LOCUS       NM_053772               1971 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus cAMP-dependent protein kinase inhibitor alpha
            (Pkia), mRNA.
ACCESSION   NM_053772
VERSION     NM_053772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1971)
  AUTHORS   Vetter,M.M., Zenn,H.M., Mendez,E., van den Boom,H., Herberg,F.W.
            and Skalhegg,B.S.
  TITLE     The testis-specific Calpha2 subunit of PKA is kinetically
            indistinguishable from the common Calpha1 subunit of PKA
  JOURNAL   BMC Biochem 12, 40 (2011)
   PUBMED   21812984
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1971)
  AUTHORS   Collins,S.P. and Uhler,M.D.
  TITLE     Characterization of PKIgamma, a novel isoform of the protein kinase
            inhibitor of cAMP-dependent protein kinase
  JOURNAL   J Biol Chem 272 (29), 18169-18178 (1997)
   PUBMED   9218452
REFERENCE   3  (bases 1 to 1971)
  AUTHORS   Wen,W., Taylor,S.S. and Meinkoth,J.L.
  TITLE     The expression and intracellular distribution of the heat-stable
            protein kinase inhibitor is cell cycle regulated
  JOURNAL   J Biol Chem 270 (5), 2041-2046 (1995)
   PUBMED   7836431
REFERENCE   4  (bases 1 to 1971)
  AUTHORS   Baude,E.J., Dignam,S.S., Olsen,S.R., Reimann,E.M. and Uhler,M.D.
  TITLE     Glutamic acid 203 of the cAMP-dependent protein kinase catalytic
            subunit participates in the inhibition by two isoforms of the
            protein kinase inhibitor
  JOURNAL   J Biol Chem 269 (3), 2316-2323 (1994)
   PUBMED   7905001
REFERENCE   5  (bases 1 to 1971)
  AUTHORS   Van Patten,S.M., Howard,P., Walsh,D.A. and Maurer,R.A.
  TITLE     The alpha- and beta-isoforms of the inhibitor protein of the
            3',5'-cyclic adenosine monophosphate-dependent protein kinase:
            characteristics and tissue- and developmental-specific expression
  JOURNAL   Mol Endocrinol 6 (12), 2114-2122 (1992)
   PUBMED   1491692
REFERENCE   6  (bases 1 to 1971)
  AUTHORS   Knighton,D.R., Zheng,J.H., Ten Eyck,L.F., Ashford,V.A., Xuong,N.H.,
            Taylor,S.S. and Sowadski,J.M.
  TITLE     Crystal structure of the catalytic subunit of cyclic adenosine
            monophosphate-dependent protein kinase
  JOURNAL   Science 253 (5018), 407-414 (1991)
   PUBMED   1862342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM055544.1 and JAXUCZ010000002.1.
            
            On Dec 23, 2009 this sequence version replaced NM_053772.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM055544.1, SRR26643299.9213.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760433 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-562               FM055544.1         6-567
            563-1971            JAXUCZ010000002.1  96308084-96309492   c
FEATURES             Location/Qualifiers
     source          1..1971
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..1971
                     /gene="Pkia"
                     /note="cAMP-dependent protein kinase inhibitor alpha"
                     /db_xref="GeneID:114906"
                     /db_xref="RGD:621021"
     exon            1..112
                     /gene="Pkia"
                     /inference="alignment:Splign:2.1.0"
     exon            113..226
                     /gene="Pkia"
                     /inference="alignment:Splign:2.1.0"
     exon            227..349
                     /gene="Pkia"
                     /inference="alignment:Splign:2.1.0"
     exon            350..527
                     /gene="Pkia"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..607
                     /gene="Pkia"
                     /note="PKI-alpha; protein kinase inhibitor, alpha; protein
                     kinase (cAMP-dependent, catalytic) inhibitor alpha"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase inhibitor alpha"
                     /protein_id="NP_446224.1"
                     /db_xref="GeneID:114906"
                     /db_xref="RGD:621021"
                     /translation="MTDVETTYADFIASGRTGRRNAIHDILVSSASGNSNELALKLAG
                     LDINKTEGEDDGQRSSTEQSGEAQGEAAKSES"
     exon            528..1971
                     /gene="Pkia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcagctgc aggtggggcg ggggccttgc gagcccagag agcccagcac acgcggccgg
       61 gcgggcggga ctgctgccgg gggcagccgg gacgcgcctc tccatcccga agcttcctga
      121 ataccaagac ctgatgtgtc caagaggccg tttctagtag aaacctgaag aacatctcta
      181 agaaagaata atccaatgaa ttgagaacaa gaaggtttct aatcaggtac tgccactgtg
      241 ctctctctct ctttcacctt tggttccatt ggaacaggat cccagatctc aaaccctttc
      301 ctaccatcag agactgcccc tgtaaagagc actgttcctc aggctagagt ccctgctatg
      361 tggatatttg ttagcaatga ctgatgtgga aactacgtat gcagatttta ttgcctcagg
      421 aagaacaggt agaagaaatg caatacatga tatcttggtt tcctctgcaa gtggcaacag
      481 caatgaatta gccttgaaat tagcaggtct tgatattaac aagacagaag gtgaagatga
      541 tggacagaga agctccacag aacaaagtgg cgaagcccag ggagaagcag ccaagtctga
      601 aagctaacac tccattctga cggtcatcaa cacctgacga tgtggcgaat ctcctggcat
      661 tgctcggatg aatttgcggc catgggtgaa acggaggaga agaaaatggc cgtgatgaat
      721 ggcaagaagc cgttggttgc catgtcacga atgggggcag agcctgtgtc tgcacacagc
      781 ctttccccca cctctctcat tagcaatggt tgaaatcacc tggcctgtgc ttggatatca
      841 tttttgtatg ggtcctttca cttgaccgtt taatgaaatg cttgtagaga gtagcactga
      901 cctagctgat gattcctgta gcatctggcc cctcatgatg tcagaggatt taattgtgtc
      961 taattgaaaa gggttggttg aaccccagag tttccatatc tctggctgga gtattggctc
     1021 accaaaagaa ccatccagag agcacagtta gcattatgtc tctgtgtgtg agtgctgtgt
     1081 tatttacacc gttttgtatc gtacagtata cctgctcagc actgcccttt gattgcttat
     1141 gtaaaacaaa atgaagtaca ttgactgtga atttttatac cactcatttt tttaaagggc
     1201 tgccttttta atttcccata gtgttgtggt gtgcacgggg cagaacctgc ttttgtaaaa
     1261 cacgactttc ctcttgatga cttctgaggg ttatatccaa cagactcact gagcccccct
     1321 ttgctttatt atacaggcat gtggaaatat ccattaatgt gaatattgcc tgagttcagt
     1381 tttagtatct acacagacca gtgttctgtc tgtcaatatt gattttattt ccaagtaagt
     1441 tctttcagct aacaacttca tttttcatga ttaagaattt ttaagaattg acaaggtaga
     1501 caaagaaagt cagataatgc aaaggactgg aaacattgtg ttctgtggat cactttggtc
     1561 acattgatgg gtaccactgt ttaacttggg aggacagctt gtgaaggaag tgttctcctc
     1621 aaagcctgtg ggcacccgtc tataaaggaa agtccttggg atgtgttctc ccatgtcccc
     1681 tctcagccct ttcataatgt tattatgcac tttttaatgt ttgtaaaatt ttactaataa
     1741 tttgtgtgaa ttgctttgag atataataat tatcacccaa ccacactttt actgacgctg
     1801 ttgatggact atgctgtgtt ttgacatcac gattcttgta tggggaatgt ctgtggccta
     1861 tgtaaccccc tctggtcagt attatgaagc caactatctt tggtaataaa taaggatcca
     1921 gttagatgcc cagggttaat ctggggcatc ttatgggcaa ataacagatg a
//
