LOCUS       NM_001394216            4665 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus plakophilin 1 (Pkp1), mRNA.
ACCESSION   NM_001394216 XM_006249884
VERSION     NM_001394216.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4665)
  AUTHORS   Fischer-Keso R, Breuninger S, Hofmann S, Henn M, Rohrig T, Strobel
            P, Stoecklin G and Hofmann I.
  TITLE     Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA
            stability of desmosomal proteins
  JOURNAL   Mol Cell Biol 34 (23), 4244-4256 (2014)
   PUBMED   25225333
REFERENCE   2  (bases 1 to 4665)
  AUTHORS   Acehan D, Petzold C, Gumper I, Sabatini DD, Muller EJ, Cowin P and
            Stokes DL.
  TITLE     Plakoglobin is required for effective intermediate filament
            anchorage to desmosomes
  JOURNAL   J Invest Dermatol 128 (11), 2665-2675 (2008)
   PUBMED   18496566
REFERENCE   3  (bases 1 to 4665)
  AUTHORS   Hofmann I, Mertens C, Brettel M, Nimmrich V, Schnolzer M and
            Herrmann H.
  TITLE     Interaction of plakophilins with desmoplakin and intermediate
            filament proteins: an in vitro analysis
  JOURNAL   J Cell Sci 113 (Pt 13), 2471-2483 (2000)
   PUBMED   10852826
REFERENCE   4  (bases 1 to 4665)
  AUTHORS   McGrath JA, McMillan JR, Shemanko CS, Runswick SK, Leigh IM, Lane
            EB, Garrod DR and Eady RA.
  TITLE     Mutations in the plakophilin 1 gene result in ectodermal
            dysplasia/skin fragility syndrome
  JOURNAL   Nat Genet 17 (2), 240-244 (1997)
   PUBMED   9326952
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000242.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001394216.2.
            
            On Apr 8, 2021 this sequence version replaced XM_006249884.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487231.78346.1,
                                           SRR8487230.94511.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132300,
                                           SAMD00155322 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-393               JACYVU010000242.1  33718310-33718702   c
            394-500             JACYVU010000242.1  33708016-33708122   c
            501-895             JACYVU010000242.1  33688871-33689265   c
            896-1040            JACYVU010000242.1  33685989-33686133   c
            1041-1248           JACYVU010000242.1  33683685-33683892   c
            1249-1426           JACYVU010000242.1  33682690-33682867   c
            1427-1541           JACYVU010000242.1  33681231-33681345   c
            1542-1697           JACYVU010000242.1  33679483-33679638   c
            1698-1874           JACYVU010000242.1  33678618-33678794   c
            1875-2028           JACYVU010000242.1  33677331-33677484   c
            2029-2215           JACYVU010000242.1  33676883-33677069   c
            2216-2303           JACYVU010000242.1  33676271-33676358   c
            2304-2410           JACYVU010000242.1  33675170-33675276   c
            2411-4665           JACYVU010000242.1  33670877-33673131   c
FEATURES             Location/Qualifiers
     source          1..4665
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..4665
                     /gene="Pkp1"
                     /note="plakophilin 1"
                     /db_xref="GeneID:304822"
                     /db_xref="RGD:1307472"
     exon            1..393
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..2378
                     /gene="Pkp1"
                     /codon_start=1
                     /product="plakophilin-1"
                     /protein_id="NP_001381145.1"
                     /db_xref="GeneID:304822"
                     /db_xref="RGD:1307472"
                     /translation="MNHSPLKTALAYECFQDQDNSTLALPSDQKMKTGTSGRQRVQEQ
                     VMMTVKRQKSKSSQSSTLSHSNRGSMYDGLVDNYNNYGTTSRSSYFSKFQAGNGSWGY
                     PIYNGTLKREPDNRRFSSYSQMENWSRHYPRGSCATTGAGSDICFMQKIKASRSEPDL
                     YCDPRGTLRKGTLGGKGQKTTQNRYSFYSTCSGQKAVKKCPVRPPSCTSKQDPVCMPP
                     ISCNKDMSFGHSRASSKICSEDIECSGLTIPKAVQYLCSQDEKYQAIGAYYIQHTCFQ
                     DESAKQQVYQLGGICKLVDLLRSPNQNVQQAAAGALRNLVFRSTTNKLETRRQNGIRE
                     AVSLLRRSGSTEIQKQLTGLLWNLSSTDELKEELVADALPVLTDRVIIPFSGWCDGNS
                     NMSREVVDPEVFFNATGCLRNLSSADAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDK
                     SVENCMCILHNLSYRLDAEVPTRYRQLEYNTRNAYTEKSSTGCFSNRGDKMMNNNYDC
                     PLPEEETNPKGSSWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSNGM
                     SQLIGIKEKGLPQIARLLQSGNSDVVRSGASLLSNMSRHPVLHRVMGNQVFPEVTRLL
                     TSHTGNTSNSEDILSSACYTVRNLMTSQPQMAKQYFSNSMLNNVFNLCRNSASSPKAA
                     EAARLLLSDMWASKELQSVLRQQGFDRNMMGNIAGANNFRNFTSRF"
     exon            394..500
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..895
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1040
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1248
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1426
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1541
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1697
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1874
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1875..2028
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2215
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2303
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2410
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2411..4665
                     /gene="Pkp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcctact gagggacgag ccggggcgga ggtgccagga gcagcagccg ggagccctca
       61 cgcggaccag ccctctatgg ccatagggag ccgctgagag gagaacacgc gctcacaccc
      121 cggctcgcac tctttgctcc cctggcctgc gctcgcactc gcggctcccc tggcccgcgc
      181 ctcccgccac catgaaccac tcgccgctca agaccgcgct ggcctacgaa tgcttccagg
      241 accaggacaa ctccacgctc gctttgccct ctgaccagaa gatgaagacc ggcacgtcgg
      301 gcaggcagcg tgtgcaggag caggtgatga tgacggtcaa acggcagaag tccaagtctt
      361 cgcagtcgtc caccttgagt cactccaacc gaggttccat gtacgatggg ctggttgaca
      421 attacaacaa ctatggcacc acgagcagaa gcagctactt ctccaagttc caagcaggga
      481 atggctcctg gggatatccg atctataatg ggaccctcaa gcgggagcct gacaacagac
      541 gcttcagctc ctatagccag atggagaact ggagccggca ctatccccga gggagctgtg
      601 ccaccacagg cgctggcagt gacatctgct tcatgcagaa aatcaaggca agccgcagcg
      661 agcctgacct ctactgtgac ccgaggggca cactgcgcaa gggcacactg ggcggcaagg
      721 gccaaaagac cacccagaac cgatacagct tttacagcac ttgcagcggt cagaaggctg
      781 tcaagaagtg tcccgtgagg ccgccctcct gcacctccaa gcaagaccca gtgtgcatgc
      841 cgcctatctc ctgcaacaag gacatgtcct ttggccactc aagggccagt tccaagatct
      901 gcagtgagga cattgagtgt agcgggctga ccatccccaa ggctgtgcag tacctgtgct
      961 cccaggacga gaagtaccag gccatcggag cctattacat ccagcacacc tgcttccagg
     1021 atgaatctgc caagcaacag gtctatcagc tggggggcat ctgcaagctg gtggacctcc
     1081 tccgcagccc caatcagaat gtccagcagg ctgctgccgg ggctctgcgc aatctggtgt
     1141 tcaggagcac cactaacaag ctggagacca ggaggcagaa tgggatccgt gaggctgtca
     1201 gcctcctgag gagaagcggg agcacggaga tccagaaaca gttgactggg ctgctctgga
     1261 acctgtcttc cactgacgag ctaaaggagg aactggtggc cgatgccctg cctgttctga
     1321 ctgaccgggt catcatccct ttctctggct ggtgtgatgg taacagcaac atgtcccggg
     1381 aagtagtgga ccccgaggtc ttcttcaatg ccacaggctg cctgaggaat ctgagttcag
     1441 ctgatgctgg ccgccagact atgcggaact actctgggct cattgactcc ctcatggcct
     1501 atgtccagaa ctgtgtggct gccagccgct gcgatgacaa gtctgtggag aactgcatgt
     1561 gtatcctgca taacctctca taccgcctgg acgccgaggt gcccacccgc taccggcagc
     1621 tggagtacaa cacccgcaat gcctacaccg agaagtcctc cactggctgc ttcagcaaca
     1681 ggggtgacaa gatgatgaac aacaactatg actgcccact ccctgaggaa gagaccaacc
     1741 ccaagggcag cagctggctg taccactcag atgccatccg cacctacctg aacctcatgg
     1801 gcaagagcaa gaaagacgct accttggagg cctgtgccgg ggccctgcag aacctgaccg
     1861 ccagcaaggg cctgatgtcg aatggtatga gtcagttgat tggaataaag gaaaagggct
     1921 tgccacaaat agcccgtctc ctgcaatctg gcaattcgga tgtggtgcgg tctggggcct
     1981 ctctgctgag caacatgtct cgccaccctg tgctgcacag agtgatgggg aatcaggtgt
     2041 tcccagaggt aaccagactc ctcactagcc acaccggcaa taccagcaac tctgaagata
     2101 tcctgtcctc tgcctgctac actgtgagga acctgatgac ctcgcagcct cagatggcca
     2161 agcagtactt ctccaacagc atgctcaaca atgtcttcaa cttgtgccgc aacagtgcct
     2221 cctcacctaa ggctgccgag gctgcccggc tactcctgtc tgacatgtgg gccagcaagg
     2281 agctgcagag tgtcctcagg cagcaaggtt tcgataggaa catgatggga aacatagctg
     2341 gggccaacaa cttcagaaac ttcacctccc ggttctaaga agagagtgtg caagcaagtt
     2401 caacttgcag aaagacacga cccagctgag aagacctcag gccttgagga tgggtaacct
     2461 gctccatcct gggcagtatc tggagacgtt cagatgcaac caagagcagc ctgaaaactg
     2521 tggatgatgg aaataatttt tgattccttt ttttttcctt aggggaactg gcaggctata
     2581 gggttgggga ggttgggtgg ggggactttc ttgagttaaa gggggcttac atctgatgtc
     2641 aatactttct tctctgagaa acagtatata tataatgtgt ataatgtaag tatgtgtgtg
     2701 cggtatacct gtgtgtgtcc acgcatgtgt ttgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2761 gtgtgtgtgt gtgtgtgcgc ctaaaagcat aaccaacaag tgaaacaggc tgggtgtgca
     2821 gatcctttgc agttcacagg cagcacgggg gactctcggt gtctcccttt atagacacat
     2881 gggctgcacc tacatgaaag ttttagccag tggagcccca gacttcagag agtctgcaag
     2941 cagctatttt gggagaaagg aagtaagaat agcactggaa gccagagctg tggggatgac
     3001 tacttgtgtt ctctcgtctc ctcaagggga tggggtggga acaggtgggc actgggcacc
     3061 tgcctgctca ggcttctcac agaacaggag aggaaaactg gaaattattt gcaatgtgct
     3121 tcagaccccg cttgctgagt gtcaggtgag ggagtgcttg gggcagggag agtgacccag
     3181 aggctgacag aagggaattt ggatggatga accatgaaaa ggaagtgtcc tgttagggca
     3241 tcagctagcc cacatcccag ccattagctt ctttcttcat gaacgctggc tgtcctgtct
     3301 gcactctgtc tctgtgaaac aaaatgccta gtggggtaga ggtggccaac cccagggacc
     3361 cagacttccc actgcagact gtattaccaa agaacttctg agaaccacat gagtgagcct
     3421 gtctgtgtga agctccctgg acggatgact gggtgggaca gcgctcagcc ttccccctgg
     3481 agctcctcat gtctaggcta gtgcttctcc gctggtgtgg ttagtgctga gtggacaaga
     3541 gggatcaggg ccacacctct ctcgaggagg atacagaatg ctccctggcc cagccctctt
     3601 cttaccccag ctgtaagacc gaaaaacccc tctgtggctc agggtggcct agtaaaagat
     3661 ctgtccattg agggtggagg tcagatacat gagacattgt ccctgagggg tgtcctaagt
     3721 catctatccg gtgtactctg gcactttaag tctgcaacat ctttccctgt ttggctcata
     3781 tgggaatctg cctcctacct caccttttct ccaataccag tgtgggatgt tgtcccagca
     3841 cactctcctc gggtatgctt cctgtgatct cccttgacaa tcactgggat ccaaaacagt
     3901 ctatttctta aaacatgcca ttgtcacact actctgtaca gacagtgtct gaaggaagca
     3961 cttaaagtat aacaataaat aaaacctacc atacccctgc cccatatagt atatgtccac
     4021 ccaagaaagg atacccaggt cctgggctgt aaggactatc cacttactca gtaagtttga
     4081 gagaatcttg gagagtgctc aagtcaccaa gtgaaactgt taaaggccct gaacaatgac
     4141 attcccaccc aacaccccca gcacagtcct cacttcctgc agcccatggg ctgttctcct
     4201 ttccctggga ggaagatttg ttgggcccac gctttgcttt ggggatgaag caggtcttag
     4261 acaccaaggg atcaggccaa ttatggtaac ttcttccatg acctcaagct ggccaggtag
     4321 gctgggccca acatatgcct gtcattcagg ggcaaaatga agaggactta tgagtacatt
     4381 cctagaagca gggagtaagg ggctggctgg actttatccc agacctgtct tcatgtttta
     4441 aatcaaatat gtctcctact tccatgccta aaacaggtca caatttagga ccaaaggaca
     4501 gaggccctgt atcttccttg acttttgcgc ttgctgcagt gtctgggacc ctccgtccag
     4561 ccctcattct ccttgatcca tcttgtatgt ttccttgtat gatacatcat gtatttgctt
     4621 tgtcaaaata taggaaatca ataaactgct tagtgtttct ttgaa
//
