LOCUS       NM_001271278            3096 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus PBX/knotted 1 homeobox 2 (Pknox2), transcript
            variant 1, mRNA.
ACCESSION   NM_001271278 XM_003750468 XM_003754405 XM_003754406 XM_003754407
            XM_003754408 XM_003754409
VERSION     NM_001271278.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3096)
  AUTHORS   Chen,G., Zhang,F., Xue,W., Wu,R., Xu,H., Wang,K. and Zhu,J.
  TITLE     An association study revealed substantial effects of dominance,
            epistasis and substance dependence co-morbidity on alcohol
            dependence symptom count
  JOURNAL   Addict Biol 22 (6), 1475-1485 (2017)
   PUBMED   27151647
REFERENCE   2  (bases 1 to 3096)
  AUTHORS   Zhang,X., Rowan,S., Yue,Y., Heaney,S., Pan,Y., Brendolan,A.,
            Selleri,L. and Maas,R.L.
  TITLE     Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic
            development
  JOURNAL   Dev Biol 300 (2), 748-757 (2006)
   PUBMED   17049510
REFERENCE   3  (bases 1 to 3096)
  AUTHORS   Ferretti,E., Villaescusa,J.C., Di Rosa,P., Fernandez-Diaz,L.C.,
            Longobardi,E., Mazzieri,R., Miccio,A., Micali,N., Selleri,L.,
            Ferrari,G. and Blasi,F.
  TITLE     Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major
            reduction of Pbx and Meis proteins and a pleiotropic embryonic
            phenotype
  JOURNAL   Mol Cell Biol 26 (15), 5650-5662 (2006)
   PUBMED   16847320
REFERENCE   4  (bases 1 to 3096)
  AUTHORS   Haller,K., Rambaldi,I., Daniels,E. and Featherstone,M.
  TITLE     Subcellular localization of multiple PREP2 isoforms is regulated by
            actin, tubulin, and nuclear export
  JOURNAL   J Biol Chem 279 (47), 49384-49394 (2004)
   PUBMED   15339927
REFERENCE   5  (bases 1 to 3096)
  AUTHORS   Haller,K., Rambaldi,I., Kovacs,E.N., Daniels,E. and Featherstone,M.
  TITLE     Prep2: cloning and expression of a new prep family member
  JOURNAL   Dev Dyn 225 (3), 358-364 (2002)
   PUBMED   12412021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Sep 13, 2012 this sequence version replaced
            XM_003754405.1, XM_003754406.1, XM_003754407.1, XM_003754408.1,
            XM_003754409.1, XM_003750468.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the genome
            assembly. The genomic coordinates used for the transcript record
            were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.800411.1,
                                           SRR26360190.461727.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760475 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000008.1  44979680-44979754   c
            76-181              JAXUCZ010000008.1  44884102-44884207   c
            182-290             JAXUCZ010000008.1  44865498-44865606   c
            291-430             JAXUCZ010000008.1  44850349-44850488   c
            431-602             JAXUCZ010000008.1  44832871-44833042   c
            603-791             JAXUCZ010000008.1  44820833-44821021   c
            792-921             JAXUCZ010000008.1  44808586-44808715   c
            922-1019            JAXUCZ010000008.1  44808025-44808122   c
            1020-1139           JAXUCZ010000008.1  44807138-44807257   c
            1140-1216           JAXUCZ010000008.1  44794078-44794154   c
            1217-1395           JAXUCZ010000008.1  44793087-44793265   c
            1396-3096           JAXUCZ010000008.1  44789947-44791647   c
FEATURES             Location/Qualifiers
     source          1..3096
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..3096
                     /gene="Pknox2"
                     /note="PBX/knotted 1 homeobox 2"
                     /db_xref="GeneID:680549"
                     /db_xref="RGD:1590611"
     exon            1..75
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            76..181
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..290
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1631
                     /gene="Pknox2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein PKNOX2; homeobox protein Meis2-like"
                     /codon_start=1
                     /product="homeobox protein PKNOX2 isoform 1"
                     /protein_id="NP_001258207.1"
                     /db_xref="GeneID:680549"
                     /db_xref="RGD:1590611"
                     /translation="MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVH
                     IAAPSATASTPVPSAPIDPQAQLEADKRAVYRHPLFPLLTLLFEKCEQATQGSECITS
                     ASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQVLRIHLLELEKVNELCKDFCN
                     RYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVSNNPQGIVV
                     PASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLD
                     LTSLLDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQ
                     VNNWFINARRRILQPMLDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGTP
                     GTNPDGSINLDNLQSLSSDNATMAMQQAMMAAHDDSLDGTEEEDEDDMEEEEEEEEEL
                     EEEEADELQTTNVSDLGLEHSDSLE"
     exon            291..430
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..602
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..791
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..921
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1019
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1139
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1216
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1395
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..3096
                     /gene="Pknox2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggtgaagc ctggaacaag actttaaagg gtttctggtc ttccatgctg ctcactagaa
       61 aagaggccct gaactgtact ctccctgtag ctgactagaa gtgtttctgg cccagctgga
      121 agtgagaaga gggggctgaa ccccctgaag accatcctag aggcggtggc atcatccaac
      181 aatcctccat gtgaatcaat cccatgatgc aacatgcctc cccagcccca gctctgacaa
      241 tgatggccac gcagaatgtc cctcccccac cctaccagga cagcccccag atgacagcaa
      301 ctgcccagcc accttccaag gcccaggctg ttcacatcgc agcaccctca gccaccgcca
      361 gcacacctgt gcccagtgcc cccattgatc cccaggccca gcttgaagca gacaagcgag
      421 ctgtgtacag gcaccctctt ttcccgctcc tgacgctgct gtttgagaaa tgtgaacagg
      481 ccacccaggg ctcagagtgc atcacctccg ccagctttga tgtggacatc gagaactttg
      541 tccaccagca ggagcaggaa cacaaaccct tcttcagcga tgacccagaa ctggacaatc
      601 tgatggtgaa ggcgatccag gtcctgagga tccacctgct agagttggaa aaagtcaatg
      661 aactctgcaa ggacttttgc aaccgttata tcacctgcct caaaaccaag atgcacagcg
      721 ataacctgct caggaatgac ctcggggggc cctactcccc caaccagccc tccataaacc
      781 ttcactcaca ggacctcctg cagaattccc ccaattccat gtctggagtc tccaataacc
      841 cccagggaat tgtggtccca gcctcagcac tccagcaggg caacatcgcc atgacaaccg
      901 tcaactcaca agtcgtgtca ggtggagcct tatatcaacc ggttaccatg gtaacctccc
      961 agggtcaggt ggtcacccaa gcaatccccc agggagccat ccagatccag aacacacagg
     1021 ttaaccttga cctcacctcc ctcctggaca atgaggataa gaagtccaag aacaaacgag
     1081 gagtcttgcc caagcatgcc accaatataa tgcgttcttg gctcttccag catctcatgc
     1141 acccctaccc aaccgaagat gagaagaggc agattgcagc ccagacaaac ctcaccctcc
     1201 tgcaagtaaa caactggttc atcaatgcca ggaggcgcat cctgcagccc atgcttgatg
     1261 ccagcaaccc agatcctgct cccaaagcca agaaaatcaa gtctcagcac cggcccaccc
     1321 aaagattctg gcccaattcc attgctgctg gagtcctgca gcagcagggt ggcaccccag
     1381 ggacgaaccc tgatggttcc atcaacttgg acaacctgca gtccctgtcc tcagacaatg
     1441 ccaccatggc catgcagcag gcaatgatgg ctgcccatga tgactccttg gatgggacag
     1501 aagaagagga tgaagatgat atggaggagg aggaagagga ggaggaggag ctggaggagg
     1561 aggaggctga tgagctacag acaacaaatg tcagcgacct gggcttggaa cacagtgact
     1621 ccctggagta gtcaggcagc ccagatggca ttggtcaccg ggcaggaaag gagtgtcatc
     1681 aggagggttc agggtggggg gaagggaata tgggcaggca gcattaagaa agttgggccc
     1741 tagcttcccc ggaatcatag cttgaagaaa tgcagagaca ccctgttcct ttccaaccac
     1801 caagcttcag tgaaaaccta gtcccagacc ctcagactgc agtgcactcc attgccgggg
     1861 gccagtcaaa cagcctgtga agaaagacag cttgagatct ggactcacca caaaccggag
     1921 gacagatgac acccgtggct ccacacggaa aaggacttga gttgtttaca agccctgccc
     1981 tgtgaggtgg acaggcgcta tttgcagagt ggacctttgc taaggggcag acttgggagg
     2041 gaaggatgag agagaagggg tctaacattt tcccccagga gaatctgagc tcccttgaaa
     2101 gacactcatg gacaggaggg agcctaaatg cataaccagt ggccagagga gtaggagggc
     2161 ctgagacaac accacacact gcctatcaga gtgagacatg gatggcacag ggctccaact
     2221 tgccctgccg gggccctgtc tcttagcaca gtggccatgg actaaggaga gggggaagga
     2281 aaccaaagag actccttctt cctctctctc ggaaatatat tgtcggtggg tccaccctga
     2341 agaggttaaa agcaactctc catctgggtc agctctagga ccaagcaggc ggcagaacct
     2401 ggatcgggag ccatattaag atgactctgg ggatcgcagc agtccctaag tgatcacatc
     2461 acagctcctg taacagtagg acatgatatc ttatgagatg ctcctaccct cagtggagtt
     2521 cttcagaaac ccagcctcct ccataagcct tgagagaggt ggggccaggg attcttttca
     2581 ctccgcaggt ctccgtgcaa ccctctgctc ccaagctggc actaccagct tctggccgcc
     2641 tccttcattc tattctccag agaaggcaga agaaacagtg gaaagcatta tcccaatggg
     2701 aagccagggt ctgaagaagg tgctactgct cttcccttcg gtacccaaca tggcagagga
     2761 tatagcgcac agctaatctg tacacgccat tgtgcttggc gctggaggaa ctggggcagc
     2821 ctgggaggaa gcttcctacc atctgccctc atacacaccc tccaagccca gcatggagga
     2881 tccaggattg gcatctgctg ctcctgtccc ctcccaccct atggctgtga aagacaggac
     2941 tgaccacacg tgtgttttcc attgggttta atgtgacgga tgtgcagttt catttgtaaa
     3001 tgtgcattgg ccatctcctt cagtgctggg atgtgaacgg ctatctggct caaccagagg
     3061 ggacccttgg gaccttctga gccttctcct cctcta
//
