LOCUS       NP_001402765             763 aa            linear   ROD 09-APR-2024
DEFINITION  polycystin-2-like protein 1 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001402765 XP_038964804
VERSION     NP_001402765.1
DBSOURCE    REFSEQ: accession NM_001415836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 763)
  AUTHORS   Liu,X., Rich,K., Nasseri,S.M., Li,G., Hjaeresen,S., Finsen,B.,
            Scherberger,H., Svenningsen,A. and Zhang,M.
  TITLE     A Comparison of PKD2L1-Expressing Cerebrospinal Fluid Contacting
            Neurons in Spinal Cords of Rodents, Carnivores, and Primates
  JOURNAL   Int J Mol Sci 24 (17), 13582 (2023)
   PUBMED   37686387
  REMARK    GeneRIF: A Comparison of PKD2L1-Expressing Cerebrospinal Fluid
            Contacting Neurons in Spinal Cords of Rodents, Carnivores, and
            Primates.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 763)
  AUTHORS   Hulse,R.E., Li,Z., Huang,R.K., Zhang,J. and Clapham,D.E.
  TITLE     Cryo-EM structure of the polycystin 2-l1 ion channel
  JOURNAL   Elife 7, e36931 (2018)
   PUBMED   30004384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 763)
  AUTHORS   Su,Q., Hu,F., Liu,Y., Ge,X., Mei,C., Yu,S., Shen,A., Zhou,Q.,
            Yan,C., Lei,J., Zhang,Y., Liu,X. and Wang,T.
  TITLE     Cryo-EM structure of the polycystic kidney disease-like channel
            PKD2L1
  JOURNAL   Nat Commun 9 (1), 1192 (2018)
   PUBMED   29567962
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 763)
  AUTHORS   Shimizu,T., Higuchi,T., Toba,T., Ohno,C., Fujii,T., Nilius,B. and
            Sakai,H.
  TITLE     The asparagine 533 residue in the outer pore loop region of the
            mouse PKD2L1 channel is essential for its voltage-dependent
            inactivation
  JOURNAL   FEBS Open Bio 7 (9), 1392-1401 (2017)
   PUBMED   28904867
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 763)
  AUTHORS   Zocchi,D., Wennemuth,G. and Oka,Y.
  TITLE     The cellular mechanism for water detection in the mammalian taste
            system
  JOURNAL   Nat Neurosci 20 (7), 927-933 (2017)
   PUBMED   28553944
REFERENCE   6  (residues 1 to 763)
  AUTHORS   Ishimaru,Y., Inada,H., Kubota,M., Zhuang,H., Tominaga,M. and
            Matsunami,H.
  TITLE     Transient receptor potential family members PKD1L3 and PKD2L1 form
            a candidate sour taste receptor
  JOURNAL   Proc Natl Acad Sci U S A 103 (33), 12569-12574 (2006)
   PUBMED   16891422
REFERENCE   7  (residues 1 to 763)
  AUTHORS   Murakami,M., Ohba,T., Xu,F., Shida,S., Satoh,E., Ono,K.,
            Miyoshi,I., Watanabe,H., Ito,H. and Iijima,T.
  TITLE     Genomic organization and functional analysis of murine PKD2L1
  JOURNAL   J Biol Chem 280 (7), 5626-5635 (2005)
   PUBMED   15548533
REFERENCE   8  (residues 1 to 763)
  AUTHORS   Li,Q., Liu,Y., Shen,P.Y., Dai,X.Q., Wang,S., Smillie,L.B.,
            Sandford,R. and Chen,X.Z.
  TITLE     Troponin I binds polycystin-L and inhibits its calcium-induced
            channel activation
  JOURNAL   Biochemistry 42 (24), 7618-7625 (2003)
   PUBMED   12809519
REFERENCE   9  (residues 1 to 763)
  AUTHORS   Li,Q., Liu,Y., Zhao,W. and Chen,X.Z.
  TITLE     The calcium-binding EF-hand in polycystin-L is not a domain for
            channel activation and ensuing inactivation
  JOURNAL   FEBS Lett 516 (1-3), 270-278 (2002)
   PUBMED   11959145
REFERENCE   10 (residues 1 to 763)
  AUTHORS   Chen,X.Z., Vassilev,P.M., Basora,N., Peng,J.B., Nomura,H.,
            Segal,Y., Brown,E.M., Reeders,S.T., Hediger,M.A. and Zhou,J.
  TITLE     Polycystin-L is a calcium-regulated cation channel permeable to
            calcium ions
  JOURNAL   Nature 401 (6751), 383-386 (1999)
   PUBMED   10517637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 3, 2023 this sequence version replaced XP_038964804.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760434
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..763
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     Protein         1..763
                     /product="polycystin-2-like protein 1 isoform 1"
                     /note="polycystic kidney disease 2-like 1 protein;
                     polycystin-2-like protein 1"
                     /calculated_mol_wt=87410
     Region          147..342
                     /region_name="Polycystin_dom"
                     /note="Polycystin domain; pfam20519"
                     /db_xref="CDD:466668"
     Region          343..567
                     /region_name="PKD_channel"
                     /note="Polycystin cation channel; pfam08016"
                     /db_xref="CDD:462341"
     Region          569..>745
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          702..735
                     /region_name="Fer4_24"
                     /note="Ferredoxin I 4Fe-4S cluster domain; pfam18109"
                     /db_xref="CDD:436280"
     CDS             1..763
                     /gene="Pkd2l1"
                     /coded_by="NM_001415836.1:175..2466"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:293937"
                     /db_xref="RGD:1306261"
ORIGIN      
        1 mnimenskeq elqtlgsrvw dnpaysspps pngtprictv ssvalpetqp kkpevrrqek
       61 tprvpvsgcc llicrgirgl wgttltenta enrelyvktt lrelvvyivf lvdvclltyg
      121 mtsssayyyt kvmselflht psesavsfqt issmsdfwdf aqgplldsly wtkwynnqsl
      181 gssshsfiyy enlllgvprl rqlrvrndsc vvhedfredi lncydvyspd kedqlpfgpl
      241 ngtawtyhsq nelggsshwg rltsysgggy yldlpgsrqa saealqglqe glwldrgtrv
      301 vfidfsvyna ninlfcilrl vvefpatgga ipswqirtvk liryvnnwdf fivgcevifc
      361 ififyyvvee ileirvhrfr ylssvwnild lvvillsiva vgfhvfrtle vnrlmgellq
      421 qpdtypdfef lafwqtqynn mnavnlffaw ikifkyisfn ktmtqlsstl arcakdilgf
      481 aimffivffa yaqlgyllfg tqvesfstfv kciftqfrii lgdfdynaid nanrilgpvy
      541 fityvffvff vllnmflaii ndtysevkee lagqrdqlql sdllkqsysk tlqrlrlrke
      601 rvsdvqkvlk ggepeiqfed ftntlrelgh aereisevsa aftrfdrdgd hildeedqaq
      661 mrqgleeerm tlsaetenlg rsvghsppge ldaeaargrs wvsgeefdml trrvlqlqrv
      721 legvvsqvda lssklkmler kgelapspgm eepavwenpy nps
//
