LOCUS       NM_001395579            1519 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phospholipase A2, group XIIA (Pla2g12a),
            transcript variant 1, mRNA.
ACCESSION   NM_001395579 XM_039102720
VERSION     NM_001395579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1519)
  AUTHORS   Ee,S.M., Lo,Y.L., Shui,G., Wenk,M.R., Shin,E.J., Kim,H.C. and
            Ong,W.Y.
  TITLE     Distribution of secretory phospholipase A2 XIIA in the brain and
            its role in lipid metabolism and cognition
  JOURNAL   Mol Neurobiol 50 (1), 60-75 (2014)
   PUBMED   24464264
  REMARK    GeneRIF: the results show an important role of sPLA(2)-XIIA in
            lipid metabolism, prefrontal cortical function, and cognition.
REFERENCE   2  (bases 1 to 1519)
  AUTHORS   Ho,I.C., Arm,J.P., Bingham,C.O. 3rd, Choi,A., Austen,K.F. and
            Glimcher,L.H.
  TITLE     A novel group of phospholipase A2s preferentially expressed in type
            2 helper T cells
  JOURNAL   J Biol Chem 276 (21), 18321-18326 (2001)
   PUBMED   11278438
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FM046181.1 and FM059472.1.
            
            On Jul 20, 2021 this sequence version replaced XM_039102720.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159417.1, SRR26643298.13568.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                JAXUCZ010000002.1  221110722-221110737
            17-420              FM046181.1         1-404
            421-423             JAXUCZ010000002.1  221121697-221121699
            424-523             FM046181.1         408-507
            524-935             JAXUCZ010000002.1  221126555-221126966
            936-994             FM046181.1         509-567
            995-1518            FM059472.1         184-707
            1519-1930           JAXUCZ010000002.1  221126555-221126966
FEATURES             Location/Qualifiers
     source          1..1519
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1519
                     /gene="Pla2g12a"
                     /note="phospholipase A2, group XIIA"
                     /db_xref="GeneID:362039"
                     /db_xref="RGD:1304662"
     exon            1..309
                     /gene="Pla2g12a"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..671
                     /gene="Pla2g12a"
                     /EC_number="3.1.1.4"
                     /note="group XIIA secretory phospholipase A2"
                     /codon_start=1
                     /product="group XIIA secretory phospholipase A2 precursor"
                     /protein_id="NP_001382508.1"
                     /db_xref="GeneID:362039"
                     /db_xref="RGD:1304662"
                     /translation="MVAPPPAPARGPALLLLLLLVTARGQEQDQTTDWRATLKTIRNG
                     IHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPAPRYGYKPSPPNGCGSPLFGVHLNIG
                     IPSLTKCCNQHDRCYETCGKGKNDCDEEFQSCLSKICRDVQKTLGLSQNVQACETTVE
                     LLFDSVIHLGCKPYLDSQRAACWCRYEEKTDL"
     exon            310..386
                     /gene="Pla2g12a"
                     /inference="alignment:Splign:2.1.0"
     exon            387..552
                     /gene="Pla2g12a"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1519
                     /gene="Pla2g12a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgacgggg cgcgagctcg cgagcgcgga ggaggccggg gcttgaggcg gagcgcgcgc
       61 cgctgccgag ccccgccgcc ccggccctgc cgatggtggc tccgccgccc gcgcccgccc
      121 ggggccctgc gctcctgctc ctgctcttgc tggtcaccgc tcgcggccag gaacaggacc
      181 agaccaccga ctggagggcc accctcaaga ccatccgaaa cggcatccac aagatagaca
      241 cgtacctcaa cgccgcgctg gacctgctgg gcggagagga cgggctctgc cagtacaagt
      301 gtagcgacgg atcgaagcct gccccacgct atggatataa accatcacca ccaaatggat
      361 gtggctctcc attgtttggt gttcatctga acattggcat cccttccctg accaagtgct
      421 gcaaccagca cgacaggtgc tatgagacct gcgggaaagg caagaacgac tgtgacgagg
      481 agttccagtc ctgcctctcc aagatctgca gagacgtgca gaagacactc ggactctctc
      541 agaatgtcca ggcatgcgag acgacagtgg agctcctctt tgacagcgtc atccatttag
      601 gctgcaagcc gtacctggat agccagcggg ctgcgtgttg gtgtcgttat gaagaaaaga
      661 cggatctgta aagaagcccc tgacagcggg tgagcaggcg agagtggagg acaacccttg
      721 tcaaaggtcc gatgctttca cagcctaaag ctgccttggt tttgtgacgg gtcattttga
      781 gtccttacca gactgtgtct tgatggtaaa acctcgaagt gaaaagggta ggggccagga
      841 agaggcagaa gggaaggcgt acccgagact gggagcgagc aagacatctg agagcgagcc
      901 gtcctgggcc ttgctgtctg ggtggctccc ctaactgggc agacagcccc gagcccgtgt
      961 ggcttggttt cgtagctgta cttaacaata aaagtgaaag caaatgtgaa attcattgta
     1021 aggacttttc agcattatct tattttgaaa aatagaacaa ctttccctca gaactattat
     1081 ttattttgaa attccaaatg tacctttaca ccaggagaaa ctattatttc tccattttaa
     1141 ttatatataa catgttgttt ctctggatcc cactaagaca ggtataaata tgtttctcac
     1201 agtcacaagg tttccaagtg cgcgtctctt gtacagttgg aatcactggt tgatgcttct
     1261 cttcagaggt cacccaggac atctaagtat tgtgacgtgc acagtatcca gaaacacagc
     1321 actcctgttt cacccaccac tcatagcaat cgccgtcttt tgctatgaat tgtaggaatg
     1381 acgggtttaa tgagccaaat ctgtgcacta catgctgctg agttcgtggt tattccccat
     1441 tcctcatctt ctattctgga atattgttaa aagtctgacg ttttctaatg gaggtcttaa
     1501 taaaagctat tcttggtaa
//
