LOCUS       NM_001008316            3347 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus PLAG1 zinc finger (Plag1), mRNA.
ACCESSION   NM_001008316 XM_232651
VERSION     NM_001008316.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3347)
  AUTHORS   Gu,Q. and Wei,H.F.
  TITLE     PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of
            Retinal Endothelial Cells by Regulating the Wnt/beta-Catenin
            Signalling Pathway
  JOURNAL   Folia Biol (Praha) 68 (1), 25-32 (2022)
   PUBMED   36201855
  REMARK    GeneRIF: PLAG1 Promotes High Glucose-Induced Angiogenesis and
            Migration of Retinal Endothelial Cells by Regulating the
            Wnt/beta-Catenin Signalling Pathway.
REFERENCE   2  (bases 1 to 3347)
  AUTHORS   Hide,T., Takezaki,T., Nakatani,Y., Nakamura,H., Kuratsu,J. and
            Kondo,T.
  TITLE     Sox11 prevents tumorigenesis of glioma-initiating cells by inducing
            neuronal differentiation
  JOURNAL   Cancer Res 69 (20), 7953-7959 (2009)
   PUBMED   19808959
REFERENCE   3  (bases 1 to 3347)
  AUTHORS   Hensen,K., Braem,C., Declercq,J., Van Dyck,F., Dewerchin,M.,
            Fiette,L., Denef,C. and Van de Ven,W.J.
  TITLE     Targeted disruption of the murine Plag1 proto-oncogene causes
            growth retardation and reduced fertility
  JOURNAL   Dev Growth Differ 46 (5), 459-470 (2004)
   PUBMED   15606491
REFERENCE   4  (bases 1 to 3347)
  AUTHORS   Voz,M.L., Agten,N.S., Van de Ven,W.J. and Kas,K.
  TITLE     PLAG1, the main translocation target in pleomorphic adenoma of the
            salivary glands, is a positive regulator of IGF-II
  JOURNAL   Cancer Res 60 (1), 106-113 (2000)
   PUBMED   10646861
REFERENCE   5  (bases 1 to 3347)
  AUTHORS   Astrom,A.K., Voz,M.L., Kas,K., Roijer,E., Wedell,B., Mandahl,N.,
            Van de Ven,W., Mark,J. and Stenman,G.
  TITLE     Conserved mechanism of PLAG1 activation in salivary gland tumors
            with and without chromosome 8q12 abnormalities: identification of
            SII as a new fusion partner gene
  JOURNAL   Cancer Res 59 (4), 918-923 (1999)
   PUBMED   10029085
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Mar 18, 2025 this sequence was replaced by
            NM_001008316.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001008316.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085871.1, CK601489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               JAXUCZ010000005.1  21711074-21711240   c
            168-267             JAXUCZ010000005.1  21710736-21710835   c
            268-626             JAXUCZ010000005.1  21706208-21706566   c
            627-3347            JAXUCZ010000005.1  21702973-21705693   c
FEATURES             Location/Qualifiers
     source          1..3347
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q12"
     gene            1..3347
                     /gene="Plag1"
                     /note="PLAG1 zinc finger"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
     exon            1..167
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..267
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     exon            268..626
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1884
                     /gene="Plag1"
                     /note="pleiomorphic adenoma gene 1 protein"
                     /codon_start=1
                     /product="zinc finger protein PLAG1"
                     /protein_id="NP_001008317.1"
                     /db_xref="GeneID:297804"
                     /db_xref="RGD:1305286"
                     /translation="MATVIPGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFN
                     SVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCEKMFH
                     RKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHAATSGDLTCKVCLQTFE
                     STGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRRHMVVHTGRKDFLCQYC
                     AQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDELLPVMSLPSSE
                     LLSKPFTNTLQLNLYNTPFQSMQSSGSTHQMITTLPLGMTCPIDMDTVHPSHHLAFKC
                     PFSSTSYAISIPEKEQPLKGEIESYLMELQGGAPSSSQDSQASSSKLGLEPQSGSPDD
                     GAGDLSLSKSSISISDPLNTPALDFSQLFNFIPLNGPPYNPLSVGSLGMSYSQDEAHS
                     SVSQLPTQTQDLQDPANTVGLGSLHSLSAAFTSSLSSSTTLPRFHQAFQ"
     exon            627..3347
                     /gene="Plag1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aactgtggca gtgtgggtgg cagtactgta atcaggagga aactgagttc tattaagctc
       61 aatgaatttt tatctgtttt gtttacagtc cgtaactctt gcttagattt cttttttatt
      121 aacaagtggg gagccattca gcatcacaaa ttgacatttt tttctagatt ggccaaaatg
      181 ggaagggatg gattctgctc tcttccacga agagttaatg ggactggcta agatcaaagt
      241 ctgaggcttt tttccatcac taatcagtcc ctttttgctt tcttttacga ccacatgaaa
      301 cttgagaagc cacctaaagc taaatcactt agtggagttg ggcagttccc aggtgtccaa
      361 cgagaaggcc tggtttaggc tgcgatggcc actgtcattc ctggtgattt gtcagaagta
      421 agagataccc agaaagcccc ttcagggaaa cgtaagcgtg gtgaaagcaa accaagaaaa
      481 aactttcctt gccaactgtg tgacaaggcc tttaacagtg ttgagaaatt aaaggttcac
      541 tccttctctc acacgggaga gaggccctac aagtgcacac accaagactg caccaaggcc
      601 tttgtttcta agtacaaatt acaaaggcac atggctactc actctcctga gaaaacccac
      661 aagtgtaatt attgtgagaa aatgtttcac cggaaagacc atctgaagaa ccacctccat
      721 acacacgacc ccaacaaaga gacttttaaa tgcgaagagt gtggcaagag ctacaacacc
      781 aagcttgggt ttaagcgaca cttggccttg cacgctgcca ccagtggcga cctcacctgc
      841 aaggtgtgtt tgcagacttt tgagagcaca ggtgtgctcc tagagcacct gaaatctcac
      901 gcaggcaagt cctctggggg cgtgaaagag aaaaagcacc agtgtgagca ctgcgagcgc
      961 aggttctaca cccggaagga tgttcggaga cacatggtgg tgcacacggg aagaaaggac
     1021 ttcctctgtc agtactgtgc acagagattt ggacgaaagg atcacctcac tcgacacatg
     1081 aagaagagtc acaatcaaga gcttctgaag gtcaaaactg aaccagtcga tttcctggac
     1141 ccattcacct gcaacatgtc tgtgcctata aaagatgagc tcctgccggt catgtccttg
     1201 ccttccagcg aactcttgtc aaagccattc accaacactt tgcagttaaa cctctataac
     1261 actccatttc agtccatgca gagctctggg tctactcacc aaatgataac aactttacct
     1321 ttgggaatga cgtgccccat agatatggac actgttcacc cctctcatca tcttgctttc
     1381 aaatgcccgt tcagttctac ctcatacgca atctctattc ccgagaaaga acagccctta
     1441 aagggggaaa tcgagagtta tctgatggag ttacaaggtg gcgcaccatc ttcatcccag
     1501 gattctcaag catcatcgtc taagttaggg ttagagcctc agagtggctc cccagacgat
     1561 ggtgctgggg acctctccct gtcaaagagc tctatctcta tcagtgaccc cctgaacaca
     1621 ccagcattgg atttctctca gttgttcaat ttcataccat taaatggtcc tccttacaat
     1681 ccgctctccg tgggaagcct tgggatgagc tattcccagg acgaggcgca ttcttctgtt
     1741 tctcagctgc ccacacaaac acaggatctt caggatcctg cgaacacagt gggccttggc
     1801 tctctgcact cactgtcagc agctttcacc agcagcctaa gctcaagcac taccctgccc
     1861 cgtttccacc aggcctttca gtagggtctg ggccgaggga ttcaccggag gtgcttgtgc
     1921 agccccgcct gcaaagacca tttatattct agtgcctact ttaacacaac acagaaactt
     1981 ctccttttgt ataatatcag gttttatgaa gccagtaaat aggaattagc ctctttgata
     2041 agctttgaaa tggttcgtgt ttaactacgt ttgctgtttc tcctgatttc ctgccagttg
     2101 tcatagtctc ggagttttat ttcatagagg agcgccatta ttatcactaa attttacaag
     2161 tcctgtgttc aaattactgt tagaccttaa cattctcact tttgtctaat agcaatgggc
     2221 attggacttt tttttttttg caaatgtgca gtacaatgta aatcttctat gaaatgtgtg
     2281 tgaagaactg aagtgtttca catttcttta ctagccacta aatggattca taatcaagtg
     2341 tgttttaaat gagttaagaa tccagtttgg ggagagtata gtggtttcct aaatacacca
     2401 tcatttgaga tcaatatatt ttgaagactg ctattgtctg gctaaaataa gaagtttcag
     2461 tatctattta atagaaacct agagatgtta cggggtgttc tgtgttagaa ctagccctca
     2521 ggctgatttg ccacatttca accatctttc cgttaacagt gtgtggcctc ggagtcttca
     2581 ggatcagtgt agaagtgttc tgttgtatgc ccttcacctt tcatacccca ggatggcttc
     2641 acaataccag cattcttact ttgcatgttg gtccagttag tgcagagtct tagaaccatt
     2701 gtgggacaat agacagtaaa tatatgaagc ccagagtggc tggctgcctg aatcgtcggg
     2761 gtgatagact cctcaccagg aagatggatg taaaacgtac agccaaaccc cagcacttgt
     2821 ctagagaatg tccactgttg ccagaactga gaactggact cctatcgcat cacttctaaa
     2881 acagcagtct tgcccgtgcg cccttgctca gtgcatatac atctttccct gccgtgtttg
     2941 gatggagaac ttaaaaatta aacacatcaa aaagcaactt gacgagttcc acagttttac
     3001 accaccaaaa gttgttaaga gcccactttt acacatctcc aggagacagg aggaatgtta
     3061 gaaataagtt gaatttatag aggaaacaga ggaaaataaa gcaaacacca aatgaatacg
     3121 aatgcaccaa ggatgtggtg ctcactgagc aaggtagcaa tgggcttcct cttgtcagac
     3181 agccaccaag aatgtcatcg gtagctccgc gtatatcttc ctaagggtta tttgtggcat
     3241 caacctacga gacttactaa gcacttgtta acaccttatt ctggacccct tctgttgggg
     3301 cagggagttt tatagaagag tatatatctc tttaaaaaaa aaaaaaa
//
