LOCUS       XM_008766937           15644 bp    mRNA    linear   ROD 11-JUN-2023
DEFINITION  PREDICTED: Rattus norvegicus PKHD1 ciliary IPT domain containing
            fibrocystin/polyductin (Pkhd1), transcript variant X1, mRNA.
ACCESSION   XM_008766937
VERSION     XM_008766937.3
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051344.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            [WARNING] On Feb 22, 2024 this sequence was replaced by
            XM_008766937.4.
            
            On Jan 21, 2021 this sequence version replaced XM_008766937.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_015227675.2-RS_2023_06
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 06/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..15644
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /sex="male"
                     /tissue_type="kidney"
                     /geo_loc_name="USA: Wisconsin, Milwaukee, Medical College
                     of Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..15644
                     /gene="Pkhd1"
                     /note="PKHD1 ciliary IPT domain containing
                     fibrocystin/polyductin; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 4 ESTs, 4 Proteins, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 3 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:301287"
                     /db_xref="RGD:1308476"
     CDS             315..12470
                     /gene="Pkhd1"
                     /codon_start=1
                     /product="fibrocystin isoform X1"
                     /protein_id="XP_008765159.2"
                     /db_xref="GeneID:301287"
                     /db_xref="RGD:1308476"
                     /translation="MPAWRISLLSVELLLLANAYSSFRIEPTEGSLAGGTWITLVFDG
                     LETSILYPNNGSQLAIDLVNVATPALKIPCDISPLFVDLPVVTCQTRSLPSEAPEGLY
                     SLEIRSGDQLLGSPCARLLDNCTFKFSKEQTPVLYQVNPSSGVPGEVVHVYGWVITDR
                     MEIFDPDVDYMESPLILEAGGDKWLTPCSLINRKTGICFPIQEEHGLGTVQCRVEGSY
                     IGSQNVSFSVFNKGRSMVHKEAWLISAKQELFLYQTYPEIHSVFPKVGSLGGRTDITI
                     TGDFFDPSARVTIAGIPCDIRHVSPRKIECTTRAPGNGARLTAPQAGNRGLLFEVGNA
                     VKDEELTEATPGYRWQIVPNASSPSGFWSKEGRPFRARLSGFFVAPETNNYTFWIQAD
                     SQAFLRFSSSEEPRMKVEVASIAVGTADWFDSWEQNGNEGSWQQKTNKLELQGGAKYY
                     LEAEQHGIAPSRGMRIAVQIHNTWLNPDVVNTYLLEKHQIRAQAQRLPEIQVLNMSGK
                     GNFFLTWGNVSSQPVPANATAQQIQTIIEELLVVKCNLVPLSARVLLWLGFEQGLDGS
                     RSDGVLTSSTEPFCGRFSLGQLRHLILSPGAVSKGYQLDRYPYLCFAYRGHMNRTLDM
                     TVSFLFGFQNVMKNITCDWSLMEPHPESWHFTCNNLWDTCVRHSEELQSSLANTPLLV
                     HRIDIFPVVPEADLLYVDEIILADTNVTVSQADSGVARPGGNVVESVSVVGVPPVYSI
                     ASWMAGCGSELPLITACYVPTQGTGEGSELIEVTAKRLQRTSPPLGGHFSLHLSDTVI
                     PDVPVHVSARQLHKLLQDNADESTSGYLNADDFIVTKDQNSCYEHVWTLSWTTQIGDL
                     PNFIRVSDQNLTGLNPTITARVVYDGGVFLGPILGDTLATANQQTQVTVQVNDIPAHC
                     SGSCSFQYQRASTPSVDCVWYSLGSDVNLLVHFTGNGFPRDAQFLQVTVINTSCEVIF
                     SNETNVACELALLPVGVHRVFMLVRPSGLALNASGEGLFLRVEPRLDAVEPSTGAEIG
                     GWWVTLRGSSLEGVSLVLFGTRSCVIDVIRSNSQQIQCKVPPRGKDGYTVNVTVINGD
                     HSTVLARAFTYVSSLNPVIVSLSRNRSNIAGGEILFLGMTLMVNYTDLNVQIYIQNTS
                     AQVLAKTAWGLEVLLPPLLPGIYVISAFINGISIRSQGVDLHIQYLTEVFSMEPCSGS
                     LLGGTILRLSGAGLGRDPALIRVLVDNRPCDTVKLTEVNIWCETPRVLLPPRADVLTV
                     PASVEIWAGNTSFVGKAFIFTYEAAATPVVTAMWGELMNNSVRFYVEGNNLSDSVILL
                     GSLKCDLQVQLFGDNMNLSGCSLLLHSLEAGVYALQVRHKRMGFANMSAVPQKFELSP
                     QIIDIFPTHGSIYGGTVLTVKGTAFRSRRRSVHVDLSGPFTCVILSLGDHTVLCQTKF
                     VGDQFSETSLALNITVLVNGLTSKCEGNCTLFLEEAATPIVDALTISISGSLTTVLMR
                     GQRLGSAGEPTAFVDGQLLCHTTFFNTSYVACQMRDLAPGFHYLSAVRTSAGYACLNS
                     VSRNFFVVPQVFDYFPKDFSIHGGSLLTIKGTTLRGWKTTFVYVGQQACLTVNISSEF
                     IQCIVPAGNGSAALEIDVDGVLYHMGFVDYSSIFTPELLSVSRSHDILTFTVARISGA
                     ANVDILIGTSPCLDVAGNRTILRCMVPLLPAGEYAVTGYDHSRGWVSSTLILVLRATV
                     TSVTENYGCLGGRLLHVLGAGFSPGNISAAVCGAPCQVLANATVSAFSCLVLPLDASL
                     AFLCNLRHAEDSCGVSRPTYLQCDLTVSVGMERLPGSWPYVYLCEESSQGLFVPDHQI
                     FLSFSGLFLSPKVERDEVLIYNSSCNITMETEAEMECGTPNQPITAKITEIQKSRGQN
                     TQGNFSFQFCRRWSRPHSWFPHRVPQDGDNVTVETSHLLLLDANTSLLNSLHIKGGKL
                     IFMEPGPIDLRAHSILITDGGELHIGSEDKPFQGKARIKLYGSVHSTSFFPYGVKFLA
                     VRNGTLSLHGSVPEVTFTYLRAAACAGDTVLALEEAVAWHPGDEAVISSGATVEGAEA
                     TEEVVVVETVHDADLHLRNPLRYSYNFTENWVTGVNHILKATVALLSRNIIVQGNLTL
                     ERVKLLDSCQEAGAAEGNLKHCLYSKSEKMLGARNLGARVIIQSFPEEPSLVKLKGVQ
                     FRDLGQAFHKHLSSLTLVGAMRGSYLHSCSMWGSFSRGLSIHRTWGLKVENNIFYKIV
                     GHALLVGSYMDRSFSTSEAVIGRKNGWWEEGSMIRNNVIINVSGAEGLSSSEMLAPAG
                     IYTFSPTSAIEGNRVCAAGYGYVLHLVTSQTVQAPLLSFNWNTAHSCTRYGLLVYPEF
                     QPPWNNDTGFTLFQNFMVWGSAGGAQIFRSNNLHLRNFQVYACRDFGIDILESDTNTL
                     VTDSFLLGHFTHEGSLCMSVGIKTPKRWGLTISNTTFVNFDLNCVAIRTCSGCSQGQG
                     GFPVKTRQLKFVNSSNLVAFPFPHAAVLQDLDGSLSGKNGSHVLASMETLSDTCLTNA
                     SFSQIVSGSVCGEAVLFHRMSIGLAKSLDVPKNLTMTDIRNRTITINYVDDTLSNSYG
                     WMALLLDQETYLLQFEGPWTDGSLQYSATFDNFAPGNYLLLMHRDLLPYPDILLRCGS
                     RVGQSLPSHPLPSRDGACDWFFHRQLRQLTYLVSGEGQVHVFLQVKHGAPPTVSASTS
                     VSESALKWSLPETWQDVEKGWGGYNHTIPGPGDDVLILPNKTVLVDTDLPVLRCLYVM
                     GTLEFPVDRSNVLSVACLLIAGGELKVGTLENPLGKDQRLLILLRASEEIFCDRFDGI
                     RVDPGTIGVYGKLRLHSAYPKKSWVHLGADIAPGNERIIVHNAVDWQPHDKIVLSSSS
                     YEPHEAEVLTVKEVKDHHIRIYERLKHRHIGSAHTLEDSRQICLAAEVGLLTRNIRIQ
                     SDSSCRGRLLVGSFRKSSGEEFSGILQLLNVEIQNMGSPLYASIEFTGVSAGSWVISS
                     TVHQSCTVGIHASSSRGMVLNDNIVFGTKGHGIDVEGQNYSLTNNLVILSMQSANSLP
                     WVAGIKVNYAEDIILHGNVVAGSERLGFHVRGHGCSSEVLWSDNVVHSSLHGIHLYKK
                     REPNNCTGVSGFLAFKNFDYGAMVQTENSVDIQNITLVDNTVGLLAISYVSSAPLRSG
                     STLQITLRNSVIVATSSSFDCIQDRKAPQSANWTSTDRAPSNPRGGRIGILWPVSASE
                     PNGWPQEPWHKVRGGHSVPGIMKLQDVTFSSFVKSCYSDDLDVCILTNEHSTGIMYPI
                     TAERTRMLKIKDKNKFYFLPLQSGKDLVGTICPASSDCEIPRKYLFTDLDGRTLGLSP
                     PVSVFPRIEEGWTGSFFNTGIFREEQKCTFRAMIQGFFCKQTEHAVLILDNVDVTWTI
                     PKFYPLVSITNGFVDTFSIVKDSGLCFPTSSPSTFYSILPTRQMTKVCFPERTPPFLH
                     FFLLANRRASKLILAVFYNEIQSPYVFLDKSFIPPTPVESAFSLLDEPVGANYFDIMN
                     NLLYVVLQGEEAVEIRSSVSIHLALTVTFSVLEKGWEKAVLESLRGFFQIDQNQIRLT
                     LEMPGNKETLKAIANSEGKRKRSCPTVTCAVPSSRYVQRRPLMAEMASFTITPATTLE
                     TFSKVIVFEIGDLPNARDSEFIQSLPSNRLQKLAHQVITAQQTGVLENVLGMTVGALL
                     VAQSEGVTGYRNASSLITGNQIYTRPSVVSILVQPSDGEVGIELPIQPRLIFLDEKNE
                     RVEALGLPSEPWIISVSLEGTSESMLKGCTQAETQDGYVTFSRLAVLTSGSNWHLVFT
                     VTFPPGTNLTARSKTFAVLPVAGKERSTIILALSLCSVASWVALSCLICCWFKKSKTR
                     KIKPEDISESQAKEQKKNTHISSKPRELQVKTAKEDAMMGEDMRMKVMEGRQNQFSQH
                     SMDGVSKRKVSRRAVPEERTATPALKIPRTTCVPGALPQQLTLPEPGNWQEAQQQLLR
                     YQLAGRDQLLLLCPDLRQERQQGQEPSQLNKGSGRCMGLSQEKATCVPTETFCLHTAP
                     PETIQ"
ORIGIN      
        1 gtggctcacg ttaattatta aacttgccct gtggtcattt ttgaactttt actctggtgc
       61 acgtttggcc aggccagaaa cgagttaggt gagttacact ccaatatgaa gcgagctacc
      121 tgcatggtag ctagctagct gcaggctggc ccatcaccag ataacgcggc gtcattttga
      181 agggaccggt ttctctcatt tgaagcacaa agcggacaca gcatcaggca caaaagctac
      241 atcatgccag tcgaccctaa aaatgtgctt ctaacatatg agaggtctca agagagctga
      301 gctaccctga tgtgatgcct gcctggcgga tctctctgtt gagtgtggaa ctactacttt
      361 tagcaaatgc ttactcaagt ttccggattg aaccgacaga aggtagcctt gcagggggaa
      421 catggatcac acttgttttt gacggtttgg aaacaagtat tctttacccc aacaatggct
      481 ctcagctggc gatagacctg gtgaatgtgg caacacccgc cttgaagatc ccttgtgaca
      541 tctctcccct cttcgtggat ttgcccgtgg tgacgtgcca gacgaggtct cttccatcag
      601 aagcacctga aggtctttat tctctggaga tacgctctgg ggatcaactg ctaggcagcc
      661 cgtgtgccag attactggac aactgtactt tcaagttttc caaggagcag acacctgttt
      721 tatatcaagt taacccatca agtggagttc caggagaagt agtgcatgtg tatggctggg
      781 tcattactga tcggatggaa atttttgatc ctgatgtgga ctacatggag agcccattaa
      841 tcctggaagc tggaggagac aaatggctta ctccttgttc tcttataaac aggaagacag
      901 gaatctgttt tcccatccag gaggaacatg gccttgggac tgtgcagtgt cgcgtggaag
      961 gcagttatat tggttcccag aatgttagtt tctcagtatt taacaaagga aggtcgatgg
     1021 tgcataagga agcctggctg atcagtgcta aacaggaact gttcctgtac cagacatacc
     1081 cagaaatcca ctctgtgttt ccaaaagttg ggagccttgg gggaagaaca gacatcacta
     1141 ttactggaga tttctttgac ccttctgccc gggttaccat tgcaggcatt ccatgtgata
     1201 ttagacatgt gtctcccagg aagattgagt gcaccaccag ggctccagga aatggagcaa
     1261 ggctcactgc tccccaggca ggtaatcgag gactcctttt tgaagttgga aatgctgtta
     1321 aggatgagga gctgactgaa gccaccccag ggtacaggtg gcagatagtt cctaatgcta
     1381 gttctccatc tggcttttgg tccaaggaag ggagaccttt cagagcacgg ctcagcgggt
     1441 tcttcgtggc tccagagacc aacaattaca cattctggat ccaggcagac agccaagctt
     1501 tcttgcgttt cagttcttca gaggagccaa ggatgaaggt agaagtggct tccattgcag
     1561 ttggcactgc tgactggttt gactcttggg agcagaacgg gaatgaaggg agctggcaac
     1621 agaagacaaa taagctagaa ctgcagggcg gagccaagta ctacttggaa gcagagcagc
     1681 atgggatagc tcccagcagg gggatgagaa ttgctgtcca gatccacaac acctggctga
     1741 atccagatgt ggtcaacact taccttctgg agaaacacca gatccgagcc caagcccaga
     1801 gacttccaga aatacaggtg ttgaacatgt caggtaaagg aaactttttc cttacttggg
     1861 gcaatgtctc cagccaacca gttcctgcaa atgccacagc ccaacagatc caaaccatca
     1921 tcgaggagtt gctggtggtg aaatgcaatc tggtacccct ttcagctcgt gttctcctct
     1981 ggcttggatt tgagcaaggc ttagatggct ccaggtctga tggggtcctc accagttcaa
     2041 ccgaaccatt ctgtggcaga ttcagccttg gtcaacttcg acatcttatc ctaagccctg
     2101 gggctgtcag taagggctat cagctggatc gatacccata tttgtgcttt gcatacagag
     2161 gtcatatgaa caggaccctg gacatgactg tttctttcct atttggcttc caaaatgtca
     2221 tgaagaatat cacctgtgac tggagtctga tggaacccca ccctgagagc tggcacttta
     2281 cttgcaataa cctctgggac acatgtgtac gccattctga ggagctccag tcttctctgg
     2341 caaacacccc attgctggtt catcggatcg acatcttccc tgtggttcca gaggcagact
     2401 tgctctatgt ggatgaaatt attcttgcag ataccaacgt aacagtttct caagccgatt
     2461 ctggagtagc ccgcccaggt gggaatgtgg tggagtcagt gtctgtggtg ggagtccctc
     2521 cagtctacag catagcctct tggatggcag gatgtggctc agaacttcct ctcatcactg
     2581 catgctatgt gcccacccag gggacaggcg aaggatcaga actgattgag gtgacagcga
     2641 aaagactcca gaggacaagc ccacctttgg gaggacactt ctccctccac ctctctgata
     2701 cagtgatacc tgatgttcca gtgcatgtgt ctgccagaca gcttcataag ctactgcagg
     2761 acaatgctga tgagtccaca tctggatatc tcaatgccga tgacttcatt gtgacaaagg
     2821 atcaaaattc ctgctatgaa catgtgtgga ctctttcctg gaccactcag attggggatt
     2881 tgcccaattt catcagggtc tccgatcaaa atcttacggg gttgaatccc accataactg
     2941 ctcgtgtagt atacgatggc ggagttttcc ttgggcccat tcttggagac acactggcta
     3001 ctgccaacca gcagactcag gtgactgtac aagtgaatga cataccagcc cattgttcag
     3061 gctcctgctc cttccaatac cagcgagcgt caactcccag cgtggactgt gtgtggtatt
     3121 cccttggtag tgatgtcaac ctgctggttc attttactgg aaatggtttc cctagagatg
     3181 cccagttctt acaggtcacg gtgatcaaca cgagttgtga agttattttc tcaaatgaaa
     3241 ccaacgttgc ctgtgagctt gccctactac cagttggagt gcaccgggtt tttatgctgg
     3301 tgagaccttc tggccttgct cttaatgcca gtggagaagg cctcttccta cgtgtggaac
     3361 ccaggctgga tgctgtggag ccttctacag gcgcagagat tggaggatgg tgggttacac
     3421 tccgaggctc tagtctagaa ggcgttagcc tggtgttatt tggaactcgg tcgtgtgtca
     3481 ttgatgtcat tagaagcaat tcgcaacaga ttcaatgcaa agtcccacct agggggaaag
     3541 atggatacac tgtgaatgtg actgtgatca atggggacca ctccacagtt cttgccagag
     3601 catttactta tgtctcctct ttaaatccag tgattgtgtc tttgagcaga aatagaagca
     3661 acatagcagg aggtgagatt ctgttccttg ggatgacact gatggtgaac tatacagatc
     3721 tgaatgtgca aatctacatt cagaacactt ctgctcaggt ccttgcaaag acggcatggg
     3781 gactggaggt gctgttgcct ccgttgctgc ctggcatcta tgtgatttca gcattcatca
     3841 atggaatcag cattcgttca caaggggttg atctccacat ccagtacctc actgaagttt
     3901 tcagcatgga accttgctcc gggtctctct tgggtggaac tatcctcaga ctctcaggag
     3961 caggactggg cagagaccca gctctgattc gggtgcttgt ggacaaccgt ccttgtgata
     4021 ctgtgaagtt aacagaagtg aacatttggt gtgagactcc ccgagtccta ctaccaccca
     4081 gagcagatgt tctcactgtc ccagcatctg tggagatctg ggctggcaac acttccttcg
     4141 tggggaaggc cttcatcttc acatatgaag ctgcagcaac tccagtggtc actgctatgt
     4201 ggggtgaact catgaacaac agtgtaaggt tttatgtgga aggaaataac ctctccgact
     4261 cagtcattct tttgggatcc ttgaaatgtg accttcaagt gcaattgttt ggtgataaca
     4321 tgaacctgtc tgggtgctcc cttcttctcc acagtttgga agctggggtc tatgctctcc
     4381 aagttcgtca caagaggatg gggtttgcca atatgtctgc ggtgcctcag aagtttgagc
     4441 tgtcaccgca gattatcgac atcttcccaa cacatggttc tatatatggt gggacagtgc
     4501 ttactgtgaa gggcacggct ttcaggtcca gaaggaggtc tgttcatgtt gacctttcag
     4561 gtccttttac ttgcgtgatt ttgagtttgg gagaccacac agtcctatgc cagaccaagt
     4621 ttgtgggtga tcagttttct gaaacatcac tggctctaaa catcacagtt ctggtcaatg
     4681 ggctgaccag caagtgtgag gggaactgta ctctcttcct ggaggaagca gcaactccta
     4741 ttgtggatgc tttgactata agtatcagtg gctctctaac cacagtgctg atgagaggac
     4801 agaggttagg ctctgctggt gagccaacag cctttgtgga tggtcaactt ctttgccata
     4861 caactttctt taataccagc tatgtggcat gccagatgag agatttggcc ccggggttcc
     4921 actatctgtc agctgttcgt acaagtgctg gatatgcttg cctcaatagt gtttctagaa
     4981 acttcttcgt tgtgcctcag gtgttcgatt attttcctaa ggattttagc atccatggtg
     5041 gaagtctctt gactataaaa ggcacaaccc ttcgaggatg gaaaactaca tttgtctatg
     5101 ttggccagca ggcttgtcta acagtgaaca tcagttctga gttcatccag tgcattgttc
     5161 ccgcaggaaa tggctctgct gctctggaaa tagatgtaga tggagtttta taccacatgg
     5221 gatttgttga ctacagcagc atctttaccc cagaattgct ttctgtttca cggagtcatg
     5281 acatcttgac ctttacagtg gcccggatct caggggctgc aaatgttgac attcttattg
     5341 ggacgtcacc gtgtctagat gttgctggta accgtacgat tctccggtgc atggtccctc
     5401 tgcttcctgc tggggagtat gctgtcacag gttatgacca cagcagagga tgggtctcat
     5461 ccactctcat tctcgtgctg agagccactg tgacctcagt gactgagaac tatggctgcc
     5521 tgggtggaag gcttttgcat gtgctcggag caggattttc tccagggaac atctcagctg
     5581 ctgtatgtgg tgctccgtgc caagtcttgg ctaatgcgac agtgtctgcc ttcagctgct
     5641 tggttctgcc cctggatgcg tccttggctt tcctctgtaa cctgaggcat gcagaagaca
     5701 gctgtggagt tagcaggccc acctacttgc aatgtgactt gactgtctcc gtggggatgg
     5761 agagactgcc tggatcctgg ccttacgtct acctttgtga agagagttcc cagggcctct
     5821 tcgtaccaga tcaccagatc ttcctttcct tctcaggcct cttcctcagc cctaaagtgg
     5881 aaagagatga agttctcatc tataatagct cctgtaacat taccatggaa actgaggcag
     5941 agatggagtg cgggacacct aatcagccaa ttaccgccaa gattactgaa atacagaaaa
     6001 gccggggcca gaacactcag ggcaactttt ccttccaatt ctgccgaagg tggtccaggc
     6061 ctcacagttg gtttcctcac agagtgccac aagatggcga caatgtcaca gtggagacca
     6121 gtcacctgct actgctagat gcgaatacaa gtctcctgaa ctccctgcac attaaaggtg
     6181 gcaagctgat tttcatggag cccggaccca ttgatctcag agcccattct atcctaatta
     6241 cagacggtgg agagctccat attggatctg aggacaagcc tttccaaggc aaagctcgga
     6301 tcaaactcta tggaagtgtc cactccactt ccttctttcc ctatggagtc aagttcctgg
     6361 ctgtgaggaa tggaactctt tctctgcatg gttctgttcc agaagttact tttacctatc
     6421 ttcgagcagc tgcatgtgca ggagacaccg tgttggctct ggaagaggcc gtggcttggc
     6481 accctgggga tgaggctgtc attagcagtg gagcgactgt agaaggtgct gaagcaacag
     6541 aagaggtggt tgttgtagaa actgtccacg atgcggacct ccatctcagg aaccccctga
     6601 gatactccta caacttcaca gaaaactggg taactggagt gaatcatatt ttgaaggcta
     6661 cagtggctct tctcagcagg aacattattg tccaaggaaa tctcactctc gagagggtaa
     6721 agcttcttga ttcatgccag gaggccggtg ctgctgaagg aaacctgaag cattgtttat
     6781 attctaagag tgagaagatg ctgggagcca ggaatctggg ggccagagtt atcattcagt
     6841 ccttcccaga ggaacccagc ttggtcaagc tgaagggagt gcagttccga gacctgggac
     6901 aagccttcca taagcatcta agctcactca ccctggtggg agctatgaga ggttcttatc
     6961 tccacagctg ttcaatgtgg ggctccttca gcagaggcct cagcatacac aggacctggg
     7021 gtctgaaggt ggaaaataat atattctata agattgtagg tcatgcccta ctggtggggt
     7081 cctacatgga cagaagtttt agcactagtg aggctgttat tggaagaaaa aatggttggt
     7141 gggaagaggg aagtatgata agaaacaatg tgatcatcaa tgtttctggg gctgagggac
     7201 tgtccagttc tgaaatgttg gcaccagcag gcatctacac tttcagtccc accagtgcga
     7261 ttgagggcaa cagagtgtgt gcagctggtt atggctatgt tctccacctt gtgaccagcc
     7321 aaacagtgca agctccacta ctctcattca actggaatac tgcacattct tgtacaagat
     7381 atggtctcct tgtatatcct gaatttcaac cgccttggaa taatgacact ggcttcactc
     7441 tgtttcaaaa cttcatggtt tggggaagtg ctggtggtgc ccagattttt agaagtaaca
     7501 atctgcacct gagaaacttc caagtttatg catgcagaga ctttgggatt gacattttgg
     7561 aaagtgacac gaacactttg gttactgaca gcttcttact aggtcacttc acccacgagg
     7621 gaagtctatg tatgtcagtt ggcatcaaaa ctcccaaaag atggggactg acgatttcta
     7681 acacaacttt cgttaatttt gatctcaact gtgtggccat cagaacctgt tctggctgtt
     7741 cccaaggaca gggtggattt cctgtcaaga ccaggcaatt gaagtttgtc aactcttcaa
     7801 atttagtagc atttcctttt cctcatgcag cagttttgca agacttagat gggtccctgt
     7861 ctgggaaaaa tggatctcat gttcttgctt ctatggaaac cctctcagac acatgtttga
     7921 ccaatgcaag cttcagccag attgtctctg gcagcgtctg tggggaagct gttctcttcc
     7981 atcgtatgtc tattggttta gctaagagcc tcgacgttcc taagaattta accatgactg
     8041 acatcagaaa taggacaatc actatcaatt atgtggatga cacgttgtct aactcttatg
     8101 gctggatggc tctactcttg gaccaagaga cctacttgct gcagtttgag ggtccttgga
     8161 cggacggatc tttgcagtac tcagcaacct ttgacaactt tgcccctgga aattacctcc
     8221 tgctaatgca cagggaccta ctaccttatc ccgacattct cctcagatgt gggagtcggg
     8281 tgggccagtc acttccctct catcctttgc cgagtcgaga cggagcctgt gattggttct
     8341 tccacaggca gttaaggcag ctcacctacc tggtttcagg ggaaggtcaa gttcacgtat
     8401 tcctccaggt gaagcatggt gcacctccaa ctgtttcagc ttctacatct gtatctgaat
     8461 cagctttaaa atggtccctt cctgaaacat ggcaagatgt tgaaaaaggc tggggaggat
     8521 acaaccacac catcccagga cccggtgatg acgtcttgat tttacccaac aagacggttc
     8581 ttgtggatac tgatctcccc gtgcttagat gcctctatgt gatgggtacc ttagaattcc
     8641 ctgtggacag aagcaacgtt ctgagtgtgg cgtgcttact cattgcagga ggggagctga
     8701 aagtaggtac tttggaaaac cccttaggaa aagaccaaag acttctgata ctcctcagag
     8761 cctcagaaga aatcttctgt gaccgttttg acggaatacg tgttgaccct ggaacaattg
     8821 gagtttatgg gaaacttcgc cttcacagcg catatcctaa gaaatcctgg gtacaccttg
     8881 gagctgacat tgccccggga aatgagagga ttatagtaca taatgcagtg gattggcagc
     8941 cccatgacaa aatcgtcctc agctcttctt cttatgagcc tcatgaggca gaggtcctca
     9001 ctgtgaagga agtcaaggac catcacatca ggatctatga acgtctaaaa cacaggcaca
     9061 ttggaagtgc ccacaccctg gaggatagtc gacagatttg tttggctgct gaggttggat
     9121 tgttgaccag aaacattaga attcagtctg actcatcctg tagagggaga ctccttgtgg
     9181 ggtccttcag gaaatctagc ggagaagagt tttctggcat tcttcaactt ctaaatgtag
     9241 aaattcaaaa catggggtca ccactgtatg catctattga attcaccggt gtgtcagctg
     9301 gatcctgggt tatatcttct actgtacatc aaagctgcac tgtgggcatc catgcatctt
     9361 ctagtcgtgg gatggtctta aatgacaaca tagtgtttgg cacaaaaggc catggaatcg
     9421 atgtggaggg tcagaactat tctctcacca ataaccttgt cattctgtca atgcagtcag
     9481 caaactccct tccttgggtg gcaggaatca aagtgaacta tgccgaagat atcattctcc
     9541 acggcaatgt ggtggcagga tctgagagac ttggctttca tgtccgtggc catgggtgct
     9601 cctctgaagt gctttggtct gacaatgtgg tccactcaag cctccatggc attcacctct
     9661 acaagaaacg tgaacctaat aactgtactg gtgtctctgg atttctggct tttaagaact
     9721 ttgactatgg tgccatggtt cagacagaga atagtgtgga catacagaat atcactctgg
     9781 tggataatac tgttggtctt ttggccatct cgtatgtatc ttcggctcca ctgagatctg
     9841 gcagcactct acagattact cttaggaatt cagtcatcgt agccactagc tcctcttttg
     9901 actgcatcca agacagaaag gctcctcagt cggccaactg gacctccaca gatagagcgc
     9961 cttccaatcc cagaggaggc cggatcggta ttctgtggcc tgtatctgcc tcagaaccaa
    10021 atggatggcc ccaggagcca tggcacaaag taaggggcgg tcattcagtt ccaggaatta
    10081 tgaagcttca agatgtcacc ttttctagtt tcgtgaagag ttgctatagc gacgatctgg
    10141 atgtctgcat cctgactaat gagcacagca ctggaatcat gtacccaata acagcagaga
    10201 ggaccagaat gctgaagata aaggacaaaa acaagttcta ctttcttcca ttacagtctg
    10261 ggaaagactt agtgggaacc atctgccctg catcatcgga ctgtgaaatt ccaagaaaat
    10321 acctcttcac agatctggat gggagaaccc tgggtctgtc cccaccagtt tctgtgtttc
    10381 caaggataga ggaaggatgg actggatcct tcttcaacac aggtatattc agagaagaac
    10441 agaaatgcac atttcgagcc atgatccagg gcttcttctg taagcagact gagcatgcag
    10501 tcctaattct tgataatgtt gatgtaactt ggacaatccc caaattctac ccacttgtat
    10561 ccattactaa tggttttgtg gacacgttca gtattgtgaa ggacagtggt ctatgctttc
    10621 ccacaagctc cccgtctact ttttattcca ttttaccaac cagacaaatg accaaagtat
    10681 gctttccaga gcgaactccc ccattcctgc acttttttct actggcaaac agaagagcgt
    10741 ccaagctcat cttggctgtg ttctacaatg agattcagag cccctacgtt ttcttagaca
    10801 agagctttat tccacctaca ccagtagagt cagcattttc actgttggat gagcctgttg
    10861 gtgccaacta tttcgacatc atgaataacc tcttgtatgt tgtcctgcaa ggagaggagg
    10921 ctgttgaaat acgttcaagt gtttccattc atttggcttt gacagtgaca ttttcagtcc
    10981 tagaaaaggg ctgggagaaa gcagtgcttg aaagtctaag aggcttcttc cagattgacc
    11041 aaaaccaaat cagactcact cttgagatgc ctggcaacaa agagacctta aaggccattg
    11101 caaacagtga aggaaaacga aagcgcagtt gcccaactgt gacttgtgct gtcccttcta
    11161 gcagatatgt tcaacgcaga cctctcatgg cagaaatggc atcatttaca atcacaccag
    11221 caaccactct ggaaactttc tcaaaggtga ttgtctttga aatcggtgat ctgccaaatg
    11281 caagggacag tgaattcatt cagtccttac caagtaacag attacagaaa ttggctcacc
    11341 aggttatcac tgctcaacag actggagttc tggaaaatgt ccttggtatg actgttgggg
    11401 ccctactagt ggctcagtca gagggagtca caggatatag aaatgcaagt agtttaataa
    11461 ctggaaacca gatatatacc cggccctctg tggtttccat cctggtgcag ccttcagatg
    11521 gggaagtggg aatagaatta ccgattcagc cacggctcat cttcctggat gagaagaatg
    11581 agagagtgga agctttgggt ctcccctcag aaccttggat tatttcagtt tccctggaag
    11641 ggacatctga atcaatgcta aaagggtgta cccaggcaga aacacaggat ggctatgtga
    11701 ccttctccag attggctgtc ttgacctctg ggtcaaactg gcacttagtt tttactgtca
    11761 ctttccctcc aggtactaat ttaacagctc gatccaagac ctttgctgtc ctgcctgtgg
    11821 ccggcaagga gaggtcaact atcatcctgg ccttgtccct gtgctcagtg gcgtcttggg
    11881 tggctctaag ttgtctcatt tgctgctggt ttaagaaaag caaaaccaga aaaataaaac
    11941 cagaagacat atctgaatcc caggctaagg aacaaaagaa gaatacccat atctcttcca
    12001 aacccagaga actacaagta aagaccgcaa aagaagacgc tatgatggga gaagacatga
    12061 gaatgaaggt catggaggga aggcagaacc agttttccca acactcaatg gatggagtgt
    12121 ccaaaagaaa agttagccgc cgtgctgtcc cagaggaaag aacagctaca cctgccctga
    12181 agattcccag aaccacctgt gtcccaggag ctcttcctca gcagttgact ctgccggagc
    12241 ctgggaactg gcaggaggcc caacagcagc tgcttagata ccagctggca ggccgcgatc
    12301 agctgcttct gttatgccca gacctcaggc aagagaggca gcagggtcag gagcctagcc
    12361 agctgaacaa agggagtggc cgctgcatgg ggctgtctca agagaaggcc acttgcgttc
    12421 ccactgagac cttctgcctt cacacagctc caccagaaac tatccagtaa cagctgtggg
    12481 cgcggagcac tgtgggcgtt tgtatgaaaa ggagaaactg ttcaaaatta tttctacatg
    12541 gtgaacgggg gaggagaggt ctgatctgtt tggacaacta agggagaatg gggacgactg
    12601 taattaagct tctcttagag ccaacactca ggatgcttca ggcttgtctt atggaagacc
    12661 tgtgatagat ttagttagct gatgttgtat ctgcaggact acagaaatac tcaggagata
    12721 tcttacacca aagcttatcc cccaaacaga ggtaacgtaa taagagttac ttgtagattt
    12781 tatttcgtgg tttaaattta gtaattattg ggagctttct gcattgcaag cattattatt
    12841 tgcacctcat gagtatttgt acatgaaaga tgatggtcac ataggctttg ttgggatttc
    12901 agttaagaaa aagatatgaa aacactaaat ttaggcaatt tttatgtact ataggtacat
    12961 ttcacaccag gtatttatat gaaaagggga aatattcaaa gctacttctc tgtggtaagt
    13021 gggaaaagag aggtctgatc tgtttggaca actaagggaa aaatgtggac tctcaatatt
    13081 ttgacttaat agttctaata atttcttcta gttgggtaaa atttacaact accagggaat
    13141 ttttctagaa gactaaacat aatctaatgg taaagtggac taatggctct cttatttatc
    13201 agagaactga tttttgtttc ccacaaaaag caagtataag gagtgcccaa gagactagaa
    13261 aagaaatctt aggtatggtc ttttgaagct gtgtttaggg agatgaagca aagaggtagc
    13321 tgatgcttta agaaagaaag tgcatcaatc accctctcta aactgctgaa aattttataa
    13381 ggaatagata gatgccaaag gattttcctg aactgattga tatatttatg tgacctttta
    13441 tcttctttag tttactgata cagtaatgca ttccgtgact tggattcaaa cgctgaacca
    13501 aatttacata ccttaaataa atcctgctgg catatttttt gatatactaa caggtttagt
    13561 ttgctgatat tttattgtat tttatatcta aatgatataa aatattataa aataatataa
    13621 aatgatatga gatattcgat cataatttca gtttattttt tcaattaact ttagccatgc
    13681 atagtttgaa tgcctgtagc ctaagctttc ccaaaagaga cggccggaaa atgctttagc
    13741 acgggaattc aaggccagtc tgaaccccat agcaagacaa aataatttct ttaaaacgtg
    13801 aattaggtgt agggcatctg gtgacacatg cctctggccc cagtactcaa gagatagaat
    13861 agcaggcatc acaaatttaa aggtagcctg ggatccacaa tatgctgcaa gccaacatga
    13921 cttatccaca aagaacttgt ctcaatagag aaaaaagaat taggaatgct ctgtattttc
    13981 tggaagaaat tctgtgaagt tggagggggg aaatggaact tttgttgttg ttttctgtag
    14041 tctgtaaaaa cattgtatgg aatagacatg actcttctcc atctatttgg tcggtttcag
    14101 tatcaaaatt gcttggccta cacatggctt tttcaaattt ttttaaatta tggattcaat
    14161 tttttataga ttatagaact attcaattaa aaaaaaagaa agaaagtgca gaccacttta
    14221 acatactcat ccatctctac ttaaactaaa gaatacttta agtgcactga cttatcacat
    14281 ttgtctgctt ctcagaaagc cttataacat gagaatatga agaaaagata tggaagacag
    14341 tcaggcagtg aaaagaattt ctacattttt ccgtggaaaa atgtcagatt ttcccacagt
    14401 ttaaaccaag atttttccaa tctccttatg gctaaaggag ctcttctggg gttgagacga
    14461 gacacaggca agcaatcctg tcttctatgg ctaactctta aatgatggca gcttagaaat
    14521 tgaaaccata ggatgtattg gtaaggagta atcatcaact agaaagcatt atctctttcc
    14581 accacgagtc ggccacagct atctctgcct cttctttaaa cattcttgaa gtagctcata
    14641 aagctccttg tttctaagat tacttagttc tgaggtgttg actctttcct gtggctctct
    14701 actgactgct gagaggagga atgatgacgc tgagtccgat gctccctgga gatgaaaatc
    14761 cagtctatat gcgtgctgag atggcataaa tcaattgcaa tgatacaaaa ttaccattaa
    14821 gctataaact agcttcctca ggataaatct tatagatgta tcttttcaga caacaaaggt
    14881 actttagaat tagctaccaa aacccaacac ttctgcgtag cattccttct cccatttaat
    14941 tagcccttgc aataactctt ttattatatt tcatttagta accttttgat ctttaaaacc
    15001 attggccttg gcaaactcta gtgcatactc ttaattctca agaactgtga tcttcctgga
    15061 ccataccctt tcagaaatta aggagtttga ggactgcagg agagtagcct tcagtcactg
    15121 tgttggttcc tgtttgtctt cgccttacat ctgcactcgg gtaactgcct tcaactcttc
    15181 caatctctgc cctgactttt ggtgaactct attccgtgta cctactgaga cttttcacag
    15241 ccactgtgga gtcagtgcag agctcaaccc tgctccagct cgctattttc ccctcctcat
    15301 tcaataaatg gcactatatc gtaacagcaa tcatgaccct tttttatatg tcaacgttct
    15361 cagtcaactc ccaagactca tttatacaca tttctgcagt ctaatgttaa tctcctcatc
    15421 cgtaccccat gcagttcagg atcgcctttg tgtgagataa gttttgagct ggttctcttt
    15481 ttcactgctt aaaaagaaaa aagatgggtg agtgggataa atgctgggag caggaaaaga
    15541 agctaagatc atttgtggct tagaacaagt ctgtaactgc accattgatg aaggtaaata
    15601 tttctgagct actcctatta accaaataaa ccatgggata aaca
//
