LOCUS       NM_001393690            3677 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus phospholipase A2 group IVC (Pla2g4c), mRNA.
ACCESSION   NM_001393690
VERSION     NM_001393690.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3677)
  AUTHORS   Nanashima,N., Yamada,T., Shimizu,T. and Tsuchida,S.
  TITLE     Deletion of phospholipase A2 group IVc induces apoptosis in rat
            mammary tumour cells by the nuclear factor-kappaB/lipocalin 2
            pathway
  JOURNAL   Biochem J 469 (2), 315-324 (2015)
   PUBMED   26013918
  REMARK    GeneRIF: This is the first report on Pla2g4c gene-deficient rats
            and their low susceptibility to mammary carcinogenesis by enhancing
            NF-kappaB/Lcn2-induced apoptosis.
REFERENCE   2  (bases 1 to 3677)
  AUTHORS   Vitale,A., Perlin,J., Leonelli,L., Herr,J., Wright,P., Digilio,L.
            and Coonrod,S.
  TITLE     Mouse cPLA2gamma, a novel oocyte and early embryo-abundant
            phospholipase A2 gamma-like protein, is targeted to the nuclear
            envelope during germinal vesicle breakdown
  JOURNAL   Dev Biol 282 (2), 374-384 (2005)
   PUBMED   15950603
REFERENCE   3  (bases 1 to 3677)
  AUTHORS   Shinzawa,K. and Tsujimoto,Y.
  TITLE     PLA2 activity is required for nuclear shrinkage in
            caspase-independent cell death
  JOURNAL   J Cell Biol 163 (6), 1219-1230 (2003)
   PUBMED   14676306
REFERENCE   4  (bases 1 to 3677)
  AUTHORS   Pickard,R.T., Strifler,B.A., Kramer,R.M. and Sharp,J.D.
  TITLE     Molecular cloning of two new human paralogs of 85-kDa cytosolic
            phospholipase A2
  JOURNAL   J Biol Chem 274 (13), 8823-8831 (1999)
   PUBMED   10085124
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN06680412, SAMN06680422
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               JAXUCZ010000001.1  83315017-83315123
            108-256             JAXUCZ010000001.1  83316093-83316241
            257-368             JAXUCZ010000001.1  83326990-83327101
            369-505             JAXUCZ010000001.1  83327313-83327449
            506-695             JAXUCZ010000001.1  83332331-83332520
            696-816             JAXUCZ010000001.1  83336128-83336248
            817-957             JAXUCZ010000001.1  83337667-83337807
            958-1011            JAXUCZ010000001.1  83338669-83338722
            1012-1065           JAXUCZ010000001.1  83399915-83399968
            1066-1215           JAXUCZ010000001.1  83400852-83401001
            1216-1371           JAXUCZ010000001.1  83401383-83401538
            1372-1467           JAXUCZ010000001.1  83401905-83402000
            1468-1622           JAXUCZ010000001.1  83403090-83403244
            1623-1794           JAXUCZ010000001.1  83405259-83405430
            1795-1945           JAXUCZ010000001.1  83407568-83407718
            1946-2042           JAXUCZ010000001.1  83408374-83408470
            2043-3677           JAXUCZ010000001.1  83409708-83411342
FEATURES             Location/Qualifiers
     source          1..3677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3677
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /note="phospholipase A2 group IVC"
                     /db_xref="GeneID:691810"
                     /db_xref="RGD:1594658"
     exon            1..107
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            108..256
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2033
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2, group IVC-like 1; phospholipase
                     A2, group IVC (cytosolic, calcium-independent);
                     phospholipase A2, group IVC-like 2"
                     /codon_start=1
                     /product="cytosolic phospholipase A2 gamma"
                     /protein_id="NP_001380619.1"
                     /db_xref="GeneID:691810"
                     /db_xref="RGD:1594658"
                     /translation="MSCAESPKSQHKRSGVYFATGLQEEERRAVHKRSFKVLEGLKKL
                     NIQADQAPVIAVLGSGGGLRAHIACLGVLSAMKELGLLDAVTYLAGVSGSTWALSSFY
                     TKNGNMQGIEEELKHRYEKNEWHFDESLDKAIQASRRENYSLTDFWAYLVVSRQTREL
                     HDSNLSSFKKQVEEGVLPYPIFAAIDDDLQDDWREKKVQNSWFEFTPHHAGYPALRAY
                     VPITEFGSRFENGKLVRPEPERDLTFLRGLWGSALADIKEDKAFIRDYFKDMHEKLKK
                     KYLHRGGAKTVTYSNAEQMDVDEMFLDLLMAYAIDQDDPSIKDKLCVMQQALGPETGE
                     FGKEMAEIIQNWNEISPEKKEQFLDYLLDYLKKPQEPITYSLRSIGNWIGDLFYDALT
                     FVRKTGMCLWEWQWGTVYNFLYKHGNIADETMCNREFLHLVDAGLAINTPYPLILTPV
                     REAHLILSFDFSAGDPFETIRVTADYCHQHKIPFPEVSEDQLKELAKSPKSCYILRGE
                     TGPVVMHFPLFNKDNCGDDIETWRKKYKTMKLSDSYTPSMVTDLLRVSKENVQKNKEK
                     IVNEMREVTGKHGNFLRVNKSAYFGDRVQDIQQHRHDL"
     exon            257..368
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..505
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..695
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..816
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..957
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1011
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1065
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1215
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1371
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1467
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1622
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1794
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1945
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2042
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..3677
                     /gene="Pla2g4c"
                     /gene_synonym="Pla2g4cl1; Pla2g4cl2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgccacttt gaagcaaccc atgatctagt ccctcaggat atattgctgg ttgccatttt
       61 tccctatcta tctttcctct acaggaggcc tgctgggcat catcaagaaa ccacagctag
      121 agccaacatt gacatctgaa ccccactctc tcaccacaaa gcggtgcgtg attgtaccac
      181 aggtgaaagc aacactgaaa gtggtagaag tcaggaagat gagctgtgca gagtctccta
      241 agtcacaaca taagcgctct ggggtttact ttgccactgg actccaggaa gaagaaaggc
      301 gtgctgtgca caaacgcagt ttcaaggtgt tggagggtct aaaaaagctg aacatccaag
      361 cagaccaggc tccagtcatt gctgtcctgg gctctggtgg ggggcttcga gcccatatcg
      421 cttgtcttgg ggtgctgagt gctatgaaag aacttggcct gttggatgct gtcacatacc
      481 tcgcaggggt ttctggatcc acttgggcac tgtcttcatt ctataccaag aatggaaata
      541 tgcaagggat agaagaggag ctgaaacatc ggtatgagaa gaatgagtgg cactttgatg
      601 agagcctgga caaagccatc caggcatcaa ggagggagaa ttattccctg actgactttt
      661 gggcctattt ggttgtttca aggcaaacca gagagcttca tgattcaaat ttgtccagct
      721 tcaagaagca agtggaagaa ggagtgttgc cctatcccat ctttgcagcc attgatgatg
      781 accttcagga tgattggagg gagaaaaaag ttcaaaattc ctggtttgaa ttcactcctc
      841 atcatgctgg atatcctgca cttagggctt atgtcccaat cacagagttt ggaagcagat
      901 ttgaaaatgg aaaactggtt agacctgagc ctgagagaga cctgactttc ctgagaggtt
      961 tatggggaag tgcccttgct gatattaaag aagataaggc atttattagg gactatttca
     1021 aggacatgca tgaaaaactg aagaaaaaat acctgcatag aggaggggct aaaacagtga
     1081 catactcaaa tgcagaacaa atggatgtgg atgaaatgtt cttggattta ctgatggctt
     1141 atgccataga tcaggatgac cctagcatca aggataagct ctgtgtcatg cagcaggccc
     1201 tgggtcctga gacaggtgag tttggcaaag agatggctga gatcatccag aattggaatg
     1261 agatttcccc agagaagaag gagcaatttc tggactatct gttggattac ttgaagaagc
     1321 cacaagagcc catcacatac agcttgagga gtatcgggaa ctggattggg gatttattct
     1381 atgatgctct aacttttgtg agaaaaactg gaatgtgcct ttgggagtgg cagtggggaa
     1441 cagtttacaa cttcctttat aaacacggta atattgcaga tgagaccatg tgcaaccggg
     1501 agtttctcca tctggtggac gctggtcttg ccatcaacac tccgtaccca cttattctga
     1561 ctcctgtgcg tgaagctcat ctcatcctct catttgactt cagtgctgga gacccatttg
     1621 agaccatcag ggtcacagca gactactgtc accagcataa aatccctttt cctgaagtga
     1681 gtgaagatca gctgaaggag ttggccaaat ccccgaagag ctgctacatc ctcagagggg
     1741 aaacaggacc tgttgtcatg cactttcctc tcttcaacaa agacaactgt ggagatgaca
     1801 ttgagacttg gagaaaaaaa tataagacaa tgaaactatc tgattcatac actccgagca
     1861 tggtgacaga tttgctgagg gtatctaagg agaatgtgca gaaaaacaaa gaaaaaattg
     1921 tcaatgaaat gagggaagtc actgggaaac atgggaactt cctaagggtg aacaagtcag
     1981 cctacttcgg agacagagta caggatattc aacaacacag acatgacctt taaggatcct
     2041 ttgcactact tgcagagaac caccccctgt gctctctcca aaatccacca ttagctgtct
     2101 ctctgtgaag aagtactgta gcttccaggg cactgtgtgt actgttttac aagggcccaa
     2161 gtgtccacct ggcttgatgt tctctgttcc cttcaactat gccactgata aaattgcatt
     2221 ttctttagcg attataactg aaccaatgtc cagagacctg cagagaaagt ctttgacaac
     2281 atcattcagg acaatgagtt accagagcta aaggtggcaa agtgttttgt tcataagcca
     2341 cagggtaccc taatgctaga acacaactca gtgatcacca aagtcaacca tgtggctaaa
     2401 atgaatgtac tgattgaaac caaaacatct taaatttgtc tctcattcta tatcaactca
     2461 ttttataccc caagtcttaa ccagttttgt gctgttaatg gagagccctt agcataaatt
     2521 atggcccgtc tattcagggc aataaaaaaa tccaaataac tccgagaagg cttgttctgt
     2581 aagtgcttgc ttccttacca acagattgat gatgcaatta ttagttcttc accatctcct
     2641 gtatcctctg tcaccttgat gcatccttta tttctctgct tcccaccatg ctgttgtggc
     2701 ttgtgttctc tctcaagatc ttcccttcaa tgtatttcag gtagctattc accttgcctg
     2761 tctcatctgc tgcctcagtg ccttcttcct gctagtctgc cttgttccct ttccatcctt
     2821 tcatctgtat ctcaatggtc agtcttaaag gatcttttct gatttgggtc tcacttccac
     2881 aatctaagaa cacagtaaag ttccctcatt caagttcctc actttattca tctgtagaat
     2941 aggtttgcat tgggcctatg ctctggtccc aagaccttag tcctgctctg gtgcagagaa
     3001 agttttcaag aggcattact aatttttccc caagcaaatg caggtttatt tttgttaaaa
     3061 catactgttt ttagatgact ttccagataa ggatgtttat catggcattt tatacacata
     3121 gataattgat ctttgtttat atttgtttcc attacctcct tttggccttc tttctttccc
     3181 ctgtgggtct tcttcctcct ttcaaataat ctcctcttcc tcttgtttgt gtgcacagat
     3241 tgatatttgt gcacaaatac aaattaaata ttcatctttt tcatctccca atgtccttct
     3301 tgttctccaa ctctttggac ctctttacct ccaagaaatt accctttttg tagtttcatg
     3361 acaggtacaa tacattaagg tggatatgag aaagacagat aaataggtaa caaagagatg
     3421 gtagatacaa tgtaatcaga gaagatagat aataataaat tgatcataga tataatgtcg
     3481 atagataaga tgaacaatga ataaatgaca gaaaaaagat attgtgaaga tagatacctg
     3541 ctacacttat gaaacaaaca tgatacttgg tttttggggt tggtttattt tgtttaacat
     3601 gatgtgatcc aggtctatcc atttttctac agtgtaattt tacttttctt gatgactcaa
     3661 taaacattaa agactgc
//
