LOCUS       NM_001100499            2861 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus plakophilin 2 (Pkp2), mRNA.
ACCESSION   NM_001100499 XM_001065241 XM_213560
VERSION     NM_001100499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Moncayo-Arlandi,J., Guasch,E., Sanz-de la Garza,M., Casado,M.,
            Garcia,N.A., Mont,L., Sitges,M., Knoll,R., Buyandelger,B.,
            Campuzano,O., Diez-Juan,A. and Brugada,R.
  TITLE     Molecular disturbance underlies to arrhythmogenic cardiomyopathy
            induced by transgene content, age and exercise in a truncated PKP2
            mouse model
  JOURNAL   Hum Mol Genet 25 (17), 3676-3688 (2016)
   PUBMED   27412010
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Dubash,A.D., Kam,C.Y., Aguado,B.A., Patel,D.M., Delmar,M.,
            Shea,L.D. and Green,K.J.
  TITLE     Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic
            gene expression in cardiomyocytes
  JOURNAL   J Cell Biol 212 (4), 425-438 (2016)
   PUBMED   26858265
  REMARK    GeneRIF: Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent
            fibrotic gene expression in cardiomyocytes.
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Fischer-Keso,R., Breuninger,S., Hofmann,S., Henn,M., Rohrig,T.,
            Strobel,P., Stoecklin,G. and Hofmann,I.
  TITLE     Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA
            stability of desmosomal proteins
  JOURNAL   Mol Cell Biol 34 (23), 4244-4256 (2014)
   PUBMED   25225333
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Gerull,B., Kirchner,F., Chong,J.X., Tagoe,J., Chandrasekharan,K.,
            Strohm,O., Waggoner,D., Ober,C. and Duff,H.J.
  TITLE     Homozygous founder mutation in desmocollin-2 (DSC2) causes
            arrhythmogenic cardiomyopathy in the Hutterite population
  JOURNAL   Circ Cardiovasc Genet 6 (4), 327-336 (2013)
   PUBMED   23863954
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Franke,W.W., Borrmann,C.M., Grund,C. and Pieperhoff,S.
  TITLE     The area composita of adhering junctions connecting heart muscle
            cells of vertebrates. I. Molecular definition in intercalated disks
            of cardiomyocytes by immunoelectron microscopy of desmosomal
            proteins
  JOURNAL   Eur J Cell Biol 85 (2), 69-82 (2006)
   PUBMED   16406610
  REMARK    Erratum:[Eur J Cell Biol. 2006 Jun;85(6):577.]
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Gerull,B., Heuser,A., Wichter,T., Paul,M., Basson,C.T.,
            McDermott,D.A., Lerman,B.B., Markowitz,S.M., Ellinor,P.T.,
            MacRae,C.A., Peters,S., Grossmann,K.S., Drenckhahn,J., Michely,B.,
            Sasse-Klaassen,S., Birchmeier,W., Dietz,R., Breithardt,G.,
            Schulze-Bahr,E. and Thierfelder,L.
  TITLE     Mutations in the desmosomal protein plakophilin-2 are common in
            arrhythmogenic right ventricular cardiomyopathy
  JOURNAL   Nat Genet 36 (11), 1162-1164 (2004)
   PUBMED   15489853
  REMARK    Erratum:[Nat Genet. 2005 Jan;37(1):106]
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Grossmann,K.S., Grund,C., Huelsken,J., Behrend,M., Erdmann,B.,
            Franke,W.W. and Birchmeier,W.
  TITLE     Requirement of plakophilin 2 for heart morphogenesis and cardiac
            junction formation
  JOURNAL   J Cell Biol 167 (1), 149-160 (2004)
   PUBMED   15479741
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Hofmann,I., Mertens,C., Brettel,M., Nimmrich,V., Schnolzer,M. and
            Herrmann,H.
  TITLE     Interaction of plakophilins with desmoplakin and intermediate
            filament proteins: an in vitro analysis
  JOURNAL   J Cell Sci 113 (Pt 13), 2471-2483 (2000)
   PUBMED   10852826
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Gallicano,G.I., Kouklis,P., Bauer,C., Yin,M., Vasioukhin,V.,
            Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is required early in development for assembly of
            desmosomes and cytoskeletal linkage
  JOURNAL   J Cell Biol 143 (7), 2009-2022 (1998)
   PUBMED   9864371
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Nov 30, 2008 this sequence version replaced
            XM_001065241.1, XM_213560.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2861
                     /gene="Pkp2"
                     /note="plakophilin 2"
                     /db_xref="GeneID:287925"
                     /db_xref="RGD:1306533"
     exon            1..260
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..2425
                     /gene="Pkp2"
                     /codon_start=1
                     /product="plakophilin-2"
                     /protein_id="NP_001093969.1"
                     /db_xref="GeneID:287925"
                     /db_xref="RGD:1306533"
                     /translation="MAIPGSLGECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSS
                     GRGDPVARSQRIQEQVQQTLARRGRSSVVGGNLHRTSSVPEYVYKLHLVENDFVGRQS
                     PAARDYDMLKAGVTATYGSRWGRGTAQYSSQKSVEERSWRQPLRRLEISPDSSPERAH
                     YGHSEYQYAWRSHVVPGGRLTLPRYARSEILGLRQTGTARRAPGCGSVSDAVFDNGPL
                     NPTIPTHPPGTSHSAGSLLEETTVRVSQARFQGLQSRAGRSSWPRSSVHSTLRESGRM
                     LPTAGQAAVGSGDAHRDRSAFADSQLGNADLEMTLERAVNMLDADHVPLSKISAAATF
                     IQHESFQKSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVFEDNDNKLEVA
                     ELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIPFS
                     GWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTI
                     ADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRS
                     RKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLT
                     AGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAK
                     ETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTIS
                     IGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD"
     exon            261..373
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..945
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1081
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1289
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1467
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1585
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1750
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1924
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2078
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2268
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2356
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2861
                     /gene="Pkp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctggcag tcctttcctg gtcaccttgc ggacgccatg gcgatcccag gctcactggg
       61 cgagtgtggt tacatccgga ccgtgctggg ccagcagatc ctgggtcacc tggacagctc
      121 cagcctggcc ttgccctccg aggccaggct gaggctagcg ggcagcagcg gccgcggcga
      181 cccggtggcc cggagccagc ggatccagga gcaggtgcag caaaccctgg ctcgccgggg
      241 ccggagctct gtagtcggcg ggaaccttca ccgaaccagc agtgttcctg agtatgtcta
      301 caagctgcac ttggttgaga atgactttgt tggaaggcag tcacctgccg ctagggacta
      361 tgacatgctt aaggctggag tgactgccac ttacggaagt cgttggggga gaggaacagc
      421 acagtatagt tcgcagaagt cagtagagga gagatcctgg aggcagcccc tgaggagact
      481 tgagatttcc ccagatagca gcccggagag agcccactat gggcacagcg aataccaata
      541 tgcctggcgg agccatgtgg tgcctggtgg gcgccttacc cttccacgct atgctcgctc
      601 agagatcctg ggcctgcgcc agactggcac agcccgaagg gcacctgggt gcgggtcagt
      661 cagcgatgct gtctttgaca atggcccgct taaccccacc atacccaccc accctcctgg
      721 caccagccac agcgcaggca gcctgctgga ggagaccact gtgcgtgtga gccaggctcg
      781 atttcagggc ctgcagagca gagccggccg ctcctcctgg ccccggagct cagtccacag
      841 taccttgcgg gagtcaggaa gaatgctgcc caccgcaggc caggctgcgg tgggcagcgg
      901 ggatgcgcat cgggacagga gcgccttcgc tgactcccag ctcgggaatg cagacttaga
      961 gatgaccttg gagcgagctg tgaatatgct ggatgcagac catgtaccac tgtccaagat
     1021 ctctgctgcg gctaccttca tacagcatga gagcttccaa aaatctgaag cacggaaaag
     1081 ggtcaatcaa cttcaaggca tccctaaact tctgcagctg ctcaaagttc agaatgaaga
     1141 cgttcagcgg gctgtgtgtg gggccctgag aaatttggta tttgaagaca atgataacaa
     1201 gttggaggtc gctgaactga atggagtgcc tcggctgctg caggtgctga agcaaaccag
     1261 agacttggag acaaagaagc aaataacagg tttgctctgg aacttgtcct ctagtgataa
     1321 actcaagcat ctcatgataa cagaagcctt gctcaccttg acagagagtg tcatcatccc
     1381 cttctcaggg tggcctgaag gagactaccc caaagccaat ggcttgcttg attttgatat
     1441 attctacaat gtcactggat gcctaagaaa catgagctcc gctggccctg atgggaggaa
     1501 ggtgatgagg aggtgtgatg gtctcattga ttcattggtc cattacgtca gaggaaccat
     1561 tgcagactac cagccagatg ataaggccac agagaactgc gtatgcattc ttcataacct
     1621 ctcctaccag ctggaggctg agctcccaga gaaatattcc cagagtatct acatgcaaaa
     1681 ccggaatatc cagaccaaca gtaacaaaag catcgggtgt tttggcagcc ggagtagaaa
     1741 agtaaaggag caataccaag acacgccgat gccagaggaa aggagcagtc cccgtggcat
     1801 tgagtggctg tggcattcca ttgtgataag gatgtatttg tccttaattg ccaagagttc
     1861 ccgaaactat acccaagagg catcattggg agctctccag aacctcacag caggaagcgg
     1921 cccgataccc acatcggtag ctcgcatggt tgtccagaag gaaaatggtc ttcagcacac
     1981 ccggaagatg ctgcacgtgg gtgatcccag tgtgaaaaag actgcagtct ccctgctgag
     2041 gaatttgtca cggaatcttt ctctgcagaa tgaaattgct aaagaaactc taccagattt
     2101 ggtttctata attcctgaca cagtcccaag tactgacctc ctcattgaaa ctacagcttc
     2161 tgcttgctat acgttgaaca atttaatgca aaatagttac cagaatgcac gagaccttct
     2221 gaacactgga gggctgcaga aaattatgac catcagcata ggagaaggct atgcccccaa
     2281 caaggccagc aaagctgcct ctgtcctcct gtactctctg tgggcacaca ccgagctcca
     2341 taatgcctac aagaaggctc agtttaagaa gacggacttc gtcaacagcc ggactgccaa
     2401 ggcctcccac tcccttaaag actaataagg agaagacgac tcaggaactc cagcttcaca
     2461 attctccact gaaaaaataa aacaaaaaac aaaaaacaaa aaaaaaatcc ccaaagaaaa
     2521 cacctatttt tctactaact gacccaagaa acctcaaaaa gcatgctttg tttatactct
     2581 tttctatttt catcccccaa atctagtaac gaatatctga atatgatttt gttagacatc
     2641 ctggagactt gccaggtcgc accagtgtgg aatccgtgtt ccctgtgcag atgatgggca
     2701 tcagtatcca ggcttatgta cacccatgtg ggtgctcatc ggaggaatct gaggaagcct
     2761 agtcacttgt ctgcatgtca cctccttagt gagccagagg tgtgtgtgca ccagtgctgc
     2821 acaggaccca agtgcaggaa taaagctttg atggcagatc a
//
