LOCUS       NM_053866               2694 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus phospholipase A2, activating protein (Plaa),
            mRNA.
ACCESSION   NM_053866
VERSION     NM_053866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2694)
  AUTHORS   Hall,E.A., Nahorski,M.S., Murray,L.M., Shaheen,R., Perkins,E.,
            Dissanayake,K.N., Kristaryanto,Y., Jones,R.A., Vogt,J.,
            Rivagorda,M., Handley,M.T., Mali,G.R., Quidwai,T., Soares,D.C.,
            Keighren,M.A., McKie,L., Mort,R.L., Gammoh,N., Garcia-Munoz,A.,
            Davey,T., Vermeren,M., Walsh,D., Budd,P., Aligianis,I.A.,
            Faqeih,E., Quigley,A.J., Jackson,I.J., Kulathu,Y., Jackson,M.,
            Ribchester,R.R., von Kriegsheim,A., Alkuraya,F.S., Woods,C.G.,
            Maher,E.R. and Mill,P.
  TITLE     PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by
            Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic
            Proteins
  JOURNAL   Am J Hum Genet 100 (5), 706-724 (2017)
   PUBMED   28413018
REFERENCE   2  (bases 1 to 2694)
  AUTHORS   Falik Zaccai,T.C., Savitzki,D., Zivony-Elboum,Y., Vilboux,T.,
            Fitts,E.C., Shoval,Y., Kalfon,L., Samra,N., Keren,Z., Gross,B.,
            Chasnyk,N., Straussberg,R., Mullikin,J.C., Teer,J.K., Geiger,D.,
            Kornitzer,D., Bitterman-Deutsch,O., Samson,A.O., Wakamiya,M.,
            Peterson,J.W., Kirtley,M.L., Pinchuk,I.V., Baze,W.B., Gahl,W.A.,
            Kleta,R., Anikster,Y. and Chopra,A.K.
  TITLE     Phospholipase A2-activating protein is associated with a novel form
            of leukoencephalopathy
  JOURNAL   Brain 140 (2), 370-386 (2017)
   PUBMED   28007986
REFERENCE   3  (bases 1 to 2694)
  AUTHORS   Papadopoulos,C., Kirchner,P., Bug,M., Grum,D., Koerver,L.,
            Schulze,N., Poehler,R., Dressler,A., Fengler,S., Arhzaouy,K.,
            Lux,V., Ehrmann,M., Weihl,C.C. and Meyer,H.
  TITLE     VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of
            ruptured lysosomes by autophagy
  JOURNAL   EMBO J 36 (2), 135-150 (2017)
   PUBMED   27753622
REFERENCE   4  (bases 1 to 2694)
  AUTHORS   Liu,N.K., Deng,L.X., Zhang,Y.P., Lu,Q.B., Wang,X.F., Hu,J.G.,
            Oakes,E., Bonventre,J.V., Shields,C.B. and Xu,X.M.
  TITLE     Cytosolic phospholipase A2 protein as a novel therapeutic target
            for spinal cord injury
  JOURNAL   Ann Neurol 75 (5), 644-658 (2014)
   PUBMED   24623140
  REMARK    GeneRIF: Cytosolic phospholipase A2 mRNA is expressed in rat
            injured spinal cord at 7 days after spinal cord injury.
REFERENCE   5  (bases 1 to 2694)
  AUTHORS   Sabapatha,A., Gercel-Taylor,C. and Taylor,D.D.
  TITLE     Specific isolation of placenta-derived exosomes from the
            circulation of pregnant women and their immunoregulatory
            consequences
  JOURNAL   Am J Reprod Immunol 56 (5-6), 345-355 (2006)
   PUBMED   17076679
REFERENCE   6  (bases 1 to 2694)
  AUTHORS   Li,F., Zhang,C., Schaefer,S., Estes,A. and Malik,K.U.
  TITLE     ANG II-induced neointimal growth is mediated via cPLA2- and
            PLD2-activated Akt in balloon-injured rat carotid artery
  JOURNAL   Am J Physiol Heart Circ Physiol 289 (6), H2592-H2601 (2005)
   PUBMED   16024570
  REMARK    GeneRIF: These data suggest that the ANG II-induced neointimal
            growth is mediated by the activation of Akt through a mechanism
            dependent on cPLA2 and PLD2 activation in balloon-injured rat
            carotid arteries.
REFERENCE   7  (bases 1 to 2694)
  AUTHORS   Schwartz,Z., Graham,E.J., Wang,L., Lossdorfer,S., Gay,I.,
            Johnson-Pais,T.L., Carnes,D.L., Sylvia,V.L. and Boyan,B.D.
  TITLE     Phospholipase A2 activating protein (PLAA) is required for
            1alpha,25(OH)2D3 signaling in growth plate chondrocytes
  JOURNAL   J Cell Physiol 203 (1), 54-70 (2005)
   PUBMED   15368540
  REMARK    GeneRIF: PLAA is a specific activator of PLA2 in growth plate
            chondrocytes, suggesting that it mediates the membrane effect of
            1alpha,25(OH)2D3, thereby modulating physiological response.
REFERENCE   8  (bases 1 to 2694)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   9  (bases 1 to 2694)
  AUTHORS   Wang,H., Lemasters,J.J. and Herman,B.
  TITLE     Cloning of a rat cDNA encoding a protein with high homology to
            mouse phospholipase A2-activating protein
  JOURNAL   Gene 161 (2), 237-241 (1995)
   PUBMED   7665086
REFERENCE   10 (bases 1 to 2694)
  AUTHORS   Clark,M.A., Ozgur,L.E., Conway,T.M., Dispoto,J., Crooke,S.T. and
            Bomalaski,J.S.
  TITLE     Cloning of a phospholipase A2-activating protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (12), 5418-5422 (1991)
   PUBMED   2052621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK366206.1, CV109083.1, CB701630.1, CV110320.1, CF110238.1 and
            BP498567.1.
            
            On Oct 17, 2007 this sequence version replaced NM_053866.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211509.1, FQ223782.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               CK366206.1         1-634
            635-1069            CV109083.1         208-642
            1070-1214           CB701630.1         153-297
            1215-1784           CV110320.1         75-644
            1785-2548           CF110238.1         156-919
            2549-2694           BP498567.1         22-167
FEATURES             Location/Qualifiers
     source          1..2694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..2694
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /note="phospholipase A2, activating protein"
                     /db_xref="GeneID:116645"
                     /db_xref="RGD:621245"
     exon            1..262
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2501
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /codon_start=1
                     /product="phospholipase A-2-activating protein"
                     /protein_id="NP_446318.3"
                     /db_xref="GeneID:116645"
                     /db_xref="RGD:621245"
                     /translation="MASGAARYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTR
                     LWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSP
                     MPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKIL
                     PEQGLMLTGSADKTIKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQ
                     ITGECLGVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWC
                     CCVLDNGDIVVGASDGIIRVFTEADERTASAEEIKAFERELSQATIDSKTGDLGDINA
                     EQLPGREHLNEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSG
                     KVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKF
                     IIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMD
                     TTMAGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGSAPEEK
                     KLTEDDLVLLEKILSLICGNASEKPTAQQLQVLWKAINWPEDIVFPALDILRLSIKHP
                     SVNENFCNEKEGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRES
                     LMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLE
                     ATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYASVSEPAKVSECCRLILNLL"
     exon            263..456
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            457..557
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            558..678
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            679..846
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            847..982
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1152
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1310
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1530
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1599
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1668
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1770
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1935
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2694
                     /gene="Plaa"
                     /gene_synonym="PLA2P; Plap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcccctc tcttgcaggc gggtctcggg ccgcatcctg gcgcacgcca gctcgggcct
       61 gtggacgagt ctcgcgctgt gccggggagc cgggctccgg atccacgctg gccatggcga
      121 gcggtgccgc cagataccgg ctgagctgct cgctcccggg ccacgaactg gacgtgaggg
      181 gcctggtgtg ctgcctctac ccaccgggag cctttgtgtc tgtgtcccgg gatcgtacca
      241 cccgcctctg ggctccagac agtcctaaca ggggctttac agaaatgcac tgtatgagcg
      301 gccactctaa ttttgtgtct tgtgtgtgca tcataccctc aagtgacata tatcctcatg
      361 gactaattgc cactggagga aatgaccaca atatttgcat tttctcgctg gacagtccga
      421 tgccacttta tattttaaag ggtcacaaag atactgtttg tagtctttct tctggaaaat
      481 ttgggacatt acttagtggc tcatgggaca ccactgctaa agtctggctg aatgacaaat
      541 gcatgatgac attacagggt cacacagctg cagtatgggc agtaaagatt ttacctgaac
      601 agggcttaat gttaactgga tcagcagaca aaacaattaa actatggaag gccggaagat
      661 gtgagaggac tttttcaggg catgaagact gtgtaagagg tttggcaatt ttgagtgaaa
      721 cagaatttct ttcctgtgca aatgatgcta gtattagaag gtggcagatt actggcgagt
      781 gtcttggagt atactacgga catacaaatt atatttatag catatctgtc tttccaaatt
      841 gtagagattt tgtgacaact gcagaagaca gatctctaag aatatggaaa catggtgaat
      901 gtgcccaaac aatccgactt ccagctcagt ctatatggtg ctgctgcgta ctggacaatg
      961 gtgacattgt ggttggtgcg agtgatggta ttattagagt gtttacagag gcagacgagc
     1021 ggacagccag tgctgaggaa atcaaggctt ttgagagaga gctctctcag gcaactatag
     1081 actccaaaac tggcgacttg ggggacatta atgctgagca gcttcctggg agggaacatc
     1141 tgaatgagcc aggtactaga gaaggacaga ctcgtctaat cagagatgga gagagagttg
     1201 aagcctatca atggagtgtt agtgatggca ggtggataaa aattggtgat gttgttggct
     1261 catctggtgc taatcagcaa acatctggaa aagttttata tgaagggaaa gaatttgatt
     1321 atgttttctc catcgatgtg aatgaaggcg gaccatcata taaattacca tataatgtca
     1381 gtgacgaccc ctggctggtt gcatacaact tcttgcagaa aaatgatttg aatcccatgt
     1441 ttttggatca ggtggctaaa tttattattg ataacacaaa aggtcaaaca ctgggacttg
     1501 gaaataccag tttttcagac ccatttacag gtggtggtcg ctatgttcca ggaacttcag
     1561 ggccttccaa cacagtgcag acagcagatc ctttcacagg tgctggtcgt tatatgccag
     1621 ggtctgcagg gatggatacc accatggctg gagttgatcc atttacagga aatagtgcct
     1681 accgatcagc tgcgtctaaa acagtgaata tttatttccc caaaaaagaa gctcttacct
     1741 tcgaccaagc aaaccctaca caaatattag gaaaactgaa ggaacttaat ggaagtgcac
     1801 ctgaagagaa gaagctaact gaagatgact tggtacttct ggaaaagata ctgtccctga
     1861 tttgtggtaa tgcttcagaa aagccgacgg cccagcagct tcaggttctg tggaaagcca
     1921 tcaactggcc tgaagacatt gtctttcccg cacttgacat tcttcggcta tcaattaagc
     1981 atcccagtgt gaatgagaat ttctgcaatg aaaaagaagg agaccagttc agcagccacc
     2041 ttatcaacct tctgaaccct aaaggaaagc cagcaaacca gctgcttgct cttaggactt
     2101 tttgcaattg ctttgttagt caggcaggac aaaagctcat gatgtcccag agggagtcat
     2161 tgatgtcaca tgcaatagaa ctgaaatccg ggagcaataa gaacattcat attgctctgg
     2221 ctacactgac cttgaactat tctgtttgtt tccataaaga ccataacatt gaagggaaag
     2281 cccaatgctt gtcagtgatt agcacaatct tggaagttgt acaagaccta gaagccacat
     2341 ttagactcct tgtggctctt gggacactta tcagtgatga ttcaaatgct atacaattag
     2401 ccaaatcttt aggtgttgat tctcaaataa aaaagtatgc ttctgtatca gagccagcta
     2461 aagtaagtga atgctgtaga cttatcttaa atttgctgta gcagtgggga aaggaagctg
     2521 aggggtttgg ttttttttgt tttgtttttt tccccacatt ttacatgact gattgtagat
     2581 atttaaaaag aaagaaagaa agaaaagaaa actggattaa gttcagatat tataaagttg
     2641 tgttgaggag atacaaatta taaataaagt ttttgcactg atggttgtga ggtt
//
