LOCUS       NM_001106015            2526 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Rattus norvegicus phospholipase A2, group III (Pla2g3), mRNA.
ACCESSION   NM_001106015 XM_001066611 XM_223553
VERSION     NM_001106015.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Feng,H.N., Zhong,L.Q., Xu,C.X., Wang,T.T., Wu,H., Wang,L.,
            Traub,R.J., Chen,X. and Cao,D.Y.
  TITLE     Up-regulation of IL-1beta and sPLA2-III in the medial prefrontal
            cortex contributes to orofacial and somatic hyperalgesia induced by
            malocclusion via glial-neuron crosstalk
  JOURNAL   Eur J Pharmacol 982, 176933 (2024)
   PUBMED   39182540
  REMARK    GeneRIF: Up-regulation of IL-1beta and sPLA2-III in the medial
            prefrontal cortex contributes to orofacial and somatic hyperalgesia
            induced by malocclusion via glial-neuron crosstalk.
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Yui,D., Nishida,Y., Nishina,T., Mogushi,K., Tajiri,M.,
            Ishibashi,S., Ajioka,I., Ishikawa,K., Mizusawa,H., Murayama,S. and
            Yokota,T.
  TITLE     Enhanced Phospholipase A2 Group 3 Expression by Oxidative Stress
            Decreases the Insulin-Degrading Enzyme
  JOURNAL   PLoS One 10 (12), e0143518 (2015)
   PUBMED   26637123
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2526)
  AUTHORS   Taketomi,Y., Ueno,N., Kojima,T., Sato,H., Murase,R., Yamamoto,K.,
            Tanaka,S., Sakanaka,M., Nakamura,M., Nishito,Y., Kawana,M.,
            Kambe,N., Ikeda,K., Taguchi,R., Nakamizo,S., Kabashima,K.,
            Gelb,M.H., Arita,M., Yokomizo,T., Nakamura,M., Watanabe,K.,
            Hirai,H., Nakamura,M., Okayama,Y., Ra,C., Aritake,K., Urade,Y.,
            Morimoto,K., Sugimoto,Y., Shimizu,T., Narumiya,S., Hara,S. and
            Murakami,M.
  TITLE     Mast cell maturation is driven via a group III phospholipase
            A2-prostaglandin D2-DP1 receptor paracrine axis
  JOURNAL   Nat Immunol 14 (6), 554-563 (2013)
   PUBMED   23624557
REFERENCE   4  (bases 1 to 2526)
  AUTHORS   Yang,H., Siddiqi,N.J., Alhomida,A.S. and Ong,W.Y.
  TITLE     Expression and localization of sPLA2-III in the rat CNS
  JOURNAL   Neurochem Res 38 (4), 753-760 (2013)
   PUBMED   23371482
  REMARK    GeneRIF: The localization of mature/cleaved form of sPLA(2)-III in
            postsynaptic structures suggest a physiological role of the enzyme
            in neurotransmission or synaptic plasticity.
REFERENCE   5  (bases 1 to 2526)
  AUTHORS   Sato,H., Taketomi,Y., Isogai,Y., Miki,Y., Yamamoto,K., Masuda,S.,
            Hosono,T., Arata,S., Ishikawa,Y., Ishii,T., Kobayashi,T.,
            Nakanishi,H., Ikeda,K., Taguchi,R., Hara,S., Kudo,I. and
            Murakami,M.
  TITLE     Group III secreted phospholipase A2 regulates epididymal sperm
            maturation and fertility in mice
  JOURNAL   J Clin Invest 120 (5), 1400-1414 (2010)
   PUBMED   20424323
REFERENCE   6  (bases 1 to 2526)
  AUTHORS   Kim,J., Lee,J.E., Heynen-Genel,S., Suyama,E., Ono,K., Lee,K.,
            Ideker,T., Aza-Blanc,P. and Gleeson,J.G.
  TITLE     Functional genomic screen for modulators of ciliogenesis and cilium
            length
  JOURNAL   Nature 464 (7291), 1048-1051 (2010)
   PUBMED   20393563
REFERENCE   7  (bases 1 to 2526)
  AUTHORS   DeCoster,M.A.
  TITLE     Group III secreted phospholipase A2 causes apoptosis in rat primary
            cortical neuronal cultures
  JOURNAL   Brain Res 988 (1-2), 20-28 (2003)
   PUBMED   14519523
  REMARK    GeneRIF: Group III secreted phospholipase A2 causes apoptosis in
            rat primary cortical neuronal cultures, but not in cortical
            astrocytes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473963.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_223553.4, XM_001066611.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN14984024 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2526
                     /gene="Pla2g3"
                     /note="phospholipase A2, group III"
                     /db_xref="GeneID:289733"
                     /db_xref="RGD:1305323"
     exon            1..568
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1575
                     /gene="Pla2g3"
                     /EC_number="3.1.1.4"
                     /note="group 3 secretory phospholipase A2"
                     /codon_start=1
                     /product="group 3 secretory phospholipase A2 precursor"
                     /protein_id="NP_001099485.1"
                     /db_xref="GeneID:289733"
                     /db_xref="RGD:1305323"
                     /translation="MGVLGILLGVLAFLGVVPEGSHTLHWDSTSCHLVRSISGSPLGS
                     LSFLGEDAQGLALFQALWDAHHRLQVCIRQDESELIAAFRALCAHEPLRHAFIHTPGP
                     ELQRALATLQSQWEACRRSEASPTGAREKRETEHRGAPAGEHQRRRRGWTIPGTLWCG
                     VGNSAENASELGMFHGPDFCCREHDQCPQTISPLQYNYGIRNFRFHTISHCDCDARFQ
                     QCLRSQGDSIADIMGVAFFNVLEIPCFVLKEQETCVAWHWWGGCRTYGSLPLAHLQPR
                     TYYNASWKAEATPLTPSPQSPAPSWKRGPQQTPARHHSTTTVTPLQTPAISSRPDMMI
                     PRGQPGVSHPGLQDGPKRQGAHRVCRSLRHLDQCEHQIKPQETKFHLLNSAQTPLFHC
                     NCTRRLARFLRHHSLPANTNKVWELLGTTCFKLAPQLNCPEGKGCSRDHRAIKVSARH
                     LQRLHQNGLHFWDKGTGEVLAQPLEPPGTLMSFYSQCLQLTQAIWRPGGQKKFWSS"
     exon            569..701
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
     exon            702..836
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1114
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1244
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1361
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2526
                     /gene="Pla2g3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccaaaggc aggcatccag ggggctttgt ctgaccaggc tgggctagga tagaatgggg
       61 gtcctgggga tacttctggg ggtgctggct ttcctggggg ttgttccaga aggctcccat
      121 accctccatt gggacagtac ctcctgccat ttggtccggt ccatctctgg tagccctctg
      181 ggctccctga gcttcttggg cgaagatgcc caaggcctgg cattattcca ggccctctgg
      241 gatgcgcacc acaggctgca ggtttgtatc aggcaggatg aatccgagct catcgcagcc
      301 ttcagggctc tctgtgctca tgagcccttg cggcacgcct tcatccacac ccctggacca
      361 gagctgcaga gagcactggc cactctgcag agccagtggg aggcctgccg aaggtctgag
      421 gctagtccca cgggagccag ggagaagcga gaaacagagc accgcggagc acctgccgga
      481 gagcaccaac gaaggagaag aggctggacc attcctggca cgctgtggtg cggtgttggg
      541 aactctgctg agaatgcctc agaactgggt atgttccacg gccctgattt ctgctgccgg
      601 gagcacgacc agtgcccaca aaccatctca cccttgcagt ataattacgg catccgaaac
      661 ttccgattcc acaccatctc tcactgcgac tgtgatgcca ggtttcaaca gtgcctgagg
      721 agccagggtg actccatcgc ggacatcatg ggcgtggctt tcttcaacgt gctggagatc
      781 ccctgctttg tgctgaagga gcaggagacc tgtgtggctt ggcactggtg gggcgggtgc
      841 aggacatatg gctccttacc ccttgctcac ctgcagccca ggacttacta caacgcctcc
      901 tggaaggctg aagccacccc acttactccc agcccccaaa gcccagcacc cagctggaag
      961 aggggcccac agcagacacc agccagacac cacagcacaa ccaccgtcac tcccctccag
     1021 acccctgcca tctcctccag acctgatatg atgatcccga gaggccagcc aggagtctcc
     1081 catcccggcc tccaggatgg cccaaaacgt caaggtgccc accgtgtctg tcgaagcctt
     1141 cgccacctgg atcagtgcga gcaccagatc aagccccagg aaaccaagtt ccacctgctc
     1201 aacagcgccc agacgcccct tttccattgc aattgcaccc gccgtctggc acgtttcctg
     1261 aggcaccaca gcctgcctgc aaacaccaac aaggtttggg agctcctggg tactacctgc
     1321 ttcaagctgg ccccacaact caactgtcct gagggcaaag gctgttccag agaccatagg
     1381 gccatcaagg tgtcagctcg gcatttgcag aggcttcatc agaatggact ccatttctgg
     1441 gataaaggca ccggggaggt tctggcacag cctttggagc ccccggggac cctcatgtca
     1501 ttctacagcc aatgtctgca actaacccag gcaatctgga gacccggggg acagaagaaa
     1561 ttctggagct catgacctca gtttcaccag cctggacctc cttcctgctg ttgctatgtc
     1621 ctgagagact tggtctgttc ttcgaggaac agcatggctc tcatagatta caggaggctt
     1681 ggtggaagga agcttaacgt ccgaatgttg gaccacatct cctgctgtac tgggtgacct
     1741 tgaactggtg acacaacccc tctgtgtctg gatgtgctgt tcagagtcta ttctgatgcc
     1801 ttgggcttag accttgtcag gtaacttcag acacagatag aatgggggga gtggctgatt
     1861 gcaggagtcc aggaggtacc agaagcaggt acctgggtgt ctctgtcact agacctgcct
     1921 ctctgagtcc agcatttgac agtgaggcct aaagctgcag gtgagaaacc aaggatacaa
     1981 aagaaaggct tgttcttgaa tccagggtgt gcagcgcgtt cccacattct cccccttctt
     2041 ttaatagttt ctgggtcctt cctggcctga actaatcttt ctgttctaac tctaaattga
     2101 aatcttttcc atgcccatga ggagttaggg caagggacct ccctcctcca cgctgagcct
     2161 tagttccctc ctctgaaaaa gagggtaggg gtgtccttat cgtgtgtctg tctgagtggg
     2221 ggtctcacta tagcccaggc tagcttctgc tatgtatagg aatacagcct tgaacttctg
     2281 gtccactttc ctctacctcc aaagtgctgg aattgcaggc atacaccacc acaccaagtt
     2341 tttaggtgat actggggagg gaaaccggag tgtcaacgct tcaacctgct caaagcatgc
     2401 tcccgactaa attacacccc cagcttgaaa ggggaacttg taaacatgaa ctacctcata
     2461 ggggtgctga ggaataaatg aattaataaa tacgcatacg ctcagtaaac attcttttcc
     2521 tctaac
//
