LOCUS       NM_017035               2766 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus phospholipase C, delta 1 (Plcd1), mRNA.
ACCESSION   NM_017035
VERSION     NM_017035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2766)
  AUTHORS   Nomikos,M., Thanassoulas,A., Beck,K., Theodoridou,M., Kew,J.,
            Kashir,J., Calver,B.L., Matthews,E., Rizkallah,P., Sideratou,Z.,
            Nounesis,G. and Lai,F.A.
  TITLE     Mutations in PLCdelta1 associated with hereditary leukonychia
            display divergent PIP2 hydrolytic function
  JOURNAL   FEBS J 283 (24), 4502-4514 (2016)
   PUBMED   27783455
  REMARK    GeneRIF: Data suggest that these phospholipase C delta-1
            (PLCdelta1) mutations associated with hereditary leukonychia do not
            uniformly alter the enzymatic ability of this protein leading to
            loss/gain of function, but result in significantly divergent
            enzymatic properties.
REFERENCE   2  (bases 1 to 2766)
  AUTHORS   Nakamura,Y., Kanemaru,K., Kojima,R., Hashimoto,Y., Marunouchi,T.,
            Oka,N., Ogura,T., Tanonaka,K. and Fukami,K.
  TITLE     Simultaneous loss of phospholipase Cdelta1 and phospholipase
            Cdelta3 causes cardiomyocyte apoptosis and cardiomyopathy
  JOURNAL   Cell Death Dis 5 (5), e1215 (2014)
   PUBMED   24810051
  REMARK    GeneRIF: Results indicate that PLCdelta1 and PLCdelta3 are required
            for cardiomyocyte survival and normal cardiac function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2766)
  AUTHORS   Cai,J., Guo,S., Lomasney,J.W. and Roberts,M.F.
  TITLE     Ca2+-independent binding of anionic phospholipids by phospholipase
            C delta1 EF-hand domain
  JOURNAL   J Biol Chem 288 (52), 37277-37288 (2013)
   PUBMED   24235144
  REMARK    GeneRIF: Ca2+-independent binding of anionic phospholipids by
            phospholipase C delta1 EF-hand domain.
REFERENCE   4  (bases 1 to 2766)
  AUTHORS   Kim,N.Y., Ahn,S.J., Kim,M.S., Seo,J.S., Kim,B.S., Bak,H.J.,
            Lee,J.Y., Park,M.A., Park,J.H., Lee,H.H. and Chung,J.K.
  TITLE     PLC-delta1-Lf, a novel N-terminal extended phospholipase C-delta1
  JOURNAL   Gene 528 (2), 170-177 (2013)
   PUBMED   23892088
REFERENCE   5  (bases 1 to 2766)
  AUTHORS   Chung,E., Jakinovich,P., Bae,A. and Rebecchi,M.
  TITLE     Phospholipase C-delta(1) regulates interleukin-1beta and tumor
            necrosis factor-alpha mRNA expression
  JOURNAL   Exp Cell Res 318 (16), 1987-1993 (2012)
   PUBMED   22710061
  REMARK    GeneRIF: Phospholipase C delta 1 regulates interleukin-1beta and
            tumor necrosis factor-alpha mRNA expression.
REFERENCE   6  (bases 1 to 2766)
  AUTHORS   Katsuya,T., Higaki,J., Miki,T., Kohara,K., Yagisawa,H., Tanase,H.,
            Mikami,H., Serikawa,T., Nojima,H. and Ogihara,T.
  TITLE     Hypotensive effect associated with a phospholipase C-delta 1 gene
            mutation in the spontaneously hypertensive rat
  JOURNAL   Biochem Biophys Res Commun 187 (3), 1359-1366 (1992)
   PUBMED   1358065
REFERENCE   7  (bases 1 to 2766)
  AUTHORS   Kanematsu,T., Takeya,H., Watanabe,Y., Ozaki,S., Yoshida,M.,
            Koga,T., Iwanaga,S. and Hirata,M.
  TITLE     Putative inositol 1,4,5-trisphosphate binding proteins in rat brain
            cytosol
  JOURNAL   J Biol Chem 267 (10), 6518-6525 (1992)
   PUBMED   1313009
REFERENCE   8  (bases 1 to 2766)
  AUTHORS   Kato,H., Fukami,K., Shibasaki,F., Homma,Y. and Takenawa,T.
  TITLE     Enhancement of phospholipase C delta 1 activity in the aortas of
            spontaneously hypertensive rats
  JOURNAL   J Biol Chem 267 (10), 6483-6487 (1992)
   PUBMED   1313006
REFERENCE   9  (bases 1 to 2766)
  AUTHORS   Yagisawa,H., Tanase,H. and Nojima,H.
  TITLE     Phospholipase C-delta gene of the spontaneously hypertensive rat
            harbors point mutations causing amino acid substitutions in a
            catalytic domain
  JOURNAL   J Hypertens 9 (11), 997-1004 (1991)
   PUBMED   1684614
REFERENCE   10 (bases 1 to 2766)
  AUTHORS   Suh,P.G., Ryu,S.H., Moon,K.H., Suh,H.W. and Rhee,S.G.
  TITLE     Cloning and sequence of multiple forms of phospholipase C
  JOURNAL   Cell 54 (2), 161-169 (1988)
   PUBMED   3390863
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017035.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582419.2760477.1,
                                           SRR26643299.37726.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-254               JAXUCZ010000008.1  127695686-127695939 c
            255-419             JAXUCZ010000008.1  127686628-127686792 c
            420-648             JAXUCZ010000008.1  127683013-127683241 c
            649-778             JAXUCZ010000008.1  127677671-127677800 c
            779-1010            JAXUCZ010000008.1  127677350-127677581 c
            1011-1212           JAXUCZ010000008.1  127676470-127676671 c
            1213-1357           JAXUCZ010000008.1  127676234-127676378 c
            1358-1507           JAXUCZ010000008.1  127676008-127676157 c
            1508-1666           JAXUCZ010000008.1  127675763-127675921 c
            1667-1826           JAXUCZ010000008.1  127675342-127675501 c
            1827-1943           JAXUCZ010000008.1  127675048-127675164 c
            1944-2122           JAXUCZ010000008.1  127673892-127674070 c
            2123-2255           JAXUCZ010000008.1  127673672-127673804 c
            2256-2405           JAXUCZ010000008.1  127673441-127673590 c
            2406-2766           JAXUCZ010000008.1  127672959-127673319 c
FEATURES             Location/Qualifiers
     source          1..2766
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2766
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /note="phospholipase C, delta 1"
                     /db_xref="GeneID:24655"
                     /db_xref="RGD:3346"
     exon            1..254
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2491
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /EC_number="3.1.4.11"
                     /note="phospholipase C delta 1 long form; PLC-III;
                     PLC-delta-1; phosphoinositide phospholipase C;
                     phospholipase C-III; phosphoinositide phospholipase
                     C-delta-1; Phospholipase C-delta1"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase delta-1"
                     /protein_id="NP_058731.2"
                     /db_xref="GeneID:24655"
                     /db_xref="RGD:3346"
                     /translation="MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKL
                     QEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFK
                     DQRNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKM
                     NFKELKDFLKELNIQVDDGYARKIFRECDHSQTDSLEDEEIETFYKMLTQRAEIDRAF
                     EEAAGSAETLSVERLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFL
                     MYLLSADGNAFSLAHRRVYQDMDQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALC
                     KGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENH
                     CSLEQQRVMARHLRAILGPMLLDQPLDGVTSSLPSPEQLKGKILLKGKKLGGLLPAGG
                     ENGSEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMIIYCKSVHFGGFS
                     SPGTSGQAFYEMASFSESRALRLLQESGNGFVRHNVSCLSRIYPAGWRTDSSNYSPVE
                     MWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPNTTFNSRALTQGP
                     WWAPKRLRVRIISGQQLPKVNKNKNSIVDPKVIVEIHGVGRDTASRQTAVITNNGFNP
                     RWDMEFEFEVTVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNG
                     DQHPSATLFVKISIQD"
     exon            255..419
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            420..648
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..778
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1010
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1212
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1357
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1507
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1666
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1826
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1943
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2122
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2255
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2405
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2766
                     /gene="Plcd1"
                     /gene_synonym="Plc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccccctgctc cgcgtccttt ctcggtcccc tggagggggc ggggagaggc gcgggttggc
       61 gggcccgggg ggcggtacgg tgtcctggac ccaccccccc ggccgcctcc cgccgcagtt
      121 cagttgggtc cttgtaccgg cctgcgcaag gaccccaggc cgctcggttg ttgctcaagt
      181 gaatcacgcc gggtcccctc cgccgcgcgc cccgacgggc atggactcgg gtagggactt
      241 cctgaccctg cacgggctcc aggatgaccc ggaccttcag gcccttctga agggcagcca
      301 gcttctgaag gtgaagtcca gctcgtggcg tagggaacgc ttctacaagc tacaggagga
      361 ctgcaagacc atctggcagg aatctcgaaa ggtcatgagg tccccggagt cgcagctgtt
      421 ctccatcgag gacattcagg aggtacggat gggacaccgc acagaaggcc tggagaagtt
      481 tgcccgagac atccccgagg atcgatgctt ctccattgtc ttcaaggacc agcgcaacac
      541 cctagacctc attgccccat caccagctga cgctcagcac tgggtgcagg gcctgcgcaa
      601 gatcatccac cactccggct ccatggacca gcggcagaag ctgcagcact ggattcactc
      661 ctgcttgcga aaggctgata aaaacaagga caacaagatg aacttcaagg agctgaagga
      721 cttcctgaag gagctcaaca tccaggtgga tgacggctac gccaggaaga tcttcaggga
      781 atgtgaccac tcccagacag actcgctgga ggatgaggag attgagacct tctacaagat
      841 gctgacccag cgcgcagaga tcgaccgtgc ttttgaggag gccgcaggat ccgcggagac
      901 cctgtcggtg gagaggctag tgacgtttct gcagcaccag cagcgggagg aggaggcagg
      961 gccagccttg gccctctctc tcattgagcg ctacgagccc agtgagactg ccaaggccca
     1021 gcggcagatg accaaggatg gcttcctcat gtacttgctg tcggctgacg gtaacgcctt
     1081 cagcctggca caccgccgtg tctaccagga catggaccag ccactgagtc actacttagt
     1141 gtcttcttcc cacaacacct acctgctgga agaccagctc acagggccca gcagcacgga
     1201 ggcctacatc cgggctctgt gcaaaggctg ccggtgcttg gagctcgact gctgggatgg
     1261 tcccaaccag gaacccatca tctaccacgg ctacactttt acctctaaga tacttttctg
     1321 tgacgtgctc agggccatca gggactatgc cttcaaggca tccccctacc cagtcatcct
     1381 gtccctggag aaccactgta gcctggagca acaacgagtc atggcccgtc acctgagggc
     1441 tatcctgggg cccatgctgt tggaccagcc actggatggg gttacctcga gcctgccttc
     1501 acctgagcaa ctgaagggca agatcctgtt gaaagggaag aagctgggag ggctgctgcc
     1561 tgctggaggg gagaatgggt ccgaagccac tgacgtgtct gacgaggatg aggctgctga
     1621 aatggaggac gaggctgtgc gcagccaagt gcaacacaag cccaaggagg ataaactaaa
     1681 gctggtgccg gagctctccg acatgatcat ttactgcaag agcgtccact ttggtggctt
     1741 ctccagtcct ggcacctctg ggcaggcatt ctatgagatg gcttcctttt ctgagagccg
     1801 tgccctccgg ttgctgcaag aatcaggaaa tggttttgtc cgtcataacg tgagctgtct
     1861 gagcaggatc tacccggctg ggtggagaac agattcctcc aactacagtc ctgtggagat
     1921 gtggaacggg ggctgccaga ttgtggctct gaacttccaa acccctgggc cagaaatgga
     1981 tgtttacctt ggctgcttcc aggacaatgg aggctgtggg tatgtgctga aacccgcctt
     2041 tctgagagac cccaacacca ccttcaactc acgtgccctg actcaggggc cctggtgggc
     2101 tccgaagagg ctccgtgtcc ggatcatctc tggacagcag ctgccaaagg tcaataagaa
     2161 taagaattct atcgtggacc ccaaggtgat cgtggagatc catggcgtgg gccgggacac
     2221 ggctagccgt cagacagcag ttattaccaa taatggtttc aacccacggt gggacatgga
     2281 gtttgagttt gaggtaacag tgcctgacct tgccctcgta cgcttcatgg tagaggatta
     2341 tgattcctct tctaagaacg actttattgg ccagagtact atcccctgga acagcctcaa
     2401 gcaggggtac cgccatgtcc acctcttgtc taagaatgga gaccagcatc catcagccac
     2461 actttttgtg aagatctcca tccaggacta agcccggggg tctgatgcag tccgacctga
     2521 gtgagtggag ctgtgtccgc acctcggcca aggctgacat tattgcaccg acctctggcg
     2581 cggagcctga ggccctgaac tgccttcagt gccaacacat cgcttgagct tctgcctctc
     2641 tggaggccca ggagtggtcc gatccccgga gcgctccaaa attccgttag gaacaacact
     2701 gcatccctct ccctaccctc tagctgtctt tatgaataag tttttataaa aaaaaaaatc
     2761 aaaaga
//
