LOCUS       NM_053456               5235 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus phospholipase C-like 1 (Plcl1), mRNA.
ACCESSION   NM_053456
VERSION     NM_053456.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5235)
  AUTHORS   Oue,K., Zhang,J., Harada-Hada,K., Asano,S., Yamawaki,Y.,
            Hayashiuchi,M., Furusho,H., Takata,T., Irifune,M., Hirata,M. and
            Kanematsu,T.
  TITLE     Phospholipase C-related Catalytically Inactive Protein Is a New
            Modulator of Thermogenesis Promoted by beta-Adrenergic Receptors in
            Brown Adipocytes
  JOURNAL   J Biol Chem 291 (8), 4185-4196 (2016)
   PUBMED   26706316
REFERENCE   2  (bases 1 to 5235)
  AUTHORS   Calvisi,D.F., Pinna,F., Ladu,S., Muroni,M.R., Frau,M., Demartis,I.,
            Tomasi,M.L., Sini,M., Simile,M.M., Seddaiu,M.A., Feo,F. and
            Pascale,R.M.
  TITLE     The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin
            ligase is genetically controlled in rodent liver cancer and
            contributes to determine the susceptibility to the disease
  JOURNAL   Int J Cancer 126 (5), 1275-1281 (2010)
   PUBMED   19533683
REFERENCE   3  (bases 1 to 5235)
  AUTHORS   Kanematsu,T., Yasunaga,A., Mizoguchi,Y., Kuratani,A., Kittler,J.T.,
            Jovanovic,J.N., Takenaka,K., Nakayama,K.I., Fukami,K., Takenawa,T.,
            Moss,S.J., Nabekura,J. and Hirata,M.
  TITLE     Modulation of GABA(A) receptor phosphorylation and membrane
            trafficking by phospholipase C-related inactive protein/protein
            phosphatase 1 and 2A signaling complex underlying brain-derived
            neurotrophic factor-dependent regulation of GABAergic inhibition
  JOURNAL   J Biol Chem 281 (31), 22180-22189 (2006)
   PUBMED   16754670
REFERENCE   4  (bases 1 to 5235)
  AUTHORS   Yamaguchi,T., Kubota,T., Kanematsu,T., Nakayama,K., Hirata,M. and
            Yamamoto,T.
  TITLE     Hypersensitivity to pentylenetetrazol-induced convulsion in mice
            lacking the PLC-related inactive protein-1
  JOURNAL   Brain Res 1025 (1-2), 237-240 (2004)
   PUBMED   15464766
REFERENCE   5  (bases 1 to 5235)
  AUTHORS   Kanematsu,T., Misumi,Y., Watanabe,Y., Ozaki,S., Koga,T.,
            Iwanaga,S., Ikehara,Y. and Hirata,M.
  TITLE     A new inositol 1,4,5-trisphosphate binding protein similar to
            phospholipase C-delta 1
  JOURNAL   Biochem J 313 (Pt 1) (Pt 1), 319-325 (1996)
   PUBMED   8546702
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053456.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D45920.1, SRR26643298.48873.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-711               JAXUCZ010000009.1  64395976-64396686
            712-3186            JAXUCZ010000009.1  64672555-64675029
            3187-3390           JAXUCZ010000009.1  64678535-64678738
            3391-3466           JAXUCZ010000009.1  64690319-64690394
            3467-3576           JAXUCZ010000009.1  64692304-64692413
            3577-5235           JAXUCZ010000009.1  64731513-64733171
FEATURES             Location/Qualifiers
     source          1..5235
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q31"
     gene            1..5235
                     /gene="Plcl1"
                     /note="phospholipase C-like 1"
                     /db_xref="GeneID:84587"
                     /db_xref="RGD:708420"
     exon            1..711
                     /gene="Plcl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             469..3759
                     /gene="Plcl1"
                     /note="p130; PRIP1; PLC-L1; phospholipase C-related but
                     catalytically inactive protein; 130kDa-Ins(1,4,5)P3
                     binding protein"
                     /codon_start=1
                     /product="inactive phospholipase C-like protein 1"
                     /protein_id="NP_445908.2"
                     /db_xref="GeneID:84587"
                     /db_xref="RGD:708420"
                     /translation="MAEGAASREAPAPLDVAEGEDDPRAGADAASGDAAPEASGGRMR
                     DRRSGVALPGNAGVPADSEAGLLEAARATPRRSSIIKDPSNQKCGGRKKTVSFSSMPS
                     EKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLD
                     ISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSG
                     LRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTL
                     KESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDAN
                     DLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDP
                     EQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDG
                     PDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQRVMVQQM
                     KKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDEDEEAEMS
                     RRVSGDYNGEQKHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEICSFSETLASRI
                     ANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLH
                     TGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNFPKPKGA
                     CAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFV
                     ILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGK
                     AQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKE
                     LCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAY
                     DLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAW
                     NITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGSAAEAKGKRSLEAIEEKE
                     SSEENGKL"
     exon            712..3186
                     /gene="Plcl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3390
                     /gene="Plcl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3391..3466
                     /gene="Plcl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3576
                     /gene="Plcl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3577..5235
                     /gene="Plcl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagccgc cgccgcactt cctgaggccg ccgctccgcg gtcggcgggc aggtggctgg
       61 tggccggtcc gcagtcgccg ctcgggccgc gcgcgtccag gcttcggagg gttcggaggc
      121 tccgggctcc ggcgcccgct gtcttttgtc tgcgcagagc cggcgctcgc ctcccgtcgc
      181 cggtacctcc cgctgctttt cgcctgcttc tccctcccgc tcacatcttc tccccgcccc
      241 cgccgccggt ccgcgccggc ccgctgacct cctggaccac agcccgagga cgcctctgcc
      301 cgagtgatgt ctcctctcta caaagttgcg gccgccgctg cagccgccgt cgcgcgctga
      361 aacaaagtct agcggcgttt ccttctggtg cctgagcgca cccttactca gggctggacg
      421 ccgctggcgg tcgtgctgtc tcgccgggag cctagaacgt gcttggccat ggctgagggc
      481 gcggctagca gggaggctcc ggcgcctctc gacgttgcgg agggcgaaga cgaccctcga
      541 gccggcgccg atgctgcctc cggggacgct gcacccgagg cctcgggggg ccggatgagg
      601 gaccgtcgca gcggggttgc gctgccgggc aatgcggggg tccccgcgga tagcgaggct
      661 ggcctcctgg aggcggcacg agcgaccccc cggcgcagca gcatcatcaa ggatccttca
      721 aaccaaaaat gtggtggcag aaagaaaaca gtgtctttca gcagcatgcc atcggagaag
      781 aagattagca gtgcccatga ctgcattagc ttcatgcagg ctggctgcga gctgaagaaa
      841 gtgcgaccga actctcgcat ctacaaccga tttttcaccc tagacactga cctccaggct
      901 ctacgctggg aaccttccaa gaaagacctc gaaaaagcca agctggacat ttctgccatc
      961 aaagagatca ggctggggaa gaacacggag acattcagaa acaatggcct tgctgaccag
     1021 atctgtgaag actgtgcctt ctccatactc catggggaaa attacgagtc tctggaccta
     1081 gttgccaatt cagcagatgt agcaaacatc tgggtgtcgg ggttacggta cctggtctct
     1141 cgtagtaagc aaccacttga ctttatggag ggcaaccaga acacaccacg gttcatgtgg
     1201 ctgaaaacgg tgtttgaagc agcagatgtt gatgggaatg ggattatgtt agaagatacc
     1261 tcggtggagt taataaaaca actcaaccct actctgaagg aatctaagat caggttaaag
     1321 tttaaagaaa tccagaagag caaagaaaaa ctaactaccc gggtaacaga agaggaattc
     1381 tgtgaagcgt tctgtgaact ttgcactaga ccagaagtgt atttcttact tgttcagata
     1441 tctaagaaca aagagtatct ggatgctaat gacctcatgc tctttttaga agttgagcaa
     1501 ggggtcaccc atgtcactga ggatatgtgc ttagacatca ttaggagata cgaactttct
     1561 gaagatggcc gccagaaagg cttccttgca attgatggct ttacccagta tttattatct
     1621 ccagaatgcg acatttttga tccagagcaa aagaaggttg cccaagacat gacccaaccc
     1681 ttatctcact actatatcaa tgcgtcccat aatacctacc tgatagaaga tcagttcagg
     1741 gggccagctg atatcaatgg gtatgtgagg gctttgaaga tgggctgtcg aagcattgag
     1801 cttgatgtaa gtgacggtcc agataatgaa cccatcctgt gcaataggaa caacatggcc
     1861 atgctccttt cctttcgaag tgttctggag gtgataaata agttcgcctt cgtcgcttca
     1921 gagtacccac tcattctctg cttggggaat cactgttccc tgccacagca gagggtcatg
     1981 gttcagcaga tgaaaaaggt gtttggcaat aaactttata cagaagcacc tctgtcttca
     2041 gaatcctacc tcccgtcacc tgaaaaacta aaacatatga tcattgtgaa aggaaagaaa
     2101 ttgccttcgg agtcagatct gttagaggga gaagtgaccg acgaggatga agaagctgag
     2161 atgtcccgga gggtgtcggg agattacaac ggtgagcaga aacatatctg gctctgccga
     2221 gagctctctg acttggtatc catctgtaaa tccgttcagt acagggattt tgaactgtct
     2281 atgaaaaccc agaactactg ggaaatttgt tcatttagtg aaacattggc cagccggatc
     2341 gcaaatgagt atccagagga tttcgtgaat tataacaaga agttcttatc aagggtctac
     2401 cctagtgcca tgaggataga ttctagtaat ttgaacccac aggacttctg gaattgtggc
     2461 tgtcagattg tggcaatgaa ttttcaaact cctggtccaa tgatggacct ccacaccggc
     2521 tggtttcttc aaaatggggg ctgtggctac gtcctcaggc catctatcat gcgagatgaa
     2581 gtttcgtact ttagtgcaaa cacaaagggc attgtccctg gagtgtctcc cctgcttctt
     2641 cacatcaaga tcatcagtgg tcagaacttc ccaaagccca aaggagcttg tgccaaaggg
     2701 gatgtcatag acccctacgt ttgtgtagag attcatggaa ttccagctga ttgctccgag
     2761 caaagaacta aaactgtaca acagaacagc gataatccca ttttcgatga aactttcgag
     2821 tttcaagtca accttcccga gctgaccatg gtccgttttg tcattttgga tgatgattac
     2881 attggagatg agttcattgg gcaatacacg ataccgtttg aatgtctgca acctgggtac
     2941 cggcatgtcc ccttgcgctc ctttgtgggg gatatcatgg aacatgtgac cctttttgtc
     3001 cacatagcaa taaccaatcg gagtggcgga ggaaaagcgc agaagcgaag tctttccgtg
     3061 agaatgggga agaaagttcg agaatacacc atgctcagaa atatcggtct taaaaccata
     3121 gatgatatct tcaaaatagc agttcatcct ttgcgagaag ccatagatat gagagaaaac
     3181 atgcagaacg ccatagtgtc tgttaaggag ctgtgtggac tcccaccgat tgccagtctg
     3241 aaacagtgcc tgttaaccct gtcctctcgt ctcatcacca gtgatagtac tccctccgtg
     3301 tctctggtga tgaaggactg ctttccttac ctggagcctc tgggcacaat tccagatgtg
     3361 cagaagagga tgctggctgc atatgatctg atgattcaag agagtcgggt cctcatagaa
     3421 atggctgaca cagtccagga aaaaattgta cagtgtcaga aagcagggat ggaattccat
     3481 gaagaacttc ataatctagg ggcaaaggaa ggcttgaagg gaagaaaact caacaaggcc
     3541 atcgagagct tcgcttggaa tattactgta ttgaagggac aaggagacct gctgaagaat
     3601 gccaagaatg aagccgtaga gaacataaag cagatccagc tggcctgttt gtcttgtgga
     3661 ctgagtaaag gccctggcag cgctgcagag gccaagggca agcgcagctt ggaagccata
     3721 gaggagaagg aaagcagtga agagaacggg aagttgtgag ctgggcagtg cgcaggccct
     3781 tgtccaacac tctggtttct cattcttctc gttttgtttt gtttttacat tcttcagatg
     3841 ttcacagaaa tgatgccctt tgcggggtgt tgtacataaa catatatttt cacagtgtca
     3901 gtattttact gtagttaatt tatctaagtt aaaactttta gtagcagtgt tttaaacttt
     3961 gagctgtgag tatatactta catgtggctg cctgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4021 tgtttgtgtg tgtgtgtgtg tgtgtgtgtg agagagagag agagagagag agagagagag
     4081 agagagagag agagtaagag ttcctgttaa aatattctct gtcgcattgt tggttttaat
     4141 aagttattct tttatcttta agatcatttg gggatagttg ataatctgaa ttctaatgag
     4201 catttattat aaccccttgc tgtcattagt tttacctctc tgcctttgtc atataatttg
     4261 gagatctcag cacagcttat gattgaagaa aaccaaattt ataagagcaa aggtgtttta
     4321 tagattacat agagatttaa aagttcctaa acattacatt agaaatgaaa gtgaatagaa
     4381 aaatctttta aaatcataat tctggaaaga taaacaaatt catttcttca ttagcaaaat
     4441 ctttgagata tttattaact aaaatcacat ttaggaagtt tctgtagctg tttactgagc
     4501 atgtggtttc ggtagaagag ctgagtgcag agaacctgta gccactgggc agtactttga
     4561 agcccactaa atgctctact gaactagcac tgttgatgtg accataacac tcagttgtgc
     4621 aatttcaagg tttgcagaaa gacctcattc tcctgggccg ggagtatgga attcattttc
     4681 tattaccagt ggtgggcaga tccaagtgct tggccaggac tagatctagt atagattact
     4741 aaatttaagt gtcaacacct tgttaaaata atatattatc atgttgagct ggcataaatt
     4801 ctgtaagtcc gataacatct ttctgatgat ttgagaacta actaattaga caacatgtat
     4861 ggtataattt taaaacatac agtaaaaacc aagagcaagt ggctaattag ggtacattta
     4921 taattatatc tagataatct taccctaatg tcttcataaa cttcttaaat gtcatgttca
     4981 ttcattacca ccaacagaac taaatgttct atgattatga aagaatatat ttgtttaaaa
     5041 cattgctttt attttgaaaa gcttcttaat taatttgatt aacaaatata ttaatttggg
     5101 ggagcctaga gaagataatc attgaaattt tgcaaatata aacatcctct acagctacta
     5161 tgttatttct gactgttctt aatactactc tgttcttgtc gcacattacc aaaagagtaa
     5221 agatactgaa aacag
//
