LOCUS       NM_017174               1804 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phospholipase A2, group V (Pla2g5), mRNA.
ACCESSION   NM_017174
VERSION     NM_017174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Sato,H., Taketomi,Y., Ushida,A., Isogai,Y., Kojima,T.,
            Hirabayashi,T., Miki,Y., Yamamoto,K., Nishito,Y., Kobayashi,T.,
            Ikeda,K., Taguchi,R., Hara,S., Ida,S., Miyamoto,Y., Watanabe,M.,
            Baba,H., Miyata,K., Oike,Y., Gelb,M.H. and Murakami,M.
  TITLE     The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E
            play distinct roles in obesity
  JOURNAL   Cell Metab 20 (1), 119-132 (2014)
   PUBMED   24910243
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Ma,J., Qiao,Z. and Xu,B.
  TITLE     Expression of sPLA2-V, estrogen and its target protein in
            myocardium tissue
  JOURNAL   Int J Biol Macromol 58, 176-178 (2013)
   PUBMED   23567287
  REMARK    GeneRIF: Prostaglandin E1 plays a role in therapy of coronary heart
            disease and atherosclerosis by regulating serum estrogen and FSH
            levels, and myocardium sPLA2-V protein expression.
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Hsu,Y.H., Dumlao,D.S., Cao,J. and Dennis,E.A.
  TITLE     Assessing phospholipase A2 activity toward cardiolipin by mass
            spectrometry
  JOURNAL   PLoS One 8 (3), e59267 (2013)
   PUBMED   23533611
  REMARK    Erratum:[PLoS One. 2013;8(6).
            doi:10.1371/annotation/47607b18-ed69-4a08-8619-60c39bd83a13]
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Munoz,N.M., Desai,A., Meliton,L.N., Meliton,A.Y., Zhou,T.,
            Leff,A.R. and Dudek,S.M.
  TITLE     Group V phospholipase A(2) increases pulmonary endothelial
            permeability through direct hydrolysis of the cell membrane
  JOURNAL   Pulm Circ 2 (2), 182-192 (2012)
   PUBMED   22837859
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Boilard,E., Lai,Y., Larabee,K., Balestrieri,B., Ghomashchi,F.,
            Fujioka,D., Gobezie,R., Coblyn,J.S., Weinblatt,M.E.,
            Massarotti,E.M., Thornhill,T.S., Divangahi,M., Remold,H.,
            Lambeau,G., Gelb,M.H., Arm,J.P. and Lee,D.M.
  TITLE     A novel anti-inflammatory role for secretory phospholipase A2 in
            immune complex-mediated arthritis
  JOURNAL   EMBO Mol Med 2 (5), 172-187 (2010)
   PUBMED   20432503
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Murakami,M., Koduri,R.S., Enomoto,A., Shimbara,S., Seki,M.,
            Yoshihara,K., Singer,A., Valentin,E., Ghomashchi,F., Lambeau,G.,
            Gelb,M.H. and Kudo,I.
  TITLE     Distinct arachidonate-releasing functions of mammalian secreted
            phospholipase A2s in human embryonic kidney 293 and rat mastocytoma
            RBL-2H3 cells through heparan sulfate shuttling and external plasma
            membrane mechanisms
  JOURNAL   J Biol Chem 276 (13), 10083-10096 (2001)
   PUBMED   11106649
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   van der Helm,H.A., Buijtenhuijs,P. and van den Bosch,H.
  TITLE     Group IIA and group V secretory phospholipase A(2): quantitative
            analysis of expression and secretion and determination of the
            localization and routing in rat mesangial cells
  JOURNAL   Biochim Biophys Acta 1530 (1), 86-96 (2001)
   PUBMED   11341961
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Murakami,M., Shimbara,S., Kambe,T., Kuwata,H., Winstead,M.V.,
            Tischfield,J.A. and Kudo,I.
  TITLE     The functions of five distinct mammalian phospholipase A2S in
            regulating arachidonic acid release. Type IIa and type V secretory
            phospholipase A2S are functionally redundant and act in concert
            with cytosolic phospholipase A2
  JOURNAL   J Biol Chem 273 (23), 14411-14423 (1998)
   PUBMED   9603953
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Balboa,M.A., Balsinde,J., Winstead,M.V., Tischfield,J.A. and
            Dennis,E.A.
  TITLE     Novel group V phospholipase A2 involved in arachidonic acid
            mobilization in murine P388D1 macrophages
  JOURNAL   J Biol Chem 271 (50), 32381-32384 (1996)
   PUBMED   8943302
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Chen,J., Engle,S.J., Seilhamer,J.J. and Tischfield,J.A.
  TITLE     Cloning, expression and partial characterization of a novel rat
            phospholipase A2
  JOURNAL   Biochim Biophys Acta 1215 (1-2), 115-120 (1994)
   PUBMED   7947992
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_017174.3.
            
            On Nov 26, 2020 this sequence version replaced NM_017174.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03763.1, BC085745.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000005.1  156345717-156345922 c
            207-256             JAXUCZ010000005.1  156332571-156332620 c
            257-401             JAXUCZ010000005.1  156330801-156330945 c
            402-508             JAXUCZ010000005.1  156326732-156326838 c
            509-1673            JAXUCZ010000005.1  156324801-156325965 c
            1674-1804           JAXUCZ010000005.1  156324654-156324784 c
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1804
                     /gene="Pla2g5"
                     /note="phospholipase A2, group V"
                     /db_xref="GeneID:29354"
                     /db_xref="RGD:62051"
     exon            1..206
                     /gene="Pla2g5"
                     /inference="alignment:Splign:2.1.0"
     exon            207..256
                     /gene="Pla2g5"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..630
                     /gene="Pla2g5"
                     /EC_number="3.1.1.4"
                     /note="calcium-dependent phospholipase A2; group V
                     phospholipase A2; PLA2-10; phosphatidylcholine
                     2-acylhydrolase 5; phospholipase A2, group 5"
                     /codon_start=1
                     /product="phospholipase A2 group V precursor"
                     /protein_id="NP_058870.1"
                     /db_xref="GeneID:29354"
                     /db_xref="RGD:62051"
                     /translation="MKRLLTLAWFLACSVPAVPGGLLELKSMIEKVTGKNAVKNYGFY
                     GCYCGWGGHGTPKDGTDWCCRMHDRCYGLLEEKHCAIRTQSYDYRFTQDLVICEHDSF
                     CPVRLCACDRKLVYCLRRNLWSYNRLYQYYPNFLC"
     exon            257..401
                     /gene="Pla2g5"
                     /inference="alignment:Splign:2.1.0"
     exon            402..508
                     /gene="Pla2g5"
                     /inference="alignment:Splign:2.1.0"
     exon            509..1804
                     /gene="Pla2g5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggggctgag caggatgttg actggctatc gttcattgag cactctcacg atcagcatca
       61 cgcacggaat ccatccttcc tgtgttgcag cttgtagacc ctgatgcttg ggctgccagc
      121 cataaacgtg gggatccaga ctctgtctac cgaggctgcc catagggaca ggccctggga
      181 agaggagctg agaccaggct aaaaagaacc caagaaatga agcgcctcct cacgctggct
      241 tggttcctgg cttgcagtgt gcctgcagtc ccagggggct tgctagaact gaagtccatg
      301 attgagaagg tgactgggaa gaatgccgta aagaactatg gcttctacgg ctgctactgt
      361 ggctggggcg gccacgggac ccctaaggat ggcactgatt ggtgctgtcg gatgcacgac
      421 cgttgttatg ggctactgga ggagaaacac tgtgccatcc ggacccagtc ctatgactac
      481 agattcacac aggacttagt catctgcgaa cacgactcct tctgtccagt gaggctttgt
      541 gcttgtgacc ggaagctggt ctactgcctg aggagaaacc tctggagtta caaccgtctt
      601 taccagtatt accccaactt cctctgctaa tgtcctctgc gggctctgcc ccgggagtgc
      661 ctcccacagt ggcggccccc ctctgctgta ttcctgatcc gtccacccaa ggtcttggat
      721 ctgccttcct ctgtgtacca ctgggctgga cagagcccca gggttacact ctaccctcca
      781 gaatcctaga gagggactct gatgtagagt ctgcggactc tggatagctg agcctgcact
      841 tgcagaattt ggcgctgggc cccggagctc cctcagctcc aggccagtgt cgtgttgact
      901 ttcctttcaa tttctggaac ccaactgcca ttaccaccct ccagagacct cttactagag
      961 gagaagccaa attaactcta taaatctgcc atgtagctat taaataaaac ccattcacga
     1021 ggcgagaaga acaccacccc agcactccct ctgacagggc tggggtagga gtgccaatgc
     1081 ttctctaacc cctgaggcat ctgtgcaccc tctaggatgg aggtcaggaa acaggtgggg
     1141 gccttacatg cctttcatgg tttgtcttga gtttattttc ttaaacctta gggtctttca
     1201 agccagacct ggagctcaag attcttctgg aggaaggtga gacacagccc tatgccacct
     1261 tgagctccag gctagaaagg gacagcccct agccctggct tctgcaactg tgtggtcttg
     1321 aacctccgta tagtccgaat ccctctggct ctcctcaaaa tataaaacaa gcctccttcc
     1381 aatagcatat tggtgcacac ccctaatccc agcacctggg aggaggaggc ggcaggagca
     1441 tcaggagttc aaggccagct cctgccccct agcagggatg gtaggctgca tgagagtgtg
     1501 tctcagaaag aaccacctgg tgcgggtaca gggatgctgg gattctgaga tgtcactcag
     1561 tgcgggaaaa gattcaagga ggggaacaga tcaatggcag aatgactgtc tgtgccgagt
     1621 taagggcact gaaaatctca gctcatctat cgctttatag aagatagagc tttgggagga
     1681 agcaaggcac tctacagtaa aggagtggcc tttccaagga agggtctagg ctccttcttc
     1741 tccagaacat gcacaggaca taggagatcc atatttagag acctttcgtg ttcgaacgtt
     1801 ttct
//
