LOCUS       NM_001004277            2672 bp    mRNA    linear   ROD 16-JUN-2024
DEFINITION  Rattus norvegicus phospholipase A2, group XV (Pla2g15), mRNA.
ACCESSION   NM_001004277 XM_341681
VERSION     NM_001004277.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Abe,A., Kelly,R. and Shayman,J.A.
  TITLE     The measurement of lysosomal phospholipase A2 activity in plasma
  JOURNAL   J Lipid Res 51 (8), 2464-2470 (2010)
   PUBMED   20410020
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Abe,A., Hiraoka,M. and Shayman,J.A.
  TITLE     The acylation of lipophilic alcohols by lysosomal phospholipase A2
  JOURNAL   J Lipid Res 48 (10), 2255-2263 (2007)
   PUBMED   17626977
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Abe,A., Hiraoka,M. and Shayman,J.A.
  TITLE     Positional specificity of lysosomal phospholipase A2
  JOURNAL   J Lipid Res 47 (10), 2268-2279 (2006)
   PUBMED   16837646
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Hiraoka,M., Abe,A., Lu,Y., Yang,K., Han,X., Gross,R.W. and
            Shayman,J.A.
  TITLE     Lysosomal phospholipase A2 and phospholipidosis
  JOURNAL   Mol Cell Biol 26 (16), 6139-6148 (2006)
   PUBMED   16880524
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Taniyama,Y., Fuse,H., Satomi,T., Tozawa,R., Yasuhara,Y.,
            Shimakawa,K., Shibata,S., Hattori,M., Nakata,M. and Taketomi,S.
  TITLE     Loss of lysophospholipase 3 increases atherosclerosis in
            apolipoprotein E-deficient mice
  JOURNAL   Biochem Biophys Res Commun 330 (1), 104-110 (2005)
   PUBMED   15781238
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Abe,A., Hiraoka,M., Wild,S., Wilcoxen,S.E., Paine,R. 3rd and
            Shayman,J.A.
  TITLE     Lysosomal phospholipase A2 is selectively expressed in alveolar
            macrophages
  JOURNAL   J Biol Chem 279 (41), 42605-42611 (2004)
   PUBMED   15294901
  REMARK    GeneRIF: LPLA2 may be a major enzyme of pulmonary surfactant
            phospholipid degradation by alveolar macrophages
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Hiraoka,M., Abe,A. and Shayman,J.A.
  TITLE     Cloning and characterization of a lysosomal phospholipase A2,
            1-O-acylceramide synthase
  JOURNAL   J Biol Chem 277 (12), 10090-10099 (2002)
   PUBMED   11790796
REFERENCE   10 (bases 1 to 2672)
  AUTHORS   Fisher,A.B. and Dodia,C.
  TITLE     Lysosomal-type PLA2 and turnover of alveolar DPPC
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 280 (4), L748-L754 (2001)
   PUBMED   11238016
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098894.1.
            
            On Jul 31, 2005 this sequence version replaced NM_001004277.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098894.1, AY490816.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132262, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2672
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /note="phospholipase A2, group XV"
                     /db_xref="GeneID:361401"
                     /db_xref="RGD:1302982"
     exon            1..155
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1270
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="lysophospholipase 3; lysosomal phospholipase A and
                     acyltransferase; 1-O-acylceramide synthase; lysosomal
                     phospholipase A2; LCAT-like lysophospholipase; group XV
                     phospholipase A2"
                     /codon_start=1
                     /product="lysosomal phospholipase A and acyltransferase
                     precursor"
                     /protein_id="NP_001004277.1"
                     /db_xref="GeneID:361401"
                     /db_xref="RGD:1302982"
                     /translation="MDRHLCICREIQLRSGLLFPFLLLMMLADLALPAQRHPPVVLVP
                     GDLGNQLEAKLDKPKVVHYLCSKRTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTS
                     RTTQFPDGVDVRVPGFGETFSLEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAP
                     YDWRRAPNENGPYFLALQEMIEEMYQMYGGPVVLVAHSMGNMYMLYFLQRQPQAWKDK
                     YIQAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTW
                     SHEKVFVYTPTANYTLRDYHRFFQDIGFEDGWFMRQDTQGLVEALVPPGVELHCLYGT
                     GVPTPNSFYYENFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHKVSLQELPGSEH
                     IEMLANATTLAYLKRVLLEEP"
     exon            156..312
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            313..431
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..530
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            531..755
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /inference="alignment:Splign:2.1.0"
     exon            756..2647
                     /gene="Pla2g15"
                     /gene_synonym="1-O-acylceramidesynthase; ACS; LLPL; LPLA2;
                     Lypla3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggacctg cggccacagt ctcatgccat ggatcgccat ctctgcattt gtcgcgagat
       61 ccagctccgg agtggcctcc tgttcccttt tcttctacta atgatgctgg cagacctagc
      121 gctcccggcc caacgtcacc ccccggtggt gctggtgcct ggtgatttgg gtaaccagtt
      181 ggaagcaaag ctggataagc caaaggttgt acactacctg tgctccaaga ggacggacag
      241 ttacttcaca ctctggctga atcttgaact gctcctgcca gttatcattg actgctggat
      301 tgacaatatc aggctggttt acaacagaac atctcggact acccagtttc ctgatggtgt
      361 agatgtgcgt gttcctggct ttggggaaac attttctctg gaattcctag acccaagcaa
      421 aaggaacgtg ggttcctatt tctacactat ggtggagagt cttgtgggct ggggctacac
      481 acggggggaa gatgtccgtg gtgctcccta tgattggcgc agagccccaa atgaaaacgg
      541 gccttacttc ttggccctcc aagagatgat cgaggagatg taccagatgt atgggggccc
      601 cgtggtgctg gtcgcccaca gcatgggcaa catgtacatg ctctactttc tgcagcggca
      661 accacaggcc tggaaggaca agtatatcca agccttcgtc tcactgggtg cgccctgggg
      721 gggcgtggcc aagaccctgc gtgtcctggc ctcaggagac aacaaccgta tccctgtcat
      781 tgggccactg aagatccggg aacagcagcg atctgcagtc tccaccagct ggctactgcc
      841 gtacaaccac acgtggtcac atgaaaaggt gtttgtgtac acacccacag ctaactacac
      901 actccgggac tatcaccggt tcttccaaga catcggcttt gaagacggct ggttcatgag
      961 gcaggacaca caagggctgg tggaagccct ggtaccgcct ggtgtagagc tgcactgcct
     1021 gtacgggacc ggtgttccca caccaaactc tttctactac gagaactttc ctgatcgtga
     1081 cccaaaaatc tgctttgggg atggtgacgg cacagtgaac ttggagagtg tcctgcagtg
     1141 ccaagcctgg cagagccgcc aagagcacaa agtgtcattg caggagctgc cagggagcga
     1201 acacattgag atgctggcca atgccactac cttggcttat ctgaaacgtg tgcttctaga
     1261 agaaccttga tttcctgtgc caggcaaggc tgctgcatgg ctggaccacg gagcttctct
     1321 tggcctctct gactctttca tggtctgcaa acctggcaaa gtttgtgacc gtcatccaag
     1381 gtcctaagtc ttaggaggca tctgcctcag gggaaatgct atttctcaac cttcttatgt
     1441 agaatggcaa tgaagaagga agaagaagtg agtgtggact cagaggacat ttgatggaaa
     1501 gaatgctgct actgatgctg aattgtgacc tcacgctggc tctggaggct ggattgtttg
     1561 tccctaactt gggccatgca atcctcttat cttctctggt ctttctactc tagctcactg
     1621 ggccctagcc ttcctgtgag tgagggatgt tagttactga gctgacgtcc tgtcatagaa
     1681 ggttccacag agatcctcgg gtgaccttcc cccatactgg cctcaggttg cctactgcac
     1741 tggccgtagg tggctagagc tgctggcttc cctgtgacct cactggtagg cattctgagt
     1801 gtggggtctt ctggaggcag tcaggtaaac cccctgcagg cagggcagtt ggtcgtgtct
     1861 ccctgattcc ttcgggttgg gttatttaca gtccgttcct acctctcatt tagtggcatc
     1921 ctagctctgg actggacagc agaggacctc tcaattctgg gggccatgtc ctaggattcc
     1981 tgatctccct gcccgtgatg caggttccag tactgaagct ggttctgttg gttctgggac
     2041 tgtagtttaa gaggggcggg gcctaatgtc atgccttctc ttaaggtcct aggaagaaaa
     2101 cgagctcaag ggaataacca tgcttgctta gagcttccca tgagccacct tcttgagaat
     2161 tccaccacca tggtgcgccc tgctctgggg cctttctacc atctacttgg gctgtcacag
     2221 ggttgagagg tggtagagtc cctgcccaac acttgctacc agctgaatgg gttttggttt
     2281 gcggggaaac agtccagaga tttgaaaggg cccccaagag agctaggaac ttagagtccc
     2341 agctaggggc ttttgtttgt ttgtcccagg gatgccacat agtctctgtg acagcaggga
     2401 tggggaatct cggcctgcct tagggacagt ggacctgact ataagcttgg atcagctttt
     2461 aggtcagggt ctcaaaacca cttggaggct ggaccacact gccttcccat accgtttctg
     2521 gcgctggact taccttgtta agcacattcc tatcatctgt ccctcacctg agtggtggga
     2581 cccccactct gggtcctgag caagctgtac ctcgattttg gcaataaaag tattctggat
     2641 gctgtaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
