LOCUS       NM_001106880            3933 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phospholipase C-like 2 (Plcl2), mRNA.
ACCESSION   NM_001106880 XM_001056257 XM_217326
VERSION     NM_001106880.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3933)
  AUTHORS   Oue,K., Zhang,J., Harada-Hada,K., Asano,S., Yamawaki,Y.,
            Hayashiuchi,M., Furusho,H., Takata,T., Irifune,M., Hirata,M. and
            Kanematsu,T.
  TITLE     Phospholipase C-related Catalytically Inactive Protein Is a New
            Modulator of Thermogenesis Promoted by beta-Adrenergic Receptors in
            Brown Adipocytes
  JOURNAL   J Biol Chem 291 (8), 4185-4196 (2016)
   PUBMED   26706316
REFERENCE   2  (bases 1 to 3933)
  AUTHORS   Kanematsu,T., Yasunaga,A., Mizoguchi,Y., Kuratani,A., Kittler,J.T.,
            Jovanovic,J.N., Takenaka,K., Nakayama,K.I., Fukami,K., Takenawa,T.,
            Moss,S.J., Nabekura,J. and Hirata,M.
  TITLE     Modulation of GABA(A) receptor phosphorylation and membrane
            trafficking by phospholipase C-related inactive protein/protein
            phosphatase 1 and 2A signaling complex underlying brain-derived
            neurotrophic factor-dependent regulation of GABAergic inhibition
  JOURNAL   J Biol Chem 281 (31), 22180-22189 (2006)
   PUBMED   16754670
REFERENCE   3  (bases 1 to 3933)
  AUTHORS   Takenaka,K., Fukami,K., Otsuki,M., Nakamura,Y., Kataoka,Y.,
            Wada,M., Tsuji,K., Nishikawa,S., Yoshida,N. and Takenawa,T.
  TITLE     Role of phospholipase C-L2, a novel phospholipase C-like protein
            that lacks lipase activity, in B-cell receptor signaling
  JOURNAL   Mol Cell Biol 23 (20), 7329-7338 (2003)
   PUBMED   14517301
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474081.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217326.4, XM_001056257.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132293 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3933
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..3933
                     /gene="Plcl2"
                     /note="phospholipase C-like 2"
                     /db_xref="GeneID:301173"
                     /db_xref="RGD:1305941"
     exon            1..299
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..2786
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..3356
                     /gene="Plcl2"
                     /codon_start=1
                     /product="inactive phospholipase C-like protein 2"
                     /protein_id="NP_001100350.1"
                     /db_xref="GeneID:301173"
                     /db_xref="RGD:1305941"
                     /translation="MPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQ
                     SLRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISEQISEDCAFSVIYGENYES
                     LDLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTCWVSQMFSEIDVDDLGH
                     ITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKTGTEITKEEFVEVFHELCTRPEI
                     YFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSI
                     DGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYI
                     RALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILC
                     LENHCSIKQQKVMVQHMKKILGDKLYTTSPNMEESYLPSPDVLKGKILIKAKKLSSNC
                     SGVEGDVTDEDEGAEMSQRMGKENVEQPNHVPVKRFQLCKDLSELVSICKSVQFKEFQ
                     VSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDF
                     WKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPG
                     VSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQRTKTVNQNGDA
                     PMFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTG
                     EVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGKKSREYASLRTLWIKTVDEVFKNAQ
                     PPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCMLAVSPRFLGPDNTPLVVLNLSE
                     PYPTMELQAIVPEVLKKIVTTYDMMIQSLKALIENADAVYEKIVHCQKAAMEFHEHLH
                     SIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNETLENLKQIHYAAVSCGLN
                     KPGTENSEAQKPRRSLEVIPEKTSDENGD"
     exon            2787..2990
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3066
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3176
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3933
                     /gene="Plcl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccctgcc cacctccccg ggcccggccc tcggcgccaa gggcgccctg aaagcgggag
       61 ccggggaagg cggcggtagc ggcgggggag gtcgcctcgg ccacgggcgg gcgcgctatg
      121 acagcggcgg ggtttccaac ggagactgca gcctcggagt gtccggggac gaagcccggg
      181 ccagccctgc caggggacct cgaggcgtgg cgctcgcgcg gacccctagc ccggctgcgg
      241 gtccggtccc cagggacagc aagccgggcg gcctgccccg ccggagcagc atcatcaagg
      301 atggcacgaa gcagaaaaga gagcggaaga agaccgtgtc attcagcagc atgccaacag
      361 agaagaagat cagcagtgca agcgactgca tcaactcaat ggtggagggc tctgaactca
      421 agaaggttcg ttcaaactcc agaatttacc atcggtactt tctgctggac gccgacatgc
      481 aaagcctgag gtgggagcca tccaagaagg attctgagaa agccaagatt gacatcaagt
      541 ccatcaagga agttagaacg gggaaaaaca cagatatatt ccgcagcaat ggcatttctg
      601 agcaaatatc tgaagattgt gcgttttcag tcatatatgg agaaaattat gagtcactcg
      661 atttggttgc caattctgca gatgttgcaa acatctgggt gacaggactc cggtacctga
      721 tttcttatgg gaaacataca cttgatatgt tagaaagtag ccaagacaac atgaggactt
      781 gttgggtttc acagatgttt agtgaaattg atgtagatga ccttggacat ataactctgt
      841 gtaatgctgt tcagtgtatc agaaacctca atcctggctt aaaaacaagc aaaattgagc
      901 ttaagttcaa agaactgcat aaatcaaagg acaaaactgg tactgaaatc acaaaggaag
      961 aatttgttga ggtttttcat gaactttgca ctagacctga aatttacttc cttttagttc
     1021 agttttcaag caataaagaa ttccttgata ccaaggacct tatgatgttt cttgaggcag
     1081 aacagggtgt agcacatata aatgaggaaa taagcctgga aattattcac aaatatgagc
     1141 catccaaaga aggccaggaa aagggctggc tctccataga tgggttcact aattacctga
     1201 tgtcacctga ttgttacatc tttgatccgg aacataagaa ggtctgtcag gatatgaagc
     1261 aacctctgtc tcattacttc ataaactcat ctcataatac atacttaata gaggaccagt
     1321 tccggggtcc ctctgacatt acaggatata tccgtgctct taaaatgggt tgcaggagtg
     1381 ttgagttgga tgtgtgggat gggccagata atgagcccgt gatttacaca ggccacacca
     1441 tgacctctca gatagtcttc cgcagtgtca tcgatatcat taacaagtat gcattctttg
     1501 cttctgagta tcctctcatc ctgtgtttag aaaatcattg ttctattaaa caacaaaagg
     1561 tgatggttca acacatgaag aaaattttag gagacaagct gtataccaca tcacccaaca
     1621 tggaggaatc ttatctacca tcccccgatg tcctgaaagg gaaaatacta atcaaagcaa
     1681 agaagctgtc ttcaaattgc tctggtgtgg aaggggatgt tactgatgaa gatgaagggg
     1741 cagaaatgtc tcagaggatg gggaaagaga atgtggaaca acccaaccat gtgcctgtga
     1801 agcgatttca gctttgcaaa gacctgtctg aactggtcag catctgtaag tcagtccagt
     1861 tcaaggagtt ccaggtgtcg tttcaggtgc agaagtactg ggaagtgtgt tcattcaatg
     1921 aagtgctagc cagtaaatac gccaatgaga atcctgggga ctttgtaaat tacaataagc
     1981 gtttcctcgc cagagtcttt cctagtccaa tgagaattga ttctagtaac atgaaccctc
     2041 aagatttttg gaaatgtggc tgtcaaatcg tagccatgaa ctttcagact ccagggctaa
     2101 tgatggatct gaacattggc tggtttaggc agaatggaaa ctgtggctat gttcttcgac
     2161 cagccatcat gagggaagaa gtctccttct tcagtgccaa cacaaaggac tctgtccctg
     2221 gagtttcgcc tcagttgctt cacatcaaaa tcatcagtgg ccagaacttt cccaagccca
     2281 aagggtcagg tgccaaaggg gatgtggtgg acccttatgt ctatgtggaa atccatggca
     2341 ttcctgctga ctgcgcagaa cagaggacga aaactgtgaa ccagaatgga gatgctccta
     2401 tgtttgatga aagctttgaa tttcaaatca acctccccga actagccatg gtgcgctttg
     2461 tagtgctgga tgatgactac attggcgatg aatttattgg ccagtacacg attccctttg
     2521 aatgtttaca aacgggctac cgccatgtgc ctctgcagtc cttgactgga gaggtccttg
     2581 cccatgcttc tctgttcgtc cacgtggcta ttactaacag aagaggagga gggaagcctc
     2641 ataaacgggg cctttctgtg aggaaaggga agaagtcccg ggaatatgca tctctgagaa
     2701 cactgtggat taaaactgta gatgaggtgt tcaagaatgc ccagcccccc atccgggatg
     2761 ccacagacct gagagagaac atgcagaatg cagtggtttc tttcaaggaa ttatgtggcc
     2821 tctcctcagt ggccaacctt atgcagtgca tgctggccgt gtctcctcga ttcctggggc
     2881 ctgacaatac tcccctggtg gtcttgaatc ttagtgagcc ctaccccacc atggaactgc
     2941 aggccatcgt gcctgaggtt ctgaagaaga tcgtcacaac ttatgacatg atgattcagt
     3001 ccctcaaggc actgattgaa aatgcagatg ctgtgtatga aaagattgtg cactgtcaga
     3061 aggcagccat ggaatttcat gaacacttgc acagcatagg caccaaggag ggactgaagg
     3121 aacggaaact acagaaggcg gtggagagct ttacctggaa tattacgatt ttaaagggac
     3181 aagcggacct tctgaaatat gctaagaatg agaccctgga gaacctgaag cagatccatt
     3241 atgcagccgt ttcctgtgga ctgaacaaac caggcaccga aaactcagag gcccagaagc
     3301 cacgccggag cctggaagtg atccccgaga aaaccagtga tgaaaatgga gattaagggg
     3361 cctccccaag gactccccac tgaggaccag tcagcaagcg cactgctcac tgattcggat
     3421 aaggtctggg atattgtgca caactggaat acccaactgc aggccatcac agctgtgaat
     3481 gtacgtagca acccacgtgt gaaggcaaat aaactcttta acacgaaact ctgtcctggc
     3541 ccaaacatgc tgtctttgta tacaaagcgc cctgagcccc actgtgaagg acagtgcact
     3601 gctgtagttc ctctgtgaaa gcagttcctc gggtggaagt ggatcggatg gttgaattcg
     3661 tatttattgg tgaaaccgtg aatgtgcaca cctaactggt gtgtgtgtcc cggtcttggc
     3721 actgcagggg atttggtggc ctgcttgctg agccgtattt accagcagaa tgtaagaacc
     3781 caggagctga gggcagtgtg cagtgtggct gggctgcctg gctaacgatg tgctgtgtca
     3841 gcatgggcag ccgagtggaa gccacacctt gtacatagtt tttcattgta tgatgcagtg
     3901 gtcacattaa agatatcttt tatgggattt ctc
//
