LOCUS       NM_053478               4004 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus phospholipase C, beta 2 (Plcb2), mRNA.
ACCESSION   NM_053478
VERSION     NM_053478.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4004)
  AUTHORS   Ubba,V., Gupta,R.K., Hakim,B.A., Bora,H.K., Sachdev,M., Tripathi,R.
            and Jha,R.K.
  TITLE     PKC-betaII is downregulated in the premature ovarian failure SD rat
            model
  JOURNAL   Reprod Biol 23 (2), 100754 (2023)
   PUBMED   36934663
  REMARK    GeneRIF: PKC-betaII is downregulated in the premature ovarian
            failure SD rat model.
REFERENCE   2  (bases 1 to 4004)
  AUTHORS   Voigt,A., Hubner,S., Lossow,K., Hermans-Borgmeyer,I., Boehm,U. and
            Meyerhof,W.
  TITLE     Genetic labeling of Tas1r1 and Tas2r131 taste receptor cells in
            mice
  JOURNAL   Chem Senses 37 (9), 897-911 (2012)
   PUBMED   23010799
REFERENCE   3  (bases 1 to 4004)
  AUTHORS   Krasteva,G., Canning,B.J., Hartmann,P., Veres,T.Z., Papadakis,T.,
            Muhlfeld,C., Schliecker,K., Tallini,Y.N., Braun,A., Hackstein,H.,
            Baal,N., Weihe,E., Schutz,B., Kotlikoff,M., Ibanez-Tallon,I. and
            Kummer,W.
  TITLE     Cholinergic chemosensory cells in the trachea regulate breathing
  JOURNAL   Proc Natl Acad Sci U S A 108 (23), 9478-9483 (2011)
   PUBMED   21606356
REFERENCE   4  (bases 1 to 4004)
  AUTHORS   Descorbeth,M. and Anand-Srivastava,M.B.
  TITLE     Role of vasoactive peptides in high glucose-induced increased
            expression of Galphaq/11 proteins and associated signaling in
            vascular smooth muscle cells
  JOURNAL   Can J Physiol Pharmacol 88 (3), 331-340 (2010)
   PUBMED   20393598
  REMARK    GeneRIF: levels of Galphaq, Galpha11, PLCbeta-1, and PLC-beta2
            proteins, as determined by western blotting, are significantly
            higher in vascular smooth muscle cells exposed to high glucose than
            in control cells.
REFERENCE   5  (bases 1 to 4004)
  AUTHORS   Descorbeth,M. and Anand-Srivastava,M.B.
  TITLE     High glucose increases the expression of Gq/11alpha and PLC-beta
            proteins and associated signaling in vascular smooth muscle cells
  JOURNAL   Am J Physiol Heart Circ Physiol 295 (5), H2135-H2142 (2008)
   PUBMED   18820027
  REMARK    GeneRIF: High glucose increases the expression of Gq/11alpha and
            PLC-beta proteins and associated signaling in vascular smooth
            muscle cells.
REFERENCE   6  (bases 1 to 4004)
  AUTHORS   Wang,T., Pentyala,S., Rebecchi,M.J. and Scarlata,S.
  TITLE     Differential association of the pleckstrin homology domains of
            phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid
            bilayers and the beta gamma subunits of heterotrimeric G proteins
  JOURNAL   Biochemistry 38 (5), 1517-1524 (1999)
   PUBMED   9931017
REFERENCE   7  (bases 1 to 4004)
  AUTHORS   Blayney,L., Gapper,P. and Rix,C.
  TITLE     Identification of phospholipase C beta isoforms and their location
            in cultured vascular smooth muscle cells of pig, human and rat
  JOURNAL   Cardiovasc Res 40 (3), 564-572 (1998)
   PUBMED   10070498
REFERENCE   8  (bases 1 to 4004)
  AUTHORS   Rossler,P., Kroner,C., Freitag,J., Noe,J. and Breer,H.
  TITLE     Identification of a phospholipase C beta subtype in rat taste cells
  JOURNAL   Eur J Cell Biol 77 (3), 253-261 (1998)
   PUBMED   9860142
REFERENCE   9  (bases 1 to 4004)
  AUTHORS   Paterson,A., Boyer,J.L., Watts,V.J., Morris,A.J., Price,E.M. and
            Harden,T.K.
  TITLE     Concentration of enzyme-dependent activation of PLC-beta 1 and
            PLC-beta 2 by G alpha 11 and beta gamma-subunits
  JOURNAL   Cell Signal 7 (7), 709-720 (1995)
   PUBMED   8519600
REFERENCE   10 (bases 1 to 4004)
  AUTHORS   Jhon,D.Y., Lee,H.H., Park,D., Lee,C.W., Lee,K.H., Yoo,O.J. and
            Rhee,S.G.
  TITLE     Cloning, sequencing, purification, and Gq-dependent activation of
            phospholipase C-beta 3
  JOURNAL   J Biol Chem 268 (9), 6654-6661 (1993)
   PUBMED   8454637
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053478.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000003.1  126158040-126158221 c
            183-260             JAXUCZ010000003.1  126155004-126155081 c
            261-329             JAXUCZ010000003.1  126154361-126154429 c
            330-470             JAXUCZ010000003.1  126153666-126153806 c
            471-550             JAXUCZ010000003.1  126153455-126153534 c
            551-604             JAXUCZ010000003.1  126153294-126153347 c
            605-680             JAXUCZ010000003.1  126153119-126153194 c
            681-781             JAXUCZ010000003.1  126149853-126149953 c
            782-948             JAXUCZ010000003.1  126149535-126149701 c
            949-1095            JAXUCZ010000003.1  126149297-126149443 c
            1096-1253           JAXUCZ010000003.1  126149001-126149158 c
            1254-1336           JAXUCZ010000003.1  126148711-126148793 c
            1337-1421           JAXUCZ010000003.1  126148370-126148454 c
            1422-1584           JAXUCZ010000003.1  126147509-126147671 c
            1585-1709           JAXUCZ010000003.1  126147319-126147443 c
            1710-1806           JAXUCZ010000003.1  126147139-126147235 c
            1807-1891           JAXUCZ010000003.1  126145627-126145711 c
            1892-2016           JAXUCZ010000003.1  126145392-126145516 c
            2017-2171           JAXUCZ010000003.1  126144700-126144854 c
            2172-2336           JAXUCZ010000003.1  126144006-126144170 c
            2337-2436           JAXUCZ010000003.1  126143444-126143543 c
            2437-2541           JAXUCZ010000003.1  126142684-126142788 c
            2542-2636           JAXUCZ010000003.1  126142454-126142548 c
            2637-2709           JAXUCZ010000003.1  126142256-126142328 c
            2710-2754           JAXUCZ010000003.1  126141854-126141898 c
            2755-2965           JAXUCZ010000003.1  126141522-126141732 c
            2966-3128           JAXUCZ010000003.1  126141279-126141441 c
            3129-3205           JAXUCZ010000003.1  126141005-126141081 c
            3206-3301           JAXUCZ010000003.1  126140820-126140915 c
            3302-3359           JAXUCZ010000003.1  126140310-126140367 c
            3360-3446           JAXUCZ010000003.1  126139685-126139771 c
            3447-4004           JAXUCZ010000003.1  126138736-126139293 c
FEATURES             Location/Qualifiers
     source          1..4004
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q35"
     gene            1..4004
                     /gene="Plcb2"
                     /note="phospholipase C, beta 2"
                     /db_xref="GeneID:85240"
                     /db_xref="RGD:621004"
     exon            1..182
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..3650
                     /gene="Plcb2"
                     /EC_number="3.1.4.11"
                     /note="PLC-beta-2; phosphoinositide phospholipase
                     C-beta-2; PKC beta II"
                     /codon_start=1
                     /product="1-phosphatidylinositol 4,5-bisphosphate
                     phosphodiesterase beta-2"
                     /protein_id="NP_445930.1"
                     /db_xref="GeneID:85240"
                     /db_xref="RGD:621004"
                     /translation="MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKG
                     YYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVV
                     SGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLS
                     PEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPR
                     PEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEP
                     SGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAG
                     QFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIA
                     ESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPS
                     PEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEG
                     EEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFE
                     FSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMF
                     WNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDV
                     VVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEE
                     PFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPA
                     LFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVAS
                     QSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRE
                     LERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLE
                     GPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSF
                     KETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQM
                     TETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKA
                     CFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL"
     exon            183..260
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..329
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            330..470
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            471..550
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..604
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..680
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..781
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..948
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1095
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1253
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1336
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1421
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1584
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1709
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1806
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1891
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2016
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2171
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2336
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2436
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2541
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2636
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2709
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2754
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2965
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3128
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3129..3205
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3301
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3359
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3446
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3447..4004
                     /gene="Plcb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagcctag cttcccctcc agttcaccct ccttccttct ctcctcctgt ccactggaga
       61 ggtttgccca acctctgcaa agagggacaa ttgacatcat gtctttgctc aaccctgtcc
      121 tgttgccccc taaggtgaag gcatatctga gccaagggga gcgcttcatc aagtgggacg
      181 atgaaacctc aatagcctcc cctgttatcc ttcgggtgga tcccaagggc tattacttat
      241 actggacaca tcaaagtaag gagatggaat ttctggatgt cacgagcatc cgagacactc
      301 gctttgggaa gtttgccaag atacccaaga gccagaaact ccgggaggta ttcaacatgg
      361 actttccaga caaccacttc ctgctgaaaa cattcacagt ggtatccggc ccggacatgg
      421 tgggcctcac cttccacaat tttgtctctt acaaggagaa cgtaggcaag gattgggctg
      481 aggatgtact ggctctggcc aaacacccaa tgacagccaa tgcttctcga agcacattcc
      541 tagacaagat cctggtgaag cttaaaatgc agctgagccc tgaagggaag atccctgtga
      601 agaatttttt ccagatgttt cctgccgatc gcaaacgtgt agaagctgcc ctcagtgcct
      661 gtcaccttgc aaaaggcaag aatgatgcta tcaatcccga ggacttccca gaatctgtgt
      721 acaagagctt cctcatgagc ctctgtcctc ggccagaaat tgatgagatc ttcacttctt
      781 atcatgctaa agccaaaccc tacatgacca aggagcacct gaccaaattc atcaatcaga
      841 agcaacgaga ccctcgactc aattccttgc tgttcccacc agcccggcct gagcaggtgc
      901 aggcgctcat tgacaagtac gagcccagcg gcatcaatgt gcagaggggc caactgtcac
      961 cagagggcat ggtctggttt ctctgtggac cagagaacag tgtcctggcc catgatactc
     1021 tgcggatcca ccaagacatg acacagcctc tgaatcacta cttcatcaac tcctcacaca
     1081 acacctacct gacagctggc cagttttcag gcccttcctc ggctgagatg taccgccagg
     1141 tgctgctatc tggctgccgt tgtgtagaat tagattgttg gaaaggaaag ccccccgacg
     1201 aagaacccat catcacccac ggcttcacta tgaccacaga tatcttgttc aaggaagcag
     1261 tcgaagccat tgcagaaagt gcctttaaga cctccccata tcctgtcatc ctgtcatttg
     1321 aaaaccacgt ggactcaccc cgccaacagg ctaagatggc cgagtactgc cggaccatgt
     1381 ttggagagac cttgctcaca gagcccctgg aaaactttcc tctgaaacct ggcatgcctc
     1441 tgcctagccc tgaggacctc cggggcaaga tcctcattaa gaataagaag aaccagtttt
     1501 ctgggccagc atcccccaac aagaagcctg atggggtgtc tgagggcggc ttcccatcta
     1561 gtgtccctgt agaagaggac acggggtgga ctgctgagga ccggactgag gtggaggagg
     1621 gagaggagga ggaggaggtg gaagaagagg aagaggagga gtcaggaaac ctggatgaag
     1681 aagaaattaa gaagatgcag tctgatgagg gcacagcagg cttggaggtg acagcttatg
     1741 aggaaatgtc cagccttgtc aattacatcc agcccaccaa gtttatctcc ttcgagttct
     1801 ctgcacagaa gaacaggagt taccttgtct cttccttcac ggagctcaag gcctacgagc
     1861 tgctctccaa ggcctccatg cagtttgtgg actataataa acgccagatg agccgcgtgt
     1921 accccaaggg cacgcgcatg gactcttcca actacatgcc ccagatgttc tggaatgccg
     1981 gatgtcagat ggttgccctc aatttccaga caatggatct gcccatgcag cagaacatgg
     2041 cactgtttga gttcaacggg cagagtggct acctcctaaa gcacgagttc atgcgcaggc
     2101 aggacaagca gttcaacccc ttctcggtgg accgcattga tgtggtggtt gccactaccc
     2161 tttccattac ggtcatctct gggcagttcc tgtcagagcg cagtgtgcgc acctatgtgg
     2221 aagtagaact gtttggcctc ccaggggacc ccaagaggcg ctatcgtacc aagctgtcac
     2281 ctactgctaa ctccatcaat cctgtctgga aggaggaacc cttcattttt gagaagatct
     2341 tggtgcctga gctggcctcc ctcaggatag ctgtaatgga agaaggcggc aaatttattg
     2401 gacatcgcat catccccatc aatgccttac attccggata ccaccatctg tgcctgcgca
     2461 gtgagagcaa catgcctctc accatgcctg ctctcttcgt cttcctggag atgaaggact
     2521 atgtacctga cacgtgggca gatcttactg tggctcttgc caaccccatc aagtacttca
     2581 gtgcccatga taagaagtct gtgaagctca aagaagtgac aggaagtctg cctgagaagc
     2641 tcttctctgg gattcctgtt gccagccagt ccaacggggc tccagtctcc gcaggcaatg
     2701 ggtcaacagc gcctgggacc aaggccaagg aggaagctac gaaggaagtg gcagagccac
     2761 agaccactag cttggaagag ctgcgggagc tgaagggcgt ggtgaagctg cagcggagac
     2821 atgagaagga gcttcgagag ctggagcggc gtggagcccg gcgctgggag gagctgctgc
     2881 agcgtggcgc tgcacagcta gcggagctcc aggacccagc agcaagctgc aagctccgcc
     2941 cgggcaaggg ctcccgcaag aagaggatcg tgccctgtga ggagaccatc gtggtgccta
     3001 gggaggtcct cgagggaccg gacccccgcg tgcaggatct gaaggacagg ctggagcagg
     3061 agctgcagca gcaaggcgag gagcagtacc gctctgtcct caagcgtaag gagcagcacg
     3121 tgaccgagca aatcgccaag atgatggagc tggccagaga gaaacaggct gctgaactca
     3181 agagcttcaa ggagacctcg gaaactgaca ccaaagagat gaagaaaaaa ctggaggcca
     3241 aaaggctgga gcggatccaa gccatgacca aagtcaccac agacaaggtg gcccaggaga
     3301 ggctcaagag agaaattaac aactcccaca tccaggaggt ggtgcaggct gtcaagcaga
     3361 tgacagagac cctggagcgt caccaggaga agctggaaga gaagcagaca gcctgcctgg
     3421 agcagatcca ggcaatggaa aagcagttcc aggagaaggc gctggcagag tatgaggcca
     3481 agatgaaggg cctggaggct gaagtaaagg agtcaatgcg ggcttgcttc aaggcctgct
     3541 tccccacgga agcagaagag aagcctgaga ggccctgtga ggcctctgag gagtcgtgtc
     3601 cacaggagcc acttgtgaac aagacagaca ctcaggagag ccgcctctga atgccagcat
     3661 ctcactccga cattttagca aggatatcca cgcctttctc ctcgggagaa aaggacctta
     3721 ttactctggg gctgtgggag cctggggctg ccttggctgc cgcagccccg cttctcagcc
     3781 acataaggca gaaatgggag accattgggg caagagcccc atggaacccg agtcttttct
     3841 aagctggctt cttctgtcgt cccacctgta gtgccatata cttattgaag gcaaaggaat
     3901 atggaccaag agagaggaaa ttgggtcctg gtctcccctc tgcctttcct aacatacatg
     3961 caggggctct ccacttggag ctccgttccc tttcctggat gctt
//
