LOCUS       NM_001398724            2948 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus praja ring finger ubiquitin ligase 1 (Pja1),
            transcript variant 3, mRNA.
ACCESSION   NM_001398724 XM_006257105
VERSION     NM_001398724.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2948)
  AUTHORS   Watabe,K., Kato,Y., Sakuma,M., Murata,M., Niida-Kawaguchi,M.,
            Takemura,T., Hanagata,N., Tada,M., Kakita,A. and Shibata,N.
  TITLE     Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal
            cytoplasmic TDP-43 aggregate formation
  JOURNAL   Neuropathology 40 (6), 570-586 (2020)
   PUBMED   32686212
  REMARK    GeneRIF: Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal
            cytoplasmic TDP-43 aggregate formation.
REFERENCE   2  (bases 1 to 2948)
  AUTHORS   Sasaki,A., Masuda,Y., Iwai,K., Ikeda,K. and Watanabe,K.
  TITLE     A RING finger protein Praja1 regulates Dlx5-dependent transcription
            through its ubiquitin ligase activity for the Dlx/Msx-interacting
            MAGE/Necdin family protein, Dlxin-1
  JOURNAL   J Biol Chem 277 (25), 22541-22546 (2002)
   PUBMED   11959851
REFERENCE   3  (bases 1 to 2948)
  AUTHORS   Mishra,L., Tully,R.E., Monga,S.P., Yu,P., Cai,T., Makalowski,W.,
            Mezey,E., Pavan,W.J. and Mishra,B.
  TITLE     Praja1, a novel gene encoding a RING-H2 motif in mouse development
  JOURNAL   Oncogene 15 (19), 2361-2368 (1997)
   PUBMED   9393880
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 22, 2021 this sequence version replaced XM_006257105.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.1575898.1,
                                           SRR26643299.68132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000021.1  68625870-68625950   c
            82-2948             JAXUCZ010000021.1  68621101-68623967   c
FEATURES             Location/Qualifiers
     source          1..2948
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..2948
                     /gene="Pja1"
                     /note="praja ring finger ubiquitin ligase 1"
                     /db_xref="GeneID:683077"
                     /db_xref="RGD:1591532"
     exon            1..81
                     /gene="Pja1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..2948
                     /gene="Pja1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2138
                     /gene="Pja1"
                     /EC_number="2.3.2.27"
                     /note="isoform 3 is encoded by transcript variant 3; E3
                     ubiquitin-protein ligase Praja-1; praja ring finger 1, E3
                     ubiquitin protein ligase"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase Praja-1 isoform 3"
                     /protein_id="NP_001385653.1"
                     /db_xref="GeneID:683077"
                     /db_xref="RGD:1591532"
                     /translation="MGQGSSKPVRPPPAGGYQSGPGRSYGRRHAYVSFRPSMSQQERI
                     ASQRRTTSEVPMHRSTANQSKRSRSPFASTRRRWEDNEGSGASLAVENEDYSRYPPRE
                     YRASGSRRGMAYGHIDTLVARDSEEEGAGPVDRLPVRGKTGKFKDDPEKGARSSRFSS
                     VNHDVKEERGKVESPPAARCSARRAELSKQNGSLASQISSAEGRAAVKGNHSLERERQ
                     NLPARPSRAPVSICGGGENTPKSAEEPVVRPKVRNVAAPNCMKPKVFFDTDDDDDVPH
                     STSRWRDAADAEEAHADGLARRGRGEAAGGSSEPRYAEDQDARNEQAKPEKVSRRRRT
                     MADPDFWAYSDDYYRYYEEDSDSDKEWMAALRRKYRSRDQPQSSSGESWEPLPGKEDQ
                     EPQQARGNVNTAGAGSLAGAGSNGSGYPEEVQEPSLQEEEQASLEEGEIPWLRYNENE
                     SSSEGDNESTHELMQPGMFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAIS
                     YVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDH
                     GAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL"
ORIGIN      
        1 gagacccgga gcagcagcag tggtggtggc gtccagaggt ccgacagctc tgcagctctg
       61 agcgcgcgac tggccaggaa ggtccacagc agtcactgga atgctacctc aggccttaga
      121 agactgattt ttaaagggcc cctatcagtc tattacctgc ctcctgaagg aaaaaaatag
      181 atgttcttgt ttctgtagtt ctgaactggg agcaagaacc tttacacctg cctcccagct
      241 ctgttggaaa ctcctgagtc agagccatgg gtcagggatc tagcaagcct gttcggcccc
      301 caccagcagg agggtatcag tcaggtccag gcaggagtta tggaaggagg catgcttatg
      361 tcagtttcag gccatccatg agccagcagg agaggattgc cagccagaga aggacaacat
      421 ccgaagtccc aatgcacaga tcaactgcca atcaaagcaa gaggagccgg tcaccatttg
      481 ccagcactcg tcgtcgctgg gaagacaacg agggctcggg agccagcctg gctgttgaga
      541 atgaggatta ttccaggtat cctccaagag agtacagggc ctcagggagc cgaagaggaa
      601 tggcttatgg acacattgac actttagtgg ctcgtgatag tgaggaggag ggggctgggc
      661 ctgttgatcg actgccagtg agagggaaaa ctggcaagtt taaggatgat cccgagaagg
      721 gggcaaggtc ttcccgcttt tctagtgtta accatgatgt gaaagaggaa cgtggcaagg
      781 tagaatcacc ccctgctgcg aggtgctctg ctcgcagagc tgagctctcg aagcagaatg
      841 gctccttggc ctctcagatt tcttctgctg aaggcagagc agctgtaaaa ggtaatcaca
      901 gcttggaaag ggagaggcag aatttaccag ctcgtcctag cagggctcct gtgagtattt
      961 gtggtggtgg ggaaaacacc ccaaagagtg ctgaggaacc ggtggtgaga cccaaagtcc
     1021 ggaatgtggc ggctccaaac tgcatgaaac caaaagtgtt ttttgatact gatgatgatg
     1081 atgatgtacc acacagtact tccaggtgga gggatgccgc tgatgctgag gaagctcatg
     1141 ccgacggtct agccagaaga ggccgaggtg aggctgccgg tggctcatct gagccacggt
     1201 atgctgaaga ccaggatgcc aggaatgagc aagcgaagcc agagaaagtg tcaagacggc
     1261 gccgaaccat ggcagaccct gatttctggg catacagtga tgattactac cgttactacg
     1321 aggaagattc tgacagcgac aaagagtgga tggctgcact gcgcaggaag taccgaagca
     1381 gggatcaacc ccagtcttca agtggagaaa gctgggagcc tctcccagga aaggaagatc
     1441 aggaacccca gcaagctaga gggaatgtga acaccgctgg agccgggagc cttgcgggtg
     1501 ctggcagtaa tggcagtggc tatcctgaag aagtacaaga gccatctctt caggaagaag
     1561 agcaggcctc tctggaagaa ggagaaattc cttggctccg ctacaatgag aatgaaagca
     1621 gcagcgaggg tgataatgag tctactcatg agctgatgca gcctgggatg ttcatgctgg
     1681 acggaaacaa caatctggaa gacgactcca gcgtgagcga agaccttgaa gtggactgga
     1741 gcctgtttga tggatttgca gatggcctgg gagtggcgga agccatctcc tatgtggatc
     1801 ctcagttcct cacctacatg gctctcgaag agcgtctggc ccaggcgatg gagacagccc
     1861 ttgcccactt ggagtctctt gctgttgatg tcgaagtggc taacccacct gcaagcaagg
     1921 agagcattga tgcgctgcct gagatcttgg tcaccgaaga tcacggtgca gtgggccagg
     1981 aaatgtgctg tcctatctgc tgcagcgagt atgtgaaggg ggaggtggca acagagctac
     2041 catgccacca ctatttccac aagccgtgcg tgtccatctg gcttcagaag tctggcacct
     2101 gcccagtgtg ccgctgcatg ttccctcccc cgctctaaaa accaaggctc ttaacagtca
     2161 gcctggttat gttccctgtc taaaacccac aatactacag gagcccttgt tcaaaattta
     2221 ccagtggcaa tgaaatcagt cagtcaatta gactacagtt gttgattcct tgtgattatt
     2281 tccatgtgaa aatgattgtg tacaattaca tttaaaaatc atcctctcgt ttagaaggta
     2341 gaagggggaa agtcagcttt ctaaatgcta cttgagattg cagtaagaac atacgttttc
     2401 taacctgaaa gttgaaacaa atcatacttg ttctgtagac tgtgtctctc ttacctgttg
     2461 acgtcaggat tatctgttaa atatgtcaga aagacaaaat tacttttgtt gcatgtcatg
     2521 ggttactgtt cctgtatttg cagtggtgta aaagcttatt aaagttcttc ttttgctttg
     2581 acacagaaca atggcatcat ttggttttgt ttgaaattgt gataccaggt aactctaaat
     2641 ttatcccttg catttgcaac aaaagtattg tgtttcagtg ttctcacctc tagaaaaact
     2701 agttttcact agaaatgctc atcagaacac caaaaaactt ctttaatagg aataaggtgt
     2761 ataattgtct gctgtagaga aaagattgac ttaagagagg aaaacaagtg tggaaaaaaa
     2821 accacagaga aacagtggtt aaaaaatgaa tccaaagtgt acaggtgaac atgttcaaat
     2881 cacctttgag aaaaagaaac tgtcaaaatg gtaaaaataa taaaaataaa taaaaaaata
     2941 aaaataaa
//
