LOCUS       NM_033350               3726 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phospholipase C beta 3 (Plcb3), mRNA.
ACCESSION   NM_033350 XM_342005
VERSION     NM_033350.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Wu,J., Zhang,C., Liu,C., Zhang,A., Li,A., Zhang,J. and Zhang,Y.
  TITLE     Aortic constriction induces hypertension and cardiac hypertrophy
            via (pro)renin receptor activation and the PLC-beta3 signaling
            pathway
  JOURNAL   Mol Med Rep 19 (1), 573-580 (2019)
   PUBMED   30431106
  REMARK    GeneRIF: High phospholipase C beta 3 expression is associated with
            hypertension and cardiac hypertrophy.
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Friedrich,B., Euler,P., Ziegler,R., Kuhn,A., Landwehrmeyer,B.G.,
            Luthi-Carter,R., Weiller,C., Hellwig,S. and Zucker,B.
  TITLE     Comparative analyses of Purkinje cell gene expression profiles
            reveal shared molecular abnormalities in models of different
            polyglutamine diseases
  JOURNAL   Brain Res 1481, 37-48 (2012)
   PUBMED   22917585
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Singal,T., Dhalla,N.S. and Tappia,P.S.
  TITLE     Reciprocal regulation of transcription factors and PLC isozyme gene
            expression in adult cardiomyocytes
  JOURNAL   J Cell Mol Med 14 (6B), 1824-1835 (2010)
   PUBMED   19538471
  REMARK    GeneRIF: Silencing of either c-Fos or c-Jun also depressed the
            norepinephrine-mediated increases in PLC beta(1), beta(3) and
            gamma(1) protein content and activity in an isozyme specific
            manner.
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Lyssand,J.S., DeFino,M.C., Tang,X.B., Hertz,A.L., Feller,D.B.,
            Wacker,J.L., Adams,M.E. and Hague,C.
  TITLE     Blood pressure is regulated by an alpha1D-adrenergic
            receptor/dystrophin signalosome
  JOURNAL   J Biol Chem 283 (27), 18792-18800 (2008)
   PUBMED   18468998
REFERENCE   6  (bases 1 to 3726)
  AUTHORS   Wang,S., Gebre-Medhin,S., Betsholtz,C., Stalberg,P., Zhou,Y.,
            Larsson,C., Weber,G., Feinstein,R., Oberg,K., Gobl,A. and
            Skogseid,B.
  TITLE     Targeted disruption of the mouse phospholipase C beta3 gene results
            in early embryonic lethality
  JOURNAL   FEBS Lett 441 (2), 261-265 (1998)
   PUBMED   9883896
REFERENCE   7  (bases 1 to 3726)
  AUTHORS   Ju,H., Zhao,S., Tappia,P.S., Panagia,V. and Dixon,I.M.
  TITLE     Expression of Gq alpha and PLC-beta in scar and border tissue in
            heart failure due to myocardial infarction
  JOURNAL   Circulation 97 (9), 892-899 (1998)
   PUBMED   9521338
REFERENCE   8  (bases 1 to 3726)
  AUTHORS   Kang,J.S., Lee,H.B., Rhee,S.G., Park,K. and Yoo,O.J.
  TITLE     The 5'-upstream region of the rat phospholipase C-beta 3 gene
            contains two critical Sp1 sites and an HIV Inr-like element
  JOURNAL   Gene 197 (1-2), 19-28 (1997)
   PUBMED   9332346
REFERENCE   9  (bases 1 to 3726)
  AUTHORS   Smrcka,A.V. and Sternweis,P.C.
  TITLE     Regulation of purified subtypes of phosphatidylinositol-specific
            phospholipase C beta by G protein alpha and beta gamma subunits
  JOURNAL   J Biol Chem 268 (13), 9667-9674 (1993)
   PUBMED   8387502
REFERENCE   10 (bases 1 to 3726)
  AUTHORS   Jhon,D.Y., Lee,H.H., Park,D., Lee,C.W., Lee,K.H., Yoo,O.J. and
            Rhee,S.G.
  TITLE     Cloning, sequencing, purification, and Gq-dependent activation of
            phospholipase C-beta 3
  JOURNAL   J Biol Chem 268 (9), 6654-6661 (1993)
   PUBMED   8454637
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ120508.1.
            
            On Aug 8, 2005 this sequence version replaced XM_342005.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ120507.1, DQ120508.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="SHR"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3726
                     /gene="Plcb3"
                     /note="phospholipase C beta 3"
                     /db_xref="GeneID:29322"
                     /db_xref="RGD:61993"
     exon            1..111
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..3723
                     /gene="Plcb3"
                     /EC_number="3.1.4.11"
                     /note="PLC-beta-3; phosphoinositide phospholipase
                     C-beta-3; phospholipase C, beta 3
                     (phosphatidylinositol-specific)"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-3"
                     /protein_id="NP_203501.1"
                     /db_xref="GeneID:29322"
                     /db_xref="RGD:61993"
                     /translation="MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLR
                     VDPNGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEK
                     LMTVVAGPDPVNTTFLNFMAVQDDTVKVWSEELFKLAMNILAQNASRNTFLRKAYTKL
                     KLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLN
                     KLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRSSQARLLI
                     EKYEPNKQFLERDQMSMEGFSRYLGGEENGILPLEALDLSMDMTQPLSAYFINSSHNT
                     YLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDV
                     LEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGEALLIDPLDKYPLSAG
                     TPLPSPQDLMGRILVKNKKRHRPSTGVPDSSVRKRPLEQSNSALSESSAATEPSSPQL
                     GSPSSDSCPGLSNGEEVGLEKTSLEPQKSLGEEGLNRGPNVLMPDRDREDEEEDEEEE
                     ETTDPKKPTTDEGTASSEVNATEEMSTLVNYVEPVKFKSFEAARKRNKCFEMSSFVET
                     KAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDL
                     PMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLS
                     DRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIA
                     AFEEGGRFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDY
                     AEALINPIKHVSLMDQRAKQLAALIGESEAQASTEMCQETPSQQQGSQLSSNPAPNPL
                     DASPRWPPGPTTSPTSTSLSSPGQRDDLIASILSEVTPTPLEELRSHKAMVKLRSRQD
                     RDLRELHKKHQRKAVALTRRLLDGLAQARAEGKCRPSSSALSRATNVEDVKEEEKEAA
                     RQYREFQNRQVQSLLELREAQADAETERRLEHLKQAQQRLREVVLDAHTTQFKRLKEL
                     NEREKKELQKILDRKRNNSISEAKTREKHKKEVELTEINRRHITESVNSIRRLEEAQK
                     QRHERLLAGQQQVLQQLVEEEPKLVAQLTQECQEQRERLPQEIRRCLLGETSEGLGDG
                     PLVACASNGHAAGSGGHQSGADSESQEENTQL"
     exon            112..189
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            190..258
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            259..399
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            400..479
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            480..533
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            534..609
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            610..710
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            711..877
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1024
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1265
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1350
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1537
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1746
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1843
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1928
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2053
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2208
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2370
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2470
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2575
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2667
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2821
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2857
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3050
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3051..3207
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3284
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3374
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3432
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3519
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3726
                     /gene="Plcb3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctggcttgg ccatggcggg cgcgaggccc ggcgtccacg cgctgcagct ggagccgccc
       61 accgtggtgg agaccctgcg gcgcgggagt aaattcatca aatgggacga ggaggcctcc
      121 agtcggaacc tggtgaccct gcgagtggac cccaatggct tcttcttgta ctggacagga
      181 cccaacatgg aggtggacac actggacatc agctccatca gggacacaag gacaggtcgt
      241 tatgcccgcc tgcccaagga ccccaagatt cgagaggtac tgggctttgg gggtcctgac
      301 acccggctgg aggagaaact gatgacagtg gtagcaggac cagatccagt aaacaccaca
      361 ttcttgaact tcatggccgt gcaagatgac acagtcaagg tctggtcaga ggagttgttt
      421 aagctggcta tgaacatact ggctcagaac gcctcccgga acacgttcct tcggaaagca
      481 tacacgaaac tgaagctgca ggtgaaccag gatggacgga ttccagtcaa gaacattctg
      541 aagatgttct ccgcggacaa gaagcgggtg gagactgcac tggagtcctg cggcctcaac
      601 ttcaaccgga gtgagtccat tcggcctgat gagttttcct tggaaatctt cgagcggttc
      661 ttgaataagc tgtgtctgcg accggatatt gacaagatcc tgctggagat aggtgctaag
      721 ggcaagccgt acctcactct ggagcagctc atggacttta tcaaccagaa gcaaagagac
      781 ccaagactca acgaggtgct gtacccaccg cttcgctcct cacaggctcg gctgctcatt
      841 gagaagtatg agccgaacaa acagttcctg gagcgcgacc agatgtctat ggagggtttc
      901 agccgctatc tgggagggga ggagaatggc atcctgcccc tggaggccct ggatctgagc
      961 atggacatga cgcagccact gagcgcatac ttcatcaatt cttcacacaa tacctatctc
     1021 actgcgggcc agctggctgg aacatcgtca gtggagatgt accgccaggc gctgctgtgg
     1081 ggctgccgtt gtgtggagct ggatgtatgg aagggacggc caccggagga agagcccttc
     1141 attacccatg gtttcaccat gaccactgag gtgccattgc gtgatgtgtt agaggccatc
     1201 gccgagacag ccttcaagac ctcaccctac cctgtcattc tctccttcga aaaccatgtg
     1261 gactcggcaa aacagcaggc caagatggca gagtactgcc gctctatctt tggggaagcg
     1321 ctgctcattg acccactgga caagtacccg ctgtctgcgg gcacccccct tcctagtcca
     1381 caggacctga tgggccgtat cctggtgaag aataagaagc ggcatcggcc cagcacaggt
     1441 gtccctgaca gctccgtgcg caagcggcct ctggaacaga gcaattcagc cctgagtgag
     1501 agctcagctg ccacagagcc ctcctcaccc cagctggggt cccccagctc tgacagctgc
     1561 cctggcctaa gcaatgggga agaggtggga cttgagaaga ccagcctgga gcctcagaag
     1621 tctctaggtg aggagggcct caaccgagga cctaatgttc tcatgcctga ccgtgaccga
     1681 gaggatgagg aggaagatga agaagaggag gaaacaacgg atccaaaaaa gcccaccacc
     1741 gatgagggca cagccagcag tgaggtcaac gccacagagg agatgtcgac actcgtcaat
     1801 tacgttgagc ccgtcaagtt caagtccttt gaggctgctc gaaaaaggaa caagtgcttt
     1861 gagatgtcgt cctttgtgga gaccaaggcg atggagcagc tgaccaagag ccccatggag
     1921 ttcgtggaat acaacaaaca gcagcttagt cgcatctacc ccaagggcac ccgtgtggac
     1981 tcctccaact acatgcctca gctcttctgg aacgtgggct gtcagcttgt tgccctcaac
     2041 ttccagacct tggatttgcc aatgcagctc aacgcaggcg tgtttgagta caacgggcgc
     2101 agtgggtact tgctcaagcc tgagtttatg cggcggccgg acaagtcttt tgaccccttc
     2161 actgaggtca tcgtagatgg catagtggcc aacgccttgc gggtcaaggt gatttcgggg
     2221 cagtttctgt ctgacaggaa ggtgggcatc tatgtcgagg tggacatgtt tggtctccca
     2281 gttgacacaa gacgcaaata tcgcacacgg acatcccagg ggaactcatt caaccctgtg
     2341 tgggatgaag aaccctttga cttccccaag gttgtgctgc ccacgctggc ctcacttcgc
     2401 attgcagcct ttgaggaggg tggcagattt gttgggcatc gtatcctgcc tgtctctgct
     2461 atccgctcag gataccacta cgtctgcctg cgaaatgagg ccaaccaacc gttgtgcctg
     2521 cctgccctgc ttatctacac tgaagcttct gactacatcc cagatgacca ccaggactat
     2581 gcggaggcct tgatcaaccc catcaagcac gtcagcctaa tggaccagcg ggccaagcaa
     2641 ctggctgctc tcattgggga gagtgaggct caggccagta cagaaatgtg tcaggagacc
     2701 ccgtctcaac agcaaggctc acagctctcc tccaaccccg cacctaaccc actggatgcc
     2761 tcacctcgat ggcccccagg tcctaccacc tcccccacta gcacctccct cagtagccca
     2821 gggcagcgag atgatctgat cgccagcatc ctttctgagg tgaccccaac acccctagag
     2881 gagctccgaa gccacaaggc tatggtgaag ctccggagcc ggcaggatcg agacctgagg
     2941 gaactgcata aaaaacacca gcgcaaggct gtggccctca cccgccgcct tctggatggc
     3001 ctggcccagg ccagggctga ggggaagtgc cggccctcct ccagcgccct gagcagggcc
     3061 accaatgtgg aagacgtgaa ggaggaagaa aaagaggcag ccagacagta tcgagagttc
     3121 cagaaccgac aagtacagag cctgctggag ctgagggagg cccaggcaga tgcagagaca
     3181 gaacggaggc tggagcatct gaaacaggct cagcagcggc tcagggaggt tgtcctggac
     3241 gcacatacga ctcagttcaa gaggctgaag gagttgaatg aaagggagaa gaaggagctt
     3301 cagaagatcc tggacaggaa gcgcaacaac agcatctcag aggccaagac aagggagaaa
     3361 cacaagaagg aggtggaact gacagagatc aatcggaggc acatcactga gtcagtgaac
     3421 tccatcagga ggctggaaga ggcccagaag cagcgccacg aacgcctctt ggcagggcaa
     3481 cagcaggtcc tccagcagct agtggaagag gagcccaagc tggtggccca gctgacccag
     3541 gagtgtcagg aacagcgaga gaggctgccc caggagatcc gtcggtgcct gctgggcgag
     3601 acatcagagg gattggggga tggccccctg gtggcctgtg ccagcaatgg tcatgcagct
     3661 gggagtggtg ggcaccagtc cggcgctgac tcggagagcc aggaggaaaa cacccagctt
     3721 tgaact
//
