LOCUS       NM_138898               4590 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus phospholipase B1 (Plb1), mRNA.
ACCESSION   NM_138898
VERSION     NM_138898.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4590)
  AUTHORS   Asano,A., Nelson-Harrington,J.L. and Travis,A.J.
  TITLE     Phospholipase B is activated in response to sterol removal and
            stimulates acrosome exocytosis in murine sperm
  JOURNAL   J Biol Chem 288 (39), 28104-28115 (2013)
   PUBMED   23943622
REFERENCE   2  (bases 1 to 4590)
  AUTHORS   Harrison,E.H.
  TITLE     Mechanisms involved in the intestinal absorption of dietary vitamin
            A and provitamin A carotenoids
  JOURNAL   Biochim Biophys Acta 1821 (1), 70-77 (2012)
   PUBMED   21718801
  REMARK    Review article
REFERENCE   3  (bases 1 to 4590)
  AUTHORS   Takemori,H., Zolotaryov,F.N., Ting,L., Urbain,T., Komatsubara,T.,
            Hatano,O., Okamoto,M. and Tojo,H.
  TITLE     Identification of functional domains of rat intestinal
            phospholipase B/lipase. Its cDNA cloning, expression, and tissue
            distribution
  JOURNAL   J Biol Chem 273 (4), 2222-2231 (1998)
   PUBMED   9442065
REFERENCE   4  (bases 1 to 4590)
  AUTHORS   Tojo,H., Ichida,T. and Okamoto,M.
  TITLE     Purification and characterization of a catalytic domain of rat
            intestinal phospholipase B/lipase associated with brush border
            membranes
  JOURNAL   J Biol Chem 273 (4), 2214-2221 (1998)
   PUBMED   9442064
REFERENCE   5  (bases 1 to 4590)
  AUTHORS   Rigtrup,K.M., Kakkad,B. and Ong,D.E.
  TITLE     Purification and partial characterization of a retinyl ester
            hydrolase from the brush border of rat small intestine mucosa:
            probable identity with brush border phospholipase B
  JOURNAL   Biochemistry 33 (9), 2661-2666 (1994)
   PUBMED   8117729
REFERENCE   6  (bases 1 to 4590)
  AUTHORS   Pind,S. and Kuksis,A.
  TITLE     Further characterization of a novel phospholipase B (phospholipase
            A2--lysophospholipase) from intestinal brush-border membranes
  JOURNAL   Biochem Cell Biol 69 (5-6), 346-357 (1991)
   PUBMED   1716922
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138898.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D63648.1, SRR26643288.25660.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000006.1  29930088-29930183   c
            97-152              JAXUCZ010000006.1  29917081-29917136   c
            153-225             JAXUCZ010000006.1  29915827-29915899   c
            226-284             JAXUCZ010000006.1  29914745-29914803   c
            285-331             JAXUCZ010000006.1  29908300-29908346   c
            332-375             JAXUCZ010000006.1  29907762-29907805   c
            376-469             JAXUCZ010000006.1  29905003-29905096   c
            470-521             JAXUCZ010000006.1  29904647-29904698   c
            522-608             JAXUCZ010000006.1  29901952-29902038   c
            609-671             JAXUCZ010000006.1  29896749-29896811   c
            672-751             JAXUCZ010000006.1  29896132-29896211   c
            752-827             JAXUCZ010000006.1  29893713-29893788   c
            828-926             JAXUCZ010000006.1  29892781-29892879   c
            927-983             JAXUCZ010000006.1  29891612-29891668   c
            984-1055            JAXUCZ010000006.1  29885994-29886065   c
            1056-1130           JAXUCZ010000006.1  29884311-29884385   c
            1131-1194           JAXUCZ010000006.1  29882482-29882545   c
            1195-1253           JAXUCZ010000006.1  29874760-29874818   c
            1254-1327           JAXUCZ010000006.1  29872801-29872874   c
            1328-1371           JAXUCZ010000006.1  29872130-29872173   c
            1372-1480           JAXUCZ010000006.1  29869013-29869121   c
            1481-1532           JAXUCZ010000006.1  29866621-29866672   c
            1533-1613           JAXUCZ010000006.1  29865115-29865195   c
            1614-1679           JAXUCZ010000006.1  29862470-29862535   c
            1680-1780           JAXUCZ010000006.1  29862103-29862203   c
            1781-1862           JAXUCZ010000006.1  29859535-29859616   c
            1863-1967           JAXUCZ010000006.1  29859086-29859190   c
            1968-2063           JAXUCZ010000006.1  29858892-29858987   c
            2064-2135           JAXUCZ010000006.1  29858672-29858743   c
            2136-2174           JAXUCZ010000006.1  29857658-29857696   c
            2175-2235           JAXUCZ010000006.1  29857177-29857237   c
            2236-2294           JAXUCZ010000006.1  29855143-29855201   c
            2295-2368           JAXUCZ010000006.1  29853944-29854017   c
            2369-2412           JAXUCZ010000006.1  29849764-29849807   c
            2413-2521           JAXUCZ010000006.1  29849076-29849184   c
            2522-2573           JAXUCZ010000006.1  29847459-29847510   c
            2574-2654           JAXUCZ010000006.1  29847020-29847100   c
            2655-2720           JAXUCZ010000006.1  29846437-29846502   c
            2721-2821           JAXUCZ010000006.1  29845501-29845601   c
            2822-2903           JAXUCZ010000006.1  29843739-29843820   c
            2904-3008           JAXUCZ010000006.1  29842795-29842899   c
            3009-3104           JAXUCZ010000006.1  29841298-29841393   c
            3105-3176           JAXUCZ010000006.1  29840274-29840345   c
            3177-3242           JAXUCZ010000006.1  29835732-29835797   c
            3243-3303           JAXUCZ010000006.1  29831910-29831970   c
            3304-3362           JAXUCZ010000006.1  29831398-29831456   c
            3363-3430           JAXUCZ010000006.1  29829156-29829223   c
            3431-3474           JAXUCZ010000006.1  29828599-29828642   c
            3475-3574           JAXUCZ010000006.1  29828268-29828367   c
            3575-3626           JAXUCZ010000006.1  29823674-29823725   c
            3627-3707           JAXUCZ010000006.1  29822683-29822763   c
            3708-3773           JAXUCZ010000006.1  29821530-29821595   c
            3774-3868           JAXUCZ010000006.1  29821041-29821135   c
            3869-3947           JAXUCZ010000006.1  29819577-29819655   c
            3948-4052           JAXUCZ010000006.1  29818424-29818528   c
            4053-4148           JAXUCZ010000006.1  29817839-29817934   c
            4149-4223           JAXUCZ010000006.1  29810780-29810854   c
            4224-4590           JAXUCZ010000006.1  29809290-29809656   c
FEATURES             Location/Qualifiers
     source          1..4590
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..4590
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /note="phospholipase B1"
                     /db_xref="GeneID:192259"
                     /db_xref="RGD:621565"
     exon            1..96
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..4388
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="phospholipase B1, membrane-associated; PLB/LIP;
                     phospholipase B/lipase; phospholipase A2;
                     lysophospholipase; triacylglycerol lipase"
                     /codon_start=1
                     /product="phospholipase B1, membrane-associated precursor"
                     /protein_id="NP_620253.1"
                     /db_xref="GeneID:192259"
                     /db_xref="RGD:621565"
                     /translation="MESWPGVSLVGLLLLLLLGQGPSQIHGSSGENTSQPQQVFRTLK
                     NFSFPCKPKKLELSVLSKSVHSLRPSDIKLVAAIGNLETPPAPGSGVVNMEKPQSLES
                     ELQNVCIGIMTALSDIIRHFNPSVLMPTCSPGKGTAGHTTIAEDLWIQAKELVRHLKD
                     NPELDFEKDWKLITVLFSNTSQCHLCSSDQQKRHLMKHMEMLSGVLDYLHREVPRAFV
                     NLVDLSEVLTMAQQHQETGFSPAPEICKCSEEITKLSKAVMQWSYQEAWEDLLASSKF
                     NKHETFAVVFQSFFSEVELPLERPSPQDSTTLALRIWNSMMEPVGRKDGTLNEAERKT
                     MKCPSQESPYLFTYRNSNYQARQLKPIGKFQMKEGTKFTCPDKDPSDSIPTTVHRLRP
                     ADIKVIGAMGDSLTAGNGAGSSPGNVLDVLTQYRGLSWSVGGDETIETVTTLANILRE
                     FNPSLKGFSVGTGKENTPRASFNQAVAGAKSDGLAAQAKKLVSLMKDDKTINFQEDWK
                     IITVFIGGNDLCGSCNNLARFSPQTFTDNIKTALDILHAEVPRAFVNMVSVIEITPLR
                     ELFNEPKVSCPRMILRSLCPCVLNLGENSAELAQLVERNRQYQEETGKLIESGRYDTR
                     DDFTVVLQPMFENVVMPRTLEGLPDSSFFAPDCFHFNVKTHARSAIALWKNMLEPVGR
                     KTRHQNFEIKVPIMCPNQTSPFLSTTKNSNLGHGTSMSCEEKAPSASPPTSVHTLRPA
                     DIQVVAALGDSVTAGNGISSQEGDLADVTTQYRGLSYSAGGDKFLENVTTLPNILREF
                     NGNLTGYSVGTGDVNSASAFLNQAVPGAKAENLASQVQTLIQKMKNDTRVNFHQDWKV
                     ITVMIGASDLCDFCKDSNRYSAANFSDHLRNALDILHKEVPRALVNLVDFMNPSIIRQ
                     VFLKNPDKCPVNQTSVLCNCVLTPGEDSHELARLEAFTKSYQSSMLQLVESGRYDTRE
                     DFSVVLQPFLFNIRLPILENGNPDTSFFAPDCILLSQKFHTQLARALWANMLEPLGKK
                     MDTLDPKELIALACPTKDKPFLRTFRNSNYTYPIKPAIENWGSDFLCTEQSPSSKVPT
                     SVHELRPSDIKVVAAMGDFLTTATGARPSESSSLDTPWRGLSWSIGGDGTLETHTTLP
                     NILKKFNPSILGFSTGTLENTAGLNVAEEGARAQDMPAQAQALVKKMKSTPTINIQED
                     WKLITLLIGNNDLCLYCEDPENYSTREYVKYIQHALDIFYEELPRVFINVVEVMELSG
                     LLHDQGGKCAMPLAVQKNCSCLKRSQNLMAMQELKKVNGNLQSALSELSYWHRYMQRE
                     DFAVTVQPFFRNTFVPLDERGGLDLTFFSEDCFHFSVRGHAEMAIALWNNMLEPVGKK
                     TTSNNFTYNRTKLKCPSPENPFLYTVRNSQILLDKAKENSNTLYWAVPVAAVGGLVVG
                     ILGMMLWRTVRLVQ"
     exon            97..152
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            153..225
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            226..284
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            285..331
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            332..375
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            376..469
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            470..521
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            522..608
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            609..671
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            672..751
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            752..827
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            828..926
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            927..983
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1055
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1130
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1194
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1253
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1327
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1371
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1480
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1532
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1613
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1679
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1780
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1862
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..1967
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2063
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2135
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2174
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2235
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2294
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2368
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2412
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2521
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2573
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2654
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2720
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2821
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2903
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3008
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3104
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3105..3176
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3242
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3303
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3362
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3430
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3474
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3574
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3626
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3707
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3773
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3868
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3869..3947
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4052
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4148
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            4149..4223
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4590
                     /gene="Plb1"
                     /gene_synonym="Phlpb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tactcagagg tcccagacac ctgcaagact gagggatgga gtcatggcca ggcgtttccc
       61 tggtgggact gctgctgctg ctactgctgg gacaagggcc ctcccaaatc cacggctctt
      121 ctggagaaaa cacatcgcag ccccagcaag tgtttcggac cctgaagaat ttttcattcc
      181 cttgcaagcc aaagaagtta gaactgagtg tgctttctaa gtcagttcac tctctgagac
      241 cctcagacat taaactcgtg gcagccatcg gcaacctaga aactcctcca gcccctggct
      301 caggcgtggt caacatggag aaacctcaaa gcctcgagag cgaactacag aatgtgtgca
      361 taggaatcat gacagccctt tcagatatca tcagacattt caacccttct gttctgatgc
      421 ccacgtgttc tcctgggaag ggtactgcag gccacactac tattgccgaa gacttgtgga
      481 ttcaggctaa agagctggtg aggcatctga aagacaaccc ggaacttgat tttgagaagg
      541 actggaaact catcactgtg ctcttcagta acacaagcca gtgccacctg tgttcctctg
      601 atcagcagaa aaggcacttg atgaagcaca tggagatgct gtcaggggtg ctggattacc
      661 tgcatcgtga ggtccccaga gcgtttgtga atttggtgga tctctctgag gttttgacca
      721 tggctcagca gcatcaagag actggtttca gccctgcacc agagatttgc aaatgctcag
      781 aggaaataac gaagttatcc aaggctgtca tgcagtggtc ctatcaggaa gcctgggaag
      841 atctcctggc ctccagcaag ttcaataagc atgagacctt cgctgtggtt ttccagtctt
      901 tcttctctga ggtagaacta cccttggaga ggccctcgcc ccaggattcc accacgctcg
      961 ccctcaggat ctggaatagc atgatggaac cagtgggtcg aaaggatggg acactcaatg
     1021 aagcagagag aaaaacaatg aaatgtccct ctcaggagag cccctatctg ttcacctaca
     1081 gaaatagcaa ctaccaggcc agacagctga aacccatagg aaagtttcag atgaaagaag
     1141 gaacaaaatt cacctgtcct gacaaagacc cctcggactc catccccaca acagttcaca
     1201 ggctgaggcc ggctgacatc aaggtcatcg gagccatggg tgactcgctc acggcaggca
     1261 acggggcagg gtccagccct gggaatgtct tggatgtctt aactcaatac cgaggcctgt
     1321 cgtggagtgt gggcggagat gagaccatcg agaccgtgac caccctagcc aacatcctcc
     1381 gggaattcaa cccctccttg aagggcttct ctgttggcac tgggaaagaa aacactcccc
     1441 gagcatcctt caaccaggcc gtagcaggag ccaaatctga tggcttagct gcccaggcca
     1501 aaaagctggt gagcctgatg aaggatgaca agacaataaa ctttcaggaa gactggaaga
     1561 taatcactgt gtttatagga ggcaacgacc tctgtggctc ctgcaataac ctggctcgct
     1621 tttctcccca aaccttcaca gacaacatca agacggccct ggacatcctc catgcagagg
     1681 ttccccgggc ctttgtgaac atggtctcgg tgattgagat cacccccttg agagaactgt
     1741 tcaatgaacc taaagtcagc tgcccacgga tgatcctcag gagcctgtgt ccttgtgtct
     1801 tgaaccttgg tgagaactca gcagaacttg cccaacttgt ggaaaggaac aggcagtatc
     1861 aggaagaaac tggaaaactg attgagagtg gccgatacga caccagggat gacttcaccg
     1921 tggtcctcca gcccatgttt gaaaatgtcg tcatgccacg gaccctggag ggcttgcccg
     1981 acagctcttt ctttgcccct gactgtttcc acttcaatgt caagactcac gctcgctcag
     2041 ccatcgccct ctggaagaac atgctagaac ctgtgggccg caagacaaga catcagaatt
     2101 ttgaaatcaa ggtccctatc atgtgtccaa accagacctc accgtttctg agcaccacca
     2161 agaacagcaa cctgggacat ggaacttcga tgtcttgtga ggagaaagcc ccctctgcct
     2221 caccaccaac ctcagtgcat accctgagac ctgcagacat ccaagttgtg gcagctctgg
     2281 gagactctgt gactgctggc aatggaatca gctcccaaga aggtgatctc gctgatgtta
     2341 ccacacagta tcgaggactg tcctacagtg ctggtgggga caagttcctg gagaatgtga
     2401 ccaccttgcc caacatcctc cgggaattta atggaaatct cacaggctac tcagtcggaa
     2461 ccggtgacgt caactctgca agcgcgttcc ttaaccaggc tgtccctggg gcaaaggctg
     2521 agaaccttgc aagtcaagtc cagactctga ttcagaagat gaagaatgac accagagtga
     2581 actttcacca agactggaag gtcatcactg tgatgattgg ggccagcgac ttgtgtgact
     2641 tctgcaagga ttcgaatcgt tactctgcag ccaatttttc tgaccatctc cgcaatgcct
     2701 tggacatcct gcataaggag gtacccagag ccctggtcaa ccttgtggac ttcatgaacc
     2761 ccagtatcat tcggcaagtg ttcctgaaga acccagacaa gtgccctgtg aatcagacca
     2821 gtgtcctgtg caactgtgtt ctgaccccag gggaggattc ccatgagctg gcaaggttgg
     2881 aggccttcac caaatcctac cagagtagca tgcttcaact ggttgagtca ggccgctacg
     2941 acacccggga ggatttctct gtggtactgc agccctttct cttcaacatc aggctcccca
     3001 tcctagagaa tgggaatcca gatacatcct tctttgcccc agactgcatc ctcctaagcc
     3061 agaagttcca cactcagctc gcgagagccc tttgggccaa tatgcttgaa cccctgggaa
     3121 agaaaatgga tactttggac ccgaaagaac tcatagcttt ggcctgcccc accaaggaca
     3181 agcccttcct gagaaccttc cggaacagta actacacgta ccctatcaag ccagccattg
     3241 agaattgggg cagtgacttc ctgtgcacag agcagagtcc ttccagcaag gtacccacct
     3301 cagttcatga gctccgacca tcagacatca aggtggtggc agcaatgggt gactttctga
     3361 cgacagccac cggagctcga ccaagtgagt ccagcagtct agacaccccc tggagggggc
     3421 tgtcttggag cattggagga gatggaacgt tggagaccca taccacactg cccaacatcc
     3481 tgaagaagtt caacccttcc atccttggat tctccaccgg taccctggag aacacggcag
     3541 gattaaatgt ggcagaagaa ggcgccagag ctcaggacat gccggcccag gctcaggccc
     3601 tggtgaagaa gatgaaaagc acccctacaa tcaacataca ggaagactgg aagctgatta
     3661 cactcctcat cgggaacaac gacctgtgtc tttactgtga ggatccggag aactactcaa
     3721 ccagggagta tgtcaagtac atccagcatg ccttggacat cttctatgag gagcttccca
     3781 gggttttcat caacgtggtg gaagtcatgg agctgtccgg tctgctccac gaccagggcg
     3841 ggaaatgtgc catgccgttg gctgtccaga aaaactgcag ttgccttaaa cgctctcaaa
     3901 acctcatggc aatgcaggag ctgaagaaag tcaacgggaa cctccagagt gccctctcgg
     3961 agctctccta ctggcatcgg tacatgcagc gtgaggactt tgcagtcact gtccagcctt
     4021 tcttccggaa tacctttgtc ccactggatg agcgtggggg cctcgacctc actttcttct
     4081 ctgaagactg tttccacttc tcagtccgtg ggcatgctga gatggccatt gccctctgga
     4141 acaacatgct ggaaccagtg ggcaagaaga caacctccaa taacttcaca tacaaccgga
     4201 ccaaactcaa gtgtccctcg cctgaaaacc ctttcctcta cactgtccgg aacagtcaga
     4261 ttcttctaga caaggctaaa gaaaactcca atacactcta ctgggcagtg ccagtggctg
     4321 cagtaggtgg cctggtagtt ggcatccttg gaatgatgtt gtggagaact gtgagactcg
     4381 tccaatagaa ggaggaggag acttttccaa atacaagtgt ggaccttgag ttgacccagg
     4441 atgctgtttc agaggagaag ctcagagatt gacccttggt accagacagc aattacgtaa
     4501 tctcagggat ggggactgcg tgcctttctc tcttgggagt tcaccatctt cttttggaaa
     4561 gataaataag aaagagtggc tacactcagt
//
