LOCUS       NM_001191934            4851 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus polycystin 2, transient receptor potential cation
            channel (Pkd2), mRNA.
ACCESSION   NM_001191934 XM_573552
VERSION     NM_001191934.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4851)
  AUTHORS   Wang,Z., Sa,G., Zheng,L., Wei,Z., Zhang,Z., Hu,Y. and Yang,X.
  TITLE     Intraflagellar transport protein 88 interacts with polycystin 2 to
            regulate mechanosensitive hedgehog signaling in mandibular condylar
            chondrocytes
  JOURNAL   Arch Oral Biol 143, 105548 (2022)
   PUBMED   36155344
  REMARK    GeneRIF: Intraflagellar transport protein 88 interacts with
            polycystin 2 to regulate mechanosensitive hedgehog signaling in
            mandibular condylar chondrocytes.
REFERENCE   2  (bases 1 to 4851)
  AUTHORS   He,Y., Yang,M., Chen,Z., Wei,P., Qin,K., Xie,G. and Chen,K.
  TITLE     [Effect of polycystin2 on differentiation and maturation of
            osteoblasts promoted by low-frequency pulsed electromagnetic
            fields]
  JOURNAL   Sheng Wu Gong Cheng Xue Bao 38 (3), 1159-1172 (2022)
   PUBMED   35355482
  REMARK    GeneRIF: [Effect of polycystin2 on differentiation and maturation
            of osteoblasts promoted by low-frequency pulsed electromagnetic
            fields].
REFERENCE   3  (bases 1 to 4851)
  AUTHORS   Su,Q., Hu,F., Ge,X., Lei,J., Yu,S., Wang,T., Zhou,Q., Mei,C. and
            Shi,Y.
  TITLE     Structure of the human PKD1-PKD2 complex
  JOURNAL   Science 361 (6406) (2018)
   PUBMED   30093605
REFERENCE   4  (bases 1 to 4851)
  AUTHORS   Zheng,W., Yang,X., Hu,R., Cai,R., Hofmann,L., Wang,Z., Hu,Q.,
            Liu,X., Bulkley,D., Yu,Y., Tang,J., Flockerzi,V., Cao,Y., Cao,E.
            and Chen,X.Z.
  TITLE     Hydrophobic pore gates regulate ion permeation in polycystic kidney
            disease 2 and 2L1 channels
  JOURNAL   Nat Commun 9 (1), 2302 (2018)
   PUBMED   29899465
  REMARK    Erratum:[Nat Commun. 2019 Mar 26;10(1):1452. PMID: 30914650]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4851)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   6  (bases 1 to 4851)
  AUTHORS   Foggensteiner,L., Bevan,A.P., Thomas,R., Coleman,N., Boulter,C.,
            Bradley,J., Ibraghimov-Beskrovnaya,O., Klinger,K. and Sandford,R.
  TITLE     Cellular and subcellular distribution of polycystin-2, the protein
            product of the PKD2 gene
  JOURNAL   J Am Soc Nephrol 11 (5), 814-827 (2000)
   PUBMED   10770959
REFERENCE   7  (bases 1 to 4851)
  AUTHORS   Gallagher,A.R., Cedzich,A., Gretz,N., Somlo,S. and Witzgall,R.
  TITLE     The polycystic kidney disease protein PKD2 interacts with Hax-1, a
            protein associated with the actin cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 97 (8), 4017-4022 (2000)
   PUBMED   10760273
REFERENCE   8  (bases 1 to 4851)
  AUTHORS   Wu,G., Markowitz,G.S., Li,L., D'Agati,V.D., Factor,S.M., Geng,L.,
            Tibara,S., Tuchman,J., Cai,Y., Park,J.H., van Adelsberg,J., Hou,H.
            Jr., Kucherlapati,R., Edelmann,W. and Somlo,S.
  TITLE     Cardiac defects and renal failure in mice with targeted mutations
            in Pkd2
  JOURNAL   Nat Genet 24 (1), 75-78 (2000)
   PUBMED   10615132
REFERENCE   9  (bases 1 to 4851)
  AUTHORS   Tsiokas,L., Arnould,T., Zhu,C., Kim,E., Walz,G. and Sukhatme,V.P.
  TITLE     Specific association of the gene product of PKD2 with the TRPC1
            channel
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3934-3939 (1999)
   PUBMED   10097141
REFERENCE   10 (bases 1 to 4851)
  AUTHORS   Tsiokas,L., Kim,E., Arnould,T., Sukhatme,V.P. and Walz,G.
  TITLE     Homo- and heterodimeric interactions between the gene products of
            PKD1 and PKD2
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6965-6970 (1997)
   PUBMED   9192675
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Jul 17, 2010 this sequence version replaced XM_573552.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.29832.1,
                                           SRR26643429.46017.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-589               JAXUCZ010000014.1  5584552-5585140     c
            590-703             JAXUCZ010000014.1  5577003-5577116     c
            704-837             JAXUCZ010000014.1  5572752-5572885     c
            838-1088            JAXUCZ010000014.1  5571093-5571343     c
            1089-1313           JAXUCZ010000014.1  5569878-5570102     c
            1314-1542           JAXUCZ010000014.1  5567829-5568057     c
            1543-1710           JAXUCZ010000014.1  5562726-5562893     c
            1711-1892           JAXUCZ010000014.1  5560361-5560542     c
            1893-2013           JAXUCZ010000014.1  5558828-5558948     c
            2014-2112           JAXUCZ010000014.1  5551845-5551943     c
            2113-2234           JAXUCZ010000014.1  5548721-5548842     c
            2235-2352           JAXUCZ010000014.1  5548404-5548521     c
            2353-2516           JAXUCZ010000014.1  5547961-5548124     c
            2517-2664           JAXUCZ010000014.1  5544501-5544648     c
            2665-4851           JAXUCZ010000014.1  5541821-5544007     c
FEATURES             Location/Qualifiers
     source          1..4851
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..4851
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /note="polycystin 2, transient receptor potential cation
                     channel"
                     /db_xref="GeneID:498328"
                     /db_xref="RGD:1559992"
     CDS             1..2901
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /note="polycystic kidney disease 2 homolog; polycystic
                     kidney disease 2 (autosomal dominant)"
                     /codon_start=1
                     /product="polycystin-2"
                     /protein_id="NP_001178863.1"
                     /db_xref="GeneID:498328"
                     /db_xref="RGD:1559992"
                     /translation="MVNSSRVQPQPPGDPGRSPAPRASGPGRLLAGGAGLAVPGGLRE
                     QRGLEIEMERIRQAAARDPPAGASASPSPPLSSCSRQAWSRDNPGFEAEEDDDDDEVE
                     GEEGGMVVEMDVEWRPGSRRPASSSAVSSAGARGRGLGSYRGAAYPSGRRRRLEDQGA
                     PCPSPAGGGDPLHRHLPLDGQPPRVAWAERLVRGLRGLWGTRLMEESNANREKYLRSV
                     LRELVTYLFFLILLCILTYGMMSSNVYYYTRTLSQLFIDTPVSKTEKTNFKTLSSMED
                     FWKFTEGSFLDGLYWKAQSSNHTQADNRSFIFYENLLLGVPRLRQLRVRNGSCSIPQD
                     LRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLD
                     LSRTREETAAQLAGLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLVEFPATGGVV
                     PSWQFQPVKLIRYVTAFDFFLAACEIIFCFFILYYVVEEILEIRIHRLNYFRSFWNCL
                     DVVIVVLSVVAMMINIYRMSNAEGLLQFLEDQNSFPNFEHVAYWQIQFNNIAAVMVFL
                     VWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFTIMFFIIFLAYAQLAYLVFGTQVDDF
                     STFQECIFTQFRIILGDINFAEIEEANRVLGPLYFTTFVFFMFFILLNMFLAIINDSY
                     SEVKSDLAQQKAEMELSDLIRKGCQKALVKLKLKRNTVDAISESLRQGGGKLNFDELR
                     QDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQMRDDLEREREDLDLEHSSLPRPM
                     SSRSFPRSLDDSEEEDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRMEHSIGSIVS
                     KIDAVIVKLEIMERAKVKRREVLGRLLDGVAEDARLGRDSEIHREQMERLVREELERW
                     ESDDAASQSGHGLGTQVGLGGQSHPRSSRPPSSQSAEGLEGGGGNGSTNAHA"
     exon            1..589
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..703
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..837
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1088
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1313
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1542
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1710
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1892
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2013
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2112
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2234
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2352
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2516
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2664
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..4851
                     /gene="Pkd2"
                     /gene_synonym="RGD1559992; Trpp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggtgaact ccagccgtgt gcagccgcag cctcccgggg accccggacg ctcgcccgcg
       61 ccgcgagcgt ccgggcccgg ccgcctgctg gcgggaggcg ccggcctggc agtccccggc
      121 ggcctgcggg agcagcgggg cctggagatt gagatggagc gcatccggca ggcggccgct
      181 cgggacccac cggccggagc ctcggcctcg ccttctcctc cgctgtcgtc ctgctccagg
      241 caggcatgga gccgcgacaa cccgggcttt gaggccgaag aggatgacga cgacgacgag
      301 gtggaaggag aagaaggagg gatggtggtg gagatggacg tggagtggcg tccgggcagc
      361 cgaagaccgg cctcctcttc ggccgtgagc tcggcgggcg cccgcggccg gggtctggga
      421 agctatcgcg gcgcggctta cccgagcggg agacggcgcc ggctagagga ccagggcgcg
      481 ccgtgtccca gccccgcggg cggcggggac ccgctgcatc gccacctccc gctggatggc
      541 cagccgcccc gagtggcctg ggccgagagg ctggtgcgag gactgcgagg tctctgggga
      601 acaagactca tggaagagag caacgctaac cgagagaaat acctgagaag cgtgttgcgg
      661 gagctggtca cttacctctt tttcctcata ctcttgtgca tcttgaccta tggcatgatg
      721 agctccaacg tgtactacta cactcggaca ctgtcacaac ttttcataga caccccagtg
      781 tctaaaacag agaaaaccaa ctttaaaact ctctcttcca tggaggactt ctggaagttc
      841 acagaaggct ccttcctgga tgggctgtac tggaaggcac agagcagcaa ccatacgcaa
      901 gctgacaacc ggagctttat tttctatgag aacctgctgc taggagtgcc gcgtctacgc
      961 caactccgag tcagaaacgg atcctgctcc atccctcagg acctgagaga tgaaattaaa
     1021 gaatgctatg atgtctactc tgtcagcagt gaggacaggg ctccatttgg accgcggaac
     1081 ggaactgcgt ggatctacac aagtgaaaaa gacctgaatg gcagcagtca ctggggaatc
     1141 attgcgactt acagtggagc cggttactac ctggatctgt ccagaaccag ggaggagaca
     1201 gcggcccagc ttgctggcct caggaggaat ttctggctgg accggggcac acgggcagct
     1261 ttcattgact tctcggtgta taacgcaaac attaacctgt tctgtgtggt caggttattg
     1321 gttgagttcc cagcaacggg tggcgtggtg ccctcttggc agtttcagcc tgtaaaactg
     1381 atccgctacg tcacagcctt tgatttcttc ctggcagcct gtgagattat cttttgtttc
     1441 tttatccttt actatgtggt ggaagagata ttggaaattc ggattcacag actgaactat
     1501 ttcaggagtt tctggaattg tctggatgtt gtgattgttg tgttgtccgt agtagccatg
     1561 atgattaaca tttaccggat gtccaatgct gaggggctgc tacagtttct cgaagatcaa
     1621 aattctttcc ccaactttga gcatgtggca tactggcaaa tacagttcaa caatatagct
     1681 gccgtcatgg tatttttggt ctggattaag ctcttcaaat tcatcaattt caataggacc
     1741 atgagtcagc tctccacgac catgtccaga tgtgccaaag acctctttgg cttcaccatc
     1801 atgttcttca tcatcttctt ggcatatgcc cagttggcgt accttgtctt tggcactcag
     1861 gtggatgact tcagtacttt ccaagagtgt attttcactc agttccgcat cattttgggt
     1921 gatatcaact tcgcagagat cgaggaagct aaccgagttt tggggccact ttattttact
     1981 acatttgtgt tctttatgtt cttcattctt ttgaacatgt ttctggcgat catcaatgat
     2041 tcctactctg aggtgaaatc agatctggcc cagcagaaag cagaaatgga actctcagac
     2101 cttatcagaa agggctgcca aaaagcactt gtcaaactaa aacttaaaag aaacaccgta
     2161 gacgccattt cagagagtct ccggcaaggt ggtggcaagc taaactttga tgaacttcgg
     2221 caagacctga aagggaaggg ccacacggac gcagagatcg aggccatatt cactaaatat
     2281 gaccaggacg gcgaccagga actgactgag cgtgagcatc agcagatgag agatgacttg
     2341 gagagagaga gggaggacct agacttggaa cacagctctt taccacgtcc catgagcagc
     2401 agaagtttcc ccagaagcct ggatgactct gaggaggaag acgatgaaga cagtggccat
     2461 agttccagga ggaggggaag catctccagt ggggtttcct atgaagagtt ccaagtactg
     2521 gtgagacgcg tggaccgcat ggagcactcc atcggcagca tcgtgtccaa gatcgatgct
     2581 gtgattgtca agcttgagat catggagcgg gccaaggtga agaggcgaga ggtgttagga
     2641 aggctgctgg atggagtggc tgaggatgcg cgcctgggtc gggatagtga gatccacagg
     2701 gagcagatgg agcgcctggt gcgggaagag ctggagcgct gggaatcgga tgacgcagct
     2761 tcacagtcag gtcacggtct aggcacacaa gtgggactcg gtggccagtc gcaccccaga
     2821 agctcccggc ccccttcctc ccagtctgca gagggcctgg aaggcggagg tggaaacgga
     2881 agtaccaacg cgcatgcgta acaatccaca cgtgtttgtc cctgagacgc ggagaggtgg
     2941 ttgtccggta tggtagtgac aagttcggta tttatatacc ccggctgcat tgtgatgctg
     3001 gtctttgtga ccaattgtta taattttctg cactttaatt tattttacgt aaacttaacc
     3061 cgtggttcga ggaaggttgt tttacttttt tctcatatga gaaatataga tgtaaatatt
     3121 gagttcagaa agaagagaaa tttgaaagta tactgagttg ctgccctatc cgagtctatt
     3181 tggaagttag gggagaagcg tcactagcct aagtttgtga ggagccgcca cagtcagcag
     3241 cggcagtgag acatgctaag gaaaagcatg gatggcattt ctatccatgg aggtgcacct
     3301 cggagcttac tacataccag tcttctaagg aaggagtcgt atttcagcaa ccttactggg
     3361 gtgcagagaa tggatatgta tgtagccatt gggctaaaat gtttatgaat ggctgagaca
     3421 gatagatgct aagcgtatca tttaattttt gtgtgattta gcttttgctt gaaattcagc
     3481 aaggaaagcc ccaaagataa actgaaggat aaaatgtagg attggaagag gccttcgatt
     3541 cttagtttga cttttcaatt atttgttggc atagaaattt ctgcattttt tttcttatgt
     3601 ctcattttca accaaattta atattaaaat agctaataag ccagacatac actgaatatt
     3661 ttagtacgca atgaaagttt taactcagca aacatgtaca tgcgaagcag tgttttaagg
     3721 aagttttgaa gcacgtaaaa gccctgtaaa agtaaaggct tggtttgtgc tgtatctaga
     3781 atatagttct caaatattct taatcttgta tttcagaatg aaatcatata ccacaaattc
     3841 agctcatttt tatgcgagga gcctttggta ttaagggttt atctatttgc agaagggatc
     3901 agctaaaagt tgactatcaa cgatagtttt cattaagaga gggtctcact aaatttatag
     3961 gggaaatcta tttcttcatg tcattttttt ggtccgtcaa agacaggttt tcactatata
     4021 atcctgactt gcctggaact aactgtgtaa acttggctgg cctcagactc acagtggtcc
     4081 accggctctc ggcctcttaa gtgctgggat taagggcctg tgtgaccacc agttgttgag
     4141 taacttggcc cttagtcagc aaggggatca gaagaagcaa agccaagctg gtagagaagc
     4201 cagaggtaga gaacaagtag aagagaatcc tgggcttagt gctgtccttt aaattcacaa
     4261 gagtgcattg ttttcctaga acatagcaaa cctccagcta actgctgagc ggacaggtta
     4321 ctttctgcag gagcgaggtg tgccatggtt ccctgatctg agggctccat gccaaccatt
     4381 ctcttttgag tatgctatgc tagctttttt ctccctaggt gttagatttt gcattccagg
     4441 gatatcattg tgtgtatgta tttatgtatg cgtactttgc tgttacaagt aaacaaactt
     4501 caatttgaag tgcactcaat atgtggtatc catatgtatc gaccatgtgc catatatcta
     4561 ctatggtcac tagcacgtct ttaatgatgc ttgttattac atcgtcgctt ctttttcatt
     4621 caacttgcag aacttttgta gaattctttt tttcccttta catataagtt catatatttt
     4681 tctacttcag tcctgtgaag cttatcccca atcacttttc tattagtctc ccctctgtat
     4741 atgaggggag ttattacata tacaaggttc ttttgacaat caacaatttc ttaactgtaa
     4801 taatgtgtac attacttaat aaagacttga catgctaccg tggtgtaaat a
//
