LOCUS       NM_013085               2355 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Rattus norvegicus plasminogen activator, urokinase (Plau), mRNA.
ACCESSION   NM_013085 XM_346472
VERSION     NM_013085.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Liu,Y., Zhao,K., Xiong,Z., Yi,Y., Xiong,C., Huang,D. and Zhao,H.
  TITLE     Transcriptional activation and regulation of urokinase plasminogen
            activator inducted by LPS through MyD88 independent pathway in rat
            Sertoli cells
  JOURNAL   Folia Histochem Cytobiol 59 (4), 236-244 (2021)
   PUBMED   34852179
  REMARK    GeneRIF: Transcriptional activation and regulation of urokinase
            plasminogen activator inducted by LPS through MyD88 independent
            pathway in rat Sertoli cells.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Shi,Y., Zhang,Z., Cai,D., Kuang,J., Jin,S., Zhu,C., Shen,Y.,
            Feng,W., Ying,S. and Wang,L.
  TITLE     Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model
            by Inhibition of Inflammatory Response
  JOURNAL   J Immunol Res 2018, 6941368 (2018)
   PUBMED   30671487
  REMARK    GeneRIF: that study shows that urokinase attenuates pulmonary
            thromboembolism in an animal model by inhibition of inflammatory
            response
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Li,W.D., Hu,N., Lei,F.R., Wei,S., Rong,J.J., Zhuang,H. and Li,X.Q.
  TITLE     Autophagy inhibits endothelial progenitor cells migration via the
            regulation of MMP2, MMP9 and uPA under normoxia condition
  JOURNAL   Biochem Biophys Res Commun 466 (3), 376-380 (2015)
   PUBMED   26363453
  REMARK    GeneRIF: autophagy could regulate the EPCs migration through
            mTOR-P70 S6K pathway, and MMP2, MMP9 and uPA may also involve in
            the regulation mechanism
REFERENCE   4  (bases 1 to 2355)
  AUTHORS   Longstaff,C. and Kolev,K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   5  (bases 1 to 2355)
  AUTHORS   Grundel,A., Friedrich,K., Pfeiffer,M., Jacobs,E. and Dumke,R.
  TITLE     Subunits of the Pyruvate Dehydrogenase Cluster of Mycoplasma
            pneumoniae Are Surface-Displayed Proteins that Bind and Activate
            Human Plasminogen
  JOURNAL   PLoS One 10 (5), e0126600 (2015)
   PUBMED   25978044
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2355)
  AUTHORS   Ragno,P., Cassano,S., Degen,J., Kessler,C., Blasi,F. and Rossi,G.
  TITLE     The receptor for the plasminogen activator of urokinase type is
            up-regulated in transformed rat thyroid cells
  JOURNAL   FEBS Lett 306 (2-3), 193-198 (1992)
   PUBMED   1321734
REFERENCE   7  (bases 1 to 2355)
  AUTHORS   Henderson,B.R., Tansey,W.P., Phillips,S.M., Ramshaw,I.A. and
            Kefford,R.F.
  TITLE     Transcriptional and posttranscriptional activation of urokinase
            plasminogen activator gene expression in metastatic tumor cells
  JOURNAL   Cancer Res 52 (9), 2489-2496 (1992)
   PUBMED   1568219
REFERENCE   8  (bases 1 to 2355)
  AUTHORS   Oka,T., Ishida,T., Nishino,T. and Sugimachi,K.
  TITLE     Immunohistochemical evidence of urokinase-type plasminogen
            activator in primary and metastatic tumors of pulmonary
            adenocarcinoma
  JOURNAL   Cancer Res 51 (13), 3522-3525 (1991)
   PUBMED   2054790
REFERENCE   9  (bases 1 to 2355)
  AUTHORS   Nakagawa,M., Fukuyama,K., Epstein,W.L., Hara,A. and Sawada,H.
  TITLE     Partial purification and characterization of epidermal plasminogen
            activator and their inhibitor
  JOURNAL   Chem Pharm Bull (Tokyo) 37 (7), 1859-1863 (1989)
   PUBMED   2509088
REFERENCE   10 (bases 1 to 2355)
  AUTHORS   Kohga,S., Harvey,S.R., Weaver,R.M. and Markus,G.
  TITLE     Localization of plasminogen activators in human colon cancer by
            immunoperoxidase staining
  JOURNAL   Cancer Res 45 (4), 1787-1796 (1985)
   PUBMED   3884145
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105859.1.
            
            On Apr 13, 2007 this sequence version replaced NM_013085.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105859.1, X63434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..2355
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /note="plasminogen activator, urokinase"
                     /db_xref="GeneID:25619"
                     /db_xref="RGD:3343"
     exon            1..28
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            29..116
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1361
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /EC_number="3.4.21.73"
                     /note="urokinase-type plasminogen activator; uPA;
                     U-plasminogen activator; Urinary plasminogen activator,
                     urokinase; urokinase plasminogen activator"
                     /codon_start=1
                     /product="urokinase-type plasminogen activator precursor"
                     /protein_id="NP_037217.3"
                     /db_xref="GeneID:25619"
                     /db_xref="RGD:3343"
                     /translation="MRVWLASLFLCALVAHSEGGSELGASDESNCGCQNGGVCVSYKY
                     FSSIRRCSCPKKFKGEHCEIDTSKTCYHGNGQSYRGKANTDTKGRPCLAWNSPAVLQQ
                     TYNAHRSDALSLGLGKHNYCRNPDNQRRPWCYVQIGLKQFVQECMVQDCSLSKKPSST
                     VDQQGFQCGQKALRPRFKIVGGEFTVVENQPWFAAIYLKNKGGSPPSFKCGGSLISPC
                     WVASATHCFVNQPKKEEYVVYLGQSKRNSYNPGEMKFEVEQLILHEDFSDETLAFHND
                     IALLKIRTSTGQCAQPSRTIQTICLPPRFGDAPFGSDCEITGFGQESATDYFYPKDLK
                     MSVVKIISHEQCKQPHYYGSEINYKMLCAADPEWKTDSCSGDSGGPLICNIDGRPTLS
                     GIVSWGSGCAEKNKPGVYTRVSYFLNWIQSHIGEENGLAF"
     exon            117..147
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            148..255
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            256..430
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            431..522
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            523..745
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            746..894
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1035
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1184
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..2327
                     /gene="Plau"
                     /gene_synonym="UPAM"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgccggcgcc cttccgctgc agtcaccgaa ctgctgtcta gagagagccc agcgtcagta
       61 ccatgagagt ctggcttgcg agcctgttcc tctgcgcctt ggtggcgcac tctgaaggtg
      121 gcagtgaact tggagcttct gatgaatcaa actgtggctg tcagaacgga ggagtatgtg
      181 tgtcctacaa gtacttctcc agcattcgaa gatgcagctg cccaaagaaa ttcaaagggg
      241 agcactgtga gatagataca tcaaaaacct gctatcatgg aaatggtcaa tcttaccgag
      301 gaaaggccaa tactgacacc aaaggccggc cctgcctggc ctggaattca cccgctgtcc
      361 ttcagcaaac ctacaatgct cacagatccg atgctcttag cctaggcctg gggaaacaca
      421 attactgcag gaaccccgac aaccagaggc gaccctggtg ctatgtgcaa attggcctaa
      481 agcagtttgt ccaagaatgc atggtgcagg actgctctct cagcaaaaag ccttcttcta
      541 ctgtagacca acaagggttc cagtgtggcc agaaggctct aaggccccgc ttcaagatcg
      601 ttgggggaga attcactgtc gttgagaacc agccctggtt tgcagccatc tacctgaaga
      661 ataagggagg aagccctccc tcctttaaat gtggtgggag cctcatcagt ccttgctggg
      721 tggccagcgc cacacactgc ttcgtgaatc agccaaagaa ggaagagtac gttgtctacc
      781 tgggtcagtc gaagcggaac tcctataacc ccggagagat gaagtttgag gtggagcagc
      841 tcatcttgca cgaagacttc agcgacgaaa ctctggcctt ccataatgac atagccttgc
      901 tgaagatacg taccagcacg ggccaatgcg cacagccatc caggaccata cagaccatct
      961 gcctgccccc gaggtttggt gatgctccgt ttggttcaga ctgtgagatc actggcttcg
     1021 gacaagagag tgccactgac tatttctatc cgaaggacct gaaaatgtca gttgtaaaga
     1081 ttatttctca cgaacagtgc aagcagcctc actactatgg ctctgaaatt aattataaaa
     1141 tgctgtgtgc tgctgaccca gagtggaaaa cagattcctg ctcgggagat tcaggaggac
     1201 ctcttatctg taacatcgat ggccgcccaa ctctgagcgg gattgtgagc tggggcagtg
     1261 gatgtgcaga gaaaaacaag cctggtgtct acacgagggt ctcatacttc ctgaactgga
     1321 ttcagtccca cattggagaa gagaatggcc tagccttctg atggtcccca ggcagctggg
     1381 ggaagaaacg gatgggtcgc cactcatccc cacgctgacc gtcctctgca gcagggtcat
     1441 ctccatcatg tggagggaag agctgaagaa aacaggctct gcactgattc tttgcttgtg
     1501 ctgtccacca gggtgaaccc caatagtatt accctcagac acaggtctgg gtgctggcca
     1561 tccagaccat cctgaccagg atggaaatca atcctgactc aagatgaata gatggggagt
     1621 tgccttttta tggactaaag ccatctgcag tttaaaaacc caagtgtagg aggagagttg
     1681 gttcccccta atgggtcatt catgaggtct gctgttggga aataaatgat ttcccaatta
     1741 ggaagtgtaa cagctgaggt attctgaggg tgcttgtcca atatgagcac agtagtgtga
     1801 agagtagaga cactaatggc ttgagggaac agttcttgca tcccatgagt ggatcaggaa
     1861 atattgtgtg cgtgtgcatg tgcatgtgtg tatgtgtgcg tgtgtgtgtg tgtgtgtgtg
     1921 tgtgtgtgcg tgtgtgtgtt tgctcactgt gcacaggttg tgagtataaa tctgagcaaa
     1981 gctggtgtat tcctgtatct aactgcaagt ctaggtattt ccctccctcc agactgtgat
     2041 gcggggccat ttggtcttcc gtgatgctcc acttgaatgt attattcccg ggcatgacct
     2101 gtgaccagca ctaatgtctg cttcactttt tatatagatg tccccttcct ggccagttac
     2161 catttttttt ttttttacta attagcctag ttcatccaat cctcactggg tggggtaagg
     2221 gccactcata tacttaatat ttaataatta tgttctgcct tttttattta tatctatttt
     2281 tataattcta tgtaaaggtg atcaataaaa tgtgattttt ttctgaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaa
//
