LOCUS       NM_013187               5107 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus phospholipase C, gamma 1 (Plcg1), mRNA.
ACCESSION   NM_013187
VERSION     NM_013187.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5107)
  AUTHORS   Zhao,Q., Chen,X., Qu,N., Qiu,J., Zhang,B. and Xia,C.
  TITLE     PLCgamma1 deficiency in chondrocytes accelerates the age-related
            changes in articular cartilage and subchondral bone
  JOURNAL   J Cell Mol Med 28 (16), e70027 (2024)
   PUBMED   39159149
  REMARK    GeneRIF: PLCgamma1 deficiency in chondrocytes accelerates the
            age-related changes in articular cartilage and subchondral bone.
REFERENCE   2  (bases 1 to 5107)
  AUTHORS   Xu,J., Zhong,Y., Yin,H., Linneman,J., Luo,Y., Xia,S., Xia,Q.,
            Yang,L., Huang,X., Kang,K., Wang,J., Niu,Y., Li,L. and Gou,D.
  TITLE     Methylation-mediated silencing of PTPRD induces pulmonary
            hypertension by promoting pulmonary arterial smooth muscle cell
            migration via the PDGFRB/PLCgamma1 axis
  JOURNAL   J Hypertens 40 (9), 1795-1807 (2022)
   PUBMED   35848503
  REMARK    GeneRIF: Methylation-mediated silencing of PTPRD induces pulmonary
            hypertension by promoting pulmonary arterial smooth muscle cell
            migration via the PDGFRB/PLCgamma1 axis.
REFERENCE   3  (bases 1 to 5107)
  AUTHORS   Zhang,W., Yin,Q., Huang,H., Lu,J., Qin,H., Chen,S., Zhang,W.,
            Su,X., Sun,W., Dong,Y. and Li,Q.
  TITLE     Personal Neoantigens From Patients With NSCLC Induce Efficient
            Antitumor Responses
  JOURNAL   Front Oncol 11, 628456 (2021)
   PUBMED   33928024
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5107)
  AUTHORS   Sun,M., Chen,S. and Fu,M.
  TITLE     Model establishment of prognostic-related immune genes in laryngeal
            squamous cell carcinoma
  JOURNAL   Medicine (Baltimore) 100 (2), e24263 (2021)
   PUBMED   33466212
REFERENCE   5  (bases 1 to 5107)
  AUTHORS   Saliakoura,M., Rossi Sebastiano,M., Pozzato,C., Heidel,F.H.,
            Schnoder,T.M., Savic Prince,S., Bubendorf,L., Pinton,P., A
            Schmid,R., Baumgartner,J., Freigang,S., Berezowska,S.A., Rimessi,A.
            and Konstantinidou,G.
  TITLE     PLCgamma1 suppression promotes the adaptation of KRAS-mutant lung
            adenocarcinomas to hypoxia
  JOURNAL   Nat Cell Biol 22 (11), 1382-1395 (2020)
   PUBMED   33077911
REFERENCE   6  (bases 1 to 5107)
  AUTHORS   Koblan,K.S., Schaber,M.D., Edwards,G., Gibbs,J.B. and
            Pompliano,D.L.
  TITLE     src-homology 2 (SH2) domain ligation as an allosteric regulator:
            modulation of phosphoinositide-specific phospholipase C gamma 1
            structure and activity
  JOURNAL   Biochem J 305 (Pt 3) (Pt 3), 745-751 (1995)
   PUBMED   7531435
REFERENCE   7  (bases 1 to 5107)
  AUTHORS   Rao,C.V., Rivenson,A., Simi,B. and Reddy,B.S.
  TITLE     Chemoprevention of colon carcinogenesis by dietary curcumin, a
            naturally occurring plant phenolic compound
  JOURNAL   Cancer Res 55 (2), 259-266 (1995)
   PUBMED   7812955
REFERENCE   8  (bases 1 to 5107)
  AUTHORS   Arteaga,C.L., Johnson,M.D., Todderud,G., Coffey,R.J., Carpenter,G.
            and Page,D.L.
  TITLE     Elevated content of the tyrosine kinase substrate phospholipase
            C-gamma 1 in primary human breast carcinomas
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10435-10439 (1991)
   PUBMED   1683701
REFERENCE   9  (bases 1 to 5107)
  AUTHORS   Baldassare,J.J., Henderson,P.A. and Fisher,G.J.
  TITLE     Isolation and characterization of one soluble and two
            membrane-associated forms of phosphoinositide-specific
            phospholipase C from human platelets
  JOURNAL   Biochemistry 28 (14), 6010-6016 (1989)
   PUBMED   2550068
REFERENCE   10 (bases 1 to 5107)
  AUTHORS   Suh,P.G., Ryu,S.H., Moon,K.H., Suh,H.W. and Rhee,S.G.
  TITLE     Inositol phospholipid-specific phospholipase C: complete cDNA and
            protein sequences and sequence homology to tyrosine kinase-related
            oncogene products
  JOURNAL   Proc Natl Acad Sci U S A 85 (15), 5419-5423 (1988)
   PUBMED   2840660
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_013187.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J03806.1, SRR26643295.16236.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               JAXUCZ010000003.1  169805299-169805609
            312-464             JAXUCZ010000003.1  169820975-169821127
            465-558             JAXUCZ010000003.1  169821235-169821328
            559-606             JAXUCZ010000003.1  169821491-169821538
            607-691             JAXUCZ010000003.1  169823846-169823930
            692-775             JAXUCZ010000003.1  169824025-169824108
            776-810             JAXUCZ010000003.1  169824310-169824344
            811-883             JAXUCZ010000003.1  169824507-169824579
            884-985             JAXUCZ010000003.1  169824660-169824761
            986-1104            JAXUCZ010000003.1  169824963-169825081
            1105-1190           JAXUCZ010000003.1  169825172-169825257
            1191-1311           JAXUCZ010000003.1  169825331-169825451
            1312-1480           JAXUCZ010000003.1  169826047-169826215
            1481-1603           JAXUCZ010000003.1  169826294-169826416
            1604-1705           JAXUCZ010000003.1  169826495-169826596
            1706-1893           JAXUCZ010000003.1  169826675-169826862
            1894-2094           JAXUCZ010000003.1  169827290-169827490
            2095-2214           JAXUCZ010000003.1  169827568-169827687
            2215-2395           JAXUCZ010000003.1  169827765-169827945
            2396-2473           JAXUCZ010000003.1  169828649-169828726
            2474-2577           JAXUCZ010000003.1  169829431-169829534
            2578-2674           JAXUCZ010000003.1  169829757-169829853
            2675-2744           JAXUCZ010000003.1  169830097-169830166
            2745-2902           JAXUCZ010000003.1  169830862-169831019
            2903-2999           JAXUCZ010000003.1  169832264-169832360
            3000-3224           JAXUCZ010000003.1  169832492-169832716
            3225-3373           JAXUCZ010000003.1  169832794-169832942
            3374-3488           JAXUCZ010000003.1  169833839-169833953
            3489-3650           JAXUCZ010000003.1  169834063-169834224
            3651-3739           JAXUCZ010000003.1  169834321-169834409
            3740-3924           JAXUCZ010000003.1  169834503-169834687
            3925-5107           JAXUCZ010000003.1  169834858-169836040
FEATURES             Location/Qualifiers
     source          1..5107
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..5107
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /note="phospholipase C, gamma 1"
                     /db_xref="GeneID:25738"
                     /db_xref="RGD:3347"
     exon            1..311
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3967
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /EC_number="3.1.4.11"
                     /note="PLC-II; PLC-148; PLC-gamma-1; phosphoinositide
                     phospholipase C; phosphoinositide phospholipase C-gamma-1"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase gamma-1"
                     /protein_id="NP_037319.2"
                     /db_xref="GeneID:25738"
                     /db_xref="RGD:3347"
                     /translation="MAGVGTPCANGCGPSAPSEAEVLHLCRSLEVGTVMTLFYSKKSQ
                     RPERKTFQVKLETRQITWSRGADKIEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPD
                     QSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQ
                     FYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFLRERLTDLEQRSGDITYGQFAQLYR
                     SLMYSAQKTMDLPFLETNTLRTGERPELCQVSLSEFQQFLLEYQGELWAVDRLQVQEF
                     MLSFLRDPLREIEEPYFFLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSS
                     HNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSD
                     VLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVDIAADGLP
                     SPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNGILYLEDPVNHEWYPH
                     YFVLTSSKIYYSEETSSDQGNEDEEEPKEASGSTELHSSEKWFHGKLGAGRDGRHIAE
                     RLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHSRQDAGTPKFFLT
                     DNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKEWYHASLTRAQAEHML
                     MRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISY
                     YEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKA
                     LFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQLWFPSNYVEEMINPAILE
                     PEREHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNRLFVFSISMPSVAQWSLDVAAD
                     SQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYCRPVPFDEEKIGT
                     ERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWI
                     CGSQLVALNFQTPDKPMQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPC
                     VICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFH
                     FQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELAS
                     LLIKIDIFPAKENGDLSPFSGTSLRERASDASSQLFHVRAREGSFEARYQQPFEDFRI
                     SQEHLADHFDSRERRAPRRTRVNGDNRL"
     exon            312..464
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            465..558
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            559..606
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            607..691
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            692..775
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            776..810
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            811..883
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            884..985
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1104
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1190
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1311
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1480
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1603
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1705
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1893
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2094
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2214
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2395
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2473
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2577
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..2674
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2744
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2902
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..2999
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3224
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3373
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3488
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3489..3650
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3739
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3924
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..5107
                     /gene="Plcg1"
                     /gene_synonym="PPLCA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcgcctc ccgggccgcc gccgccgcct ccgcctccgc ctccgcctcc gccgccccgg
       61 gcccgccggc ttgcgtcgcc gaggtcgctg cagcatggcg ggcgtcggga ccccctgcgc
      121 caacggctgc gggcccagcg cgccctccga agcggaggtg ctgcacctct gccgcagcct
      181 cgaggtgggc accgtcatga ctttgttcta ctccaagaag tcgcagcggc cagaacggaa
      241 gaccttccag gtcaagttgg agacgcgcca gatcacatgg agccgcggtg cggacaaaat
      301 cgaggggtcc atcgatatcc gagaaatcaa ggagatccgc ccagggaaga cttcccggga
      361 ctttgaccgc taccaagaag accctgcctt ccggccagat cagtcacact gttttgtcat
      421 cctctatgga atggaattcc gcctgaagac cctgagcctg caagccacat ctgaggatga
      481 agtgaacatg tggatcaagg gcttaacttg gctcatggaa gatacgctgc aggccgccac
      541 acccctgcaa attgagagat ggctccggaa gcagttctac tcagtggatc gtaaccgaga
      601 ggatcgtata tcagccaagg acctgaagaa catgctgtca caggtcaact accgggtccc
      661 caacatgcgc ttcctccgag agcggctgac ggaccttgaa cagcgcagcg gggacatcac
      721 ctatgggcag tttgctcagc tttaccgcag cctcatgtac agcgcccaga agacgatgga
      781 ccttccgttc ttggaaacca acactttgag gactggagag cggccagagc tttgccaggt
      841 gtccctttct gagttccagc agttccttct tgagtaccag ggggagctgt gggctgtcga
      901 ccggcttcag gtgcaggaat ttatgctcag cttccttcga gaccccttgc gagagattga
      961 ggagccatac ttcttcttgg atgagcttgt cacctttctg ttctccaaag agaacagtgt
     1021 gtggaactca cagctggatg ccgtgtgccc agaaaccatg aacaacccac tgtctcacta
     1081 ttggatctct tcctcgcata atacgtatct gactggggac cagttctcca gcgagtcctc
     1141 cctggaagcc tacgctcgct gcctgaggat gggctgtcgc tgcatcgagt tggactgctg
     1201 ggatgggcca gatgggatgc cagtcattta ccatgggcac accctcacca ccaagattaa
     1261 gttctcagat gtcctgcaca ccatcaagga gcacgcgttc gtagcctcag agtaccctgt
     1321 catcctgtcc atcgaggacc actgcagcat tgcccagcag aggaacatgg cccagcactt
     1381 caggaaggtg ctcggtgaca cgctcctcac caagcccgtg gacattgccg ctgatgggct
     1441 cccttctccc aaccagctca agaggaagat cctgattaag cataagaagc tggctgaggg
     1501 cagtgcctat gaggaggtgc ctacctctgt gatgtactcc gagaatgata tcagtaactc
     1561 catcaagaat ggtatcctct acttggagga ccccgtgaat catgagtggt acccccacta
     1621 ctttgttctg actagcagca agatctacta ctctgaggag accagcagtg accagggaaa
     1681 tgaggatgaa gaggagccga aggaggccag tggcagcaca gagctgcact cgagcgagaa
     1741 gtggttccac gggaagctcg gggctgggcg cgacgggcgg cacattgctg agcgcctgct
     1801 caccgagtac tgcatagaga ctggggctcc cgatggctcc ttcctagtgc gagaaagtga
     1861 gaccttcgtg ggggactaca cgctgtcttt ctggcggaat gggaaagtcc agcactgccg
     1921 tatccactcc cggcaggatg ctgggactcc taagttcttc ttgacagata accttgtctt
     1981 tgactctctc tatgacctca tcacacatta tcagcaagtg cccctgcgct gcaatgagtt
     2041 tgagatgcgc ctttcagagc ctgttccaca gacgaatgcc catgagagca aagagtggta
     2101 ccacgcaagc ctgactagag ctcaggctga acacatgctg atgcgagtac cccgtgatgg
     2161 ggccttcctg gtgcggaagc gcaacgagcc caactcctat gccatctctt tccgggctga
     2221 gggaaagatc aagcactgcc gagtacagca ggaaggccag actgtgatgc tggggaactc
     2281 tgagtttgac agcctggtcg acctcatcag ctactatgag aagcatcccc tgtaccgcaa
     2341 aatgaaactg cgctacccca tcaacgagga ggcgctggag aagattggga cagctgaacc
     2401 cgattatggg gcactgtatg agggccgcaa ccctggtttc tatgtggagg ccaaccctat
     2461 gccaactttc aagtgtgcag taaaagctct cttcgactac aaggcccaga gagaggatga
     2521 gctgactttt accaagagcg ccatcatcca gaatgtggaa aagcaagatg gtggctggtg
     2581 gcgtggggac tatggtggga agaagcagct gtggttcccc tcaaactatg tggaagagat
     2641 gatcaatcca gcaatcctag agccggagag ggagcatctg gatgagaaca gcccactggg
     2701 ggacttgctg cgaggggtct tagatgtgcc agcctgccag atcgccattc gtcctgaggg
     2761 caaaaacaac cggctcttcg tcttctccat cagcatgccg tcagtggctc agtggtccct
     2821 agacgttgcc gctgactcac aggaggagtt gcaggactgg gtgaaaaaga tccgtgaagt
     2881 tgcccagact gcagatgcca ggcttactga ggggaagatg atggagagga ggaagaagat
     2941 cgccttggag ctctccgagc tcgtggtcta ctgccggcct gttccctttg acgaagagaa
     3001 gattggcaca gaacgcgctt gttaccggga catgtcctcc tttccggaaa ccaaggctga
     3061 gaagtatgtg aacaaggcca aaggcaagaa gttcctccag tacaaccggc tgcagctctc
     3121 tcgcatctac cctaagggtc agaggctgga ctcctccaat tatgaccctc tgcccatgtg
     3181 gatctgtggc agccagcttg tagctctcaa ttttcagacc ccagacaagc ctatgcagat
     3241 gaaccaggcc ctcttcatgg ctggtggaca ctgtggctat gtgctgcagc caagcaccat
     3301 gagagatgaa gcctttgacc cctttgataa gagcagtctc cgaggtctgg agccctgtgt
     3361 catttgcatt gaggtgctgg gggccaggca tctgccgaag aatggccggg gtattgtgtg
     3421 tcctttcgtg gagattgaag tggctggggc agagtacgac agcaccaagc agaagacaga
     3481 gtttgtagtg gacaatggac tgaaccctgt gtggcctgca aagcccttcc acttccagat
     3541 cagtaaccca gagtttgcct ttctgcgctt tgtggtgtat gaggaagaca tgtttagtga
     3601 ccagaacttc ttggctcagg ctactttccc agtaaaaggc ctgaagacag gatacagagc
     3661 agtgcctttg aagaacaact acagtgaaga cctggagttg gcctccctgc tcatcaagat
     3721 tgacattttc cctgctaagg agaatggtga cctcagccct ttcagtggta catccctaag
     3781 ggaacgggcc tcagatgcct ccagccagct gttccatgtc cgggcccggg aagggtcctt
     3841 tgaagccaga taccagcagc catttgaaga cttccgcatc tcgcaggagc atctcgcaga
     3901 ccattttgac agtcgggaac gaagggcccc aagaaggact cgggtcaatg gagacaaccg
     3961 cctctagtca tgcccctacc ttgttggaga gcagcaggcg ctgccacctg tggaatgcca
     4021 tgaactgggt tctctgggag cggtctactg taaagccttc ctggtctcac agcctggagc
     4081 ctggattcca gcggtgaagg ctagacaaaa ccaagccatt aatgagatgt actgttttgg
     4141 gcctccatgc ccagctctgg gtgaaggcaa aaaactgtac tgtgtctcgc attaagcaca
     4201 cacatctggc cctgaatgtg gaggtgggtc cctccatctt gggccaggac tagggctgaa
     4261 gccccttgga aagagaagtt gcctcagttg gtggcatagg aagcttcaag gagctgctga
     4321 cacattcctg aaagaggaag aggaggagga agaagagcct tgctgggcca ggggaacaaa
     4381 gtttacattg tcctgtagct ttaaaaccac agctggtcag ggtgaaagag tagatgccct
     4441 gaggcttggc cctggagcca ggtcagagga atgcagggcc tgtaaggaga aggctctgct
     4501 ctgcctgagg aggaagacag cacaagggca cattgcccac ggctgggtat actacccagc
     4561 ctgaaagata caggggatca tgataaatag cagtattatt tttttttctt ctcagtggta
     4621 ttgtgactaa gttattctgt cctgctcctc accttggaag ggaagaccca gcacagagcc
     4681 tttaggaaca gcagctctat ggggtgttgt tactggaaga gggcactgtc cagaagggtg
     4741 gaggggcaga aagagagaaa atcgatgtct accctggtga gcgtttttgt ttttatggca
     4801 aggaaggctc attatgctct cccaaaggaa tggagacatg ggtaagtgga gtcaggcagt
     4861 aggcaccaaa tgaagctgct gcttggtagt ctctgtgtgg ttggtaaaaa gatgcaaagg
     4921 agatgggaag gtaagcctca cctctgagga cagggtgggg tccaggcctg tgggtgcaaa
     4981 ggtgcctcag catagccagc attcagcaca cgcaaaccca ctgcccacat ttgggctcag
     5041 ggttggccat ttgctagttc tgctgccctc ttaagatctg actgccaaat aaatcatcct
     5101 catgtcc
//
