LOCUS       NM_031598                783 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus phospholipase A2 group IIA (Pla2g2a), mRNA.
ACCESSION   NM_031598
VERSION     NM_031598.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 783)
  AUTHORS   Quindlen-Hotek,J.C., Kartha,S. and Winkelstein,B.A.
  TITLE     Immediate inhibition of spinal secretory phospholipase A2 prevents
            the pain and elevated spinal neuronal hyperexcitability and
            neuroimmune regulatory genes that develop with nerve root
            compression
  JOURNAL   Neuroreport 31 (15), 1084-1089 (2020)
   PUBMED   32881777
  REMARK    GeneRIF: Immediate inhibition of spinal secretory phospholipase A2
            prevents the pain and elevated spinal neuronal hyperexcitability
            and neuroimmune regulatory genes that develop with nerve root
            compression.
REFERENCE   2  (bases 1 to 783)
  AUTHORS   El Hadri,K., Denoyelle,C., Ravaux,L., Viollet,B., Foretz,M.,
            Friguet,B., Rouis,M. and Raymondjean,M.
  TITLE     AMPK Signaling Involvement for the Repression of the
            IL-1beta-Induced Group IIA Secretory Phospholipase A2 Expression in
            VSMCs
  JOURNAL   PLoS One 10 (7), e0132498 (2015)
   PUBMED   26162096
  REMARK    GeneRIF: The present study was designed to determine the
            relationship between phenformin coupling AMP-activated protein
            kinase (AMPK) function and the molecular mechanism by which the
            sPLA2 IIA expression was modulated in vascular smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 783)
  AUTHORS   Boudreau,L.H., Duchez,A.C., Cloutier,N., Soulet,D., Martin,N.,
            Bollinger,J., Pare,A., Rousseau,M., Naika,G.S., Levesque,T.,
            Laflamme,C., Marcoux,G., Lambeau,G., Farndale,R.W., Pouliot,M.,
            Hamzeh-Cognasse,H., Cognasse,F., Garraud,O., Nigrovic,P.A.,
            Guderley,H., Lacroix,S., Thibault,L., Semple,J.W., Gelb,M.H. and
            Boilard,E.
  TITLE     Platelets release mitochondria serving as substrate for
            bactericidal group IIA-secreted phospholipase A2 to promote
            inflammation
  JOURNAL   Blood 124 (14), 2173-2183 (2014)
   PUBMED   25082876
REFERENCE   4  (bases 1 to 783)
  AUTHORS   Sharma,P., Thakran,S., Deng,X., Elam,M.B. and Park,E.A.
  TITLE     Nuclear corepressors mediate the repression of phospholipase A2
            group IIa gene transcription by thyroid hormone
  JOURNAL   J Biol Chem 288 (23), 16321-16333 (2013)
   PUBMED   23629656
  REMARK    GeneRIF: a novel inverse recruitment mechanism in which liganded
            TRbeta recruits corepressors to inhibit PLA2g2a expression.
REFERENCE   5  (bases 1 to 783)
  AUTHORS   Pieragostino,D., Agnifili,L., Fasanella,V., D'Aguanno,S.,
            Mastropasqua,R., Di Ilio,C., Sacchetta,P., Urbani,A. and Del
            Boccio,P.
  TITLE     Shotgun proteomics reveals specific modulated protein patterns in
            tears of patients with primary open angle glaucoma naive to therapy
  JOURNAL   Mol Biosyst 9 (6), 1108-1116 (2013)
   PUBMED   23580065
REFERENCE   6  (bases 1 to 783)
  AUTHORS   Ohara,O., Ishizaki,J., Nakano,T., Arita,H. and Teraoka,H.
  TITLE     A simple and sensitive method for determining transcription
            initiation site: identification of two transcription initiation
            sites in rat group II phospholipase A2 gene
  JOURNAL   Nucleic Acids Res 18 (23), 6997-7002 (1990)
   PUBMED   2263458
REFERENCE   7  (bases 1 to 783)
  AUTHORS   Kusunoki,C., Satoh,S., Kobayashi,M. and Niwa,M.
  TITLE     Structure of genomic DNA for rat platelet phospholipase A2
  JOURNAL   Biochim Biophys Acta 1087 (1), 95-97 (1990)
   PUBMED   2400792
REFERENCE   8  (bases 1 to 783)
  AUTHORS   Komada,M., Kudo,I. and Inoue,K.
  TITLE     Structure of gene coding for rat group II phospholipase A2
  JOURNAL   Biochem Biophys Res Commun 168 (3), 1059-1065 (1990)
   PUBMED   2346480
REFERENCE   9  (bases 1 to 783)
  AUTHORS   Komada,M., Kudo,I., Mizushima,H., Kitamura,N. and Inoue,K.
  TITLE     Structure of cDNA coding for rat platelet phospholipase A2
  JOURNAL   J Biochem 106 (4), 545-547 (1989)
   PUBMED   2606907
REFERENCE   10 (bases 1 to 783)
  AUTHORS   Aarsman,A.J., de Jong,J.G., Arnoldussen,E., Neys,F.W., van
            Wassenaar,P.D. and Van den Bosch,H.
  TITLE     Immunoaffinity purification, partial sequence, and subcellular
            localization of rat liver phospholipase A2
  JOURNAL   J Biol Chem 264 (17), 10008-10014 (1989)
   PUBMED   2722857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M25148.1, X74364.1 and CB772812.1.
            
            On Mar 27, 2010 this sequence version replaced NM_031598.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ227448.1, D00523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               M25148.1           1-309
            310-399             X74364.1           190-279
            400-587             M25148.1           400-587
            588-783             CB772812.1         22-217              c
FEATURES             Location/Qualifiers
     source          1..783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..783
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /note="phospholipase A2 group IIA"
                     /db_xref="GeneID:29692"
                     /db_xref="RGD:620857"
     exon            1..47
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            48..100
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..498
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /EC_number="3.1.1.4"
                     /note="phospholipase A2, membrane associated; platelet
                     phospholipase A2; GIIC sPLA2; group IIA phospholipase A2;
                     phosphatidylcholine 2-acylhydrolase 2A; eted enzyme type
                     IIA phospholipase A2; phospholipase A2, group IIA
                     (platelets, synovial fluid)"
                     /codon_start=1
                     /product="phospholipase A2, membrane associated precursor"
                     /protein_id="NP_113786.3"
                     /db_xref="GeneID:29692"
                     /db_xref="RGD:620857"
                     /translation="MKVLLLLAVVIMAFGSIQVQGSLLEFGQMILFKTGKRADVSYGF
                     YGCHCGVGGRGSPKDATDWCCVTHDCCYNRLEKRGCGTKFLTYKFSYRGGQISCSTNQ
                     DSCRKQLCQCDKAAAECFARNKKSYSLKYQFYPNKFCKGKTPSC"
     exon            101..245
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..355
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..766
                     /gene="Pla2g2a"
                     /gene_synonym="sPLA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggcaggcc cttgaacaag aagccatacc accatcccat ccaagagagc tgacagcatg
       61 aaggtcctcc tgttgctagc agttgtgatc atggcctttg gctcaattca ggtccagggg
      121 agccttctgg agtttgggca aatgattctg tttaagacag gaaagagagc tgatgttagc
      181 tatggcttct acggttgcca ttgtggtgtg ggtggcagag gatcccccaa ggatgccaca
      241 gattggtgct gtgtgactca tgactgttgt tacaaccgtc tggagaaacg tggatgtggc
      301 acaaagtttc tgacctacaa gttctcctac cgagggggcc aaatctcctg ctctacaaac
      361 caggactcct gccggaaaca gctgtgccag tgcgataaag ctgccgctga atgttttgcc
      421 cggaacaaga aaagctacag tttaaagtac cagttctacc ccaacaagtt ttgcaaaggg
      481 aagacgccca gttgctgaaa gagacatctt ctgaaacatc cagacatcct ctaacacctc
      541 tcctagccca accaagttcc ccagtgatca agaaaacacc cctctccaac cctagaagca
      601 ggcgggccct tctgtcttca cccagaagga gccgctgaag cctgatcttt ccccaacact
      661 ccacagcctt ggatccgccc acttttccct tggcatccaa cttcctgctg cgtagtacct
      721 aagagggtcc tgagaggctc tcgcaagtaa agcaattcat caacaaaaaa aaaaaaaaaa
      781 aaa
//
