LOCUS       NM_133551               2855 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus phospholipase A2 group 4A (Pla2g4a), mRNA.
ACCESSION   NM_133551
VERSION     NM_133551.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Yao,H.H., Min,Y.J., Hong,D.Y., Wang,L., Lu,X.Y. and Yang,Y.H.
  TITLE     [Electroacupuncture improves limb motor function by down-regulating
            cytosolic phospholi-pase A2 and reducing apoptosis of nerve cells
            in rats with spinal cord injury]
  JOURNAL   Zhen Ci Yan Jiu 48 (8), 782-790 (2023)
   PUBMED   37614136
  REMARK    GeneRIF: [Electroacupuncture improves limb motor function by
            down-regulating cytosolic phospholi-pase A2 and reducing apoptosis
            of nerve cells in rats with spinal cord injury].
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Bera,A., Srivastava,A., Dubey,V., Dixit,A.B., Tripathi,M.,
            Sharma,M.C., Lalwani,S., Chandra,P.S. and Banerjee,J.
  TITLE     Altered hippocampal expression and function of cytosolic
            phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE)
  JOURNAL   Neurol Res 44 (8), 748-753 (2022)
   PUBMED   35285418
  REMARK    GeneRIF: Altered hippocampal expression and function of cytosolic
            phospholipase A2 (cPLA2) in temporal lobe epilepsy (TLE).
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Santerre-Anderson,J.L. and Werner,D.F.
  TITLE     Ethanol Stimulation of Microglia Release Increases ERK1/2-Dependent
            Neuronal cPLA2 Activity in Immature Cultured Cortical Preparations
  JOURNAL   Neurochem Res 45 (7), 1592-1601 (2020)
   PUBMED   32274627
  REMARK    GeneRIF: Ethanol Stimulation of Microglia Release Increases
            ERK1/2-Dependent Neuronal cPLA2 Activity in Immature Cultured
            Cortical Preparations.
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Rajagopal,S., Fitzgerald,A.A., Deep,S.N., Paul,S. and Poddar,R.
  TITLE     Role of GluN2A NMDA receptor in homocysteine-induced prostaglandin
            E2 release from neurons
  JOURNAL   J Neurochem 150 (1), 44-55 (2019)
   PUBMED   31125437
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Villamil-Ortiz,J.G. and Cardona-Gomez,G.P.
  TITLE     cPLA2 and desaturases underlie the tau hyperphosphorylation offset
            induced by BACE knock-down in neuronal primary cultures
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (11), 3696-3707 (2018)
   PUBMED   30251689
  REMARK    GeneRIF: Study utilizing glutamate excitotoxicity model in rat
            cortical primary cell cultures suggests for the first time a more
            direct action of BACE1 on the hyperphosphorylation state of tau
            (implemented in Alzheimer's disease pathogenesis) that is mediated
            through cPLA2 and desaturases SCD1 and FADS6 modulation during
            glutamate excitotoxicity.
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Xia,P., Kramer,R.M. and King,G.L.
  TITLE     Identification of the mechanism for the inhibition of
            Na+,K(+)-adenosine triphosphatase by hyperglycemia involving
            activation of protein kinase C and cytosolic phospholipase A2
  JOURNAL   J Clin Invest 96 (2), 733-740 (1995)
   PUBMED   7635966
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Hanel,A.M. and Gelb,M.H.
  TITLE     Multiple enzymatic activities of the human cytosolic 85-kDa
            phospholipase A2: hydrolytic reactions and acyl transfer to
            glycerol
  JOURNAL   Biochemistry 34 (24), 7807-7818 (1995)
   PUBMED   7794891
REFERENCE   8  (bases 1 to 2855)
  AUTHORS   Owada,Y., Tominaga,T., Yoshimoto,T. and Kondo,H.
  TITLE     Molecular cloning of rat cDNA for cytosolic phospholipase A2 and
            the increased gene expression in the dentate gyrus following
            transient forebrain ischemia
  JOURNAL   Brain Res Mol Brain Res 25 (3-4), 364-368 (1994)
   PUBMED   7808237
  REMARK    Erratum:[Brain Res Mol Brain Res. 1994 Dec;27(2):355. doi:
            10.1016/0169-328x(94)90023-x.. PMID: 7898324]
REFERENCE   9  (bases 1 to 2855)
  AUTHORS   Kitayama,S., Shimada,S. and Uhl,G.R.
  TITLE     Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in
            nonneuronal COS cells expressing dopamine transporter cDNA
  JOURNAL   Ann Neurol 32 (1), 109-111 (1992)
   PUBMED   1642464
REFERENCE   10 (bases 1 to 2855)
  AUTHORS   Tovey,J.A., Sundar,A.S., Ikram,S., Smith,S. and Penny,W.J.
  TITLE     Human cardiac muscle magnesium and potassium concentrations: can
            skeletal muscle, mononuclear blood cells, erythrocyte and plasma
            concentrations provide a surrogate measure?
  JOURNAL   Ann Clin Biochem 29 (Pt 4), 461-462 (1992)
   PUBMED   1642455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070940.1.
            
            On Mar 8, 2007 this sequence version replaced NM_133551.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070940.1, U38376.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2855              BC070940.1         1-2855
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q21"
     gene            1..2855
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /note="phospholipase A2 group 4A"
                     /db_xref="GeneID:24653"
                     /db_xref="RGD:67366"
     exon            1..105
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            106..204
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2430
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2 cytosolic; phospholipase A2, group
                     IVA (cytosolic, calcium-dependent); cytosolic
                     phospholipase A2-like; phospholipase A2 group IVA"
                     /codon_start=1
                     /product="cytosolic phospholipase A2"
                     /protein_id="NP_598235.2"
                     /db_xref="GeneID:24653"
                     /db_xref="RGD:67366"
                     /translation="MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDP
                     YVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETL
                     GTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQ
                     RKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGIL
                     DCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYV
                     ESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSTTLSSLKEKVSAARCPLPLFTCLHV
                     KPDVSELMFADWVEFSPYEIGMAKYGTFMTPDLFGSKFFMGTVVKKYEENPLHFLMGV
                     WGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENE
                     DAEREYQNDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLR
                     DFSPQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQR
                     GVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFK
                     PKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFN
                     FQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFN
                     KEFLSKPTAESI"
     exon            205..286
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            287..435
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            436..549
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..587
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            588..729
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            730..866
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1089
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1204
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1342
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1435
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1507
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1750
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1935
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2131
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2289
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2833
                     /gene="Pla2g4a"
                     /gene_synonym="cPLA2; Pla2c; Pla2g4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttctcaaa gtcggaactg tgaagggctc ccatcagggc tcccgactga cagagagcta
       61 gaaggcacag agaaacctga ggattctcat ttaactctgg gaactgcttc aagaagctat
      121 agtaccagag aacacctggg aagtgtgaga attcctgcag ctgggaccaa aatgtctttc
      181 atagatcctt atcagcacat aatagtggaa caccagtatt cccataagtt tacagtagtg
      241 gttctacgtg ccaccaaagt aaccaagggg acctttggcg atatgctgga cactcctgat
      301 ccttatgtgg aacttttcat ctctacaacc cctgacagca ggaagcgaac aagacacttc
      361 aataatgata taaaccctgt gtggaatgag acctttgagt tcattttgga tcctaatcag
      421 gaaaatgttt tggagatcac attgatggat gccaattacg tcatggatga aaccctaggc
      481 acagctacat ttcctgtatc ttctatgaag gtgggagaga agaaagaagt cccttttatt
      541 ttcaaccaag tcacagaaat gattctggaa atgtctcttg aagtttgctc atgcccagac
      601 ctacggttca gcatggcact gtgtgatcag gagaaaacat tcaggcagca gaggaaagag
      661 aacataaaag agaacatgaa gaaacttttg ggtccaaaaa agagcgaggg gctttattcc
      721 acacgtgatg tgcctgtggt ggccattttg ggttccggcg ggggtttccg ggccatggtg
      781 ggattctccg gtgtgatgaa ggcgctctat gaatcaggga ttttggattg tgcgacctac
      841 gttgctggtc tgtccggctc cacatggtac atgtcaacct tgtactccca ccctgatttt
      901 ccagagaaag gtcctgagga gattaatgaa gagctaatga aaaatgttag ccacaaccct
      961 ctcttacttc ttacgccaca gaaagttaaa agatatgttg agtctttatg gaagaagaaa
     1021 agttctggcc aacctgtcac ctttactgac atctttggaa tgttaatagg agaaacacta
     1081 attcaaaata gaatgagtac gaccttgagt agcttgaagg aaaaggtcag cgccgcccgg
     1141 tgtcctctgc ctctcttcac ctgtctccat gtcaaaccgg acgtgtcaga gctgatgttt
     1201 gccgattggg tagaatttag tccatacgaa attggcatgg caaaatatgg tacctttatg
     1261 actcctgacc tgtttggaag caaatttttt atgggaacag ttgtaaaaaa atatgaagaa
     1321 aaccccttgc atttcttaat gggtgtctgg ggcagtgcct tttctatact gttcaacaga
     1381 gttttgggag tttctggctc acagaataaa ggttctacaa tggaggagga attagaaaat
     1441 attacagcaa agcacattgt gagtaacgac agctctgaca gcgatgacga ggcccaagga
     1501 cccaaaggca ccgagaatga agatgcggaa agagagtacc aaaatgacaa ccaagcaagt
     1561 tgggtccatc ggatgctaat ggccttggtg agtgactcag ctttattcaa tacccgagaa
     1621 ggacgtgctg ggaaggtgca taacttcatg ttgggcttga atctcaacac atcgtatcca
     1681 ctgtctcccc tgagagactt cagcccccaa gattccttcg atgatgatga actcgacgca
     1741 gcggtagcag atccagatga atttgaacga atatatgaac cactggatgt caaaagtaaa
     1801 aagattcatg ttgtagacag tgggctcacg tttaacctgc cgtatccctt gattctgcga
     1861 cctcagagag gtgtggatct catcatttcc tttgactttt ctgcaaggcc aagtgacacc
     1921 agccctccat tcaaggaact tctgcttgca gagaagtggg ctaaaatgaa caagctccct
     1981 tttccaaaga ttgatcctta cgtgtttgat cgggaaggat tgaaggaatg ctatgtgttt
     2041 aaacctaaga atcctgatgt ggagaaggat tgcccaacca ttatccactt tgttctggcc
     2101 aacatcaact tcagaaagta caaggcccca ggtgttctga gggaaaccaa ggaagagaaa
     2161 gaaatagctg actttgacat tttcgatgac cccgaatcgc cattttcaac cttcaacttc
     2221 cagtatccaa atcaagcatt caaaaggcta catgatctga tgtacttcaa cacactgaac
     2281 aacattgatg tgataaagga tgccattgtt gagagcattg aatacagaag acagaaccca
     2341 tctcgttgct ctgtttccct cagtaatgtt gaggcaagaa aattcttcaa caaggagttc
     2401 ctaagtaaac ccacagcaga gtccatttga attccatgac tactggagtt cagagcacat
     2461 gagagatcat cttactatgc acaagagact gactgctact cagagttgtg gggacggagg
     2521 cgtgtgttag gtgaaaatgg tgttgattat gcaatacttg gcaacagttt ctgacagtat
     2581 gaattttttg acataagcat agggctatat actgtatttt aaacattcct cacattttta
     2641 cctgagcatt tttatatata tataaaaata tcctttcctt ttataaatat ttaatagttt
     2701 aactcagtaa aaaaaagctt cccattgtgt gtgaatgtta ttctgaacta gatttgttca
     2761 tgccatgtta caacactatt tttatttaaa tgttcatatc tacacatgcg aaataaatac
     2821 tttgatatac aaaaaaaaaa aaaaaaaaaa aaaaa
//
