LOCUS       NM_134352               1246 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus plasminogen activator, urokinase receptor
            (Plaur), mRNA.
ACCESSION   NM_134352 NM_017350
VERSION     NM_134352.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1246)
  AUTHORS   Wang,C., Zhu,Y., Chen,R., Zhu,X. and Zhang,X.
  TITLE     microRNA-143 targets SIRT2 to mediate the histone acetylation of
            PLAUR and modulates functions of astrocytes in spinal cord injury
  JOURNAL   Chem Biol Interact 390, 110854 (2024)
   PUBMED   38161044
  REMARK    GeneRIF: microRNA-143 targets SIRT2 to mediate the histone
            acetylation of PLAUR and modulates functions of astrocytes in
            spinal cord injury.
REFERENCE   2  (bases 1 to 1246)
  AUTHORS   Sener,M.T., Karakus,E., Halici,Z., Akpinar,E., Topcu,A. and
            Kok,A.N.
  TITLE     Can early myocardial infarction-related deaths be diagnosed using
            postmortem urotensin receptor expression levels?
  JOURNAL   Forensic Sci Med Pathol 10 (3), 395-400 (2014)
   PUBMED   24935436
  REMARK    GeneRIF: Increased postmortem PLAUR expression could serve as a
            biomarker to aid diagnosis of early myocardial infarction.
REFERENCE   3  (bases 1 to 1246)
  AUTHORS   Wu,M.J., Chang,C.H., Shu,K.H., Ho,H.C., Li,J.R. and Fu,Y.C.
  TITLE     Rapamycin promotes podocyte migration through the up-regulation of
            urokinase receptor
  JOURNAL   Transplant Proc 46 (4), 1226-1228 (2014)
   PUBMED   24815166
  REMARK    GeneRIF: Rapamycin could promote podocyte migration through the
            up-regulation of uPAR leading to proteinuria.
REFERENCE   4  (bases 1 to 1246)
  AUTHORS   Schuler,P.J., Bendszus,M., Kuehnel,S., Wagner,S., Hoffmann,T.K.,
            Goldbrunner,R. and Vince,G.H.
  TITLE     Urokinase plasminogen activator, uPAR, MMP-2, and MMP-9 in the
            C6-glioblastoma rat model
  JOURNAL   In Vivo 26 (4), 571-576 (2012)
   PUBMED   22773570
  REMARK    GeneRIF: uPA, uPAR, MMP-2 and MMP-9 play an important role in GBM
            growth. Blockade of uPA and interruption of the proteolytic cascade
            could become a useful tool in the therapy of GBM
REFERENCE   5  (bases 1 to 1246)
  AUTHORS   Kotipatruni,R.R., Nalla,A.K., Asuthkar,S., Gondi,C.S., Dinh,D.H.
            and Rao,J.S.
  TITLE     Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by
            inactivation of EGFR/STAT3 signaling in medulloblastoma
  JOURNAL   PLoS One 7 (9), e44798 (2012)
   PUBMED   22984561
REFERENCE   6  (bases 1 to 1246)
  AUTHORS   Tygstrup,N., Bangert,K., Ott,P. and Bisgaard,H.C.
  TITLE     Messenger RNA profiles in liver injury and stress: a comparison of
            lethal and nonlethal rat models
  JOURNAL   Biochem Biophys Res Commun 290 (1), 518-525 (2002)
   PUBMED   11779202
REFERENCE   7  (bases 1 to 1246)
  AUTHORS   Elfman,F., Bok,R., Conn,M., Shuman,M. and Cunha,G.
  TITLE     Urokinase plasminogen activator amino-terminal peptides inhibit
            development of the rat ventral prostate
  JOURNAL   Differentiation 69 (2-3), 108-120 (2001)
   PUBMED   11798065
  REMARK    GeneRIF: study examines the expression and function of uPAR in
            developing rat ventral prostates
REFERENCE   8  (bases 1 to 1246)
  AUTHORS   Rabbani,S.A., Rajwans,N., Achbarou,A., Murthy,K.K. and Goltzman,D.
  TITLE     Isolation and characterization of multiple isoforms of the rat
            urokinase receptor in osteoblasts
  JOURNAL   FEBS Lett 338 (1), 69-74 (1994)
   PUBMED   8307160
REFERENCE   9  (bases 1 to 1246)
  AUTHORS   Ragno,P., Cassano,S., Degen,J., Kessler,C., Blasi,F. and Rossi,G.
  TITLE     The receptor for the plasminogen activator of urokinase type is
            up-regulated in transformed rat thyroid cells
  JOURNAL   FEBS Lett 306 (2-3), 193-198 (1992)
   PUBMED   1321734
REFERENCE   10 (bases 1 to 1246)
  AUTHORS   Schnapp,L.M., Geaghan,S.M., Campagna,A., Fahy,J., Steiger,D.,
            Ng,V., Hadley,W.K., Hopewell,P.C. and Stansell,J.D.
  TITLE     Toxoplasma gondii pneumonitis in patients infected with the human
            immunodeficiency virus
  JOURNAL   Arch Intern Med 152 (5), 1073-1077 (1992)
   PUBMED   1304722
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Feb 8, 2021 this sequence version replaced
            NM_017350.1, NM_134352.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127499.1, FQ220340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                JAXUCZ010000001.1  89181363-89181436
            75-185              JAXUCZ010000001.1  89183725-89183835
            186-329             JAXUCZ010000001.1  89185497-89185640
            330-485             JAXUCZ010000001.1  89192058-89192213
            486-620             JAXUCZ010000001.1  89192729-89192863
            621-767             JAXUCZ010000001.1  89194752-89194898
            768-1246            JAXUCZ010000001.1  89195830-89196308
FEATURES             Location/Qualifiers
     source          1..1246
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1246
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /note="plasminogen activator, urokinase receptor"
                     /db_xref="GeneID:50692"
                     /db_xref="RGD:620597"
     exon            1..74
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1000
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /note="urokinase plasminogen activator receptor; urokinase
                     plasminogen activator surface receptor; U-PAR; urinary
                     plasminogen activator receptor 2; urinary plasminogen
                     activator receptor 3; plasminogen activator urokinase
                     receptor 3"
                     /codon_start=1
                     /product="urokinase plasminogen activator surface receptor
                     precursor"
                     /protein_id="NP_599179.2"
                     /db_xref="GeneID:50692"
                     /db_xref="RGD:620597"
                     /translation="MGLLRRRLLLLVVVVTTCVPASQGLRCIQCESNQDCLVEECALG
                     QDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNR
                     PRPGARGRPFPRGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSV
                     KDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCCNFTQCNGGPVLDLQSLPPNGFQCYS
                     CEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTVRGCATASWCQGSHVAD
                     SFQTHVNLSISCCNGSGCNRPTGGAPGPGPAHLILIASLLLTLRLWGIPLWT"
     exon            75..185
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            186..329
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            330..485
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            486..620
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            621..767
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            768..1246
                     /gene="Plaur"
                     /gene_synonym="Par; Plaur3; uPAR; uPAR-2; uPAR-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacgaagaa cccatgggcc tcctgaggcg gcggctgctg ctgctggtgg tggtggtgac
       61 gacctgtgtc ccagcctccc agggcctgcg gtgcatacag tgcgaaagta accaggactg
      121 cctggtggag gagtgtgccc tgggccagga cctctgcaga accacggtgc ttcgggaatg
      181 ggaagacgcc gaggagctgg aggtggtgac cagaggctgt gcccacaagg agaagaccaa
      241 caggaccatg agctaccgca tgggctcggt gatcgtcagc ctcaccgaga ccgtgtgtgc
      301 cacaaacctc tgcaacaggc ccagacccgg agcccgaggg cgaccttttc cccggggccg
      361 ttaccttgag tgtgcatcct gcacctctct ggaccagagc tgtgagaggg gccgggagca
      421 aagcctgcag tgccggtatc ctacagaaca ctgtattgaa gtggtgacgc tccaaagcac
      481 agaacggagc gtgaaggacg aaccctacac caaaggctgt ggcagtcttc ccggatgccc
      541 gggcacagca ggtttccata gcaaccagac ctttcacttc ctgaagtgct gcaacttcac
      601 ccaatgcaat ggtggcccag ttctggatct tcagagctta ccaccgaatg gcttccaatg
      661 ttacagctgt gaggggaaca gcacctttgg atgttcctac gaagagacgt ccctcattga
      721 ctgccgggga ccaatgaatc agtgcttgga ggctacaggc ttagatgtgc tgggaaaccg
      781 gagttacacc gtaagaggct gcgccacggc ttcctggtgc caaggttccc acgtggccga
      841 ctccttccag acccacgtca acctctctat ctcctgctgt aatggcagtg gctgtaaccg
      901 ccctacaggg ggcgcccccg ggccaggccc tgctcatctt atcctcattg cctccctgct
      961 cctgaccctc agactgtggg gcatccctct ctggacctga atcctgagcc gtctgccctg
     1021 gctggaccca gggacttttg acctcctccc ctctgctcca tctttgagga caggcgtgct
     1081 gtattgtctt cttggggcct caagaactgg aagagaattg agaaaagggc tgcgggcagc
     1141 agggggcctc ttggttgagt taatattgtt gctgttatta ttattatcat tgttattacc
     1201 ctaatttatt atgtaaatat atatataaga tttttgtacc agtgaa
//
