LOCUS       NM_001009353            1797 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus phospholipase A2 group VII (Pla2g7), mRNA.
ACCESSION   NM_001009353 XM_217358
VERSION     NM_001009353.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1797)
  AUTHORS   Goncalves I, Edsfeldt A, Ko NY, Grufman H, Berg K, Bjorkbacka H,
            Nitulescu M, Persson A, Nilsson M, Prehn C, Adamski J and Nilsson
            J.
  TITLE     Evidence supporting a key role of Lp-PLA2-generated
            lysophosphatidylcholine in human atherosclerotic plaque
            inflammation
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (6), 1505-1512 (2012)
   PUBMED   22499993
REFERENCE   2  (bases 1 to 1797)
  AUTHORS   Sternberg Z, Drake A, Sternberg DS, Benedict RH, Li F, Hojnacki D,
            Weinstock-Guttmann B and Munschauer FE.
  TITLE     Lp-PLA2: inflammatory biomarker of vascular risk in multiple
            sclerosis
  JOURNAL   J Clin Immunol 32 (3), 497-504 (2012)
   PUBMED   22246459
REFERENCE   3  (bases 1 to 1797)
  AUTHORS   Nelson TL, Biggs ML, Kizer JR, Cushman M, Hokanson JE, Furberg CD
            and Mukamal KJ.
  TITLE     Lipoprotein-associated phospholipase A2 (Lp-PLA2) and future risk
            of type 2 diabetes: results from the Cardiovascular Health Study
  JOURNAL   J Clin Endocrinol Metab 97 (5), 1695-1701 (2012)
   PUBMED   22399516
REFERENCE   4  (bases 1 to 1797)
  AUTHORS   Colak Y, Senates E, Ozturk O, Doganay HL, Coskunpinar E, Oltulu YM,
            Eren A, Sahin O, Ozkanli S, Enc FY, Ulasoglu C and Tuncer I.
  TITLE     Association of serum lipoprotein-associated phospholipase A2 level
            with nonalcoholic fatty liver disease
  JOURNAL   Metab Syndr Relat Disord 10 (2), 103-109 (2012)
   PUBMED   22112193
REFERENCE   5  (bases 1 to 1797)
  AUTHORS   Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL,
            Shah R, Mucksavage MI, Bradfield JP, Hakonarson H, Wang X, Master
            SR, Rader DJ, Li M and Reilly MP.
  TITLE     Translational studies of lipoprotein-associated phospholipase A in
            inflammation and atherosclerosis
  JOURNAL   J Am Coll Cardiol 59 (8), 764-772 (2012)
   PUBMED   22340269
REFERENCE   6  (bases 1 to 1797)
  AUTHORS   Xu H, Iijima K, Shiozawa S, Tanaka SS, Inoue Y, Shirakawa T,
            Nishiyama K, Miwa M, Nakamura H and Yoshikawa N.
  TITLE     Platelet-activating factor acetylhydrolase gene mutation in
            Japanese nephrotic children
  JOURNAL   Kidney Int 54 (6), 1867-1871 (1998)
   PUBMED   9853251
REFERENCE   7  (bases 1 to 1797)
  AUTHORS   Mimura K, Zhao B, Muguruma K, Frenkel RA and Johnston JM.
  TITLE     Changes in glycerophospholipid profile in experimental nephrotic
            syndrome
  JOURNAL   Metabolism 45 (7), 822-826 (1996)
   PUBMED   8692015
REFERENCE   8  (bases 1 to 1797)
  AUTHORS   Tew DG, Southan C, Rice SQ, Lawrence MP, Li H, Boyd HF, Moores K,
            Gloger IS and Macphee CH.
  TITLE     Purification, properties, sequencing, and cloning of a
            lipoprotein-associated, serine-dependent phospholipase involved in
            the oxidative modification of low-density lipoproteins
  JOURNAL   Arterioscler Thromb Vasc Biol 16 (4), 591-599 (1996)
   PUBMED   8624782
REFERENCE   9  (bases 1 to 1797)
  AUTHORS   Iatrou C, Moustakas G, Antonopoulou S, Demopoulos CA and
            Ziroyiannis P.
  TITLE     Platelet-activating factor levels and PAF acetylhydrolase
            activities in patients with primary glomerulonephritis
  JOURNAL   Nephron 72 (4), 611-616 (1996)
   PUBMED   8730430
REFERENCE   10 (bases 1 to 1797)
  AUTHORS   Stremler KE, Stafforini DM, Prescott SM and McIntyre TM.
  TITLE     Human plasma platelet-activating factor acetylhydrolase.
            Oxidatively fragmented phospholipids as substrates
  JOURNAL   J Biol Chem 266 (17), 11095-11103 (1991)
   PUBMED   2040620
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088457.1.
            
            On Jan 7, 2005 this sequence version replaced XM_217358.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1797
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..1797
                     /gene="Pla2g7"
                     /note="phospholipase A2 group VII"
                     /db_xref="GeneID:301265"
                     /db_xref="RGD:1310734"
     exon            1..189
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            190..329
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..1546
                     /gene="Pla2g7"
                     /EC_number="3.1.1.47"
                     /note="platelet-activating factor acetylhydrolase;
                     phospholipase A2, group VII (platelet-activating factor
                     acetylhydrolase, plasma)"
                     /codon_start=1
                     /product="platelet-activating factor acetylhydrolase
                     precursor"
                     /protein_id="NP_001009353.1"
                     /db_xref="GeneID:301265"
                     /db_xref="RGD:1310734"
                     /translation="MVPLKLRVLFCLLCCLPRVHPLYWQDPSFFDFRPSVMFHKLQSV
                     MSAVSAGRCKIPKGNGSYPVGCTDMMFGYGNESIFLRLYYPAQDQGPHDTVWVPNIEY
                     FWGLSKFLGTPTFVGNILRLLYGSLTAPASWNFPLRTGEKYPLIIFSHGLGAFRTIYS
                     AIGAALASYGFIVATVEHRDGSASATYYFEDQAAAKMENRSWFYLKKIKQEESERARK
                     EQVRQRAKECSKALSAILDIEHGNPKENVLGLPFDMKQLKDSIDETKIAVMGHSFGGA
                     TVFQALSEDQRFRCGIALDPWMFPVSEELYSRVPQPLFFINSAEFQTPKDIAKMKNFY
                     QPDKERKMITIKGSVHQNFADGTFVTGKIIGNKLSLKGDIDSRVAIDLTNKASLAFLQ
                     KHLGLHKDFDQWDCLVEGENENLIPGSPFDVVTQSPALQSSPGSHNQN"
     exon            330..451
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            452..596
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            597..690
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            691..759
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            760..883
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            884..997
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1089
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1260
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1409
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1772
                     /gene="Pla2g7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcaacccg aggaggggag ggtcgagcct gaaggtagtt tttaagaagc cgtatgctca
       61 acccacctct gagataccct actccccggg aaaaaggact ctccggaagc ctttgctagg
      121 agttggctca cgctggtggc attggtgcac ccagggctca gggtacccag gagtcagcgg
      181 agtgaacaga acaacaaacg gaagccgctg ctcagctccc aggatggtgc cgctcaaact
      241 gcgcgtgctt ttctgcctcc tctgctgcct cccacgggta catcctttgt actggcaaga
      301 cccttctttt ttcgacttca ggccatcagt aatgtttcat aagctccaat cggtgatgtc
      361 tgctgtcagc gctggccgtt gtaaaatccc caaaggaaat ggatcttacc ctgtcggctg
      421 tacagacatg atgttcggtt atgggaatga gagcatcttc ttgcgtttgt actacccagc
      481 tcaagatcaa ggtcctcatg acactgtttg ggtcccaaac atagaatatt tttggggtct
      541 tagtaaattt ctcggaacac ctacttttgt aggcaacatt ttgcgcctct tatatggttc
      601 tctgacagct cctgcaagct ggaattttcc tttgcggact ggagaaaaat acccactaat
      661 tatcttttct cacggtctcg gagccttcag gacaatttat tctgctattg gcgctgcttt
      721 ggcatcctat gggtttatag tggccactgt ggaacataga gacggatctg catccgcaac
      781 ttactatttt gaagaccagg cagctgcgaa aatggaaaac aggtcttggt tttacctgaa
      841 aaagataaaa caagaggagt cggaaagagc tcggaaagag caggttcggc agagagcaaa
      901 agaatgttcc aaggctctca gtgcaattct tgacattgaa catggaaacc caaaagagaa
      961 tgtactaggt ttaccttttg atatgaaaca gctgaaggat tctatcgatg agactaaaat
     1021 agctgtgatg gggcattctt ttggaggagc aacagttttt caagccctaa gtgaagacca
     1081 gagattcaga tgtgggattg cccttgatcc gtggatgttt cccgtgagtg aggagctgta
     1141 ctccagagtt cctcagcctc tcttctttat caactctgcc gaattccaga ctccaaagga
     1201 cattgcaaaa atgaaaaact tctaccagcc tgacaaggaa aggaaaatga ttacgatcaa
     1261 gggctcagtg caccagaatt ttgctgacgg gacttttgta actggcaaaa taattggaaa
     1321 caagctgtca ctgaaaggag acatagactc cagagttgcc atagacctca ccaacaaggc
     1381 ttccttggct ttcttacaaa aacatttagg acttcataaa gactttgatc agtgggactg
     1441 tctggtggag ggagagaacg agaacctcat cccggggtca ccctttgatg tagtcaccca
     1501 gtccccggct ctgcagagtt ctcccggatc acacaaccag aattagaaga gcttgttaca
     1561 cagttgcctt ttaaaatcag agtgacgttg agagagagag agagagagag agagagagag
     1621 agagagagag agagagagaa atgtcattta cccaaataag catttggtaa atgtacactg
     1681 tactataaga tggtgatgaa tgcctggcct aagattcccc cctccccccc aaaaaaatgt
     1741 aaggaaaata aaatagagaa cataaaaaat aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
