LOCUS       NM_001108353             730 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus placenta associated 8 (Plac8), mRNA.
ACCESSION   NM_001108353 XM_001067597 XM_341188
VERSION     NM_001108353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 730)
  AUTHORS   Slade,C.D., Reagin,K.L., Lakshmanan,H.G., Klonowski,K.D. and
            Watford,W.T.
  TITLE     Placenta-specific 8 limits IFNgamma production by CD4 T cells in
            vitro and promotes establishment of influenza-specific CD8 T cells
            in vivo
  JOURNAL   PLoS One 15 (7), e0235706 (2020)
   PUBMED   32639988
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 730)
  AUTHORS   Sasaki,D., Kotoh,J., Watadani,R. and Matsumoto,K.
  TITLE     New animal models reveal that coenzyme Q2 (Coq2) and
            placenta-specific 8 (Plac8) are candidate genes for the onset of
            type 2 diabetes associated with obesity in rats
  JOURNAL   Mamm Genome 26 (11-12), 619-629 (2015)
   PUBMED   26296322
  REMARK    GeneRIF: coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are
            differentially expressed in obese rats, suggesting that these two
            genes are candidates for the onset of type 2 diabetes associated
            with obesity in rats.
REFERENCE   3  (bases 1 to 730)
  AUTHORS   Johnson,R.M., Kerr,M.S. and Slaven,J.E.
  TITLE     Plac8-dependent and inducible NO synthase-dependent mechanisms
            clear Chlamydia muridarum infections from the genital tract
  JOURNAL   J Immunol 188 (4), 1896-1904 (2012)
   PUBMED   22238459
REFERENCE   4  (bases 1 to 730)
  AUTHORS   Jimenez-Preitner,M., Berney,X., Uldry,M., Vitali,A., Cinti,S.,
            Ledford,J.G. and Thorens,B.
  TITLE     Plac8 is an inducer of C/EBPbeta required for brown fat
            differentiation, thermoregulation, and control of body weight
  JOURNAL   Cell Metab 14 (5), 658-670 (2011)
   PUBMED   21982742
REFERENCE   5  (bases 1 to 730)
  AUTHORS   Ledford,J.G., Kovarova,M. and Koller,B.H.
  TITLE     Impaired host defense in mice lacking ONZIN
  JOURNAL   J Immunol 178 (8), 5132-5143 (2007)
   PUBMED   17404296
REFERENCE   6  (bases 1 to 730)
  AUTHORS   Li,Y., Rogulski,K., Zhou,Q., Sims,P.J. and Prochownik,E.V.
  TITLE     The negative c-Myc target onzin affects proliferation and apoptosis
            via its obligate interaction with phospholipid scramblase 1
  JOURNAL   Mol Cell Biol 26 (9), 3401-3413 (2006)
   PUBMED   16611984
REFERENCE   7  (bases 1 to 730)
  AUTHORS   Yanagi,Y., Takezawa,S. and Kato,S.
  TITLE     Distinct functions of photoreceptor cell-specific nuclear receptor,
            thyroid hormone receptor beta2 and CRX in one photoreceptor
            development
  JOURNAL   Invest Ophthalmol Vis Sci 43 (11), 3489-3494 (2002)
   PUBMED   12407160
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474022.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341188.3, XM_001067597.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ221955.1, FQ222141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..730
                     /gene="Plac8"
                     /note="placenta associated 8"
                     /db_xref="GeneID:360914"
                     /db_xref="RGD:1308102"
     exon            1..84
                     /gene="Plac8"
                     /inference="alignment:Splign:2.1.0"
     exon            85..222
                     /gene="Plac8"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..452
                     /gene="Plac8"
                     /note="placenta-specific 8"
                     /codon_start=1
                     /product="placenta-specific gene 8 protein"
                     /protein_id="NP_001101823.1"
                     /db_xref="GeneID:360914"
                     /db_xref="RGD:1308102"
                     /translation="MAQAATVIVTQPGFVRAPQNSNWQTSLCDCFSDCGVCLCGTFCF
                     TCLGCQVAADMNECCLCGTTVAMRTLYRTRYGIPGSICDDYMVTLFCPVCSVCQIKRD
                     INRRRAMNAF"
     exon            223..347
                     /gene="Plac8"
                     /inference="alignment:Splign:2.1.0"
     exon            348..463
                     /gene="Plac8"
                     /inference="alignment:Splign:2.1.0"
     exon            464..730
                     /gene="Plac8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctcccttc cttgagaatc tctccatttg taggaagact caaccccaga ccacaggacc
       61 cgtcctgtcc aaaccttttg aactacctgg tctttggaga cctcgagttg aagatggctc
      121 aggcagcaac agttatcgtg actcaacctg gatttgttcg tgctccccaa aattccaact
      181 ggcagaccag cctgtgtgat tgcttcagtg actgtggagt ctgcctctgt gggacctttt
      241 gcttcacttg tcttggatgt caagtggcag ctgacatgaa tgaatgttgt ttgtgtggaa
      301 caacggtggc gatgaggact ctctaccgaa cccgatacgg cattcctggg tctatttgtg
      361 atgactacat ggtcaccctc ttctgtcctg tttgctctgt gtgccaaatc aagagagaca
      421 ttaacaggag gagagccatg aacgctttct aatgagctgg atggcgagag ctccgctgaa
      481 gcagctgaag tcagcacacg cccttcagcc cgagcccttc agacaccttt ggcaactggg
      541 ataagatgga cacatttaat tacagaatgg tgggagcttt ctaatcgggc ctttggattg
      601 attttaaatg gatgccactc cttgacttgg tttctcgttg ctcccatcat cagatattcc
      661 ggcttataat tttttacatt acactttaaa tgtaaaccaa ataaaaagat tttgctaaga
      721 agactacttt
//
