LOCUS       NM_001013074            1542 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus PBX/knotted 1 homeobox 1 (Pknox1), mRNA.
ACCESSION   NM_001013074 XM_215364
VERSION     NM_001013074.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1542)
  AUTHORS   Ye,D., Lou,G., Zhang,T., Dong,F. and Liu,Y.
  TITLE     MiR-17 family-mediated regulation of Pknox1 influences hepatic
            steatosis and insulin signaling
  JOURNAL   J Cell Mol Med 22 (12), 6167-6175 (2018)
   PUBMED   30338914
  REMARK    GeneRIF: These data implicate the upregulated hepatic expression of
            Pknox1 in type 2 diabetes mellitus (T2DM) complicated with
            nonalcoholic fatty liver disease (NAFLD) may be caused by the
            reduced expression of miR-17 family, indicating that developing
            miRNA-mediated regulation strategies on Pknox1 may provide new
            therapeutic options for metabolic disease
REFERENCE   2  (bases 1 to 1542)
  AUTHORS   Faure,A.J., Schmidt,D., Watt,S., Schwalie,P.C., Wilson,M.D., Xu,H.,
            Ramsay,R.G., Odom,D.T. and Flicek,P.
  TITLE     Cohesin regulates tissue-specific expression by stabilizing highly
            occupied cis-regulatory modules
  JOURNAL   Genome Res 22 (11), 2163-2175 (2012)
   PUBMED   22780989
REFERENCE   3  (bases 1 to 1542)
  AUTHORS   Di Rosa,P., Villaescusa,J.C., Longobardi,E., Iotti,G., Ferretti,E.,
            Diaz,V.M., Miccio,A., Ferrari,G. and Blasi,F.
  TITLE     The homeodomain transcription factor Prep1 (pKnox1) is required for
            hematopoietic stem and progenitor cell activity
  JOURNAL   Dev Biol 311 (2), 324-334 (2007)
   PUBMED   17904118
REFERENCE   4  (bases 1 to 1542)
  AUTHORS   Yoshioka,H., Geyer,C.B., Hornecker,J.L., Patel,K.T. and
            McCarrey,J.R.
  TITLE     In vivo analysis of developmentally and evolutionarily dynamic
            protein-DNA interactions regulating transcription of the Pgk2 gene
            during mammalian spermatogenesis
  JOURNAL   Mol Cell Biol 27 (22), 7871-7885 (2007)
   PUBMED   17875925
REFERENCE   5  (bases 1 to 1542)
  AUTHORS   Zhang,X., Rowan,S., Yue,Y., Heaney,S., Pan,Y., Brendolan,A.,
            Selleri,L. and Maas,R.L.
  TITLE     Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic
            development
  JOURNAL   Dev Biol 300 (2), 748-757 (2006)
   PUBMED   17049510
REFERENCE   6  (bases 1 to 1542)
  AUTHORS   Bailey,J.S., Rave-Harel,N., McGillivray,S.M., Coss,D. and
            Mellon,P.L.
  TITLE     Activin regulation of the follicle-stimulating hormone beta-subunit
            gene involves Smads and the TALE homeodomain proteins Pbx1 and
            Prep1
  JOURNAL   Mol Endocrinol 18 (5), 1158-1170 (2004)
   PUBMED   14764653
REFERENCE   7  (bases 1 to 1542)
  AUTHORS   Villaescusa,J.C., Verrotti,A.C., Ferretti,E., Farookhi,R. and
            Blasi,F.
  TITLE     Expression of Hox cofactor genes during mouse ovarian follicular
            development and oocyte maturation
  JOURNAL   Gene 330, 1-7 (2004)
   PUBMED   15087118
REFERENCE   8  (bases 1 to 1542)
  AUTHORS   Jacobs,Y., Schnabel,C.A. and Cleary,M.L.
  TITLE     Trimeric association of Hox and TALE homeodomain proteins mediates
            Hoxb2 hindbrain enhancer activity
  JOURNAL   Mol Cell Biol 19 (7), 5134-5142 (1999)
   PUBMED   10373562
REFERENCE   9  (bases 1 to 1542)
  AUTHORS   Ferretti,E., Schulz,H., Talarico,D., Blasi,F. and Berthelsen,J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
REFERENCE   10 (bases 1 to 1542)
  AUTHORS   Knoepfler,P.S., Calvo,K.R., Chen,H., Antonarakis,S.E. and
            Kamps,M.P.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            [WARNING] On Nov 15, 2024 this sequence was replaced by
            NM_001013074.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001013074.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360181.2541369.1,
                                           SRR26360181.1803180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               JAXUCZ010000020.1  9681686-9681798
            114-241             JAXUCZ010000020.1  9685888-9686015
            242-413             JAXUCZ010000020.1  9687927-9688098
            414-584             JAXUCZ010000020.1  9689376-9689546
            585-684             JAXUCZ010000020.1  9692503-9692602
            685-782             JAXUCZ010000020.1  9693257-9693354
            783-911             JAXUCZ010000020.1  9696043-9696171
            912-988             JAXUCZ010000020.1  9698893-9698969
            989-1161            JAXUCZ010000020.1  9701776-9701948
            1162-1542           JAXUCZ010000020.1  9703216-9703596
FEATURES             Location/Qualifiers
     source          1..1542
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1542
                     /gene="Pknox1"
                     /note="PBX/knotted 1 homeobox 1"
                     /db_xref="GeneID:294322"
                     /db_xref="RGD:1305003"
     exon            1..113
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1373
                     /gene="Pknox1"
                     /codon_start=1
                     /product="homeobox protein PKNOX1"
                     /protein_id="NP_001013092.1"
                     /db_xref="GeneID:294322"
                     /db_xref="RGD:1305003"
                     /translation="MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSDPDAEGVSPPP
                     IESQTPMDADKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEK
                     DGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLL
                     SGEPGSPYSPVQSQQIQSAITGTLSPQGIVVPASALQQGNVTMATVAGGTVYQPVTVV
                     TPQGQVVTQALSPGTIRIQNSQLQLQLNQDLSILHQEDGSSKNKRGVLPKHATNVMRS
                     WLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKK
                     KPAQNRPVQRFWPDSLASGVAQATPGELAMSEGAVVTITTPVNMNVDSLQSLSSDGAT
                     LAVQQVMMAGQSEDESVDSTEDEGGALAPTHISGLVLENSDSLQ"
     exon            114..241
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            242..413
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..584
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..684
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..782
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..911
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..988
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1161
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1542
                     /gene="Pknox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctagacacc attcgcttct cactcaagat gatctgatgt ctgaagtgaa ctctcatcaa
       61 ccatgatggc tacacagacg ctaagtatag acagctatca agatggacaa caaatgcagg
      121 tggtcactga gttgaaaaca gagcaggatc ccaactgctc tgacccggat gcagaaggag
      181 tgagtcctcc tcccatcgag tctcagaccc cgatggatgc cgacaagcag gccatttata
      241 ggcacccgct atttccattg ctagctttgc tgtttgagaa atgtgagcag tccacacagg
      301 gatcagaagg cacgacgtcc gccagcttcg atgtggacat tgagaacttt gtcaggaagc
      361 aagaaaagga cgggaagccc ttcttctgtg aagatccgga aacagacaac ttaatggtga
      421 aagcaatcca ggtcctgcgt attcatcttc ttgaactgga gaaggtgaac gagctctgta
      481 aagacttctg tagtcggtac attgcctgtc tgaagacaaa aatgaacagc gagaccctgc
      541 tgagtgggga gcctggaagt ccgtactccc cagtgcagtc ccagcagatt caaagcgcca
      601 tcacaggcac tctcagcccc cagggaatcg tggtgccagc atcagccctg caacagggga
      661 atgtaaccat ggcaacagtg gcaggtggca cagtgtacca gcctgtcacc gtcgtcactc
      721 cacaaggcca agtggtcacg caggcattat ctcctgggac aattaggatc cagaactcgc
      781 agcttcaatt gcagttgaac caggatctca gcatcttgca tcaagaggac ggctcctcca
      841 agaacaagag gggcgtcctg ccgaagcacg ccaccaacgt gatgcgttcc tggctcttcc
      901 agcacatagg gcatccctac cccaccgagg atgagaagaa gcagattgct gctcagacaa
      961 acttgacact gcttcaagtc aacaactggt tcatcaatgc ccgaagacgg attctccagc
     1021 caatgttgga ttccagctgt tcagagactc caaaaacaaa gaaaaagcct gctcagaaca
     1081 ggccagttca gaggttttgg ccggattctc ttgcatcagg agtggcacaa gcaacacccg
     1141 gagagctcgc catgtcggaa ggtgccgttg tgaccatcac cacacctgta aacatgaatg
     1201 tggacagcct tcagtccctg tcctcagacg gggccaccct ggcggtacag caggtcatga
     1261 tggcggggca gagtgaggac gagtcggtgg atagcacaga agatgagggt ggcgccctgg
     1321 cacccacaca catcagcggg ctggtgctgg agaacagcga ctcccttcag taggaacgga
     1381 gtggaacggc cagtgtggag cctggacgcc ggactcttta ctgtttgcac agcaaacatt
     1441 ttacagtttt ctttgtaaca tgttttatat gtagatatag aagagtgcac ttttgtatct
     1501 cacagcttca agacgtcttc gctggtgcag cagcttcctt ca
//
