LOCUS       NM_001105845            2950 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phospholipase C, delta 3 (Plcd3), mRNA.
ACCESSION   NM_001105845 XM_001081531 XM_006247494 XM_221004
VERSION     NM_001105845.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2950)
  AUTHORS   Nakamura,Y., Kanemaru,K., Kojima,R., Hashimoto,Y., Marunouchi,T.,
            Oka,N., Ogura,T., Tanonaka,K. and Fukami,K.
  TITLE     Simultaneous loss of phospholipase Cdelta1 and phospholipase
            Cdelta3 causes cardiomyocyte apoptosis and cardiomyopathy
  JOURNAL   Cell Death Dis 5 (5), e1215 (2014)
   PUBMED   24810051
  REMARK    GeneRIF: Results indicate that PLCdelta1 and PLCdelta3 are required
            for cardiomyocyte survival and normal cardiac function.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2950)
  AUTHORS   Nakamura,Y., Hamada,Y., Fujiwara,T., Enomoto,H., Hiroe,T.,
            Tanaka,S., Nose,M., Nakahara,M., Yoshida,N., Takenawa,T. and
            Fukami,K.
  TITLE     Phospholipase C-delta1 and -delta3 are essential in the trophoblast
            for placental development
  JOURNAL   Mol Cell Biol 25 (24), 10979-10988 (2005)
   PUBMED   16314520
REFERENCE   3  (bases 1 to 2950)
  AUTHORS   Pawelczyk,T. and Matecki,A.
  TITLE     Localization of phospholipase C delta3 in the cell and regulation
            of its activity by phospholipids and calcium
  JOURNAL   Eur J Biochem 257 (1), 169-177 (1998)
   PUBMED   9799116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jun 3, 2021 this sequence version replaced
            XM_006247494.4, NM_001105845.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.45998.1,
                                           SRR26643298.64467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               JAXUCZ010000010.1  88547835-88548069   c
            236-397             JAXUCZ010000010.1  88537103-88537264   c
            398-626             JAXUCZ010000010.1  88536788-88537016   c
            627-756             JAXUCZ010000010.1  88536310-88536439   c
            757-985             JAXUCZ010000010.1  88534854-88535082   c
            986-1187            JAXUCZ010000010.1  88534392-88534593   c
            1188-1332           JAXUCZ010000010.1  88534158-88534302   c
            1333-1485           JAXUCZ010000010.1  88533386-88533538   c
            1486-1632           JAXUCZ010000010.1  88531362-88531508   c
            1633-1783           JAXUCZ010000010.1  88531082-88531232   c
            1784-1900           JAXUCZ010000010.1  88530186-88530302   c
            1901-2067           JAXUCZ010000010.1  88528083-88528249   c
            2068-2203           JAXUCZ010000010.1  88527703-88527838   c
            2204-2353           JAXUCZ010000010.1  88527473-88527622   c
            2354-2950           JAXUCZ010000010.1  88526802-88527398   c
FEATURES             Location/Qualifiers
     source          1..2950
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2950
                     /gene="Plcd3"
                     /note="phospholipase C, delta 3"
                     /db_xref="GeneID:287745"
                     /db_xref="RGD:1310903"
     exon            1..235
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2442
                     /gene="Plcd3"
                     /EC_number="3.1.4.11"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-3"
                     /protein_id="NP_001099315.3"
                     /db_xref="GeneID:287745"
                     /db_xref="RGD:1310903"
                     /translation="MLCGGWRRSRRSPEEPRVSAQVAAPLAFLPSPASSDSSTKRPGL
                     RALKKMGLTEDEDVQAMLRGSKLLKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAASQ
                     HIFFVQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWV
                     RGLAKLRARLDAMSQRERLDHWIHSYLHRADSDQDSKMSFKEIKSLLRMVNVDMNDMY
                     AYRLFKECDHSNNERLEGAEIEAFLRRLLKRPELEEIFRRYSGEDRVLSASELLEFLE
                     DQGEDGATLACAQKLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALNVAHTCVFQD
                     MGQPLAHYFISSSHNTYLTDSQIGGTSSTEAYIRAFTQGCRCVELDCWEGPGGEPVIY
                     HGHTLTSKILFRDVIQAVRDHAFTLSPYPVILSLENHCGLEQQIVMARHLRNILGDML
                     VTQALDSQNPEELPSPEQLKCRVLVKGKKLPAARNEDGRILSDREDEDEDEEEAEEAL
                     ETAEQRKRAKQISPELSALVVYCCATRLRTLEPSPGPPQPCKIGSLSERKARKFTREA
                     GTSFVRHNTQQLTRVYPLGLRMTSANYNPQEMWNSGCQLVALNFQTPGYEMDLNTGRF
                     LINGQCGYVLKPAYLRQLNTTFDPECPGPPRTTLTVQVLTAQQLPKLNVEKPNSIVDP
                     LVRVEIYGVPEDCAHKETDYVLNNGFNPCWEQTLQFQLRAPELVLVRFVVEDYDTTSP
                     NDFVGQFTLPLNSLKQGYRHIHLLSKDGASLSPATLFVHIRIENS"
     exon            236..397
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            398..626
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            627..756
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..985
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1187
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1332
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1485
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1632
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1783
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1900
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2067
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2203
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2353
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2950
                     /gene="Plcd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctctggacc gcgtcgggag ctgtgttccc gctgcccggt tctcaggcac agactccggg
       61 cctggcccta ggcccttcga gatcatgctg tgcggtggct ggagaaggag ccgccgctcg
      121 ccggaggaac cccgggtgtc cgcccaggtc gcagcgcccc tcgcgttctt gccctcgccc
      181 gcgtcatccg atagcagcac caaaaggccc gggctacggg cactgaagaa gatgggcctg
      241 acggaggatg aggatgtcca agccatgctg cggggctcca agctcctcaa gatccgctca
      301 cgcacgtggc acaaggagcg gctgtaccgg ctgcaggagg atggcctgag cgtgtggttt
      361 cagcggcgca tcccccgcgc agcttcgcag cacatcttct tcgtgcagca catcgaggct
      421 gtccgggaag gccatcagtc ggagggcctg cggcggttcg ggggcgcctt tgcgcctgcg
      481 cgctgcctca ccatcgcctt caagggccgc cgcaagaacc tggacctggc agcgcccact
      541 gcggaggaag cgcagcgctg ggtgcgaggg ctggccaagc tgagggcgcg cctggatgcc
      601 atgagccagc gggagcggct agaccactgg atccattcct atctgcaccg ggccgactcc
      661 gaccaagaca gcaagatgag cttcaaggag atcaagagcc tgctgaggat ggtcaacgtg
      721 gacatgaatg acatgtacgc ctaccgcctc ttcaaggagt gtgaccattc taacaacgag
      781 cgtctggaag gggctgagat cgaggctttc ctccggaggc tgcttaaacg gcccgagctg
      841 gaggagatct tccgccgata ctccggcgag gaccgggtac tgagtgcctc tgagctgctg
      901 gagttcctgg aagaccaggg cgaggacggt gccaccctgg cctgtgccca gaagcttatc
      961 cagacgtatg agctcaacga gacagccaag cagcacgagc tgatgacgct ggatggcttc
     1021 atgatgtatc tgttgtcgcc tgagggggct gcgctgaacg tggcccacac gtgtgtgttc
     1081 caggacatgg gtcagcccct ggcccactac tttatctcgt cctctcataa tacttacctg
     1141 actgactctc agatcggagg gaccagcagc accgaggcct acatcagggc ctttacccag
     1201 ggatgccgct gtgtggaact tgactgctgg gaggggccgg gaggggagcc cgtcatctac
     1261 catgggcata cccttacttc caagattctc tttcgagatg tgatccaagc tgtgcgtgac
     1321 cacgctttca cgctgtcccc atatcctgtt atcctgtccc ttgagaatca ctgcgggttg
     1381 gaacagcaga ttgtcatggc tcgccacctt cggaacatcc tgggagacat gctggtgaca
     1441 caggccctgg actcccagaa ccccgaggag ctgccgtctc ctgagcagct caaatgccgg
     1501 gtcttggtga aggggaagaa gctgccagct gctcggaatg aggatggtcg aattctgtca
     1561 gacagggagg atgaagatga agatgaagag gaggcagaag aggctttgga gactgcagag
     1621 cagaggaagc gagccaaaca gatctcccca gagctctcag cgctggttgt gtattgctgt
     1681 gctacccgcc tgcggaccct ggagcctagt cctggtccac ctcagccttg caagattggc
     1741 tccctcagcg agcgcaaggc caggaagttc accagggagg caggaaccag ttttgtcagg
     1801 cacaacactc agcaactgac ccgagtgtac ccactggggc tgcggatgac ctcggccaac
     1861 tataaccccc aggagatgtg gaactcgggc tgtcaactgg tggctctgaa ctttcagact
     1921 cctggctatg agatggacct caacacgggg cgcttcctca taaatgggca gtgcggctat
     1981 gtcctgaaac ccgcctacct caggcaactc aacaccacct ttgaccccga gtgccctgga
     2041 ccccccagaa ctactctgac agtccaggtg ttaacggccc agcagctgcc caagctgaat
     2101 gtagagaagc ccaactccat tgtggatcct ctggtgcgtg tggagatcta cggggtgcct
     2161 gaagactgtg cgcacaagga gacggactat gtgctcaata atggcttcaa cccctgctgg
     2221 gagcagactc tgcagttcca actgcgggcc ccagagctgg ttctggtgag gtttgtggta
     2281 gaagactatg ataccacctc ccccaatgat tttgtgggac agtttacact gcccctcaac
     2341 agcctgaagc aagggtaccg ccacatccac ttgctgtcca aggatggagc ctcgctctct
     2401 ccagccacac tcttcgttca catccgcatt gagaactctt gagggcatcg ccgacttacc
     2461 caggtgctgg tatcatgcca cagagccctc tctggagcaa gggaccatgg gagtaccaac
     2521 ccctcccgcc agatccttgg tcaccaggtg ctgagcacac ctgggtgctg acgctcttcc
     2581 gtcgctcagt gagagatagg accgtgattg gtgtcctgtc cagtggattt caggggcctc
     2641 caaccttggg gcctggaggt ggtctcagat tcttcgactt gaggaggaca cgagtccctc
     2701 tgccctccag cggagtcatc tcagcctccg tccccgaaaa gggcatagcc acccacactg
     2761 cctcctttca gggcccccag agcctccctt taggctttcc tggcttctcc tttgcttctt
     2821 gactcaggtg ggtggggagc agatgagcct ggggagaacc tggcagtggg tttgtaactt
     2881 gtgtcataga agagccctgg agagggcagg agaggaacta ttttaaaaaa taaagaaaga
     2941 gtgtaccttt
//
