LOCUS       NM_001100837            5599 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus phospholipase A2 receptor 1 (Pla2r1), mRNA.
ACCESSION   NM_001100837 XM_001069062 XM_006224449 XM_215737
VERSION     NM_001100837.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5599)
  AUTHORS   Huang,B., Zhang,Z., Sui,W., Zhao,L., Li,Y., Feng,L., Yang,D. and
            Zhou,Y.
  TITLE     Effectiveness of a novel rat model of off-target PLA2R1 knockout to
            renal impairment
  JOURNAL   Genomics 116 (2), 110796 (2024)
   PUBMED   38237745
  REMARK    GeneRIF: Effectiveness of a novel rat model of off-target PLA2R1
            knockout to renal impairment.
REFERENCE   2  (bases 1 to 5599)
  AUTHORS   Pan,Y., Wan,J., Liu,Y., Yang,Q., Liang,W., Singhal,P.C.,
            Saleem,M.A. and Ding,G.
  TITLE     sPLA2 IB induces human podocyte apoptosis via the M-type
            phospholipase A2 receptor
  JOURNAL   Sci Rep 4, 6660 (2014)
   PUBMED   25335547
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5599)
  AUTHORS   Ghai,R., Bugarcic,A., Liu,H., Norwood,S.J., Skeldal,S.,
            Coulson,E.J., Li,S.S., Teasdale,R.D. and Collins,B.M.
  TITLE     Structural basis for endosomal trafficking of diverse transmembrane
            cargos by PX-FERM proteins
  JOURNAL   Proc Natl Acad Sci U S A 110 (8), E643-E652 (2013)
   PUBMED   23382219
REFERENCE   4  (bases 1 to 5599)
  AUTHORS   Augert,A., Payre,C., de Launoit,Y., Gil,J., Lambeau,G. and
            Bernard,D.
  TITLE     The M-type receptor PLA2R regulates senescence through the p53
            pathway
  JOURNAL   EMBO Rep 10 (3), 271-277 (2009)
   PUBMED   19197340
REFERENCE   5  (bases 1 to 5599)
  AUTHORS   Granata,F., Petraroli,A., Boilard,E., Bezzine,S., Bollinger,J., Del
            Vecchio,L., Gelb,M.H., Lambeau,G., Marone,G. and Triggiani,M.
  TITLE     Activation of cytokine production by secreted phospholipase A2 in
            human lung macrophages expressing the M-type receptor
  JOURNAL   J Immunol 174 (1), 464-474 (2005)
   PUBMED   15611272
REFERENCE   6  (bases 1 to 5599)
  AUTHORS   Silliman,C.C., Moore,E.E., Zallen,G., Gonzalez,R., Johnson,J.L.,
            Elzi,D.J., Meng,X., Hanasaki,K., Ishizaki,J., Arita,H., Ao,L.,
            England,K.M. and Banerjee,A.
  TITLE     Presence of the M-type sPLA(2) receptor on neutrophils and its role
            in elastase release and adhesion
  JOURNAL   Am J Physiol Cell Physiol 283 (4), C1102-C1113 (2002)
   PUBMED   12225974
REFERENCE   7  (bases 1 to 5599)
  AUTHORS   Higashino Ki,K., Yokota,Y., Ono,T., Kamitani,S., Arita,H. and
            Hanasaki,K.
  TITLE     Identification of a soluble form phospholipase A2 receptor as a
            circulating endogenous inhibitor for secretory phospholipase A2
  JOURNAL   J Biol Chem 277 (16), 13583-13588 (2002)
   PUBMED   11830583
REFERENCE   8  (bases 1 to 5599)
  AUTHORS   Fonteh,A.N., Atsumi,G., LaPorte,T. and Chilton,F.H.
  TITLE     Secretory phospholipase A2 receptor-mediated activation of
            cytosolic phospholipase A2 in murine bone marrow-derived mast cells
  JOURNAL   J Immunol 165 (5), 2773-2782 (2000)
   PUBMED   10946309
REFERENCE   9  (bases 1 to 5599)
  AUTHORS   Ancian,P., Lambeau,G., Mattei,M.G. and Lazdunski,M.
  TITLE     The human 180-kDa receptor for secretory phospholipases A2.
            Molecular cloning, identification of a secreted soluble form,
            expression, and chromosomal localization
  JOURNAL   J Biol Chem 270 (15), 8963-8970 (1995)
   PUBMED   7721806
REFERENCE   10 (bases 1 to 5599)
  AUTHORS   Higashino,K., Ishizaki,J., Kishino,J., Ohara,O. and Arita,H.
  TITLE     Structural comparison of phospholipase-A2-binding regions in
            phospholipase-A2 receptors from various mammals
  JOURNAL   Eur J Biochem 225 (1), 375-382 (1994)
   PUBMED   7925459
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473983.2.
            
            On or before Dec 15, 2013 this sequence version replaced
            XM_006224449.1, XM_215737.5, XM_001069062.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5599
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q21"
     gene            1..5599
                     /gene="Pla2r1"
                     /note="phospholipase A2 receptor 1"
                     /db_xref="GeneID:295631"
                     /db_xref="RGD:1309777"
     exon            1..248
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..4516
                     /gene="Pla2r1"
                     /note="secretory phospholipase A2 receptor; secretory
                     phospholipase A2 receptor-like"
                     /codon_start=1
                     /product="secretory phospholipase A2 receptor precursor"
                     /protein_id="NP_001094307.1"
                     /db_xref="GeneID:295631"
                     /db_xref="RGD:1309777"
                     /translation="MAQWLAMLQLLWLQQLLLGVHQGSAQDLTHTQELALEWRDKGIF
                     IIQSESLKTCIQAGKSVLTLENCTQPNEYMLWKWVSDNHLFNVGASGCLGLNISDLKR
                     PLSLYECDSTLISLRWLCDRKTIVGPLQYKVQVNHSTVVAKKTPHKWSAYMPGGGDIC
                     EHLHRDIYTLKGNAHGMPCVFPFQFKGQWHHECIREGHKEHLLWCATTSRYEEDEKWG
                     FCPDPTSTEIFCDAMWQRNDNSHICYQFNLLSSLSWNEAHSSCQMQGGALLSITDENE
                     EAFIRKELSRVAKEVWTGLNQLDEMAGWQWSDGTPLSYLNWSQEVTAGPFVEYHCGTL
                     KVASATWRSMDCESTLPYICKRHLNHTAEDILQKDSWKYHTTHCDPGWTPFNRKCYKL
                     KKEKRTWQEALHSCQSDDSMLMDVTSLAEVELLVNLLGDENASETWIGLSSNKIPVSF
                     AWSSGSSVIFTNWYLLEPRILPNRRQLCVSADQSDGRWKVKGCKETLPYICKKAGQVL
                     EDEDSGCQAGWERHGKYCYKIDTVLRSFEQASGGYYCPPALLTITSRFEQAFITSLIS
                     SVARKDSYFWIALQDQNNTGEYTWKTMGQREPVQYTHWNAHQPSYHGGCVVLRGGSSF
                     GRWEVKNCSDFKAMSLCKTPIKVWEKTEFEGRWPFHPCYMDWESETGLASCFKVFHSE
                     KVLMKRSWREAEAFCEEFGAHLASFAHIEEENFVNKLLHSKFNWTQERQFWIGFNKRN
                     PLNAGSWEWSDGSPVVSSFLDNAYFEEDAKNCAVYKANNTLLPSNCASKHEWICKIPR
                     DVKPNFPVWYQYDAPWLFYQNAEYLFHTHPAEWATFEFVCGWLRSDFLTIYSAQEQEF
                     IHSKIRALSKYGANWWIGLEDRRAGDQIHWSNGSPVIFQNWDKGRKGRMDSQRKRCVF
                     MSAITGLWGTENCSVPMPSICKRVKIWVIEKEKPPTQHGTCPKGWLYFNYKCFLVTIP
                     KDPRELKTWTGAQEFCAAKGGTLVSIESELEQAFITVNLFGQTTNVWIGLQSDNHENW
                     VNGKPVVYSNWSPSDVINIPNYNTTEVQKRAPLCALMSSNPNFHFTGKWYFDDCGKKG
                     YGFVCEKMQDTLENHVNVSDTYAVPSTLEYGNRTYKIIRANMTWYAAGKSCRMQGAEL
                     VSIPDVFHQSFLTVLLSRLGHAHWIGLSTPDNGLNFDWSDGTKSPFTYWKDEESASLG
                     DCVFADTDGHWHGTACESHLQGAVCRVLTETKSFEHPVLCSETSVPWIRFKGHCYSFS
                     TVLDSRSFEDAREFCKREGSNLLAIKDEAENLFLLEELLALGSSVQMVWLNAQLDNDN
                     KTLRWFDGAATEQSNWGVRKPDMDHLKPHPCVVLRIPEGVWQSTPCEDKTGFICKVEA
                     GIPAVTAHPEKGLSHSIMPVAAALALTIVLGILVLCLWIYKQNGGAILPRLTGSRGPY
                     YPMSSFSMAHLEENILISDLEKNNQ"
     exon            249..626
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..800
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            801..974
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1088
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1229
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1424
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1582
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1681
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1794
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1958
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2161
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2307
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2392
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2525
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2561
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2719
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2784
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2888
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3025
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3143
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3274
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3422
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3661
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3662..3830
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..3971
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            3972..4088
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4265
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4298
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
     exon            4299..5599
                     /gene="Pla2r1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgagttca tctctagggc tccggggtag cgtggtcctc gagaagagtg gaggcttttc
       61 ttgcctcctg cgccccagtc cagagcacgg gatacggttg tggtcccgtg tgtgtcacct
      121 agcgtgcctg atggcacaat ggttagcgat gctccagctg ctctggctcc agcagctgct
      181 gctgggggtt caccagggca gcgcccaaga tttgacccac acccaggaac tggccctcga
      241 gtggcgtgat aaaggaattt tcattatcca gagcgagagc ctaaagactt gcattcaggc
      301 aggtaaatcc gtactgaccc tggagaactg cacacagcca aacgagtaca tgctgtggaa
      361 atgggtttcc gacaaccacc tctttaatgt gggagccagc ggctgcctag gcctgaacat
      421 atctgatctg aaacgaccat taagtctcta tgaatgtgat tccactctca tttccttgag
      481 atggctctgt gacaggaaga cgatcgtggg cccactccag tacaaggtcc aggtgaacca
      541 cagcacggtg gtggcaaaga aaacacccca taagtggagc gcctacatgc ccggtggtgg
      601 ggacatttgt gagcatcttc acagagatat atatacctta aaagggaatg cccatgggat
      661 gccttgtgtg tttcctttcc agttcaaagg tcagtggcac cacgagtgca tccgagaagg
      721 gcataaagag cacctgctgt ggtgtgccac cacgagtcgc tacgaagagg atgagaaatg
      781 gggattctgc ccagatccta cctctacaga gatattctgt gatgctatgt ggcaaaggaa
      841 cgacaattca cacatttgct accaattcaa cctgctctca tctctctctt ggaatgaggc
      901 acattcctca tgccagatgc aaggaggtgc tttgttaagt attacggatg aaaatgaaga
      961 agctttcata aggaaggagt tgagccgggt agctaaagaa gtgtggactg gtttgaatca
     1021 gctggatgag atggctggct ggcagtggtc tgatgggaca ccactcagct acctgaactg
     1081 gagccaagag gtcactgctg ggccatttgt ggagtatcat tgtggaaccc tgaaagttgc
     1141 ctcagctacc tggagaagca tggactgcga gtctaccttg ccttatatat gcaaacggca
     1201 tctaaaccac actgccgagg acatcctgca aaaggactcc tggaaatacc ataccactca
     1261 ctgtgaccct ggctggactc ccttcaatcg taaatgctac aaacttaaga aagagaaaag
     1321 gacttggcag gaggctctgc actcttgcca gtctgatgac agcatgttga tggatgtcac
     1381 ttccctagct gaggtggagt tgcttgtaaa cctccttggg gatgaaaatg catcggaaac
     1441 atggattggt ttgagtagca ataaaattcc agtttccttc gcatggtcca gtggctcctc
     1501 tgtcatcttc actaactggt accttctcga gcctcgaatt cttccaaaca gaagacaact
     1561 gtgtgtctca gcagatcaat ctgacggacg ctggaaagtg aaaggttgta aagaaacact
     1621 cccttacatt tgtaagaaag caggacaagt ccttgaggat gaggactccg gatgtcaagc
     1681 gggctgggaa agacacggca agtattgtta caaaatcgac acagtcctga gaagctttga
     1741 gcaggcttcc ggtggttatt actgtcctcc cgccctccta accatcacca gccgatttga
     1801 acaagctttt attaccagtt tgatcagtag tgtggcaaga aaggacagtt atttttggat
     1861 tgctcttcaa gaccaaaaca atacaggaga atacacttgg aagaccatgg gacagaggga
     1921 gccggtgcag tacacacact ggaacgcaca tcaacccagc taccatggtg gctgtgttgt
     1981 cctgcgagga gggagttcat ttggtcgctg ggaagtgaag aactgtagtg actttaaggc
     2041 aatgtctctt tgcaagacac ccatcaaagt ctgggagaaa acagagtttg aagggaggtg
     2101 gccctttcac ccctgctata tggactggga atcagagact ggtctagcca gttgcttcaa
     2161 ggtctttcat agcgaaaagg tcctgatgaa aagatcatgg agggaagctg aagccttctg
     2221 tgaggagttt ggagctcacc tcgcaagttt tgcccacata gaggaagaaa acttcgtgaa
     2281 taagcttcta cactcaaaat ttaattggac acaagaaagg cagttctgga tcggatttaa
     2341 taaaaggaac ccactgaatg ccggttcttg ggagtggtct gacgggtctc ctgttgtctc
     2401 ttcattttta gacaatgctt attttgaaga agatgcaaaa aactgtgctg tgtataaggc
     2461 aaacaacaca ctgttgccct cgaactgtgc ttccaaacac gagtggatat gcaaaattcc
     2521 aagagatgtg aaacccaatt ttccagtctg gtaccagtac gatgcaccct ggctcttcta
     2581 tcagaatgcc gagtacctct tccacaccca tcctgccgag tgggccacct ttgagtttgt
     2641 ctgcggctgg ctgcgaagtg atttcctcac gatttattct gctcaggagc aagaattcat
     2701 ccacagcaaa atcagagcgc tatcaaagta cggggcgaat tggtggatcg gacttgaaga
     2761 tagaagagct ggagatcaaa ttcactggag taatgggtca cccgtgatat ttcagaactg
     2821 ggacaaagga aggaaaggaa gaatggatag ccagagaaag cgatgcgtct tcatgtctgc
     2881 tataacaggg ctctggggca ctgagaattg ctctgttcct atgcccagca tctgtaagcg
     2941 agtgaaaata tgggtcatcg agaaggagaa gccgccaaca cagcatggca cgtgccccaa
     3001 agggtggctt tattttaact ataagtgctt cctggtgaca atccccaagg acccacggga
     3061 gctgaagacc tggacaggtg ctcaggaatt ctgtgctgcc aagggtggga cgctggtctc
     3121 catcgaaagt gaactggaac aagctttcat tactgtgaat cttttcggcc agaccacgaa
     3181 tgtatggata gggttacaaa gtgacaatca tgagaattgg gtaaatggga agcctgtggt
     3241 gtattctaac tggtctccat ctgatgtaat aaatatcccc aattataaca ccactgaagt
     3301 tcaaaagcgt gctccactct gtgccctgat gtcaagtaat cctaatttcc attttactgg
     3361 aaaatggtat ttcgatgact gtgggaaaaa aggctatgga tttgtgtgtg aaaaaatgca
     3421 agataccctt gaaaaccatg taaacgtgtc tgatacctat gcagtcccca gcacattaga
     3481 atacggaaac aggacttata aaataatccg tgctaatatg acttggtacg cagcaggaaa
     3541 gtcctgccgg atgcagggag cagaactggt cagcattcca gacgtatttc accagtcctt
     3601 cctcacagtt ctcctcagca ggctggggca cgcccactgg attgggctat ccacaccaga
     3661 taatggtctg aattttgact ggtcagacgg caccaaatcc cctttcacct attggaaaga
     3721 tgaggagtca gcctctcttg gcgactgcgt ttttgccgac accgatggtc actggcatgg
     3781 cacagcctgt gagtcacatc tgcaaggcgc cgtttgtcgt gtactcactg aaacaaagtc
     3841 gtttgagcac ccagtgctgt gctcagaaac gtcagttccc tggataagat ttaaaggtca
     3901 ttgctacagt ttttctacag tcctggacag cagaagtttt gaggatgctc gagaattctg
     3961 caaaagagaa ggatccaatc ttttggcaat caaggatgag gctgaaaatt tatttctcct
     4021 ggaagagctt cttgcccttg gttcttctgt ccagatggtt tggttgaatg ctcaacttga
     4081 caatgacaac aaaaccttaa ggtggtttga cggagcagcc acagagcagt caaactgggg
     4141 cgtacggaag ccagacatgg accacctcaa gccccatccg tgtgttgtcc tgaggatccc
     4201 tgaaggagta tggcagtcta ccccatgcga agacaaaacg ggattcattt gtaaagtgga
     4261 agcaggcatc ccagctgtaa cagcacatcc agagaaagga ctaagccaca gcatcatgcc
     4321 tgttgcagca gcactggcgt tgacaatagt cctgggcatt ctcgtccttt gcctctggat
     4381 ttacaagcag aatggcggtg ccatcttgcc gagactcacg gggtcgaggg gcccttacta
     4441 ccctatgtcc agcttcagca tggcacactt agaagagaac atcctcattt ctgatcttga
     4501 gaagaataac caatgacgaa gttagagctg ctccaactac ggagagcaaa ggaggccacg
     4561 aagggcgtcc tgtctgcatt tcccctgaac atcatgccct tataatgtga attgcacctc
     4621 cgttttaatt aatcttcaag cactggcttt gaattttaag caaatcagat gagattgaat
     4681 gtattcattt cctttaactg tggcccattc tgaaaagggg tgctggttat tattttaaaa
     4741 gacaagagct attaaatagt gttcccagac cagactggta tgcattcaga atgtaagtac
     4801 actcgataca ttgaaaggga aaggggaaga ctctggctgc ataggacagg agggtgcttc
     4861 tgaaaaacca gtgcttatct gattctaatt caactgtttt ttaataccgt ggtttgggga
     4921 aaatcctaaa ttttaaactt ccagttctgg gctctcaact aatactttgg atgacattaa
     4981 gttttattag ttctcaagct agattagatc tggttctcaa gctaaatggg agaaatacca
     5041 ccttctctta gatatgaagg tctcagtaga caggtgatct caggaacaac cacatgattt
     5101 aaaaagtgcc ataaaccctc gcttgttaag ttattaccat gatttaaagg taagctcaaa
     5161 gaaatgcatt gagatttcaa taatttgttg aaagttcatg gaccttattg aaaactaaaa
     5221 tctaaagtta taaaatacta tatagtaatc ttttgttatt gtttggtttg tttgttttgt
     5281 tttgttttgt tttgtttgta agacctggct tctctgtgta agcagtcctg actgtcctgg
     5341 gactcacttt gtataccagg ctatcctcaa accctctgcc tctgcctccc gagtgctggg
     5401 atgaaaggtg tgtgccacca ttgccaggcg atatattatc taaccaggac ttacagaata
     5461 gatgcgtctc aaacttaaag agaaagcaat cgaagatctg tattatgctc ccatcagaac
     5521 caaactaaag aggatgttga aaaatactaa ataaaatgac cctggaatag aggtttaaaa
     5581 tgaactacca aatctgact
//
