LOCUS       NP_001093969             795 aa            linear   ROD 03-APR-2024
DEFINITION  plakophilin-2 [Rattus norvegicus].
ACCESSION   NP_001093969 XP_001065241 XP_213560
VERSION     NP_001093969.1
DBSOURCE    REFSEQ: accession NM_001100499.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 795)
  AUTHORS   Moncayo-Arlandi,J., Guasch,E., Sanz-de la Garza,M., Casado,M.,
            Garcia,N.A., Mont,L., Sitges,M., Knoll,R., Buyandelger,B.,
            Campuzano,O., Diez-Juan,A. and Brugada,R.
  TITLE     Molecular disturbance underlies to arrhythmogenic cardiomyopathy
            induced by transgene content, age and exercise in a truncated PKP2
            mouse model
  JOURNAL   Hum Mol Genet 25 (17), 3676-3688 (2016)
   PUBMED   27412010
REFERENCE   2  (residues 1 to 795)
  AUTHORS   Dubash,A.D., Kam,C.Y., Aguado,B.A., Patel,D.M., Delmar,M.,
            Shea,L.D. and Green,K.J.
  TITLE     Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic
            gene expression in cardiomyocytes
  JOURNAL   J Cell Biol 212 (4), 425-438 (2016)
   PUBMED   26858265
  REMARK    GeneRIF: Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent
            fibrotic gene expression in cardiomyocytes.
REFERENCE   3  (residues 1 to 795)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 795)
  AUTHORS   Fischer-Keso,R., Breuninger,S., Hofmann,S., Henn,M., Rohrig,T.,
            Strobel,P., Stoecklin,G. and Hofmann,I.
  TITLE     Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA
            stability of desmosomal proteins
  JOURNAL   Mol Cell Biol 34 (23), 4244-4256 (2014)
   PUBMED   25225333
REFERENCE   5  (residues 1 to 795)
  AUTHORS   Gerull,B., Kirchner,F., Chong,J.X., Tagoe,J., Chandrasekharan,K.,
            Strohm,O., Waggoner,D., Ober,C. and Duff,H.J.
  TITLE     Homozygous founder mutation in desmocollin-2 (DSC2) causes
            arrhythmogenic cardiomyopathy in the Hutterite population
  JOURNAL   Circ Cardiovasc Genet 6 (4), 327-336 (2013)
   PUBMED   23863954
REFERENCE   6  (residues 1 to 795)
  AUTHORS   Franke,W.W., Borrmann,C.M., Grund,C. and Pieperhoff,S.
  TITLE     The area composita of adhering junctions connecting heart muscle
            cells of vertebrates. I. Molecular definition in intercalated disks
            of cardiomyocytes by immunoelectron microscopy of desmosomal
            proteins
  JOURNAL   Eur J Cell Biol 85 (2), 69-82 (2006)
   PUBMED   16406610
  REMARK    Erratum:[Eur J Cell Biol. 2006 Jun;85(6):577.]
REFERENCE   7  (residues 1 to 795)
  AUTHORS   Gerull,B., Heuser,A., Wichter,T., Paul,M., Basson,C.T.,
            McDermott,D.A., Lerman,B.B., Markowitz,S.M., Ellinor,P.T.,
            MacRae,C.A., Peters,S., Grossmann,K.S., Drenckhahn,J., Michely,B.,
            Sasse-Klaassen,S., Birchmeier,W., Dietz,R., Breithardt,G.,
            Schulze-Bahr,E. and Thierfelder,L.
  TITLE     Mutations in the desmosomal protein plakophilin-2 are common in
            arrhythmogenic right ventricular cardiomyopathy
  JOURNAL   Nat Genet 36 (11), 1162-1164 (2004)
   PUBMED   15489853
  REMARK    Erratum:[Nat Genet. 2005 Jan;37(1):106]
REFERENCE   8  (residues 1 to 795)
  AUTHORS   Grossmann,K.S., Grund,C., Huelsken,J., Behrend,M., Erdmann,B.,
            Franke,W.W. and Birchmeier,W.
  TITLE     Requirement of plakophilin 2 for heart morphogenesis and cardiac
            junction formation
  JOURNAL   J Cell Biol 167 (1), 149-160 (2004)
   PUBMED   15479741
REFERENCE   9  (residues 1 to 795)
  AUTHORS   Hofmann,I., Mertens,C., Brettel,M., Nimmrich,V., Schnolzer,M. and
            Herrmann,H.
  TITLE     Interaction of plakophilins with desmoplakin and intermediate
            filament proteins: an in vitro analysis
  JOURNAL   J Cell Sci 113 (Pt 13), 2471-2483 (2000)
   PUBMED   10852826
REFERENCE   10 (residues 1 to 795)
  AUTHORS   Gallicano,G.I., Kouklis,P., Bauer,C., Yin,M., Vasioukhin,V.,
            Degenstein,L. and Fuchs,E.
  TITLE     Desmoplakin is required early in development for assembly of
            desmosomes and cytoskeletal linkage
  JOURNAL   J Cell Biol 143 (7), 2009-2022 (1998)
   PUBMED   9864371
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473999.2.
            
            On or before Nov 30, 2008 this sequence version replaced
            XP_001065241.1, XP_213560.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..795
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     Protein         1..795
                     /product="plakophilin-2"
                     /calculated_mol_wt=87697
     Region          311..338
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(327,331,337,371,375,379,414,418,422)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          342..382
                     /region_name="ARM"
                     /note="Armadillo/beta-catenin-like repeats; smart00185"
                     /db_xref="CDD:214547"
     Region          346..382
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          388..423
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          435..479
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          584..625
                     /region_name="Arm"
                     /note="Armadillo/beta-catenin-like repeat; pfam00514"
                     /db_xref="CDD:425727"
     Region          636..670
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          678..716
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     CDS             1..795
                     /gene="Pkp2"
                     /coded_by="NM_001100499.1:38..2425"
                     /db_xref="GeneID:287925"
                     /db_xref="RGD:1306533"
ORIGIN      
        1 maipgslgec gyirtvlgqq ilghldsssl alpsearlrl agssgrgdpv arsqriqeqv
       61 qqtlarrgrs svvggnlhrt ssvpeyvykl hlvendfvgr qspaardydm lkagvtatyg
      121 srwgrgtaqy ssqksveers wrqplrrlei spdssperah yghseyqyaw rshvvpggrl
      181 tlpryarsei lglrqtgtar rapgcgsvsd avfdngplnp tipthppgts hsagslleet
      241 tvrvsqarfq glqsragrss wprssvhstl resgrmlpta gqaavgsgda hrdrsafads
      301 qlgnadlemt leravnmlda dhvplskisa aatfiqhesf qksearkrvn qlqgipkllq
      361 llkvqnedvq ravcgalrnl vfedndnkle vaelngvprl lqvlkqtrdl etkkqitgll
      421 wnlsssdklk hlmiteallt ltesviipfs gwpegdypka nglldfdify nvtgclrnms
      481 sagpdgrkvm rrcdglidsl vhyvrgtiad yqpddkaten cvcilhnlsy qleaelpeky
      541 sqsiymqnrn iqtnsnksig cfgsrsrkvk eqyqdtpmpe erssprgiew lwhsivirmy
      601 lsliakssrn ytqeaslgal qnltagsgpi ptsvarmvvq kenglqhtrk mlhvgdpsvk
      661 ktavsllrnl srnlslqnei aketlpdlvs iipdtvpstd lliettasac ytlnnlmqns
      721 yqnardllnt gglqkimtis igegyapnka skaasvllys lwahtelhna ykkaqfkktd
      781 fvnsrtakas hslkd
//
