LOCUS       NM_001106315            2861 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus plakophilin 3 (Pkp3), transcript variant 1, mRNA.
ACCESSION   NM_001106315 XM_001059747 XM_001059803 XM_219478
VERSION     NM_001106315.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Fischer-Keso,R., Breuninger,S., Hofmann,S., Henn,M., Rohrig,T.,
            Strobel,P., Stoecklin,G. and Hofmann,I.
  TITLE     Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA
            stability of desmosomal proteins
  JOURNAL   Mol Cell Biol 34 (23), 4244-4256 (2014)
   PUBMED   25225333
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   van Hengel,J., Calore,M., Bauce,B., Dazzo,E., Mazzotti,E., De
            Bortoli,M., Lorenzon,A., Li Mura,I.E., Beffagna,G., Rigato,I.,
            Vleeschouwers,M., Tyberghein,K., Hulpiau,P., van Hamme,E.,
            Zaglia,T., Corrado,D., Basso,C., Thiene,G., Daliento,L., Nava,A.,
            van Roy,F. and Rampazzo,A.
  TITLE     Mutations in the area composita protein alphaT-catenin are
            associated with arrhythmogenic right ventricular cardiomyopathy
  JOURNAL   Eur Heart J 34 (3), 201-210 (2013)
   PUBMED   23136403
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Gosavi,P., Kundu,S.T., Khapare,N., Sehgal,L., Karkhanis,M.S. and
            Dalal,S.N.
  TITLE     E-cadherin and plakoglobin recruit plakophilin3 to the cell border
            to initiate desmosome assembly
  JOURNAL   Cell Mol Life Sci 68 (8), 1439-1454 (2011)
   PUBMED   20859650
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Cheng,X., Mihindukulasuriya,K., Den,Z., Kowalczyk,A.P.,
            Calkins,C.C., Ishiko,A., Shimizu,A. and Koch,P.J.
  TITLE     Assessment of splice variant-specific functions of desmocollin 1 in
            the skin
  JOURNAL   Mol Cell Biol 24 (1), 154-163 (2004)
   PUBMED   14673151
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 3, 2023 this sequence version replaced NM_001106315.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.4635.1,
                                           SRR26643294.4673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               JAXUCZ010000001.1  205617511-205617656
            147-342             JAXUCZ010000001.1  205619094-205619289
            343-422             JAXUCZ010000001.1  205621504-205621583
            423-1054            JAXUCZ010000001.1  205621710-205622341
            1055-1178           JAXUCZ010000001.1  205622437-205622560
            1179-1383           JAXUCZ010000001.1  205623292-205623496
            1384-1558           JAXUCZ010000001.1  205625511-205625685
            1559-1676           JAXUCZ010000001.1  205626172-205626289
            1677-1847           JAXUCZ010000001.1  205626366-205626536
            1848-2033           JAXUCZ010000001.1  205626633-205626818
            2034-2187           JAXUCZ010000001.1  205627155-205627308
            2188-2380           JAXUCZ010000001.1  205627481-205627673
            2381-2468           JAXUCZ010000001.1  205627767-205627854
            2469-2861           JAXUCZ010000001.1  205628048-205628440
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2861
                     /gene="Pkp3"
                     /note="plakophilin 3"
                     /db_xref="GeneID:293619"
                     /db_xref="RGD:1309133"
     exon            1..146
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2504
                     /gene="Pkp3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="plakophilin-3 isoform 1"
                     /protein_id="NP_001099785.1"
                     /db_xref="GeneID:293619"
                     /db_xref="RGD:1309133"
                     /translation="MEPTTGSRTRMEPRRSCPTAVTSRISQGASGIQNSGKPEAGVCS
                     LALPSDLQLDRRGAEGPEADRLRAARVQEQVRARLLQLGQQSRHNGSTELDGSAESTR
                     GLPRGQYHTMQSGFSSRSQGMSGDKTSTFRPIAKPAYNPASWSSRSAVDLTCSRRLSS
                     AHNGGSAFGAVGYGGAQPTPPMPTRPVSFHERGGAASRADYDTLSLRSLRLGPGGLDD
                     RYSVVSEQLEPAAASTYRAYAYERQASSSSSRAGGLDWPEATEGPPSRTIRAPAMRTL
                     QRFQSSHRSRGGTGSVSGAGLEPVARAPSVRSLSLSLGDSGHLPDVRGLDSYTGHRTL
                     QRLSSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHRCYSDAAAKKQARSLQAVPRLV
                     KLFNHANQEVQRHATGAMRNLIYDNVDNKLALVEENGIFELLRTLREQDDELRKNVTG
                     ILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLR
                     NLSSASQATRQKMRECHGLVDALVTYINHALDVGKCEDKSVENAVCVLRNLSYRLYDE
                     MPPSALQRLEGRGRRDMAGAPPGEVVGCFTPQSRRLRELPLTADALTFAEVSKDPKGL
                     EWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQERIL
                     NPLLDRVRTADHNQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKCPPA
                     EVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLVFIKKKRDSPDSEKSSRAASSLLAN
                     LWQYSKLHRDFRAKGYRKEDFLGP"
     exon            147..342
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            343..422
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            423..1054
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1178
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1383
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1558
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1676
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1847
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2033
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2187
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2380
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2468
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2861
                     /gene="Pkp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacagaggc tgttgcccac aggagctgag ccctgatgga gcccaccaca ggatctcgga
       61 cacggatgga gcccaggagg agttgtccta cagcagtgac ctccagaatc agccaggggg
      121 ccagtgggat ccagaacagc ggcaagcctg aggctggtgt ttgctccctg gcgctgccct
      181 cggacctgca gctggatcgc cggggtgctg aagggccgga ggctgatcgg cttcgagctg
      241 ccagagtcca ggagcaagtc cgagcccgcc tcctgcagct gggccagcag tcgcggcaca
      301 atgggtctac tgagcttgat ggctccgcgg agagcaccag aggactgccc aggggtcaat
      361 accacactat gcagagtggc ttcagctccc gatcccaggg tatgagtgga gacaagacct
      421 cgaccttccg gcccatcgcc aagccggcct acaacccagc ctcctggtcc tcccgctcag
      481 ccgtggatct gacctgcagt cggaggctga gttctgccca taatgggggc agtgcctttg
      541 gggctgtggg atatgggggt gcccagccca ctccacctat gcccacccgg ccagtgtcct
      601 tccatgagcg aggtggggca gccagcagag ctgactatga cacattgtcc ctgcgctcac
      661 tgaggctggg gccggggggc ctggacgacc gttacagcgt ggtgtctgag caactagagc
      721 ctgcagccgc ctctacctac agagcctatg cttacgaacg ccaggccagc tccagctcta
      781 gccgagcggg aggcctggac tggccagagg ccactgaggg accacccagc aggaccatcc
      841 gtgcgcctgc catgcggacc ctgcaacgat ttcagagcag ccaccgaagc cgtgggggta
      901 ccgggtcagt gtcaggagct ggcctggagc cagtggcccg agccccatct gtacgtagcc
      961 tcagtcttag cctgggtgac tcaggccacc tgccggacgt acgtgggttg gacagctaca
     1021 caggccaccg aaccctgcag aggctcagca gtggctttga tgacattgac ctgccttcag
     1081 cagtcaagta cctcatggcc tcagacccca acctgcaggt gctgggggcg gcttacatcc
     1141 agcacagatg ctacagtgat gcagcagcca agaagcaggc tcgcagcctc caggcagtgc
     1201 cgagactggt gaagctcttc aaccacgcca accaggaggt gcagcgccat gccaccggtg
     1261 ccatgcgcaa cctcatctat gacaacgtgg acaacaaact ggccttggtg gaggagaatg
     1321 gcatctttga gctgttgagg acgcttcgag agcaggacga tgagctgcgc aaaaatgtta
     1381 cagggattct atggaacctg tcctccagtg accacttgaa ggaccgcctc gcccgagata
     1441 cactggagca gctcacagat ctggtgctaa gccccctgtc aggggcaggc gggccccccc
     1501 tcatccagca gaatgcttct gaggcagaga tcttctacaa tgctactggc ttcctcagga
     1561 acctcagctc agcctcccag gccactcgcc agaagatgcg tgagtgccat gggctagtgg
     1621 atgctctggt cacctacatc aaccatgccc tggacgtggg caagtgtgag gacaagagtg
     1681 tggaaaatgc tgtgtgtgtg ctgaggaatt tgtcctaccg cctatatgat gagatgccac
     1741 catcagcact gcagcggctt gaaggccgcg gccgcaggga catggcgggg gcaccacctg
     1801 gtgaagtggt gggctgcttt acaccccaga gtcggcggct gcgagagctt cctctcacag
     1861 ccgatgcact cacttttgct gaagtatcta aggatcccaa gggccttgag tggctgtgga
     1921 gcccccagat cgtggggttg tacaaccgac tgctgcagcg ctgtgaacta aatcggcata
     1981 cgacagaggc ggctgcggga gcgctacaga atatcaccgc gggtgaccgc aggtgggcag
     2041 gtgtactgag ccgcctggcc ctggaacagg aacgcatcct gaaccccttg ctggaccgcg
     2101 ttcgcaccgc tgaccacaac cagctgcgct cactgactgg cctcatccga aacctgtctc
     2161 ggaatgctcg gaacaaggac gagatgtcca caaaggtagt gagccacctg attgagaagc
     2221 ttcctggtag tgtgggtgag aagtgtcccc cggctgaggt gctggtcaac atcatagctg
     2281 tgctcaacaa cctggtagta gccagcccta ttgctgcccg agacctgctc tacttcgatg
     2341 gactccgaaa actggtattc atcaaaaaga agagggatag ccctgacagt gagaagtcat
     2401 cccgggcagc ctccagcctc ttggccaacc tctggcagta cagcaagctc caccgtgact
     2461 tccgggcgaa aggctaccgg aaagaggact tcctgggccc ataggtgaag cctcctggag
     2521 gtgaagtgat tcagcttcca agagacaagc tcagctcctg ctgtcccaca gcatacagaa
     2581 gaagagctga tgaccacagg acttctctct ctctctctct ctctctctct ctctctctct
     2641 ctctccctgg agtcccatgt gtgctcttga gggaccaggg ccaccagaaa agaacaggcg
     2701 cttgcaactg gaaattggct tctgcaggca gggaaggggg tagggcttga gctgctctgg
     2761 tgtgctgggt ggtgatcagt cacaatggca agggtggggc tgcccctggc ctgatagctt
     2821 tgtgacgggc aacattggga ataaaggtgg ttttgaacag a
//
