LOCUS       NM_031585                543 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus phospholipase A2 group IB (Pla2g1b), mRNA.
ACCESSION   NM_031585
VERSION     NM_031585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 543)
  AUTHORS   Pan,Y., Wan,J., Liu,Y., Yang,Q., Liang,W., Singhal,P.C.,
            Saleem,M.A. and Ding,G.
  TITLE     sPLA2 IB induces human podocyte apoptosis via the M-type
            phospholipase A2 receptor
  JOURNAL   Sci Rep 4, 6660 (2014)
   PUBMED   25335547
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 543)
  AUTHORS   Yu,B.Z., Apitz-Castro,R.J., Jain,M.K. and Berg,O.G.
  TITLE     Role of 57-72 loop in the allosteric action of bile salts on
            pancreatic IB phospholipase A(2): regulation of fat and cholesterol
            homeostasis
  JOURNAL   Biochim Biophys Acta 1768 (10), 2478-2490 (2007)
   PUBMED   17603006
REFERENCE   3  (bases 1 to 543)
  AUTHORS   Pan,Y.H. and Bahnson,B.J.
  TITLE     Structural basis for bile salt inhibition of pancreatic
            phospholipase A2
  JOURNAL   J Mol Biol 369 (2), 439-450 (2007)
   PUBMED   17434532
REFERENCE   4  (bases 1 to 543)
  AUTHORS   Kolko,M., Christoffersen,N.R., Varoqui,H. and Bazan,N.G.
  TITLE     Expression and induction of secretory phospholipase A2 group IB in
            brain
  JOURNAL   Cell Mol Neurobiol 25 (7), 1107-1122 (2005)
   PUBMED   16392040
  REMARK    GeneRIF: Here, we report sPLA2-IB in rat and human brain as well as
            in neurons in primary culture. The distribution of sPLA2-IB seems
            to be mainly neuronal, with the highest abundance occurring in the
            cerebral cortex and hippocampus.
REFERENCE   5  (bases 1 to 543)
  AUTHORS   Lee,H.Y., Kim,M.K., Park,K.S., Shin,E.H. and Bae,Y.S.
  TITLE     Group IB secretory phospholipase A2 stimulates leukotriene B4
            production by a unique mechanism in human neutrophils
  JOURNAL   Biochem Biophys Res Commun 334 (2), 500-508 (2005)
   PUBMED   16005851
REFERENCE   6  (bases 1 to 543)
  AUTHORS   Kanda,A., Tamaki,M., Nakamura,E., Teraoka,H. and Yoshida,N.
  TITLE     Characterization of recombinant human and rat pancreatic
            phospholipases A2 secreted from Saccharomyces cerevisiae:
            difference in proteolytic processing
  JOURNAL   Biochim Biophys Acta 1171 (1), 1-10 (1992)
   PUBMED   1420353
REFERENCE   7  (bases 1 to 543)
  AUTHORS   Arita,H., Hanasaki,K., Nakano,T., Oka,S., Teraoka,H. and
            Matsumoto,K.
  TITLE     Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells
            via specific binding site
  JOURNAL   J Biol Chem 266 (29), 19139-19141 (1991)
   PUBMED   1918029
REFERENCE   8  (bases 1 to 543)
  AUTHORS   Sakata,T., Nakamura,E., Tsuruta,Y., Tamaki,M., Teraoka,H., Tojo,H.,
            Ono,T. and Okamoto,M.
  TITLE     Presence of pancreatic-type phospholipase A2 mRNA in rat gastric
            mucosa and lung
  JOURNAL   Biochim Biophys Acta 1007 (1), 124-126 (1989)
   PUBMED   2909239
REFERENCE   9  (bases 1 to 543)
  AUTHORS   Ohara,O., Tamaki,M., Nakamura,E., Tsuruta,Y., Fujii,Y., Shin,M.,
            Teraoka,H. and Okamoto,M.
  TITLE     Dog and rat pancreatic phospholipases A2: complete amino acid
            sequences deduced from complementary DNAs
  JOURNAL   J Biochem 99 (3), 733-739 (1986)
   PUBMED   3754861
REFERENCE   10 (bases 1 to 543)
  AUTHORS   Ono,T., Tojo,H., Inoue,K., Kagamiyama,H., Yamano,T. and Okamoto,M.
  TITLE     Rat pancreatic phospholipase A2: purification, characterization,
            and N-terminal amino acid sequence
  JOURNAL   J Biochem 96 (3), 785-792 (1984)
   PUBMED   6501264
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000012.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031585.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00036.1, CF249475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                JAXUCZ010000012.1  46812608-46812653   c
            47-206              JAXUCZ010000012.1  46806764-46806923   c
            207-334             JAXUCZ010000012.1  46805752-46805879   c
            335-543             JAXUCZ010000012.1  46802939-46803147   c
FEATURES             Location/Qualifiers
     source          1..543
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..543
                     /gene="Pla2g1b"
                     /note="phospholipase A2 group IB"
                     /db_xref="GeneID:29526"
                     /db_xref="RGD:61949"
     exon            1..46
                     /gene="Pla2g1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..453
                     /gene="Pla2g1b"
                     /EC_number="3.1.1.4"
                     /note="group IB phospholipase A2; phosphatidylcholine
                     2-acylhydrolase 1B; phospholipase A2, group 1B;
                     phospholipase A2, group IB, pancreas"
                     /codon_start=1
                     /product="phospholipase A2 precursor"
                     /protein_id="NP_113773.1"
                     /db_xref="GeneID:29526"
                     /db_xref="RGD:61949"
                     /translation="MKLLLLAALLTAGVTAHSISTRAVWQFRNMIKCTIPGSDPLREY
                     NNYGCYCGLGGSGTPVDDLDRCCQTHDHCYNQAKKLESCKFLIDNPYTNTYSYKCSGN
                     VITCSDKNNDCESFICNCDRQAAICFSKVPYNKEYKDLDTKKHC"
     exon            47..206
                     /gene="Pla2g1b"
                     /inference="alignment:Splign:2.1.0"
     exon            207..334
                     /gene="Pla2g1b"
                     /inference="alignment:Splign:2.1.0"
     exon            335..543
                     /gene="Pla2g1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcgccca agatgaaact ccttctgctg gctgctttgc tcacagcagg cgttactgca
       61 cacagcatca gcactcgggc tgtgtggcag ttccgcaata tgatcaagtg caccatcccc
      121 gggagtgatc ccctgaggga gtacaacaac tacggctgct actgtggctt gggcggctca
      181 ggcaccccag tggacgactt agacaggtgc tgccagactc atgaccactg ctacaatcag
      241 gccaagaagc tggaaagctg taaattcctc atcgacaacc cctacaccaa cacgtactca
      301 tacaagtgct ccgggaacgt gatcacctgc agcgacaaaa acaacgactg tgagagcttc
      361 atctgcaact gtgaccggca ggccgccatc tgtttctcca aggtccccta caacaaggaa
      421 tacaaagacc ttgacaccaa gaaacactgt taggctgtca ccccacttcc tgtctatgcc
      481 gtccccgctc cccttgctgt cttatttctg caccgcaccc tctaataaag taccagcaga
      541 aag
//
