LOCUS       NM_012760               5491 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus PLAG1 like zinc finger 1 (Plagl1), mRNA.
ACCESSION   NM_012760
VERSION     NM_012760.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5491)
  AUTHORS   Mirowska,A., Sledzinski,T., Smolenski,R.T. and Swierczynski,J.
  TITLE     Down-regulation of Zac1 gene expression in rat white adipose tissue
            by androgens
  JOURNAL   J Steroid Biochem Mol Biol 140, 63-70 (2014)
   PUBMED   24316431
  REMARK    GeneRIF: Zac1 is strongly expressed in white adipose tissue of
            adult rats,compared to other organs/tissues.  Androgens could play
            an important role in down-regulation of the ZAC1 mRNA and protein
            levels in rats.
REFERENCE   2  (bases 1 to 5491)
  AUTHORS   Rajan,S., Chu Pham Dang,H., Djambazian,H., Zuzan,H., Fedyshyn,Y.,
            Ketela,T., Moffat,J., Hudson,T.J. and Sladek,R.
  TITLE     Analysis of early C2C12 myogenesis identifies stably and
            differentially expressed transcriptional regulators whose
            knock-down inhibits myoblast differentiation
  JOURNAL   Physiol Genomics 44 (2), 183-197 (2012)
   PUBMED   22147266
REFERENCE   3  (bases 1 to 5491)
  AUTHORS   Czubryt,M.P., Lamoureux,L., Ramjiawan,A., Abrenica,B.,
            Jangamreddy,J. and Swan,K.
  TITLE     Regulation of cardiomyocyte Glut4 expression by ZAC1
  JOURNAL   J Biol Chem 285 (22), 16942-16950 (2010)
   PUBMED   20363751
  REMARK    GeneRIF: ZAC1 is a novel and previously unknown regulator of
            cardiomyocyte Glut4 expression and glucose uptake; MEF2 is a
            regulator of ZAC1 expression in response to induction of
            hypertrophy
REFERENCE   4  (bases 1 to 5491)
  AUTHORS   Fila,T., Trazzi,S., Crochemore,C., Bartesaghi,R. and Ciani,E.
  TITLE     Lot1 is a key element of the pituitary adenylate cyclase-activating
            polypeptide (PACAP)/cyclic AMP pathway that negatively regulates
            neuronal precursor proliferation
  JOURNAL   J Biol Chem 284 (22), 15325-15338 (2009)
   PUBMED   19346254
  REMARK    GeneRIF: Lot1 is a key element of the PACAP/cAMP pathway that
            negatively regulates neuronal precursor proliferation.
            Erratum:[J Biol Chem. 2020 Mar 13;295(11):3746. PMID: 32169856]
REFERENCE   5  (bases 1 to 5491)
  AUTHORS   Williams,J.A., Kondo,N., Okabe,T., Takeshita,N., Pilchak,D.M.,
            Koyama,E., Ochiai,T., Jensen,D., Chu,M.L., Kane,M.A., Napoli,J.L.,
            Enomoto-Iwamoto,M., Ghyselinck,N., Chambon,P., Pacifici,M. and
            Iwamoto,M.
  TITLE     Retinoic acid receptors are required for skeletal growth, matrix
            homeostasis and growth plate function in postnatal mouse
  JOURNAL   Dev Biol 328 (2), 315-327 (2009)
   PUBMED   19389355
REFERENCE   6  (bases 1 to 5491)
  AUTHORS   Arima,T., Kamikihara,T., Hayashida,T., Kato,K., Inoue,T.,
            Shirayoshi,Y., Oshimura,M., Soejima,H., Mukai,T. and Wake,N.
  TITLE     ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene
            network that may play a role in Beckwith-Wiedemann syndrome
  JOURNAL   Nucleic Acids Res 33 (8), 2650-2660 (2005)
   PUBMED   15888726
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5491)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 5491)
  AUTHORS   Varrault,A., Ciani,E., Apiou,F., Bilanges,B., Hoffmann,A.,
            Pantaloni,C., Bockaert,J., Spengler,D. and Journot,L.
  TITLE     hZAC encodes a zinc finger protein with antiproliferative
            properties and maps to a chromosomal region frequently lost in
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8835-8840 (1998)
   PUBMED   9671765
REFERENCE   9  (bases 1 to 5491)
  AUTHORS   Abdollahi,A., Godwin,A.K., Miller,P.D., Getts,L.A., Schultz,D.C.,
            Taguchi,T., Testa,J.R. and Hamilton,T.C.
  TITLE     Identification of a gene containing zinc-finger motifs based on
            lost expression in malignantly transformed rat ovarian surface
            epithelial cells
  JOURNAL   Cancer Res 57 (10), 2029-2034 (1997)
   PUBMED   9158001
REFERENCE   10 (bases 1 to 5491)
  AUTHORS   Abdollahi,A., Roberts,D., Godwin,A.K., Schultz,D.C., Sonoda,G.,
            Testa,J.R. and Hamilton,T.C.
  TITLE     Identification of a zinc-finger gene at 6q25: a chromosomal region
            implicated in development of many solid tumors
  JOURNAL   Oncogene 14 (16), 1973-1979 (1997)
   PUBMED   9150364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 11, 2021 this sequence version replaced NM_012760.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.118.1, SRR26643287.47.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000001.1  9297464-9297618
            156-192             JAXUCZ010000001.1  9298359-9298395
            193-229             JAXUCZ010000001.1  9311371-9311407
            230-257             JAXUCZ010000001.1  9317848-9317875
            258-345             JAXUCZ010000001.1  9321818-9321905
            346-699             JAXUCZ010000001.1  9330204-9330557
            700-5491            JAXUCZ010000001.1  9332603-9337394
FEATURES             Location/Qualifiers
     source          1..5491
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p13"
     gene            1..5491
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /note="PLAG1 like zinc finger 1"
                     /db_xref="GeneID:25157"
                     /db_xref="RGD:3014"
     exon            1..155
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..192
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            193..229
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..257
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            258..345
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..699
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..2299
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /note="Lost on transformation 1; pleiomorphic adenoma
                     gene-like 1"
                     /codon_start=1
                     /product="zinc finger protein PLAGL1"
                     /protein_id="NP_036892.1"
                     /db_xref="GeneID:25157"
                     /db_xref="RGD:3014"
                     /translation="MAPFRCQKCGKSFLTLEKFTIHNYSHTRERPFKCSKTECGKAFV
                     SKYKLMRHMATHSPQKTHQCTHCEKTFNRKDHLKNHLQTHDPNKMIYACEDCGKKYHT
                     MLGYKRHMALHSASSGDLTCGVCTLELGSTEVLLDHLKSHAEEKAHHAPREKKHQCDH
                     CERCFYTRKDVRRHLVVHTGCKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMQESLQA
                     GEYQGGYQPIAPPFQIKADPMPPFQLEMPPESGLDGGLPPEIHGLVLASPEEVPQPML
                     SMPPMQPMPEQPFTLHPGVVPSSPPPIILQEHKYSPVPTSFAPFVSMPMKADLKGFCN
                     MGLFEEFPLQECQSPVKFSQCFEMAKEGFGKVTLPKELLVDAVNIAIPGSLEISSLLG
                     FWQLPPPPPQNGFMNGTIPVGAGEPLPHRITCLAQQQPPPLLPPPPPLPLPEPLPQPQ
                     LPPQFQLQLQPQPQMQPQMQLQPLQLQLPQLLPQLQPEPEPEPEPEEEEEEEEEIEEE
                     EEIEEEEEAEPEAEEEEEAEDEEEAEEEEEEPQPEEAQIAMSAVNMGQPPLPPTPHVF
                     TAGTNTAILPHFHHAFR"
     exon            700..5491
                     /gene="Plagl1"
                     /gene_synonym="Lot1; Zac1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctggcagg cgggagaacg ctcgggagtt gtggccgtgg gcacggggct cgcggcaaga
       61 ggagcggaga gcgggcatct cctgagcgcc gtcatggctg cttaggctgc gcctgccagc
      121 ggaccgacgg tgtcgcccga atccggctcg gataggtctg gttggagtct gtgcctgctt
      181 gcttggcgtg tggttgttcc tgcttgattg gcacggtgcc attggcttcg tatttgggaa
      241 tcggaggagt taatcttgtc tcttctcaca ggttcgagtc ctcagacctt ctgcaggact
      301 ccatccatat ctgcctcgca gctgactctc ctgctcacac agaagacggc catcctagat
      361 ccccagctat tgtgctgacc atccccttcc tgctccggat ctcgcctggc tgctaggctg
      421 tggtgctgcc ttttcagggt caggctgtag cgactccccg ccttcgtccc ggctgggctt
      481 aggtggaaca gtggttcatc tcatctcatc agcacttctg aagaagaaag tgtgagaagc
      541 agaggccatg gctccttttc gctgtcaaaa atgcggcaag tccttcctca ccctggagaa
      601 gttcaccatc cacaattatt cccacaccag ggagcgccca ttcaagtgct ccaagactga
      661 gtgtggcaaa gccttcgtct ccaagtataa gctgatgaga cacatggcta cgcactctcc
      721 ccagaagacg caccagtgca ctcattgtga aaagactttc aaccggaagg atcatctgaa
      781 gaatcacctc cagacccacg atcccaacaa gatgatctac gcctgcgaag attgtggcaa
      841 gaaataccac accatgctgg gctacaagag gcacatggcc ctgcattcgg ccagcagcgg
      901 cgatctcacc tgcggcgtct gcaccctgga gctggggagc accgaggtcc tgctggacca
      961 cctcaagtct cacgcggaag aaaaggccca ccacgcgccc agggagaaga aacaccagtg
     1021 cgaccactgc gagagatgct tctacacccg gaaggatgtg cgtcgccacc tggtggtcca
     1081 cacaggatgc aaggacttcc tgtgtcagtt ctgcgcccag agatttgggc gcaaagacca
     1141 cctcactcgt cacaccaaga agacccactc ccaggagctg atgcaagaga gcctgcaagc
     1201 aggagaatac cagggcggtt accaacccat tgcgcctccg ttccagatca aggctgatcc
     1261 catgcctcct ttccagttag aaatgccccc cgagagcggg cttgatgggg gcttgcctcc
     1321 tgagattcat ggtctagtgc ttgcttcccc agaggaggtt ccccagccta tgctgtctat
     1381 gccgccaatg cagccaatgc cagagcagcc tttcactctg caccctgggg tagttccctc
     1441 ctctcctccc ccgatcattc ttcaggagca taagtacagc ccagttccta cctcttttgc
     1501 cccgttcgta agcatgccga tgaaagcaga tctcaagggc ttttgcaaca tgggtctctt
     1561 tgaggaattt cctctgcaag agtgtcagtc gcctgtcaag ttcagtcagt gctttgagat
     1621 ggctaaggag gggtttggga aggtcaccct gcccaaagag ctgctggtag atgctgtaaa
     1681 tatagccatt cctggctctc tggagatttc ctctctcttg gggttctggc agctgccccc
     1741 tcctcctccc cagaatggct tcatgaatgg caccatccct gtgggggccg gggagccgct
     1801 gccccatagg ataacttgcc tggcacagca gcagccacca cctctgctac ctccgccgcc
     1861 gccgctgccg ctgccagagc cgctgccaca gccacagctg ccgccacagt ttcagttgca
     1921 gctccagccc cagccccaga tgcagcccca gatgcagctg cagcctctac agctgcagct
     1981 gccccagctg ctgccccagc tgcagcccga gcctgagcca gagccagagc cagaggaaga
     2041 agaggaagaa gaggaagaga tagaagaaga ggaagagatc gaagaagagg aagaggccga
     2101 accagaggca gaagaagaag aggaggcaga agatgaagag gaggcagagg aagaggaaga
     2161 agagccacag ccagaagaag cccaaatagc aatgagcgct gtgaatatgg gccagccccc
     2221 gctacccccg acccctcatg ttttcacagc tggcaccaac accgctatcc tgccccattt
     2281 ccaccacgcg ttcagataaa ttggtttttt aagagggtgc ttctcttctg gaagatgttt
     2341 caaacaccag ttccagttcc agacatcagt tacagtttga agagaagcgt tggaaaaaca
     2401 ggaatggggt ttctagctta ttgccatgag tagattgaga aaaaggactc tcttaactgc
     2461 atgcactgtg ccaatacata tatatatata tatatcatcc ttagtattca tgctttgtac
     2521 caaacttagt gagtgcgggc gtactccata atcgaactgc aagtagtatc atattattac
     2581 cctgatattg ttagtctcat attattagcc ttgtattatt ctcatataat caaaaccaag
     2641 atccaaaaca tgagctgcta atttgtaaat atcgtgttga gtgttagccg tcgtagtgat
     2701 gttagctgcg tagttgcgtg ttagcactgc ctaggaaggg cacgagggca aagttgggct
     2761 tctccaactt ggaagatgtt ttgaagagaa gggggtgatc tccgtagggc gtccgtaact
     2821 aggccgtgtg tttcttttca gggacccgtc taccttcagg attggatgta gtttagtcgc
     2881 tcttcttctt agctcgcttt gtagtttgtc cttctggtag cctactgtgt gtgtctgtgt
     2941 gtagctttat aggaaagttc cgtgtgaagc tgtcggtgtc ttcgttttca aaagtgaatt
     3001 ttaaatgtat ttttcaatat ttttcatgtg atgttgtacc aatgtgaatt atgacttcgt
     3061 ttatcttaaa gacaaaactg gttgtcagtc atatctgaca ggaagaaaga aatccctgtg
     3121 ggtagccaag tcaagtggcc aactaatgag aagaagcatc aatcgaaagt gttggctgac
     3181 tgggacactc atgattctca caggactttg agaaaacgta ctggaattaa aaaaaaaaaa
     3241 gcttaagtac attagataag aattttcttt gcctagctta acctactact taagcctctt
     3301 aagttctgaa gtattgtgat caaccaatag gaaaatgtat ctgtagttga tgaatttcag
     3361 tccttgttac tttgtatccc aagaggtttg tgttttgcaa tgtaaccgta cttgtaatct
     3421 cagttggtat cttgctaatc gatttgaaag tgtaaaacct aacccttgaa gactatgtat
     3481 ttcctttttt gagactgtat ttcccagcat gtatacccta acctttggag actctgtatt
     3541 ctgtttttga gactttcccc ccgcccccca gcatatgtac cccgaccctt gaagactgta
     3601 tttcgttttt gagaacgtat ttcccagcat atatacacta acccttgaag actctgtatt
     3661 tccttttttg agactgtatt tcccagcata tatacactaa cctttgaaga ctctgtattc
     3721 tgtttttgag acccccccca gcatatgtac cctaaccctt gaagactgta tttcgttttt
     3781 gagaacgtat ttcccagcat atatacacta acctttgaag actctgtatt tcatttttga
     3841 gactgtgttt cttagtatac ataccctaac ctttgaagac tccatttttg agactccccc
     3901 cccccccagc atttgtaccc taacccttgg aggctttgta ttttgttttt gagacttttc
     3961 cgccagcata tatacactaa cccttgaaga ctctgtattt catttttgag acttttttcc
     4021 ccagcatata taccgtaacc cttgaagact ctgtattccg tttttgagat tttttttccc
     4081 tcagcatata taccctaacc cttgaagact ctgtattcca tttttgagac tttttcccag
     4141 catatatacc ctaacctttg aagactctgt attccgtttt tgagattttt ttacctcagc
     4201 atatataccc taaccttcga agactctgta ttccgttttt gagatttttt tcccccagca
     4261 tatataccct aacctttgaa gactctgtat ttcatttttg agactttttt cccagcatat
     4321 ataccctaac ccttgaagac tatgtattcc atttttgaga cttttttcct agcatatata
     4381 ccctaaccct tgaagattct gtattccgtt tttgaggttt tttttccctc agcatatata
     4441 ccctaaccct tgaagactct gtattccatt tttgagattt ttttcccagc atatataccc
     4501 taacctttga agactctgta ttctgttttt gagatttttt ttacctcagc atatgtaccc
     4561 taaccttcga agactctgta tttcattttt gagactcttt tcccagcata tataccctaa
     4621 ccttcgaaga ttctggtatt tcatttttga gacttttttt cccagcatat ataccctaac
     4681 ctttgaagac tctgtattcc gtttttgaga ttttttttcc ctcagcatat ataccctaac
     4741 ctttgaagac tctgtatttc atttttgaga ctttttccca gcatatatac cctaaccttt
     4801 gaagactctg tattccattt ttgagacttt ttcccctcag catatatacc ccaacctttg
     4861 aagactctgt atttcatttt tgagactttt tcccccagca tatataccct aacctttgaa
     4921 gactctgtat ttcatttttg agactttttt cccagcatat ataccctaac ccttgaagac
     4981 tctgtattct gttttttttt tttttttgag actttttccc ccagcatata tacactaacc
     5041 tttgaagact ctgtattcca ttttttgaga cttttttccc cagcatatat accctaacct
     5101 ttgaagactc tgtatttcat ttttgagact ttttccccag catatatacc ctaacctttg
     5161 aagactctgt attccgtttt tgagactccc cccccccggc atgaataccc taatctttga
     5221 agactctggt atttcatttt tgagattttt tcccctcagc atatatacac taacctttgt
     5281 agactctgta ttccgttttt gagactttcc cccccagcat gtatacccta acctttgaag
     5341 actctgtatt tcccagcatt tgtaccctac ccttgaagac tttgtatttc ccagcatttg
     5401 taccctaacc cttgaagacc ctgtatttcg tttgtaagac ttttccccag catatatatc
     5461 ctacatataa taaaccctaa gcatctagca a
//
