LOCUS       NM_017176                894 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus phospholipase A2, group X (Pla2g10), mRNA.
ACCESSION   NM_017176
VERSION     NM_017176.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Fornander,L., Ghafouri,B., Kihlstrom,E., Akerlind,B., Schon,T.,
            Tagesson,C. and Lindahl,M.
  TITLE     Innate immunity proteins and a new truncated form of SPLUNC1 in
            nasopharyngeal aspirates from infants with respiratory syncytial
            virus infection
  JOURNAL   Proteomics Clin Appl 5 (9-10), 513-522 (2011)
   PUBMED   21805676
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Shridas,P., Bailey,W.M., Gizard,F., Oslund,R.C., Gelb,M.H.,
            Bruemmer,D. and Webb,N.R.
  TITLE     Group X secretory phospholipase A2 negatively regulates ABCA1 and
            ABCG1 expression and cholesterol efflux in macrophages
  JOURNAL   Arterioscler Thromb Vasc Biol 30 (10), 2014-2021 (2010)
   PUBMED   20844270
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 894)
  AUTHORS   Curfs,D.M., Ghesquiere,S.A., Vergouwe,M.N., van der Made,I.,
            Gijbels,M.J., Greaves,D.R., Verbeek,J.S., Hofker,M.H. and de
            Winther,M.P.
  TITLE     Macrophage secretory phospholipase A2 group X enhances
            anti-inflammatory responses, promotes lipid accumulation, and
            contributes to aberrant lung pathology
  JOURNAL   J Biol Chem 283 (31), 21640-21648 (2008)
   PUBMED   18511424
REFERENCE   5  (bases 1 to 894)
  AUTHORS   Ikeno,Y., Konno,N., Cheon,S.H., Bolchi,A., Ottonello,S.,
            Kitamoto,K. and Arioka,M.
  TITLE     Secretory phospholipases A2 induce neurite outgrowth in PC12 cells
            through lysophosphatidylcholine generation and activation of G2A
            receptor
  JOURNAL   J Biol Chem 280 (30), 28044-28052 (2005)
   PUBMED   15927955
REFERENCE   6  (bases 1 to 894)
  AUTHORS   Masuda,S., Murakami,M., Takanezawa,Y., Aoki,J., Arai,H.,
            Ishikawa,Y., Ishii,T., Arioka,M. and Kudo,I.
  TITLE     Neuronal expression and neuritogenic action of group X secreted
            phospholipase A2
  JOURNAL   J Biol Chem 280 (24), 23203-23214 (2005)
   PUBMED   15781456
  REMARK    GeneRIF: group X secreted phospholipase A2 is expressed in neural
            cells and has neuritogenic action
REFERENCE   7  (bases 1 to 894)
  AUTHORS   Kolko,M., Christoffersen,N.R., Barreiro,S.G. and Bazan,N.G.
  TITLE     Expression and location of mRNAs encoding multiple forms of
            secretory phospholipase A2 in the rat retina
  JOURNAL   J Neurosci Res 77 (4), 517-524 (2004)
   PUBMED   15264221
REFERENCE   8  (bases 1 to 894)
  AUTHORS   Valentin,E., Ghomashchi,F., Gelb,M.H., Lazdunski,M. and Lambeau,G.
  TITLE     On the diversity of secreted phospholipases A(2). Cloning, tissue
            distribution, and functional expression of two novel mouse group II
            enzymes
  JOURNAL   J Biol Chem 274 (44), 31195-31202 (1999)
   PUBMED   10531313
  REMARK    Erratum:[J Biol Chem 2000 Jan 21;275(3):2246]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Apr 12, 2023 this sequence version replaced NM_017176.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF166100.1, SRR26643291.26809.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000010.1  2116065-2116172     c
            109-259             JAXUCZ010000010.1  2113610-2113760     c
            260-366             JAXUCZ010000010.1  2113176-2113282     c
            367-894             JAXUCZ010000010.1  2104927-2105454     c
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..894
                     /gene="Pla2g10"
                     /gene_synonym="PLA2GX; sPLA2-X"
                     /note="phospholipase A2, group X"
                     /db_xref="GeneID:29359"
                     /db_xref="RGD:61935"
     exon            1..108
                     /gene="Pla2g10"
                     /gene_synonym="PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..509
                     /gene="Pla2g10"
                     /gene_synonym="PLA2GX; sPLA2-X"
                     /EC_number="3.1.1.4"
                     /note="group 10 secretory phospholipase A2; group X
                     phospholipase A2; GX sPLA2; group X secretory
                     phospholipase A2; phosphatidylcholine 2-acylhydrolase GX;
                     phosphatidylcholine 2-acylhydrolase 10; phospholipase A2,
                     group 10"
                     /codon_start=1
                     /product="group 10 secretory phospholipase A2 precursor"
                     /protein_id="NP_058872.2"
                     /db_xref="GeneID:29359"
                     /db_xref="RGD:61935"
                     /translation="MLLLLLLLLLGPGSCLSEATRRSHVYKRGLLELAGTLDCVGPRS
                     PMAYMNYGCYCGLGGHGEPRDAIDWCCYYHDCCYSQAQDAGCSPKLDRYPWKCMDHRI
                     LCGPAENKCQELLCRCDETLAYCLADTEYHLKYLFFPSVLCEKDSPKCN"
     exon            109..259
                     /gene="Pla2g10"
                     /gene_synonym="PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            260..366
                     /gene="Pla2g10"
                     /gene_synonym="PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
     exon            367..894
                     /gene="Pla2g10"
                     /gene_synonym="PLA2GX; sPLA2-X"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcccacac ctgtcacgct cctatgtgtg ggccacctct gtgacgggct ataatgctgc
       61 tgctactgct gctgttgcta ctgggacctg gatcctgtct cagcgaagca accaggaggt
      121 cacatgtgta caagcgtgga ctcctggaac tggcagggac cttggattgt gttggtcctc
      181 gatcgccgat ggcttacatg aactatggtt gttattgtgg ccttggtggc cacggagagc
      241 cacgtgatgc cattgactgg tgctgctact accatgactg ctgctactct caggctcagg
      301 atgccggctg cagccccaag ctagaccgat acccgtggaa gtgcatggac catcgcatcc
      361 tgtgtggacc ggcagagaac aaatgccaag aactcctatg caggtgtgat gagacgctcg
      421 catactgcct ggcagacaca gagtaccacc tgaaatacct cttcttcccc tcggttttat
      481 gtgagaagga ctcacccaag tgcaactaat aggctgaaat gtccctttgc acatggaaat
      541 gaagttcgct ttcagtgatg aacaacagcc ttcgatttgc gcaggagtcc ctggaggcca
      601 agtgatgaag cctgggtttg ctttctccct ccattcgtga actcaggact atgagcctgt
      661 ggagctgcca gtttgatgaa ggttgagagt cctgggcctg ttttatacaa ctgcaactgt
      721 gttgggcttg atataatttt tgaagtccaa ctttacaaaa agctttacta ctgtgtaacc
      781 tgctgcagag ggttggtggt caaatgaaca cctgcttagg cttgcttgtg gtaataacat
      841 tgccacgata catctaggaa ttgttagtgt aataaagcat gttccctacc tgtc
//
