LOCUS       NP_001178636            1652 aa            linear   ROD 24-JUN-2024
DEFINITION  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
            [Rattus norvegicus].
ACCESSION   NP_001178636 XP_227208
VERSION     NP_001178636.1
DBSOURCE    REFSEQ: accession NM_001191707.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1652)
  AUTHORS   Hwang,J.I., Oh,Y.S., Shin,K.J., Kim,H., Ryu,S.H. and Suh,P.G.
  TITLE     Molecular cloning and characterization of a novel phospholipase C,
            PLC-eta
  JOURNAL   Biochem J 389 (Pt 1), 181-186 (2005)
   PUBMED   15702972
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jul 17, 2010 this sequence version replaced XP_227208.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760389
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1652
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q31"
     Protein         1..1652
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase eta-1"
                     /EC_number="3.1.4.11"
                     /note="phospholipase C-like 3"
                     /calculated_mol_wt=184097
     Region          4..110
                     /region_name="PH-like"
                     /note="Pleckstrin homology-like domain; cl17171"
                     /db_xref="CDD:473070"
     Region          128..268
                     /region_name="EFh_PI-PLCeta1"
                     /note="EF-hand motif found in phosphoinositide
                     phospholipase C eta 1 (PI-PLC-eta1); cd16220"
                     /db_xref="CDD:320050"
     Region          128..157
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320050"
     Region          164..194
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320050"
     Region          198..226
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320050"
     Region          235..268
                     /region_name="EF-hand motif"
                     /note="EF-hand motif [structural motif]"
                     /db_xref="CDD:320050"
     Region          280..683
                     /region_name="PI-PLCc_eta1"
                     /note="Catalytic domain of metazoan
                     phosphoinositide-specific phospholipase C-eta1; cd08632"
                     /db_xref="CDD:176569"
     Site            order(296..297,326,328,341,375,424,426,609,636,638)
                     /site_type="active"
                     /note="putative active site [active]"
                     /db_xref="CDD:176569"
     Site            order(296,341)
                     /site_type="active"
                     /note="catalytic site [active]"
                     /db_xref="CDD:176569"
     Site            order(297,326,328,375)
                     /site_type="other"
                     /note="putative Ca binding site [ion binding]"
                     /db_xref="CDD:176569"
     Region          713..837
                     /region_name="C2_PLC_like"
                     /note="C2 domain present in Phosphoinositide-specific
                     phospholipases C (PLC); cd00275"
                     /db_xref="CDD:175974"
     Site            order(742,766,795,797,802,804)
                     /site_type="other"
                     /note="Ca2+ binding pocket [ion binding]"
                     /db_xref="CDD:175974"
     CDS             1..1652
                     /gene="Plch1"
                     /gene_synonym="Plcl3; RGD1561991"
                     /coded_by="NM_001191707.1:1..4959"
                     /db_xref="GeneID:310463"
                     /db_xref="RGD:1561991"
ORIGIN      
        1 msvmqsgtqm iklkrgtkgl vrlfyldehr trlrwrpsrk sekakilids iykvtegrqs
       61 eifhrqaegn fdpsccftiy hgnhmesldl itsnpeeart witglkylma gisdedslak
      121 rqrthdqwvk qtfeeadkng dgllnieeih qlmhklnvnl prrkvrqmfq eadtdenqgt
      181 ltfeefcvfy kmmslrrdly llllsysdkk dhltveelaq flkveqkmsn vtldycldvi
      241 kkfevseenk vknvlgiegf tnfmrspacd vfnplhhevy qdmdqplcny yiasshntyl
      301 tgdqllsqsk vdmyarvlqe gcrcvevdcw dgpdgepvvh hgytltskil fkdvvetink
      361 hafvknefpv ilsienhcsi qqqrkiaqyl kgifqdkldl ssvdtgecrq lpspqslkgk
      421 ilvkgkklpy hlgddaeege vsdedsadei edeckfklhy sngttehqve sfirkkldsl
      481 lkesqirdke dpdsftvral lkatheglna hlkqnldvke sgkkshgrsl manfgkhkkt
      541 pksrsksyst ddeedtlqnp gkeggqlyrl grrrrtmklc relsdlvvyt nsvaaqdivd
      601 dgttgnvlsf setrahqvvq qkseqfmiyn qkqltriyps ayridssnfn plpywnagcq
      661 lvalnyqseg rmmqinrakf kangncgyil kpqqmckgtf nplsgdplpa npkkqlilkv
      721 isgqqlpkpp dsmfgdrgei idpfveveii glpvdcckdq trvvddngfn pvweetltft
      781 vhmpeialvr flvwdhdpig rdfvgqrtvt fsslvpgyrh vyleglteas ifvhitinei
      841 fgknrqlqgl kglfnknprh gssennshyv rkrsigdril rrtasapakg rkkskvgfqe
      901 mveikdsvce atrdqdgvlr rttrslqlrp vsmpvdknll galslpisea akntdgkeny
      961 laedkddgrk gpatikdphf snfnkklsss ssallhkdak nqgptasvsn peqcgglglk
     1021 sgrikphmtn dcqenrspqn flsprkhlal dpatkglqdl hgmrtdekeq erakgfvgrk
     1081 stqsesvlsq sslevenleg skakgraats fslsdvsalc sdipdlhsta ilqdteisdl
     1141 indvtltnan esgssisali gqfeesnhra nvavvsrlls tsgtsegval pvalglqtpi
     1201 kngfsqgkhk asflcsspel nkpssaettk lanntvacgv igspistpkp gddasdkakt
     1261 rvtednlpds pdafpgqfpq spthgedhrq vmsspalsmp lamedttadp alcinseess
     1321 lveidgdses lsltacdyge ealsqlvspl klqqsqetve hiqkglsngy cketllpsei
     1381 fnnipgvknq sishltyqga gfvynhfsss daktnqicgp qqprapdmhv ptptpsthap
     1441 laalklpspc kskslgdlts ediacnfesk yqcisrsfvt nsirdksvtm ktksfeplda
     1501 lteqlrklvs fdqedscqgl yskqdvnqcp ralvrklssr sqsrvrnias rakekqeagk
     1561 qkamtqnprg gvvlrskppa ptlavnrhst gsyiasylrn mkasglegrg ipegactalr
     1621 ygymdqfcsd nsvlqtepss edkpeiyfll rl
//
