LOCUS       XP_008765159            4051 aa            linear   ROD 22-FEB-2024
DEFINITION  fibrocystin [Rattus norvegicus].
ACCESSION   XP_008765159
VERSION     XP_008765159.2
DBLINK      BioProject: PRJNA1074393
DBSOURCE    REFSEQ: accession XM_008766937.4
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_086027) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 21, 2021 this sequence version replaced XP_008765159.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_036323735.1-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/09/2024
            ##Genome-Annotation-Data-END##
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     source          1..4051
                     /organism="Rattus norvegicus"
                     /strain="BN/NHsdMcwi"
                     /bio_material="RGD 61498"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /sex="male"
                     /tissue_type="kidney, spleen, liver"
                     /geo_loc_name="USA: Wisconsin, Milwaukee"
                     /lat_lon="43.05 N 88.04 W"
                     /collected_by="Rebecca Schilling, Melinda Dwinell"
     Protein         1..4051
                     /product="fibrocystin"
                     /calculated_mol_wt=444061
     Region          256..>315
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Region          <944..1005
                     /region_name="TIG"
                     /note="IPT/TIG domain; pfam01833"
                     /db_xref="CDD:460355"
     Region          1016..1100
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Region          1194..1285
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Region          1378..>1434
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Region          1561..>1628
                     /region_name="IPT_PCSR"
                     /note="IPT domain of Plexins and Cell Surface Receptors
                     (PCSR) and related proteins . This subgroup contains IPT
                     domains of plexins, receptors, like the
                     plasminogen-related growth factor receptors, the
                     hepatocyte growth factor-scatter factors, and the...;
                     cd00603"
                     /db_xref="CDD:238337"
     Region          1918..2036
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          2228..2404
                     /region_name="Beta_helix"
                     /note="Right handed beta helix region; pfam13229"
                     /db_xref="CDD:463811"
     Region          2733..2856
                     /region_name="G8"
                     /note="G8 domain; pfam10162"
                     /db_xref="CDD:462971"
     Region          2988..3160
                     /region_name="Beta_helix"
                     /note="Right handed beta helix region; pfam13229"
                     /db_xref="CDD:463811"
     CDS             1..4051
                     /gene="Pkhd1"
                     /coded_by="XM_008766937.4:255..12410"
                     /db_xref="GeneID:301287"
                     /db_xref="RGD:1308476"
ORIGIN      
        1 mpawrislls vellllanay ssfriepteg slaggtwitl vfdgletsil ypnngsqlai
       61 dlvnvatpal kipcdisplf vdlpvvtcqt rslpseapeg lysleirsgd qllgspcarl
      121 ldnctfkfsk eqtpvlyqvn pssgvpgevv hvygwvitdr meifdpdvdy mesplileag
      181 gdkwltpcsl inrktgicfp iqeehglgtv qcrvegsyig sqnvsfsvfn kgrsmvhkea
      241 wlisakqelf lyqtypeihs vfpkvgslgg rtdititgdf fdpsarvtia gipcdirhvs
      301 prkiecttra pgngarltap qagnrgllfe vgnavkdeel teatpgyrwq ivpnasspsg
      361 fwskegrpfr arlsgffvap etnnytfwiq adsqaflrfs sseeprmkve vasiavgtad
      421 wfdsweqngn egswqqktnk lelqggakyy leaeqhgiap srgmriavqi hntwlnpdvv
      481 ntyllekhqi raqaqrlpei qvlnmsgkgn ffltwgnvss qpvpanataq qiqtiieell
      541 vvkcnlvpls arvllwlgfe qgldgsrsdg vltsstepfc grfslgqlrh lilspgavsk
      601 gyqldrypyl cfayrghmnr tldmtvsflf gfqnvmknit cdwslmephp eswhftcnnl
      661 wdtcvrhsee lqsslantpl lvhridifpv vpeadllyvd eiiladtnvt vsqadsgvar
      721 pggnvvesvs vvgvppvysi aswmagcgse lplitacyvp tqgtgegsel ievtakrlqr
      781 tspplgghfs lhlsdtvipd vpvhvsarql hkllqdnade stsgylnadd fivtkdqnsc
      841 yehvwtlswt tqigdlpnfi rvsdqnltgl nptitarvvy dggvflgpil gdtlatanqq
      901 tqvtvqvndi pahcsgscsf qyqrastpsv dcvwyslgsd vnllvhftgn gfprdaqflq
      961 vtvintscev ifsnetnvac elallpvgvh rvfmlvrpsg lalnasgegl flrveprlda
     1021 vepstgaeig gwwvtlrgss legvslvlfg trscvidvir snsqqiqckv pprgkdgytv
     1081 nvtvingdhs tvlaraftyv sslnpvivsl srnrsniagg eilflgmtlm vnytdlnvqi
     1141 yiqntsaqvl aktawglevl lppllpgiyv isafingisi rsqgvdlhiq yltevfsmep
     1201 csgsllggti lrlsgaglgr dpalirvlvd nrpcdtvklt evniwcetpr vllppradvl
     1261 tvpasveiwa gntsfvgkaf iftyeaaatp vvtamwgelm nnsvrfyveg nnlsdsvill
     1321 gslkcdlqvq lfgdnmnlsg cslllhslea gvyalqvrhk rmgfanmsav pqkfelspqi
     1381 idifpthgsi yggtvltvkg tafrsrrrsv hvdlsgpftc vilslgdhtv lcqtkfvgdq
     1441 fsetslalni tvlvngltsk cegnctlfle eaatpivdal tisisgsltt vlmrgqrlgs
     1501 ageptafvdg qllchttffn tsyvacqmrd lapgfhylsa vrtsagyacl nsvsrnffvv
     1561 pqvfdyfpkd fsihggsllt ikgttlrgwk ttfvyvgqqa cltvnissef iqcivpagng
     1621 saaleidvdg vlyhmgfvdy ssiftpells vsrshdiltf tvarisgaan vdiligtspc
     1681 ldvagnrtil rcmvpllpag eyavtgydhs rgwvsstlil vlratvtsvt enygclggrl
     1741 lhvlgagfsp gnisaavcga pcqvlanatv safsclvlpl daslaflcnl rhaedscgvs
     1801 rptylqcdlt vsvgmerlpg swpyvylcee ssqglfvpdh qiflsfsglf lspkverdev
     1861 liynsscnit meteaemecg tpnqpitaki teiqksrgqn tqgnfsfqfc rrwsrphswf
     1921 phrvpqdgdn vtvetshlll ldantsllns lhikggklif mepgpidlra hsilitdgge
     1981 lhigsedkpf qgkariklyg svhstsffpy gvkflavrng tlslhgsvpe vtftylraaa
     2041 cagdtvlale eavawhpgde avissgatve gaeateevvv vetvhdadlh lrnplrysyn
     2101 ftenwvtgvn hilkatvall srniivqgnl tlervkllds cqeagaaegn lkhclyskse
     2161 kmlgarnlga rviiqsfpee pslvklkgvq frdlgqafhk hlssltlvga mrgsylhscs
     2221 mwgsfsrgls ihrtwglkve nnifykivgh allvgsymdr sfstseavig rkngwweegs
     2281 mirnnviinv sgaeglssse mlapagiytf sptsaiegnr vcaagygyvl hlvtsqtvqa
     2341 pllsfnwnta hsctrygllv ypefqppwnn dtgftlfqnf mvwgsaggaq ifrsnnlhlr
     2401 nfqvyacrdf gidilesdtn tlvtdsfllg hfthegslcm svgiktpkrw gltisnttfv
     2461 nfdlncvair tcsgcsqgqg gfpvktrqlk fvnssnlvaf pfphaavlqd ldgslsgkng
     2521 shvlasmetl sdtcltnasf sqivsgsvcg eavlfhrmsi glaksldvpk nltmtdirnr
     2581 titinyvddt lsnsygwmal lldqetyllq fegpwtdgsl qysatfdnfa pgnylllmhr
     2641 dllpypdill rcgsrvgqsl pshplpsrdg acdwffhrql rqltylvsge gqvhvflqvk
     2701 hgapptvsas tsvsesalkw slpetwqdve kgwggynhti pgpgddvlil pnktvlvdtd
     2761 lpvlrclyvm gtlefpvdrs nvlsvaclli aggelkvgtl enplgkdqrl lillraseei
     2821 fcdrfdgirv dpgtigvygk lrlhsaypkk swvhlgadia pgneriivhn avdwqphdki
     2881 vlssssyeph eaevltvkev kdhhiriyer lkhrhigsah tledsrqicl aaevglltrn
     2941 iriqsdsscr grllvgsfrk ssgeefsgil qllnveiqnm gsplyasief tgvsagswvi
     3001 sstvhqsctv gihasssrgm vlndnivfgt kghgidvegq nysltnnlvi lsmqsanslp
     3061 wvagikvnya ediilhgnvv agserlgfhv rghgcssevl wsdnvvhssl hgihlykkre
     3121 pnnctgvsgf lafknfdyga mvqtensvdi qnitlvdntv gllaisyvss aplrsgstlq
     3181 itlrnsviva tsssfdciqd rkapqsanwt stdrapsnpr ggrigilwpv sasepngwpq
     3241 epwhkvrggh svpgimklqd vtfssfvksc ysddldvcil tnehstgimy pitaertrml
     3301 kikdknkfyf lplqsgkdlv gticpassdc eiprkylftd ldgrtlglsp pvsvfpriee
     3361 gwtgsffntg ifreeqkctf ramiqgffck qtehavlild nvdvtwtipk fyplvsitng
     3421 fvdtfsivkd sglcfptssp stfysilptr qmtkvcfper tppflhffll anrrasklil
     3481 avfyneiqsp yvfldksfip ptpvesafsl ldepvganyf dimnnllyvv lqgeeaveir
     3541 ssvsihlalt vtfsvlekgw ekavleslrg ffqidqnqir ltlempgnke tlkaianseg
     3601 krkrscptvt cavpssryvq rrplmaemas ftitpattle tfskvivfei gdlpnardse
     3661 fiqslpsnrl qklahqvita qqtgvlenvl gmtvgallva qsegvtgyrn asslitgnqi
     3721 ytrpsvvsil vqpsdgevgi elpiqprlif ldeknervea lglpsepwii svslegtses
     3781 mlkgctqaet qdgyvtfsrl avltsgsnwh lvftvtfppg tnltarsktf avlpvagker
     3841 stiilalslc svaswvalsc liccwfkksk trkikpedis esqakeqkkn thisskprel
     3901 qvktakedam mgedmrmkvm egrqnqfsqh smdgvskrkv srravpeert atpalkiprt
     3961 tcvpgalpqq ltlpepgnwq eaqqqllryq lagrdqllll cpdlrqerqq gqepsqlnkg
     4021 sgrcmglsqe katcvptetf clhtappeti q
//
