoshpolipase D gene 1 probably with two splicing variants
                     A and B; phospholipase D1, phosphatidylcholine-specific"
                     /codon_start=1
                     /product="phospholipase D1 isoform 1"
                     /protein_id="NP_001386011.1"
                     /db_xref="GeneID:25096"
                     /db_xref="RGD:3349"
                     /translation="MSLKSEARVNTSTLQKIAADMSNLIENLDTRELHFEGEEVEYDA
                     SPGDPTAQEACIPFSSIYNTQGFKEPNIQIYLSGCPVKAQVLEVERFTSTSRMPSVNL
                     YTIELTHGEFTWQVKRKFKHFQEFHRELLKYKAFIRIPIPTKRHTFRRQNVKEEPREM
                     PSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLSFIHDLG
                     PKGLEGMIMKRSGGHRIPGVNCCGHGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVL
                     LVDKEFRIKVGKKETETKYGLRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTDF
                     LKDHRFGSYAAVHENILAKWYVNAKGYFEDIANAMEGATEEIFITDWWLSPEIFLKRP
                     VVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRH
                     PDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGQS
                     LGSLTAASVESMESLSLKDKHQSHKNEPVLKSVNDTDMKLKGIGKSRKFSKFSLYRQL
                     HRRNLHNSDSISSVDSASSYFNHYRSHQNLIHGLKPHLKLFRPSSESEQGLTRHSADT
                     GSIRSVQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIG
                     SVVHGKAARDVARHFIQRWNFTKIMKPKYRSLSYPFLLPKSQATAHELRYQVPGAVHA
                     KAQLLRSAADWSAGIKHHEESIHAAYTHVIENSKHYIYIENQFFISCADDKVVFNKVG
                     NAIAQRILKAHREGQRYRVYIVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGESS
                     ILEQLKPELGNKWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANI
                     NDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFAQGLRLECFRLVLGYLSDPSE
                     DIQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPILAKEDR
                     LRAEEELRKIRGFLVQFPFYFLSEENLLPSVGTKEAIVPMEVWT"
     exon            376..503
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            504..649
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            650..755
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            756..821
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            822..880
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            881..973
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1126
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1276
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1360
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1442
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1553
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1754
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1968
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2082
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2211
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2330
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2444
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2555
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2644
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2645..2758
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2808
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2943
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3097
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            3098..3215
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..4929
                     /gene="Pld1"
                     /gene_synonym="Pld1a; Pld1b; Plda; Pldb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaatttcctt agggagcctg ccaaagttga gctttggaac aggccggctt cccctgtttt
       61 tgtggatttg taggatagcc aatttccccc catctcgact ttcaactgct ttggacatta
      121 gcttcatagg aagaattcat tctttagagt aaaatggagc gccgcttttt gccaggggcc
      181 ccagcccctc tgtttttacc ctgtcagaag ttagaatgtc actaaaaagt gaggcccggg
      241 tgaacacttc tacactgcag aagatcgccg cagatatgag caacctgata gaaaatctcg
      301 acacccggga acttcacttt gagggagagg aggtggagta tgatgcatct ccaggagacc
      361 ccacggctca ggaagcgtgc atcccattct cttctattta caacactcaa ggatttaagg
      421 agcccaacat ccagatctac ctctctggct gtcctgtaaa agcacaagta ctggaagtgg
      481 agcgcttcac gtcgacctcg aggatgccaa gtgtcaacct gtacaccatc gagttaacac
      541 acggggaatt cacatggcaa gttaagagga aattcaagca cttccaagag tttcatagag
      601 agctcctcaa gtacaaagcc ttcatccgga tccccattcc caccaaaaga catacgttta
      661 gaagacaaaa tgtcaaagaa gagcccagag aaatgcccag tctgccccgt tcatcagaaa
      721 atgcaatcca ggaggagcag ttctttggca ggaggaagca actggaagat tacttgacaa
      781 aaatactaaa aatgcccatg tacagaaact atcatgccac gacagagttc cttgatgtaa
      841 gccaactgtc ttttatccat gatttgggac caaagggcct ggaaggaatg atcatgaaaa
      901 gatctggggg acacaggata ccaggtgtga attgctgtgg ccatggaaga gcctgctacc
      961 ggtggtcaaa gaggtggttg atagtgaaag actctttcct gctgtatatg aaaccagaca
     1021 gcggggcgat cgccttcgtc cttcttgtag acaaagaatt cagaatcaaa gtgggaaaga
     1081 aggagacaga aacgaaatat ggacttcgaa ttgataatct ttcaaggaca ctgattttaa
     1141 aatgtaacag ctacagacat gcccggtggt ggggaggcgc catcgaggag ttcatccaga
     1201 agcacggcac tgacttcctc aaagaccatc gcttcggctc ctacgctgcg gtccacgaga
     1261 acattttagc taaatggtac gtgaacgcca aaggttactt tgaagatatc gcaaacgcaa
     1321 tggaaggggc aacggaagag atttttatca cagattggtg gttaagtcca gaaatcttcc
     1381 tgaagcgccc agtggtggaa ggcaaccgct ggaggctgga ctgcatcctc aaacggaaag
     1441 cacaacaagg tgtgcggatt ttcataatgc tttacaaaga ggtggagcta gccctcggga
     1501 tcaacagcga gtacaccaag cggactttga tgcggctgca ccccaacata aaggtgatga
     1561 gacacccaga ccatgtgtcc tccagtgtgt atctgtgggc tcatcacgag aagctcgtca
     1621 ttatcgacca atcggtggcg tttgtgggtg ggattgacct ggcctatgga cggtgggatg
     1681 acaatgagca cagactcaca gatgtgggca gtgtcaagcg ggtcacctca ggacagtctc
     1741 tgggctctct cacagcagca tcagtagagt ctatggaatc cttaagcctc aaggacaaac
     1801 atcaatctca taaaaacgag cccgtcttaa agagtgtcaa cgataccgac atgaaactga
     1861 aaggcatagg gaagtccagg aaattctcca aatttagcct ctatcgccaa cttcaccgcc
     1921 gtaatctgca caactcggac agcattagca gcgtcgacag cgcttccagt tattttaacc
     1981 actatagaag tcatcagaat ttaatccatg ggttaaagcc ccacttgaaa ctctttcgcc
     2041 cttccagtga gtctgagcag ggcctcacta ggcacagtgc tgacaccggc tccatccgaa
     2101 gtgtgcagac aggagtggga gagctccatg gggagactag gttttggcat gggaaggatt
     2161 actgcaactt tgtcttcaag gactgggttc aactggacaa accttttgct gatttcatcg
     2221 acaggtactc caccccccgg atgccttggc atgacattgg ttctgtggtt cacggaaagg
     2281 cagctcgtga cgtggctcga cacttcatcc agcgctggaa cttcacaaag attatgaagc
     2341 caaaatatcg ttccctttct tatcctttcc tgctcccaaa gtctcaagcc acagcgcatg
     2401 agctgaggta tcaggtgcca ggggccgtcc acgccaaagc acagttgctc cgatctgctg
     2461 ctgactggtc tgctggtata aagcaccacg aggaatctat ccatgctgcc tacacccatg
     2521 tcatagagaa cagcaagcac tacatctata ttgaaaacca atttttcata agctgcgctg
     2581 atgataaagt cgtgttcaac aaggtgggca atgctatcgc ccagagaatc ctgaaagccc
     2641 acagggaagg ccagagatat cgagtgtaca tcgtgatacc actgctgccg ggattcgaag
     2701 gagacatttc cacaggcggg ggaaatgccc tacaggcaat aatgcacttc aactacagaa
     2761 ccatgtgcag aggggagagc tccatccttg aacagttaaa gccagagctt ggtaacaagt
     2821 ggataaatta catatcattt tgcggtctga gaacacatgc agagctggaa ggaaaccttg
     2881 tcactgagct catctatgtc cacagcaagt tgttaattgc tgatgataac acggttatca
     2941 taggttctgc caacatcaat gaccggagca tgctgggaaa gcgagacagc gaaatggctg
     3001 tcatagtgca ggacacagag acagtcccgt cagtgatgga tggaaaagaa tatcaagctg
     3061 gccgcttcgc tcaaggcctt cggctggagt gcttcaggct tgtcctgggt tatctttctg
     3121 acccaagtga ggacattcag gatcctgtaa gtgacaaatt cttcaaggag atttgggttt
     3181 caacggcagc tcgaaatgct accatatatg ataaggtctt ccggtgcctt cccaatgacg
     3241 aagtgcacaa tttaatccag ttgcgggact ttataaacaa gcctatattg gcaaaagagg
     3301 accgccttcg tgccgaggaa gaactgagga agatccgtgg cttcttggtg cagttcccct
     3361 tctacttctt atcagaagaa aacctgctgc cttccgttgg aaccaaggaa gccattgtgc
     3421 ccatggaggt ttggacttaa gataaacctt ttgtagttga gggtcttcca acctgaagac
     3481 tacagtatat gctgacttct aaggacttca cagccatagc caggcctgat gtcctcctgt
     3541 gaactggtgt aaggatgctg gacataaaca gggcttcatc actcctccga cttgtccttg
     3601 agaaaagtgg ctacatcctg ttgatagcat atgctcaaat aataccaaac atggagacaa
     3661 attccgtgat atatttcaaa acccattccc tttgctaaca agaatctgtc tgtaactttg
     3721 atccgggttg ccaaacgttg cctgagcact gctgttcttc gctgatgtcc gtttacacgc
     3781 tggggcccac cttgtcatcc atacagcact gtttacaaga ttgcttatca atgaaagaca
     3841 ttggagaagc tgccttgagg gtcctcaagg atccaggtga tgcctatacc caacctggtc
     3901 ctgatgtgag cttatttacc acgccaaaac ttttctctct gttctttttc agtcactgta
     3961 gggacagaac aggctttgcc tacctaccca cactaggcac ttcttaacaa caggcaggca
     4021 ttaagtccta atactgaaga agattccagt tcccagagat gctgcccagc tgtgtccttg
     4081 tcatctgata acatttgtaa acatgtgcag cgcatgtcaa tacatagcaa ccagataagc
     4141 acagatggag cctccaaggt gtcagtggga acccagttca gataaaggac aatattcctg
     4201 acagtctgtc cttcttagcc actggattga tagaaaaaaa gttgattctc tccactgtaa
     4261 gtccagtgga tgttaatttg tcttccaact gaatcaaagg ctttataatg cccttttcct
     4321 aagaaacatg agtctaacct gatttaccct tcagttttcc actaggcctt cttcagggga
     4381 aaaagcaatg attatacaag atctctcctt tgcttgtact gtcaactaca tagtaacatt
     4441 ccaacatagc ttccaaagaa gcgataattc acattgttcc aatgggatat ccacattccc
     4501 tttcagatgg tattgtgtcc tttgtagacc aaatttcaga gttccccttg tatcatggga
     4561 gtgtctgtgg gtgcctggaa gcctggagct tatgcacgtg agataactat gtgactgtaa
     4621 ccaaaagggg tcactggagt aaaatctctt caaagcagct cccgacccat gttttcatga
     4681 ataaatatgc tggtttaaaa gatgacacag gaccacaaag ccagtgatgt ggattagtaa
     4741 cagagcagca gtcacatcca aaggaggatg tcacccctga ggaacactgt acaaatgagg
     4801 tgggatttgt aatcaacaat ggaaattaac atgtttttat gaataaataa cttatttctt
     4861 atatggccaa ggatgataaa attatttcat tctataggta tggtgaataa aacactttat
     4921 gcagataaa
//
