LOCUS       NM_138882               2100 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus phospholipase A1 member A (Pla1a), mRNA.
ACCESSION   NM_138882
VERSION     NM_138882.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Asano,A., Nelson-Harrington,J.L. and Travis,A.J.
  TITLE     Phospholipase B is activated in response to sterol removal and
            stimulates acrosome exocytosis in murine sperm
  JOURNAL   J Biol Chem 288 (39), 28104-28115 (2013)
   PUBMED   23943622
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Hosono,H., Aoki,J., Nagai,Y., Bandoh,K., Ishida,M., Taguchi,R.,
            Arai,H. and Inoue,K.
  TITLE     Phosphatidylserine-specific phospholipase A1 stimulates histamine
            release from rat peritoneal mast cells through production of
            2-acyl-1-lysophosphatidylserine
  JOURNAL   J Biol Chem 276 (32), 29664-29670 (2001)
   PUBMED   11395520
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Sato,T., Aoki,J., Nagai,Y., Dohmae,N., Takio,K., Doi,T., Arai,H.
            and Inoue,K.
  TITLE     Serine phospholipid-specific phospholipase A that is secreted from
            activated platelets. A new member of the lipase family
  JOURNAL   J Biol Chem 272 (4), 2192-2198 (1997)
   PUBMED   8999922
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Mar 29, 2021 this sequence version replaced NM_138882.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D88666.1, BC078727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               JAXUCZ010000011.1  75825626-75826094
            470-671             JAXUCZ010000011.1  75845373-75845574
            672-849             JAXUCZ010000011.1  75847085-75847262
            850-958             JAXUCZ010000011.1  75847705-75847813
            959-1060            JAXUCZ010000011.1  75848533-75848634
            1061-1150           JAXUCZ010000011.1  75851041-75851130
            1151-1318           JAXUCZ010000011.1  75853451-75853618
            1319-1408           JAXUCZ010000011.1  75855428-75855517
            1409-1517           JAXUCZ010000011.1  75859361-75859469
            1518-1682           JAXUCZ010000011.1  75862105-75862269
            1683-2100           JAXUCZ010000011.1  75862879-75863296
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2100
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /note="phospholipase A1 member A"
                     /db_xref="GeneID:85311"
                     /db_xref="RGD:621261"
     exon            1..469
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1767
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /EC_number="3.1.1.111"
                     /note="phosphatidylserine-specific phospholipase A1"
                     /codon_start=1
                     /product="phospholipase A1 member A precursor"
                     /protein_id="NP_620237.1"
                     /db_xref="GeneID:85311"
                     /db_xref="RGD:621261"
                     /translation="MCPGLWGTCFWLWGSLLWLSIGRSGNVPPTTQPKCTDFQSANLL
                     RGTNLKVQFLLFTPSDPGCGQLVEEDSDIRNSEFNASLGTKLIIHGFRALGTKPSWIN
                     KFIRALLRAADANVIAVDWVYGSTGMYFSAVENVVKLSLEISRFLSKLLELGVSESSI
                     HIIGVSLGAHVGGMVGHFYKGQLGRITGLDPAGPEYTRASLEERLDSGDALFVEAIHT
                     DTDNLGIRIPVGHVDYFVNGGQDQPGCPAFIHAGYSYLICDHMRAVHLYISALENTCP
                     LMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVKIEPLPKEVRVYLQTTSSA
                     PYCVHHSLVEFNLKEKRKKDTSIEVTFLGNNVTSSVKITIPKDHLEGRGIIAHQNPHC
                     QINQVKLKFHISSRVWRKDRTPIVGTFCTAPLPVNDSKKTVCIPEPVRLQVSMAVLRD
                     LKMACV"
     exon            470..671
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            672..849
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..958
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1060
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1150
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1318
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1408
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1517
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1682
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..2100
                     /gene="Pla1a"
                     /gene_synonym="Ps-pla1; Pspla1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaattccat tacggtgaga gttttgtaac cacggggaga tgaaaggcag ccttggccat
       61 cactgacatt tcataatggg aaatgtagct gtggaaagtc atttcctgat ccttgtttgg
      121 cgcagagagg aagaacagtt tgtttcaatg ttccctgctt tcaaaaaaaa aaaaaaatgt
      181 gggaagcgcg ttcattttca ttgagaagaa gaaactggaa actccagagg ttaaacaaat
      241 aggaaggttt atttgtttat ttatttattt tacaagccgt ggagccagtt actgattact
      301 aagtcccaag tgggcgtagt gtgtttgatg ggaggctggg ctatgtgaca tcccaagctt
      361 tccccttcat tctggctcca agactccagc ccagcgatgt gtcctggcct ctgggggaca
      421 tgcttctggt tgtggggatc acttttatgg ctcagcattg gaagatcagg gaacgtaccc
      481 cctaccaccc aaccgaagtg cactgacttc cagagtgcca acctcctcag aggcaccaac
      541 ctcaaagtcc agtttctcct ctttaccccc tcggaccccg gctgtggaca actagtagaa
      601 gaggacagtg acatccggaa ctctgagttc aatgccagtc tgggaaccaa actaattatt
      661 catggattca gggcattagg aacaaaacct tcttggatca acaagtttat cagagctctc
      721 ctgcgggcag cggacgctaa tgtgattgca gtggactggg tttatggttc cacgggcatg
      781 tacttctcag ctgtggagaa tgtggtcaag ttgagcctgg agatctcccg tttcctcagc
      841 aaacttttgg agctgggtgt gtcagagtcc tcaatccaca tcattggtgt cagtctgggg
      901 gctcatgttg gaggcatggt tgggcatttc tacaaaggcc agttgggacg gatcacaggt
      961 ctggatcctg ctggaccaga gtacaccaga gccagcctgg aggaacgctt ggattctgga
     1021 gatgccctgt ttgtggaagc catccacaca gacactgaca atttgggtat ccggattcct
     1081 gtcggacatg tggactactt tgtcaatgga ggccaagacc agcctggatg ccctgcattc
     1141 attcacgcag gttacagtta cttgatctgt gatcacatga gggctgtaca tctctatatc
     1201 agtgccttgg agaacacttg cccactgatg gcctttccct gtgccagcta caaggccttc
     1261 ctcgcaggag actgtctgga ctgctttaac cctttcctgc tctcctgtcc gaggattgga
     1321 ctggtggaac gaggtggtgt caagattgag ccgctcccca aggaagtgag ggtctatctc
     1381 cagactacat ccagtgcccc atactgtgtg caccacagcc tcgtggagtt taatttgaag
     1441 gagaagagaa aaaaggatac cagcatcgag gtcacctttc ttggcaacaa tgtaacgtcc
     1501 tcggtcaaga tcaccatacc taaagatcac cttgaaggga gagggatcat cgcccatcaa
     1561 aacccacact gccagataaa ccaggtgaag ctcaagttcc acatttctag ccgggtttgg
     1621 agaaaagaca ggactcccat tgttgggact ttctgtaccg ctcctctgcc agtcaatgac
     1681 agcaagaaga cggtctgcat ccctgagcca gtgcgtctgc aagtgagcat ggctgttctc
     1741 cgggacctga aaatggcctg tgtgtagcct gagcctactc ttgaggcaga ggccggaatt
     1801 tttcgagggc agtgtggcaa gggctgtttg caagcgccat attctaccct gtttctacta
     1861 agggggggaa ggccaaattc ttggtggttt tctccataag tagttactgt ggaagggaca
     1921 ggtgactcat attacagaac ttgatctccg tcaccgactt acaaagcttt atacagatgc
     1981 catttcagct tctctatttc aacacaactg tgattgcctc acagccttaa gtatctatac
     2041 ttaggattca atggaaaatg tactcggaga aatgttttaa ataaattgtc atggaatatc
//
